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Inhibition of the immunoproteasome LMP_(2) ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway

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Military medical Research 2022年第4期9卷 404-418页

作者： Xing-Yong Chen Shao-Fen Wan Nan-Nan Yao Ze-Jing Lin Yan-Guang Mao Xiao-Hua Yu Yin-Zhou Wang Department of Neurology Fujian Provincial HospitalShengli Clinical Medical College of Fujian Medical UniversityNo.134DongjieGulou DistrictFuzhou 350001China fujian academy of medical science Fuzhou 350o01China Key Testing Laboratory of fujian Province Fuzhou 350001China.

Background:Disruption of the blood–brain barrier(BBB)after a stroke can lead to brain injury and neurological *** work confirmed the involvement of the immunoproteasome subunit of low molecular mass peptide 2(LMP2)in the pathophysiology of ischemia ***,the relationship between the immunoproteasome LMP2 and the BBB remains ***:Adult male Sprague–Dawley rats were subjected to transient middle cerebral artery occlusion/reperfusion(MCAO/R).Three days before MCAO,the rats were treated with lentivirus-mediated LMP2 shRNA preparations by stereotactical injection into the ipsilateral hemispheric *** rat brain microvascular endothelial cell(RBMVEC)line was exposed to oxygen–glucose deprivation/reperfusion(OGD/R)to mimic ischemic conditions in *** RNA interference-mediated knockdown of LMP2 orβ-catenin was analysed in vivo and in *** of the quantity of extravasated Evans blue(EB)and cerebral fluorescent angiography were performed to evaluate the integrity of the *** and Western blotting were employed to detect the expression of target *** migration was evaluated using a scratch migration *** results of immunofluorescence,Western blotting and cell migration were quantified using the software ImageJ(Version 1.53).Parametric data from different groups were compared using one-way ANOVA followed by the least significant difference(LSD)***:Cerebral ischemia led to lower levels of structural components of the BBB such as tight junction proteins[occludin,claudin-1 and zonula occludens(ZO-1)]in the MCAO/R group compared with the sham group(P<0.001).However,inhibition of the immunoproteasome LMP2 restored the expression of these proteins,resulting in higher levels of occludin,claudin-1 and ZO-1 in the LMP2-shRNA group compared with the control-shRNA group(P<0.001).In addition,inhibition of the immunoproteasome LMP2 contributed to higher microvascular density and decreased BBB perm

关键词： Immunoproteasome Blood–brain barrier Wnt/β-catenin pathway Oxygen–glucose deprivation/reperfusion Cerebral ischemia

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Hydrogen Bond Networks' QSAR and Topologica Analysis of Konjac Glucomannan Chains

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Chinese Journal of Structural Chemistry 2014年第3期33卷 480-489页

作者：庞杰马真沈本澍许庆金孙中琦傅丽群方文瑜温成荣 College of Food science Fujian Agriculture and Forestry University fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Based on the knot theory and researching of network structures of glucomannan molecules, the polysaccharides were analyzed. The link prediction analysis is to further reveal the interactions between polysaccharides, to elaborate QSAR of polysaccharides, and to analyze the network conformation relationships among polysaccharides. We made a classification for glucomannan molecules based on the related domestic and international theories, and investigated their network structures and application prospects. The knot theory and the link predictions not only simplify the glucomannan microscopic descriptions but also play a guiding role in predicting and regulating the structures.

关键词： Konjac Glucomannan (KGM) hydrogen bond network QSAR link prediction knot theory

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Enhanced selectivity of catalytic hydrogenation of halogenated nitroaromatics by interfacial effects

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无机化学学报 2025年第1期41卷 201-212页

作者： HUANG Rui LIU Shengjie WU Qingyuan ZHENG Nanfeng New Cornerstone science Laboratory State Key Laboratory for Physical Chemistry of Solid SurfacesCollaborative Innovation Center of Chemistry for Energy MaterialsNational&Local Joint Engineering Research Center of Preparation Technology of NanomaterialsCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujian 361005China Innovation Laboratory for sciences and Technologies of Energy Materials of fujian Province(IKKEM) XiamenFujian 361002China

