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magnetic resonance imaging combined with serum endolipin and galactagoglobin-3 to diagnose cerebral infarction in the elderly with diabetes mellitus

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World Journal of Diabetes 2024年第7期15卷 1509-1517页

作者： Yan-Hui Zhang Dong Liang magnetic resonance imaging Room Tianjin Huanhu HospitalTianjin 300350China Department of Endocrinology Tianjin First Central HospitalTianjin 300190China

BACKGROUND magnetic resonance imaging(MRI)combined with serum endothelin and galactagoglobin-3(Gal-3)can improve the clinical diagnosis of diabetes mellitus complicated with cerebral *** To analyze the clinical value of MRI combined with serum endolipin and Gal-3 for the diagnosis of cerebral infarction in the elderly with diabetes *** One hundred and fifty patients with acute cerebral infarction hospitalized between January 2021 and December 2023 were divided into two groups according to comorbid diabetes mellitus,including 62 and 88 cases in the diabetic and nondiabetic cerebral infarction *** samples were collected to detect the expression of serum endolipoxins,and Gal-3,and cranial MRI was performed at *** between the two groups were compared to analyze the diagnostic value of these *** Serum endolipin and Gal-3 expression were higher in the diabetic cerebral infarction group(P<0.05).The arterial wall area,vessel area,normalized wall index,and lumen stenosis rate were higher in the diabetic cerebral infarction group,while the rate of arterial lumen moderate and severe stenosis was 48.39% higher(36.36%,P<0.05).The percentage of large(29.03%)and multiple infarcts(33.87%)in the diabetic cerebral infarction group was higher(13.64% and 20.45%),and the incidence rate of lacunar infarcts was lower(37.10%vs 65.91%)(P<0.05).The total incidence of arterial plaque in patients in the diabetic cerebral infarction group was 96.77% higher(69.32%),while the incidence of necrotic lipid core plaque was 58.06%higher(26.14%)(P<0.05).Receiver operating characteristic curve analysis was performed to assess the diagnosis utility of these *** in combination with serum endoglin and Gal-3 had the highest area under the curve,the Yoden index,sensitivity and specificity(P<0.05).CONCLUSION The expression of serum endolipin and Gal-3 in elderly patients with diabetes mellitus with cerebral infarction showed an eleva

关键词： Endolipin Galectin-3 magnetic resonance imaging Elderly Diabetes mellitus Cerebral infarction

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Staging liver fibrosis with various diffusion-weighted magnetic resonance imaging models

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World Journal of Gastroenterology 2024年第9期30卷 1164-1176页

作者： Yan-Li Jiang Juan Li Peng-Fei Zhang Feng-Xian Fan Jie Zou Pin Yang Peng-Fei Wang Shao-Yu Wang Jing Zhang Department of magnetic resonance imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina Second Clinical School Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Gansu Province Clinical Research Center for functional and Molecular imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina Department of Hepatology The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina MR Scientific Marketing Siemens HealthineersXi’an 710065Shaanxi ProvinceChina

BACKGROUND Diffusion-weighted imaging(DWI)has been developed to stage liver ***,its diagnostic performance is inconsistent among ***,it is worth studying the diagnostic value of various diffusion models for liver fibrosis in one *** To evaluate the clinical potential of six diffusion-weighted models in liver fibrosis staging and compare their diagnostic *** This prospective study enrolled 59 patients suspected of liver disease and scheduled for liver biopsy and 17 healthy *** participants underwent multi-b value *** main DWI-derived parameters included Mono-apparent diffusion coefficient(ADC)from mono-exponential DWI,intravoxel incoherent motion model-derived true diffusion coefficient(IVIM-D),diffusion kurtosis imaging-derived apparent diffusivity(DKI-MD),stretched exponential model-derived distributed diffusion coefficient(SEM-DDC),fractional order calculus(FROC)model-derived diffusion coefficient(FROC-D)and FROC model-derived microstructural quantity(FROC-μ),and continuous-time random-walk(CTRW)model-derived anomalous diffusion coefficient(CTRW-D)and CTRW model-derived temporal diffusion heterogeneity index(CTRW-α).The correlations between DWI-derived parameters and fibrosis stages and the parameters’diagnostic efficacy in detecting significant fibrosis(SF)were assessed and *** CTRW-D(r=-0.356),CTRW-α(r=-0.297),DKI-MD(r=-0.297),FROC-D(r=-0.350),FROC-μ(r=-0.321),IVIM-D(r=-0.251),Mono-ADC(r=-0.362),and SEM-DDC(r=-0.263)were significantly correlated with fibrosis *** areas under the ROC curves(AUCs)of the combined index of the six models for distinguishing SF(0.697-0.747)were higher than each of the parameters alone(0.524-0.719).The DWI models’ability to detect SF was *** combined index of CTRW model parameters had the highest AUC(0.747).CONCLUSION The DWI models were similarly valuable in distinguishing SF in patients with liver *** combined index of CTRW paramet

