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Mechanisms of ultrasonic modulation of multiply scattered incoherent light based on diffusion theory

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Chinese Physics B 2015年第1期24卷 536-541页

作者：朱莉莉李晖 key laboratory of Optoelectronic Science and technology for Medicine of Ministry of Education Fujian Provincial Key Laboratory of Photonic Technology College of Photonic and Electronic Engineering Fujian Normal University

An analytic equation interpreting the intensity of ultrasound-modulated scattering light is derived, based on diffusion theory and previous explanations of the intensity modulation mechanism. Furthermore, an experiment of ultrasonic modulation of incoherent light in a scattering medium is developed. This analytical model agrees well with experimental results,which confirms the validity of the proposed intensity modulation mechanism. The model supplements the existing research on the ultrasonic modulation mechanism of scattering light.

关键词： ultrasound-modulated scattering light intensity modulation mechanism diffusion theory incoherent light

Characterizing UVB-induced skin tumor process using optical coherence tomography

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Journal of Innovative Optical Health Sciences 2016年第5期9卷 30-37页

作者： Shulian Wu Zheng Huang Yunxia Wang Hui Li key lab of OptoElectronic Science and technology for Medicine fujian provincial key lab of photonic technology College of photonic and Electronic Engineering fujian Normal University Fuzhou 350007 FujianP.R.China

The incidence of nonmelanoma skin cancer is rising *** major cardinogenic factor for most skin cancers is solar ultraviolet light,in particular,the chronic exposure to UVB(280-320nm).In this study,the optical characteristics of skin canceration process induced by UVB were *** coherence tomography(OCT)was used for monitoring the morphologic changes and compared with histological ***,the optical property,such as the attenuation cofficient(A4)was systematically extracted and *** addition,characteristic text ures,including energy,entropy and correlation were revealed from OCT *** suggest that OCT is a useful tool for monitoring the process of UVB-induced skin cancer and changes of optical property during this process.

关键词： Skin cancer UVB morphologic change attenuation coefficient texture

Scanning photoacoustic imaging of submucosal gastric tumor based on a long focused transducer in phantom and in vitro experiments

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Journal of Innovative Optical Health Sciences 2019年第3期12卷 55-66页

作者： Hua-Qin Wu Hao-Yu Wang Wen-Ming Xie Shu-Lian Wu Zhi-Fang Li Xiao-Man Zhang Hui Li key laboratory of Optoelectronic Science and technology for Medicine Ministry of Education fujian provincial key lab of photonic technology College of photonic and Electronic Engineering fujian Normal University Fuzhou 350007FujianP.R.China

Photoacoustic imaging,which can provide the maximum intensity contrast in tissue depth imaging without ionizing radiation,will be a promising imaging trend for tumor *** this paper,a column diffusionfiber was employed to carry a pulsed laser for irradiating stomach directly through esophagus based on the characteristics of gastric tissue structure.A long focused ultrasonic transducer was placed outside the body to detect photoacoustic signals of gastric *** and in vitro experiments of submucosal gastric tumors were carried out to check the sensitivity of scanning photoacoustic tomography system,including the lateral and longitudinal resolution of the system,sensitivity of different absorption coefficient in imaging,capability of transversal detection,and probability of longitudinal *** results demonstrate that our innovative technique can improve the parameters of *** lateral resolution reaches 2.09 *** a depth of 5.5mm with a longitudinal accuracy of 0.36mm below gastric mucosa of early gastric cancer(EGC)has been *** addition,the optimal absorption coefficient differences among absorbers of system are 3.3-3.9 *** indicate that our photoacoustic imaging(PAI)system,is based on a long focusing transducer,can provide a potential application for detecting submucosal EGC without obvious symptoms.

关键词： Column diffusionfiber long focusing transducer gastric tumor detection scanning photoacoustic tomography phantom experiment

Monitoring photo-thermal response and collagen remodeling of mouse skin with multiphoton microscopy

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Chinese Optics Letters 2010年第8期8卷 784-786页

作者：吴淑莲李晖章小曼 key laboratory of OptoElectronic Science and technology for Medicine Ministry of EducationFujian Provincial Key Laboratory of Photonic TechnologySchool of Physics and OptoElectronics TechnologyFujian Normal University

Two-photon excitation fluorescence （TPEF） and second-harmonic generation （SHG） are detected through multiphoton microscopy （MPM）. The major signals have the potential to monitor the process of tissue changes. TPEF and SHG are used to monitor the skin photo-thermal response to irradiation with intense pulsed light sources （A is in the range of 560-1200 nm） and trace the process of skin remodeling in vivo at different time intervals. TPEF intensity is nearly unchanged at different time intervals after irradiation, whereas SHG intensity changes considerably. The results reveal the photo-thermal effect of nonablative light sources and the process of collagen remodeling at the sub-micron level.