The highly selective catalytic hydrogenation of halogenated nitroaromatics was achieved by employing Pd‑based catalysts that were co‑modified with organic and inorganic *** was demonstrated that the catalysts contained Pd species in mixed valence states,with high valence Pd at the metal‑support interface and zero valence Pd at the metal *** the strong coordination of triphenylphosphine(PPh3)to Pd0 on the Pd surface prevents the adsorption of halogenated nitroaromatics and thus dehalogenation,the coordination of sodium metavanadate(NaVO3)to high‑valence Pd sites at the interface helps to activate H2 in a heterolytic pathway for the selective hydrogenation of nitro‑*** excellent catalytic performance of the interfacial active sites enables the selective hydrogenation of a wide range of halogenated nitroaromatics.

关键词： halogenated nitroaromatic heterogeneous catalysis hydrogenation selectivity control interfacial effect

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Wavelength dependence of soft tissue ablation by using pulsed lasers

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Chinese Optics Letters 2007年第4期5卷 235-237页

作者：张先增谢树森叶青詹振林 Key Laboratory of Optoelectronic science and Technology for Medicine of Ministry of Education fujian Normal University fujian medical University

Pulsed laser ablation of soft biological tissue was studied at 10.6-, 2.94-, and 2.08-μm wavelengths. The ablation effects were assessed by means of optical microscope, the ablation crater depths were measured with reading microscope. It was shown that Er：YAG laser produced the highest quality ablation with clear, sharp cuts following closely the spatial contour of the incident beam and the lowest fluence threshold. The pulsed CO2 laser presented the moderate quality ablation with the highest ablation efficiency. The craters drilled with Ho：YAG laser were generally larger than the incident laser beam spot, irregular in shape, and clearly dependent on the local morphology of biotissue. The ablation characteristics, including fluence threshold and ablation efficiency, varied substantially with wavelength. It is not evident that water is the only dominant chromophore in tissue.

关键词： Chromophores Laser ablation Laser beams Laser pulses Morphology Optical microscopy Tissue

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Changes in source contributions to the oxidative potential of PM_(2.5)in urban Xiamen,China

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Journal of Environmental sciences 2025年第3期149卷 342-357页

作者： Jia-Min Li Si-Min Zhao Qi-Yu Miao Shui-Ping Wu Jie Zhang James J.Schwab fujian Provincial Key Laboratory for Coastal Ecology and Environmental Studies Xiamen UniversityXiamen 361102China Center for Marine Environmental Chemistry and Toxicology College of Environment and EcologyXiamen UniversityXiamen 361102China Atmospheric sciences Research Center University at AlbanySUNYAlbany 12226USA

The toxicity of PM_(2.5)does not necessarily change synchronously with its mass *** this study,the chemical composition(carbonaceous species,water-soluble ions,and metals)and oxidative potential(dithiothreitol assay,DTT)of PM_(2.5)were investigated in 2017/2018 and 2022 in Xiamen,*** decrease rate of volume-normalized DTT(DTTv)(38%)was lower than that of PM_(2.5)(55%)between the two sampling ***,the mass-normalized DTT(DTTm)increased by 44%.Clear seasonal patterns with higher levels in winter were found for PM_(2.5),most chemical constituents and DTTv but not for *** large decrease in DTT activity(84%−92%)after the addition of EDTA suggested that watersoluble metals were the main contributors to DTT in *** increased gap between the reconstructed and measured DTTv and the stronger correlations between the reconstructed/measured DTT ratio and carbonaceous species in 2022were *** decrease rates of the hazard index(32.5%)and lifetime cancer risk(9.1%)differed from those of PM_(2.5)and DTTv due to their different main *** PMF-MLR model showed that the contributions(nmol/(min·m^(3)))of vehicle emission,coal+biomass burning,ship emission and secondary aerosol to DTTv in 2022 decreased by 63.0%,65.2%,66.5%,and 22.2%,respectively,compared to those in 2017/2018,which was consistent with the emission reduction of vehicle exhaust and coal consumption,the adoption of low-sulfur fuel oil used on board ships and the reduced production of ***,the contributions of dust+sea salt and industrial emission increased.

