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Miniaturization of a coherent monocular structured illumination system for future combination with digital holography

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Light(Advanced Manufacturing) 2022年第3期3卷 160-167页

作者： Andreas Walter Stark Eugene Wong Holger Babovsky Christian Franke Richard Kowarschik Institute of Applied Optics and Biophysics Friedrich Schiller University Jena07743 JenaGermany university Hospital 07743 JenaGermany

Holographic and 3D-measurement processes are an often-used tool in industry,medicine,and scientific *** small deviations of objects can be visualized by holographic means with high accuracy,optical systems with active structured illumination are a reliable source of absolute 3D-information in these *** combination of digital holography with structured illumination allows to simultaneously measure deformations and absolute 3D coordinates but also requires coherent light and has already been demonstrated in principle with a stereo camera ***-camera systems are limited to certain setup sizes given by the volume and distance of the *** the system to a one-camera(monocular)setup reduces space and acquisition *** using a multi-aperture illumination source an extremely high projection rate could be realized and reduced to a monocular approach with a novel voxel-calibration technique,while the projection system itself still requires a large amount of *** this paper we present a miniaturized,monocular 3D-measurement system that works with repeatable,coherent speckles,generated by a fiber-coupled laser whose light was distributed by a fiber-switch to a diffuser plate connected with a measurement-head,also including a *** addressing different fibers through the switch,varying but repeatable patterns are *** size of the device(diameterted by the volume of the camera.A first 3D-reconstruction of an object and an outlook for a combination of this system with digital holography is given,allowing absolute 3D-coordinates and relative deviations of object points to be measured simultaneously.

关键词： 3D-measurement Structured illumination Speckle projection Monocular 3D-measurement Combination 3D-measurment and holography

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Biofilms and exopolysaccharides in Pseudomonas aeruginosa:pathogenesis,immune evasion,and lung–brain signaling during pneumonia

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Signal transduction and targeted therapy 2024年第9期9卷 3550-3551页

作者： Shuaibing Zhang Pierre Stallforth Department of Paleobiotechnology Leibniz Institute for Natural Product Research and Infection Biology–Hans Knöll InstituteBeutenbergstraße 11aD-07745 JenaGermany Institute for Organic Chemistry and Macromolecular Chemistry Friedrich Schiller University JenaHumboldtstraße 10D-07743 JenaGermany Cluster of Excellence Balance of the Microverse Friedrich Schiller University JenaFürstengraben 1D-07743 JenaGermany

A recent study by Granton et *** Cell investigates the role of exopolysaccharide(EPS)in Pseudomonas aeruginosa’s biofilm formation,immune evasion,and lung–brain signaling during pneumonia.1 this research significantly advances our understanding of how ***’s biofilms influence disease symptoms and suggests potential therapeutic strategies targeting the lung–brain axis to improve clinical outcomes in pneumonia *** before the COVID-19 pandemic,social distancing from individuals suffering from severe respiratory tract infections has been an effective strategy to limit the transmission of airborne diseases.2 In their work,Granton et *** the specific mechanisms by which the bacterium *** triggers symptoms of sickness in individuals suffering from *** these mechanisms is vital as they directly influence the spread of the *** strains causing less noticeable sickness may result in symptoms undetected by others,eventually enhancing the transmission of the pathogen.

关键词： pneumonia lung

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Exchange-correlation functionals for band gaps of solids:benchmark,reparametrization and machine learning

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npj Computational Materials 2020年第1期6卷 869-885页

作者： Pedro Borlido Jonathan Schmidt Ahmad W.Huran Fabien tran Miguel A.L.Marques Silvana Botti Institut für Festkörpertheorie und-optik Friedrich-Schiller-Universität Jena and European Theoretical Spectroscopy FacilityMax-Wien-Platz 107743 JenaGermany Institut für Physik Martin-Luther-Universität Halle-Wittenberg06099 HalleGermany Institute of Materials Chemistry Vienna University of TechnologyGetreidemarkt 9/165-TC1060 ViennaAustria

We conducted a large-scale density-functional theory study on the influence of the exchange-correlation functional in the calculation of electronic band gaps of ***,we use the large materials data set that we have recently proposed to benchmark 21 different functionals,with a particular focus on approximations of the meta-generalized-gradient *** these data with the results for 12 functionals in our previous work,we can analyze in detail the characteristics of each approximation and identify its strong and/or weak *** confirming that mBJ,HLE16 and HSE06 are the most accurate functionals for band gap calculations,we reveal several other interesting functionals,chief among which are the local Slater potential approximation,the GGA AK13LDA,and the meta-GGAs HLE17 and *** also compare the computational efficiency of these different *** on these data,we investigate the potential for improvement of a promising subset of functionals by varying their internal *** identified optimal parameters yield a family of functionals fitted for the calculation of band ***,we demonstrate how to train machine learning models for accurate band gap prediction,using as input structural and composition data,as well as approximate band gaps obtained from density-functional theory.

