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Pregnancy Loss in Relation to the Risks of Female-Specific Cancers in a Population-Based Cohort and Mendelian Randomization Study — China, 2004–2017

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China CDC weekly 2023年第19期5卷 413-418,I0001,I0002页

作者： Yongle Zhan Yawen Wang Yimin Qu Lin Zhang Xuan Liu Ruiyi Liu Peng Xue Jiaxu Wang Dongxu Qin Hexin Yue Canqing Yu Jun Lyu Yu Guo Zhengming Chen Yu Jiang Liming Li China Kadoorie Biobank Collaborative Group Department of Epidemiology and Biostatistics School of Population Medicine and Public HealthChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Division of Urology Department of SurgeryLKS Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong Kong Special Administrative RegionChina Melbourne School of Population and Global Health The University of MelbourneVictoriaAustralia Centre of Cancer Research Victorian Comprehensive Cancer CentreMelbourneVictoriaAustralia Department of Epidemiology and Biostatistics School of Public HealthPeking University Health Science CenterBeijingChina fuwai hospital xishan branch court Chinese Academy of Medical SciencesBeijingChina Clinical Trial Service Unit&Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxfordUK.&Joint first authors 不详

Summary What is already known about this topic?Limited evidence exists regarding the relationship between pregnancy loss and female-specific cancers within the Chinese population from prospective cohort studies.What is added by this report?Terminations were associated with a 13%lower risk of endometrial cancer,whereas stillbirths were related to an 18%higher risk of cervical cancer.Rural residents with a history of pregnancy loss experienced a 19%and 38%increased risk of breast and cervical cancers,respectively,compared to their urban counterparts.Moreover,a positive graded relationship between live births and pregnancy loss on cervical cancer was observed.What are the implications for public health practice?This study has significant implications for identifying women at an increased risk for breast and genital cancers and contributes to the development of effective public health strategies for female cancer prevention.Future research on reproductive history,particularly in rural areas,should be given priority in efforts to improve female cancer screening and early detection.

关键词： Population Rural birth

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Characteristics, Management, and Outcomes of Acute Heart Failure in the Emergency Department： A Multicenter Registry Study with 1-year Follow-up in a Chinese Cohort in Beijing

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Chinese Medical Journal 2017年第16期130卷 1894-1901页

作者： Guo-Gan Wang Si-Jia Wang Jian Qin Chun-Sheng Li Xue-Zhong Yu Hong Shen Li-Pei Yang Yan Fu Ya-An Zheng Bin Zhao Dong-Min Yu Fu-Jun Qin De-Gui Zhou Ying Li Fu-Jun Liu Wei Li Wei Zhao Xin Gao Zheng Wang Ming Jin Hong Zeng Yi Li Guo-Xing Wang Hong Zhou Xiao-Lu Sun Peng-Bo Wang Kam-Sang Woo Emergency and Critical Center State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Emergency Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Emergency Xuanwu Hospital Capital Medical University Beijing 100053 China Department of Emergency Beijing Chao Yang Hospital Beijing 100020 China Department of Emergency Peking Union Medical College Hospital Beijing 100032 China Department of Emergency The General Hospital of Chinese People's Liberation Army Beijing 100853 China Department of Emergency Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Emergency Peking University Third Hospital Beijing 100083 China Department of Emergency Beijing Jishuitan Hospital Beijing 100035 China Department of Emergency Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Emergency Fangshan District Liangxiang Hospital Beijing 102400 China Department of Emergency The Hospital of Shunyi District Beijing 101300 China Department of Emergency People's Hospital of Beijing Daxing District Beijing 102600 China Department of Emergency The Luhe Teaching Hospital of the Capital Medical University Beijing 101100 China Medical Research and Biometrics Centre National Centre for Cardiovascular Diseases Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences Xishan Institute of Fuwai Hospital Beijing 102300 China Information Technology Centre Fuwai Hospital Beijing 100037 China Heart Center First Hospital of Tsinghua University Beijing 100016 China Department of Medicine and Th

Background： The emergency department （ED） has a pivotal influence on the management of acute heart failure （AHF）, but dataconcerning current ED management are scarce. This Beijing AHF Registry Study investigated the characteristics. ED management, and short- and long-term clinical outcomes of AHF. Methods： This prospective, multicenter, observational study consecutively enrolled 3335 AHF patients who visited 14 EDs in Beijing from January 1, 2011, to September 23, 2012. Baseline data on characteristics and management were collected in the EDs. Follow-up data on death and readmissions were collected until November 31, 2013, with a response rate of 92.80%. The data were reported as median （interquartile range） for the continuous variables, or as number （percentage） for the categorical variables. Results： The median age of the enrolled patients was 71 （58 79） years, and 46.84% wvere women. In patients with AHH coronary heart disease （43.27%） was the most common etiology, andmyocardium ischemia （30.22%） was the main precipitant. Most of the patients in the ED received intravenous treatments, including diuretics （79.28%） and vasodilators （74.90%）. Fewer patients in the ED received neurohormonal antagonists, and 25.94%, 31.12%, and 33.73% of patients received angiotensin converting enzyme inhibitors/angiotensin receptor blockers, beta-blockers, and spironolactone, respectively. The proportions of patients who were admitted, discharged, left against medical advice, and died were 55.53%, 33.58%, 7.08%, and 3.81%, respectively. All-cause mortalities at 30 days and 1 year were 15.30% and 32.27%, respectively. Conclusions： Substantial details on characteristics and ED management of AHF were investigated. The clinical outcomes of AHF patients were dismal. Thus, further investigations of ED-based therapeutic approaches for AHF are needed.

关键词： Acute Heart Failure Clinical Characteristics Clinical Outcomes Current Management Emergency Department

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