关键词： Chemical composition Oxidative potential Interannual change PMF-MLR Source apportionment

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Covalent organic frameworks derived hollow structured N-doped noble carbon for asymmetric-electrolyte Zn-air battery

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science China Chemistry 2019年第3期62卷 385-392页

作者： Pingwei Cai Xinxin Peng Junheng Huang Jingchun Jia Xiang Hu Zhenhai Wen CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Provincial Key Laboratory of Nanomaterials Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese academy of science

We report a relatively low-temperature molten salt strategy to prepare hollow structured N-doped noble carbon(h-NNC) with highly desirable features of ultra-large surface area(1957 m^2 g^(-1)) and high graphitization, endowing the h-NNC with high activity toward catalysis of oxygen reduction reaction in acidic medium. The h-NNC is applied as cathode catalyst of an asymmetrical-electrolyte Zn-air battery, which exhibits an open circuit voltage of 2.11 V, a power density up to 270 mW cm^(-2),and an energy density of 1279 W h kg^(-1), behaving advantages over the conventional Zn-air batteries.

关键词： noble carbon oxygen reduction reaction asymmetric-electrolyte Zn-air battery energy density

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Wide Pulse Width Electroacupuncture Ameliorates Denervation-Induced Skeletal Muscle Atrophy in Rats via IGF-1/PI3K/Akt Pathway

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Chinese Journal of Integrative Medicine 2021年第6期27卷 446-454页

作者： HUANG Xiao-qing XU Jin-sen YE Xiao-ran CHEN Xuan Key Laboratory of Acupuncture Instrument Fujian Academy of Chinese Medical SciencesFuzhou(350003)China fujian Key Laboratory of Propagated Sensation along Meridian Institute of Meridians and Collaterals MedicineFujian Academy of Chinese Medical SciencesFuzhou(350003)China

Objective:To evaluate the effect of the pulse width of electroacupuncture(EA)in the treatment of denervation-induced skeletal muscle atrophy in rats and examine the role of insulin-like growth factor 1(IGF-1)/phosphatidylinositol 3-kinase(PI3 K)/Akt signaling pathway during ***:Sciatic nerve functional index(SFI),muscle wet weight and the cross-sectional area(CSA)of the gastrocnemius muscle were analyzed after treatment in model rats with EA of various pulse widths(0.5,50,100 and 200 ms).The apoptosis index(AI)and paired box(PAX)3 and PAX7 protein expression were also ***,the mRNA and protein expressions of components of IGF-1/PI3 K/Akt pathway and their downstream targets were determined,along with the inhibiting effect of the pathway with a PI3-specific ***:EA with a pulse width of 200 ms was found to have the best effect with regard to increasing SFI,CSA and muscle weight,decreasing AI,and increasing the expression of PAX3 and *** IGF-1/PI3 K/Akt pathway was found to be activated by denervation,although the downstream forkhead box O(FoxO)pathway was not suppressed by its *** PI3 K/Akt pathway and its downstream molecule mammalian target of rapamycin(mTOR)were up-regulated further by EA to promote muscle protein ***,the expressions of downstream FoxO and F-box protein 32(ATROGIN-1)were down-regulated to reduce protein ***:EA with 200-ms pulse width was found to have a more significant effect than 0.5-ms *** positive effects of EA disappeared after inhibition of the PI3 K/Akt pathway.

关键词： denervation muscle atrophy electroacupuncture pulse width IGF-1/PI3K/Akt pathway

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A Corrugated 2D Mn(Ⅱ) Network:[Mn_3(μ-oxalate)_3(μ-4,4'-bpy)_2(4,4'-bpy)_2]_n

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Chinese Journal of Structural Chemistry 2006年第7期25卷 873-877页

作者： YANG E WANG Xiao-Qin CHEN Shun-Yu College of Chemistry ＆ Materials science Fujian Normal University Fuzhou 350007 China fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China