关键词： Liver fibrosis magnetic resonance imaging Diffusion-weighted magnetic resonance Liver biopsy Significant fibrosis

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Detection of a temporal salient object benefits from visual stimulus-specific adaptation in avian midbrain inhibitory nucleus

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Integrative Zoology 2024年第2期19卷 288-306页

作者： Jiangtao WANG Xiaoping RAO Shuman HUANG Zhizhong WANG Xiaoke NIU Minjie ZHU Songwei WANG Li SHI Department of Automation Zhengzhou University School of Electrical EngineeringZhengzhouChina State Key Laboratory of magnetic resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in WuhanKey Laboratory of Magnetic Resonance in Biological SystemsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanChina Department of Automation Tsinghua UniversityBeijingChina

Food and predators are the most noteworthy objects for the basic survival of wild animals,and both are often deviant in both spatial and temporal domains and quickly attract an animal’s *** stimulus-specific adaptation(SSA)is considered a potential neural basis of salient sound detection in the temporal domain,related research on visual SSA is limited and its relationship with temporal saliency is *** avian nucleus isthmi pars magnocellularis(Imc),which is central to midbrain selective attention network,is an ideal site to investigate the neural correlate of visual SSA and detection of a salient object in the time ***,the constant order paradigm was applied to explore the visual SSA in the Imc of *** results showed that the firing rates of Imc neurons gradually decrease with repetitions of motion in the same direction,but recover when a motion in a deviant direction is presented,implying visual SSA to the direction of a moving ***,enhanced response for an object moving in other directions that were not presented ever in the paradigm is also *** verify the neural mechanism underlying these phenomena,we introduced a neural computation model involving a recoverable synaptic change with a“center-surround”pattern to reproduce the visual SSA and temporal saliency for the moving *** results suggest that the Imc produces visual SSA to motion direction,allowing temporal salient object detection,which may facilitate the detection of the sudden appearance of a predator.

关键词： adaptation attention model pigeon saliency

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Operando NMR methods for studying electrocatalysis

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magnetic resonance Letters 2024年第2期4卷 54-64页

作者： Zhiyu Zhu Ruipeng Luo Evan Wenbo Zhao magnetic resonance Research Center Institute for Molecules and MaterialsRadboud University6525 AJ Nijmegenthe Netherlands

The combination of electrochemical measurements with spectroscopic characterizations provides valuable insights into reaction *** magnetic resonance(NMR)spectroscopy,as a powerful technique due to its atomic specificity and versatility in studying gas,liquid,and solid,allows the study of electrolyte solution,catalyst and catalyst-adsorbate *** applied in operando,NMR can offer molecular-level insights into various electrochemical *** NMR has been applied extensively in battery research,but relatively underexplored for electrocatalysis in the past two *** this mini review,we first introduce the operando electrochemical NMR setups,categorized by different probe *** we review the applications of operando NMR for monitoring the electrolyte solution and the catalyst-adsorbate *** the high environmental impact of electrochemical conversion of CO_(2)into value-added products,we zoom in to the use of operando NMR in studying electrochemical CO_(2)***,we provide our perspective on further developing and applying operando NMR methods for understanding the complex reaction network of Cu-catalyzed electrochemical CO_(2)reduction.

关键词： Operando NMR In situ NMR EC-NMR Electrocatalysis Electrochemical CO_(2)reduction

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Aberrant Hippocampal Development in Early‑onset Mental Disorders and Promising Interventions:Evidence from a Translational Study

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Neuroscience Bulletin 2024年第6期40卷 683-694页

作者： Jingyu Yang Huiling Guo Aoling Cai Junjie Zheng Juan Liu Yao Xiao Sihua Ren Dandan Sun Jia Duan Tongtong Zhao Jingwei Tang Xizhe Zhang Rongxin Zhu Jie Wang Fei Wang Early Intervention Unit Department of PsychiatryAffiliated Nanjing Brain HospitalNanjing Medical UniversityNanjing 210029China School of Biomedical Engineering and Informatics NanjingMedical UniversityNanjing 211166China The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University Changzhou Second People’s HospitalChangzhou Medical CenterNanjing Medical UniversityChangzhou 213004China Department of Radiology First Hospital of China Medical UniversityShenyang 110002China Department of Cardiac Function The People’s Hospital of China Medical University and the People’s Hospital of Liaoning ProvinceShenyang 110067China Key Laboratory of magnetic resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhan 430064China Institute of Neuroscience and brain Diseases Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021China functional brain imaging Institute of Nanjing Medical University Nanjing 210029China