关键词： theory functionals solids

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Yb-doped large-pitch fibres: effective single-mode operation based on higher-order mode delocalisation

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Light(Science & Applications) 2012年第1期1卷 118-122页

作者： Jens Limpert Fabian Stutzki Florian Jansen Hans-Jurgen Otto tino Eidam Cesar Jauregui Andreas tunnermann Institute of Applied Physics Abbe Center of PhotonicsFriedrich-Schiller-Universitat Jena07745 JenaGermany Helmholtz Institute jena 07743 JenaGermany Fraunhofer Institute for Applied Optics and Precision Engineering 07745 JenaGermany

Rare earth-doped fibres are a diode-pumped,solid-state laser architecture that is highly scalable in average *** performance of pulsed fibre laser systems is restricted due to nonlinear ***,fibre designs that allow for very large mode areas at high average powers with diffraction-limited beam quality are of enormous ***-doped,rod-type,large-pitch fibres(LPF)enable extreme fibre dimensions,i.e.,effective single-mode fibres with mode sizes exceeding 100 times the wavelength of the guided radiation,by exploiting the novel concept of delocalisation of higher-order transverse *** non-resonant nature of the operating principle makes LPF suitable for high power *** design allows for an unparalleled level of performance in pulsed fibre lasers.

关键词： higher-order mode delocalisation high-power fibre lasers and amplifiers photonic-crystal fibre very large mode area

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Inner-shell ionization cross sections of atoms by positron impact

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Communications in theoretical Physics 2024年第6期76卷 142-147页

作者： Yuan-Cheng Wang Jia Ma Li-Guang Jiao Stephan Fritzsche College of Physical Science and technology Shenyang Normal UniversityShenyang 110034China Helmholtz-Institut jena D-07743 JenaGermany GSI Helmholtzzentrum für Schwerionenforschung GmbH D-64291 DarmstadtGermany College of Science Shenyang Aerospace UniversityShenyang 110136China College of Physics Jilin UniversityChangchun 130012China theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena07743 JenaGermany

the relativistic binary-encounter-Bethe model with Wannier-type threshold law is employed to obtain the inner-shell ionization cross sections of multi-electron atoms(Ni,Cu,Y,Ag,Au,Yb,ta,and Pb)for positron impact energies from the thresholds up to 105ke *** is good agreement between the present calculations and the experimental *** constant in the acceleration term derived from the Wannier law is determined to be 0.2 and 0.5 for the K-and L-shells,respectively.

关键词： positron scattering ionization cross section binary-encounter-Bethe model

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Stroke-like onset of brain stem degeneration presents with unique MRI sign and heterozygous NMNAt2 variant:a case report

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translational Neurodegeneration 2016年第1期5卷 181-185页

作者： Alexander Schulz Franziska Wagner Martin Ungelenk Ingo Kurth Christoph Redecker Hans Berger Department of Neurology Jena University HospitalFriedrich Schiller University JenaJena 07747Germany Department of Genetics and Program in Cellular Neuroscience Neurodegeneration and RepairYale University School of MedicineNew HavenCT 06510USA Institute of Human Genetics Jena University HospitalFriedrich-Schiller-University JenaJena 07743Germany Institute of Human Genetics Uniklinik RWTH AachenAachen 52074Germany

Background:Acute-onset neurodegenerative diseases in older patients are rare clinical cases,especially when the degeneration only affects specific regions of the nervous *** neurological disorders have been described in which the degeneration of brain parenchyma originates from and/or primarily affects the brain *** diagnosis in these patients,however,is often complicated due to a poor understanding of these diseases and their underlying *** presentation:In this manuscript we report on a 73-year-old female who had experienced a sudden onset of complex neurological symptoms that progressively worsened over a period of 2 *** evaluation had suggested a MRI-negative stroke as underlying *** combination of patient’s medical history,clinical examination and exceptional pattern of brain stem degeneration presenting as“kissing swan sign”in MR imaging was strongly suggestive of acute onset of Alexander’s *** leukoencephalopathy is caused by GFAP(glial fibrilary acidic protein)gene mutations and may present with brain stem atrophy and stroke-like onset of symptoms in elderly ***,a pathognomonic GFAP gene mutation could not be identified by Sanger ***:After an extended differential diagnosis and exclusion of other diseases,a definite diagnosis of the patient’s condition presently remains ***,whole-exome sequencing performed from patient’s blood revealed 12 potentially disease-causative heterozygous variants,amongst which several have been associated with neurological disorders in vitro and in vivo–in particular the axon degeneration-related NMNAt2 gene.