The title complex, [Mn3（μ-oxalate）3（μ-4,4′-bpy）2（4,4′-bpy）2]n, was synthesized and structurally characterized by X-ray crystallography. It crystallizes in the monoclinic, space group P2 1/c with a = 16.3222（6）, b = 16.2594（5）, c = 16.4885（5） A, β = 94.9900（10）°, V= 4359.3（2） A^3, Z = 4, Mn3C46N8O12H32, Mr = 1053.62, Dc = 1.605 g/cm^3, F（000） = 2140 and μ（MoKa） = 0.932 mm^-1. The structure was refined to R = 0.0578 and wR = 0.1061 for 4795 observed reflections （I 〉 2σ（I））. The oxalate anions behave as the bridging ligand and link two manganese atoms repeatedly to form infinite one-dimensional chains which further extend into a two-dimensional network by bridging 4,4′-bpy ligands.

关键词： crystal structure one-dimensional chain two-dimensional layer bridging 4,4′-bpy ligands terminal 4,4′-bp)- ligands

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Enhancing low-temperature performance and suppressing cathode dissolution in aqueous zinc-ion batteries:local structure and electrochemical crosstalk control of V2O5

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science China Materials 2025年第2期68卷 503-514页

作者： Jun-Peng Wang Jia Liu Fu-Da Yu Lan-Fang Que Ming-Chun Li Can-Zhong Lu Yiming Xie Engineering Research Center of Environment-Friendly Functional Materials Ministry of EducationInstitute of Materials Physical ChemistryHuaqiao UniversityXiamen 361021China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen 361021China CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese academy of sciences Beijing 100049China

Achieving an in-depth understanding of the nexus between temperature and phase transitions is paramount for advancing the electrochemical efficiency of aqueous zinc ion ***,the intricacies of electrochemical interactions,particularly those associated with the structural evolution over extended periods,remain *** this research,we leverage V_(2)O_(5) as an initial structural model of crystals to demystify the kinetics of electrode reactions and the decay mechanism of global electrochemical degradation by meticulously controlling the crystal defects via applying different mechanical grounding *** is noted that the grounding V_(2)O_(5)(GVO)can exhibit a stable crystal structure that suppresses the dissolution/shuttling of vanadium and mitigates Zn anodes by-products caused by electrochemical ***,the GVO is utilized as the cathode material,achieving excellent Zn storage capacity at both room temperature and low temperatures,e.g.,380 and 246 mA h g^(−1) at room temperature and−20℃,***,the GVO cathode retains a specific capacity of 160 mA h g^(−1) with a capacity retention rate of 99%after 1500 cycles at−20℃ and 1 A g^(−1).This work provides a novel insight into the electrochemical crosstalk behavior of aqueous zinc-ion batteries(AZIBs)in a wide range of temperatures.

关键词： aqueous Zn-ion batteries Zn3(OH)_(2)V2O7·2H_(2)O room-/low-temperature performance mechanochemical reactions vanadium dissolution

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Longitudinal Associations between Vitamin D Status and Systemic Inflammation Markers among Early Adolescents

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Biomedical and Environmental sciences 2025年第1期38卷 94-99页

作者： Ting Tang Xinhui Wang Xue Wen Min Li Mengyuan Yuan Yonghan Li Xiaoqin Zhong Fangbiao Tao Puyu Su Xihua Yu Gengfu Wang Department of Maternal Child and Adolescent HealthSchool of Public HealthAnhui Medical UniversityHefei 230032AnhuiChina Xiamen Key Laboratory of Maternal and Fetal Health&Nutrition Products Xiamen 361000FujianChina Key Laboratory of Population Health Across Life Cycle(Anhui medical University) Ministry of Education of the People’s Republic of ChinaHefei 230032AnhuiChina Anhui Provincial Key Laboratory of Population Health and Aristogenics Hefei 230032AnhuiChina

Vitamin D deficiency(VDD)has emerged as a major nutritional problem among children and *** studies have documented the adverse health effects of VDD,including conditions such as chronic kidney diseases,hypoparathyroidism,and autoimmune ***,these studies were conducted only in adults and among individuals with underlying medical *** is at a unique stage of growth,where nutritional deficiencies may have profound implications on their future ***,there is an urgent need to conduct research on the impact of vitamin D deficiency on adolescent health.

关键词： vitamin Marker among

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