Early-onset mental disorders are associated with disrupted neurodevelopmental processes during *** methylazoxymethanol acetate(MAM)animal model,in which disruption in neurodevelopmental processes is induced,mimics the abnormal neurodevelopment associated with early-onset mental disorders from an etiological *** conducted longitudinal structural magnetic resonance imaging(MRI)scans during childhood,adolescence,and adulthood in MAM rats to identify specific brain regions and critical windows for ***,the effect of repetitive transcranial magnetic stimulation(rTMS)intervention on the target brain region during the critical window was *** addition,the efficacy of this intervention paradigm was tested in a group of adolescent patients with early-onset mental disorders(diagnosed with major depressive disorder or bipolar disorder)to evaluate its clinical translational *** results demonstrated that,compared to the control group,the MAM rats exhibited significantly lower striatal volume from childhood to adulthood(all P0.05)but was significantly lower than the control group from adolescence to adulthood(both P0.05).In the clinical trial,adolescents with early-onset mental disorders showed a significant increase in hippocampal volume after rTMS treatment compared to baseline(P<0.01),and these volumetric changes were associated with improvement in depressive symptoms(r=−0.524,P=0.018).These findings highlight the potential of targeting aberrant hippocampal development during adolescence as a viable intervent

关键词： Early-onset Mental disorder Neurodevelopment Animal model Hippocampus Repetitive transcranial magnetic stimulation

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Flexible reduced field of view magnetic resonance imaging based on single-shot spatiotemporally encoded technique

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Chinese Physics B 2015年第10期24卷 629-637页

作者：李敬蔡聪波陈林陈颖屈小波蔡淑惠 Department of Electronics Science Fujian Provincial Key Laboratory of Plasma and Magnetic ResonanceXiamen University Department of Communication Engineering Xiamen University Center for brain imaging Science and Technology Zhejiang University

In many ultrafast imaging applications, the reduced field-of-view（r FOV） technique is often used to enhance the spatial resolution and field inhomogeneity immunity of the images. The stationary-phase characteristic of the spatiotemporallyencoded（SPEN） method offers an inherent applicability to r FOV imaging. In this study, a flexible r FOV imaging method is presented and the superiority of the SPEN approach in r FOV imaging is demonstrated. The proposed method is validated with phantom and in vivo rat experiments, including cardiac imaging and contrast-enhanced perfusion imaging. For comparison, the echo planar imaging（EPI） experiments with orthogonal RF excitation are also performed. The results show that the signal-to-noise ratios of the images acquired by the proposed method can be higher than those obtained with the r FOV EPI. Moreover, the proposed method shows better performance in the cardiac imaging and perfusion imaging of rat kidney, and it can scan one or more regions of interest（ROIs） with high spatial resolution in a single shot. It might be a favorable solution to ultrafast imaging applications in cases with severe susceptibility heterogeneities, such as cardiac imaging and perfusion imaging. Furthermore, it might be promising in applications with separate ROIs, such as mammary and limb imaging.

关键词： magnetic resonance imaging spatiotemporal encoding single shot reduced field-of-view

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Dynamic Alterations in Spontaneous brain Activity in Mothers:A Resting-State functional magnetic resonance imaging Study

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Neuroscience Bulletin 2019年第4期35卷 766-770页

作者： Kaihua Zhang Mengxing Wang Jilei Zhang Junyao Xie Xueyun Su Xiaoxia Du Zhong Chen Fujian Provincial Key Laboratory of Plasma and magnetic resonance Department of Electronic Science Xiamen University Xiamen 361005 China Shanghai Key Laboratory of magnetic resonance and Department of Physics School of Physics and Materials Science East China Normal University Shanghai 200062 China Department of Special Education Faculty of Education East China Normal University Shanghai 200062 China

Becoming a mother is one of the most monumental experiences in a woman's lifetime. Women typically bear the primary caregiving responsibility for their infants, and they undergo numerous changes both mentally and physically, including behavioral, emotional, and hormonal changes, during the postpartum period. Studies have indicated that hormonal, experiential, and temporal factors significantly regulate emotional and cognitive brain functions during the postpartum period [1]. The determination of the neural basis of a maternal brain is critically important for understanding mother-infant attachments and thus perpetuating the human species. Until recently, limited investigations of the neuroanatomical and functional status of mothers have contributed to understanding the processing of maternal behaviors.