关键词： Collagen Irradiation Light sources

Diffractive beam parameters of LP_(01) mode of fiber

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Chinese Optics Letters 2009年第2期7卷 106-108页

作者：李连煌郭福源 key laboratory of Optoelectronic Science and technology for Medicine Ministry of Education of ChinaFujian Provincial Key Laboratory of Photonic Technology Institute of Laser and Optoelectronics TechnologyFujian Normal University

The diffractive beam parameters of LP01 mode of fiber are analyzed in detail. Based on solving linear equations, two formulas for two kinds of mode-field radii as functions of normalized frequency are presented, and relations between angular radius of far-field divergence, beam propagation factor, and normalized frequency are given. Numerical calculation indicates that the maximal relative error is smaller than 1% within a reasonable parameter range.

关键词： Optics

Gastroscopy-conjugated photoacoustic and ultrasonic dual-mode imaging for detection of submucosal gastric cancer:in vitro study

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Chinese Physics B 2020年第6期29卷 185-190页

作者： Huaqin Wu Haiyang Song Yudian Huang Zhifang Li Shulian Wu Xiaoman Zhang Hui Li College of photonic and Electronic Engineering Fujian Normal UniversityFujian Provincial Engineering Research Center for OptoElectronic Sensing TechnologyFujian Provincial Key Laboratory of Photonic TechnologyKey Laboratory of Optoelectronic Science and Technology for MedicineMinistry of EducationFuzhou 350007China Department of Pathology Fuzhou First Hospital Affiliated to Fujian Medical UniversityFuzhou 350009China

This paper presents photoacoustic and ultrasonic dual-mode imaging for real-time detection of submucosal gastric cancer with a combination of *** diagnostic capacity was directly addressed via several phantoms and ex vivo *** demonstrated that superficial and submucosal gastric cancer can be diagnosed with a perceptible depth of 6.33 mm,a lateral accuracy of 2.23 mm,and a longitudinal accuracy of 0.17 mm though capturing the morphology of angiogenesis,which is a main character of the therioma-related *** capability of gastroscopy-conjugated photoacoustic and ultrasonic dual-mode imaging system will own great potential in improving the clinical diagnostic rate of submucosal gastric cancer.

关键词： photoacoustic imaging intracavity pulsed laser irradiation extra abdominal receiving photoacoustic signal submucosal gastric cancer

On optics of human meridians

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Science China(Physics,Mechanics & Astronomy) 2009年第4期52卷 502-507页

作者： YANG HongQin XIE ShuSen LI Hui WANG YuHua Institute of Laser and Optoelectronics technology Fujian Provincial Key Laboratory of Photonic TechnologyKey Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of EducationFujian Normal UniversityFuzhou 350007China

A new concept and its methodology for studying human meridians are presented based on rigorous and scientific observation on the objective existence of human meridians in view of biomedical optics. According to this methodology,the infrared radiant characteristics of acupuncture meridians over human body and the optical transport properties of light propagating along the meridian are reported. This study,thus,confirms the existence of acupuncture meridians,sheds new light on an approach to investigation of human meridians and offers a new perspective in understanding the potential meridian functions such as energy and information transfer and physiological regulation.

关键词： fourteen meridians acupuncture points biomedical optics meridian optics

Optically noninvasive measurement of the light transport properties of human meridians

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Chinese Optics Letters 2008年第12期6卷 928-931页

作者：谢树森杨洪钦郭周义李晖刘颂豪 key laboratory of Optoelectronic Science and technology for Medicine of Ministry of Education fujian provincial key laboratory of photonic technology Institute of Laser and Optoelectronics TechnologyFujian Normal University laboratory of photonic Traditional Chinese Medicine and key laboratory of Laser Life Science of Ministry of Education South China Normal University

To confirm the existence and properties of human meridians, the optical transport properties along the pericardium meridian and tissues around the pericardium meridian are studied noninvasively on twenty healthy volunteers in vivo and then compared with each other. Our study shows that the light propagating along the meridian and non-meridian directions both conform to the Beer＇s exponential attenuation law. However, statistical analysis of the results suggests that the optical transport properties of human meridian differ from those of the surrounding tissues over a low modulated frequency range （P 〈 0.01）, and light attenuation along the pericardium meridian is significantly less than that along the non-meridian direction. These findings not only indicate the existence of acupuncture meridian from the point of view of biomedical optics, but also shed new light on an approach to investigation of human meridians.

关键词： Beverages Histology Light

A method based on the average granulometric size of speckle for characterizing the scattering media

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Optoelectronics Letters 2010年第5期6卷 376-379页

作者：李志芳李晖谢文明范玲玲 fujian provincial key laboratory of photonic technology and Key Laboratory of Optoelectronic Science and Technology for Medicine Ministry of Education School of Physics and Optoelectronics Technology Fujian Normal University

A method based on morphological granulometric analysis for the speckle image is presented to estimate the scattering coefficient of the scattering media. It is experimentally demonstrated that the average granulometric size, derived from the successive opening operations, is approximately in inverse proportion to the scattering coefficient of the sample in a broad illumination. Furthermore, a theoretical model based on the spatial correlation function of the back scattered intensity for the experimental phenomenon is reported. The analysis demonstrates that the explicit theoretical relationship between average granulometric size of speckle and scattering coefficient is established, and the theoretical prediction is consistent with the experimental result.

关键词：散射系数平均粒度表征方法斑点媒体空间相关函数后向散射强度实验现象