关键词： Brain stem atrophy Dementia Alexander’s disease Whole-exome sequencing Kissing swan sign NMNAt2 Axon degeneration

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A novel integrated quantum circuit for high-order W-state generation and its highly precise characterization

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Science Bulletin 2015年第1期60卷 96-100页

作者： Ren Heilmann Markus Gra¨ fe Stefan Nolte Alexander Szameit Institute of Applied Physics Abbe Center of PhotonicsFriedrich-Schiller-Universitt Jena Max-Wien-Platz 107743 Jena Germany

Multipartite entangled states like the W-class are of growing interest since they exhibit a variety of possible applications ranging from quantum computation to genuine random number generation. Here, we present a universal setup to generate high-order single photon W-states based on three-dimensional integrated-photonic waveguide struc- tures. Additionally, we present a novel method to charac- terize the device＇s unitary by means of classical light only.

关键词： Quantum information - Integrated optics Quantum computing Entangled states

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Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos J.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

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Unboundedness properties of smoothness Morrey spaces of regular distributions on domains

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Science China Mathematics 2017年第12期60卷 2349-2376页

作者： HAROSKE Dorothee D. MOURA Susana D. SCHNEIDER Cornelia SKRZYPCZAK Leszek Institute of Mathematics Friedrich Schiller University Jena CMUC Department of Mathematics University of Coimbra Mathematics Department Friedrich-Alexander University Erlangen-Nremberg Faculty of Mathematics and Computer Science Adam Mickiewicz University

We study unboundedness of smoothness Morrey spaces on bounded domains ? ? R^n in terms of growth envelopes. It turns out that in this situation the growth envelope function is finite—in contrast to the results obtained by Haroske et al.(2016) for corresponding spaces defined on R^n. A similar effect was already observed by Haroske et al.(2017), where classical Morrey spaces M_(u,p)(?) were investigated. We deal with all cases where the concept is reasonable and also include the tricky limiting cases. Our results can be reformulated in terms of optimal embeddings into the scale of Lorentz spaces L_(p,q)(?).

关键词： Morrey spaces Besov spaces triebel-Lizorkin spaces growth envelopes atomic decompositions inequalities

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Multimodal nonlinear endomicroscopic imaging probe using a double-core double-clad fiber and focus-combining micro-optical concept

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Light(Science & Applications) 2021年第11期10卷 2173-2183页

作者： Ekaterina Pshenay-Severin Hyeonsoo Bae Karl Reichwald Gregor Matz Jörg Bierlich Jens Kobelke Adrian Lorenz Anka Schwuchow tobias Meyer-Zedler Michael Schmitt Bernhard Messerschmidt Juergen Popp GRINtECH GmbH Schillerstr.107745JenaGermany Leibniz Institute of Photonic technology Member of Leibniz Health TechnologiesAlbert-Einstein-Str.907745JenaGermany Institute of Physical Chemistry and Abbe Center of Photonics Friedrich Schiller University JenaHelmholtzweg 407743JenaGermany

Multimodal non-linear microscopy combining coherent anti-Stokes Raman scattering,second harmonic generation,and two-photon excited fluorescence has proved to be a versatile and powerful tool enabling the label-free investigation of tissue structure,molecular composition,and correlation with function and disease *** a routine medical application,the implementation of this approach into an in vivo imaging endoscope is ***,this is a difficult task due to the requirements of a multicolour ultrashort laser delivery from a compact and robust laser source through a fiber with low losses and temporal synchronization,the efficient signal collection in epi-direction,the need for small-diameter but highly corrected endomicroobjectives of high numerical aperture and compact ***,we introduce an ultra-compact fiber-scanning endoscope platform for multimodal non-linear endomicroscopy in combination with a compact four-wave mixing based fiber *** heart of this fiber-scanning endoscope is an in-house custom-designed,single mode,double clad,double core pure silica fiber in combination with a 2.4 mm diameter NIR-dual-waveband corrected endomicroscopic objective of 0.55 numerical aperture and 180µm field of view for non-linear imaging,allowing a background free,low-loss,high peak power laser delivery,and an efficient signal collection in backward direction.A linear diffractive optical grating overlays pump and Stokes laser foci across the full field of view,such that diffraction-limited performance is demonstrated for tissue imaging at one frame per second with sub-micron spatial resolution and at a high transmission of 65%from the laser to the specimen using a distal resonant fiber scanner.

关键词： fiber double scanner

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