关键词： Dynamic Alterations Spontaneous brain Activity imaging Study

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Quantum age of vector magnetic field measurements

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 164-165页

作者： Min Jiang CAS Key Laboratory of Microscale magnetic resonance and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China

magnetic fields are ubiquitous,and precise measurements of them can serve as powerful tools for deep understanding and accurate detection across multiple disciplines,including physics,biology,and chemistry[1].For instance,by measuring the magnetic fields within the human heart and brain,the medical community could obtain accurate disease diagnoses.

关键词： magnetic Quantum precise

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brain structural plasticity in rats subjected to early binocular enucleation characterized by high resolution anatomical magnetic resonance imaging and diffusion tensor imaging

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magnetic resonance Letters 2023年第1期3卷 14-21,I0002页

作者： Xuxia Wang Fuchun Lin Yan Kang Hao Lei Center for brain Science State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanKey Laboratory of Magnetic Resonance in Biological SystemsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan430071China

Visual deprivation leads to structural neuroplasticity in the blind subjects,including gray matter(GM)and white matter(WM)atrophy and alterations in structural *** rat model of binocular enucleation(BE)is a frequently used animal model for studying brain plasticity induced by early *** few neuroimaging studies have been performed on this model to investigate whether or not the BE rats have image phenotypes similar to or comparable to,those observed in the early blind *** current study aimed to assess brain structural plasticity in BE rats using anatomical magnetic resonance imaging(MRI)and diffusion tensor imaging(DTI).The results demonstrated that early BE at postnatal day 4(P4)caused almost complete degeneration of optic nerve(ON)and optic chiasma(OCH),atrophy in a number of visual and non-visual structures,including optic tract(OT),dorsal lateral geniculate nucleus(DLG)and corpus callosum(CC).The BE rats also exhibited impairments of WM microstructural integrity in the OT,and reduction of structural connectivity between the normal-appearing visual cortex(VC)and somatosensory/motor cortices at 4 months of age,likely as manifestations of deafferentationinduced *** structural neuroplasticity in BE rats observable to structural MRI parallels largely with what has been reported in blind subjects,suggesting that longitudinal neuroimaging studies on animal models of sensory deprivation can provide insights into how the brain changes its wiring and function during development/adaption in response to the lack of sensory stimuli.

关键词： Blindness brain Structural plasticity MRI Rats

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A Non-canonical Excitatory PV RGC–PV SC Visual Pathway for Mediating the Looming-evoked Innate Defensive Response

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Neuroscience Bulletin 2024年第3期40卷 310-324页

作者： Man Yuan Sen Jin Gao Tan Siyuan Song Yizong Liu Huadong Wang Yin Shen Eye Center Renmin Hospital of Wuhan UniversityWuhan UniversityWuhan430060China The brain Cognition and brain Disease Institute Shenzhen Key Laboratory of Viral Vectors for BiomedicineShenzhen Institute of Advanced TechnologyChinese Academy of Sciences(CAS)Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsNational Medical Products Administration Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal ProductsShenzhen Key Laboratory of Quality Control Technology for Virus-Based TherapeuticsGuangdong Provincial Medical Products AdministrationShenzhen518055China Jan and Dan Duncan Neurological Research Institute Baylor College of MedicineHouston77030USA State Key Laboratory of magnetic resonance and Atomic and Molecular Physics Key Laboratory of Magnetic Resonance in Biological SystemsWuhan Center for Magnetic ResonanceInnovation Academy for Precision Measurement Science and TechnologyCASWuhan430071China Frontier Science Center of Immunology and Metabolism Medical Research InstituteWuhan UniversityWuhan430071China

Parvalbumin-positive retinal ganglion cells(PV+RGCs)are an essential subset of RGCs found in various ***,their role in transmitting visual information remains ***,we characterized PV+RGCs in the retina and explored the functions of the PV+RGC-mediated visual *** applying multiple viral tracing strategies,we investigated the downstream of PV+RGCs across the whole ***,we found that the PV+RGCs provided direct monosynaptic input to PV+excitatory neurons in the superficial layers of the superior colliculus(SC).Ablation or suppression of SC-projecting PV+RGCs abolished or severely impaired the flight response to looming visual stimuli in mice without affecting visual ***,using transcriptome expression profiling of individual cells and immunofluorescence colocalization for RGCs,we found that PV+RGCs are predominant glutamatergic ***,our findings indicate the critical role of PV+RGCs in an innate defensive response and suggest a non-canonical subcortical visual pathway from excitatory PV+RGCs to PV+SC neurons that regulates looming visual *** results provide a potential target for intervening and treating diseases related to this circuit,such as schizophrenia and autism.

关键词： Parvalbumin-positive retinal ganglion cell Innate fear Superior colliculus Excitatory-excitatory neuronal connection Looming-evoked defensive response Subcortical pathway

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