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Signal Transduction and Targeted Therapy 2024年第8期9卷 3153-3154页

作者： Edda S.F.Matthees Carsten Hoffmann Institut fur Molekulare Zellbiologie CMB-Center for Molecular BiomedicineUniversitatsklinikum JenaHans-Knoll StraBe 2D-07745 JenaGermany friedrich-schiller-Universitat jena Hans-KnollStraBe2D-07745 JenaGermany

In a recent paper published in Nature,the relatively understudied Ca^(2+)-sensing,receptor(CasR)within the Gprotein-coupled receptor(GPCR)family C,gained attention due to pioneering research led by Georgios Skiniotis ... 详细信息

关键词： Stanford gained Skin

Prosaposin hyperglycosylation: a novel tumor immune escape mechanism and implications for cancer immunotherapy

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3150-3152页

作者： Matthias Peipp Diana Dudziak Christian Kellner Division of Antibody-Based Immunotherapy Department of Medicine IChristian-Albrechts University and University Hospital Schleswig-HolsteinKielGermany institute of Immunology Jena University HospitalFriedrich-Schiller-UniversityJenaGermany Comprehensive Cancer Center Central Germany jena/Leipzig JenaGermany Division of Transfusion Medicine Cell Therapeutics and HaemostaseologyLMU University HospitalLMU MunichMunichGermany

In a recent article published in Science,Sharma et *** the essential role of saposins in cross-presentation of tumor membraneassociated antigens by dendritic cells(DC)to CD8^(+)T cells.1 However,antigen cross-presentation,which is fundamental in cancer cell elimination,is hindered in tumor DC by hyperglycosylation of the common saposin precursor prosaposin(pSAP)leading to impaired T cell tumor immunity-yet,the potential of recombinant pSAP to re-establish T cell responses may offer a novel way to counteract immune evasion in a therapeutic approach.

关键词： impaired immunity al.

Inner-shell ionization cross sections of atoms by positron impact

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Communications in Theoretical Physics 2024年第6期76卷 142-147页

作者： Yuan-Cheng Wang Jia Ma Li-Guang Jiao Stephan Fritzsche College of Physical Science and Technology Shenyang Normal UniversityShenyang 110034China Helmholtz-Institut jena D-07743 JenaGermany GSI Helmholtzzentrum für Schwerionenforschung GmbH D-64291 DarmstadtGermany College of Science Shenyang Aerospace UniversityShenyang 110136China College of Physics Jilin UniversityChangchun 130012China Theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena07743 JenaGermany

The relativistic binary-encounter-Bethe model with Wannier-type threshold law is employed to obtain the inner-shell ionization cross sections of multi-electron atoms(Ni,Cu,Y,Ag,Au,Yb,Ta,and Pb)for positron impact energies from the thresholds up to 105ke *** is good agreement between the present calculations and the experimental *** constant in the acceleration term derived from the Wannier law is determined to be 0.2 and 0.5 for the K-and L-shells,respectively.

关键词： positron scattering ionization cross section binary-encounter-Bethe model

Foam rolling and stretching do not provide superior acute flexibility and stiffness improvements compared to any other warm-up intervention: A systematic review with meta-analysis

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Journal of Sport and Health Science 2024年第4期13卷 509-520页

作者： Konstantin Warneke Gerit Plöschberger Lars H.Lohmann Eric Lichtenstein Daniel Jochum Stanislav D.Siegel Astrid Zech David G.Behm Institute of Sport Science University of KlagenfurtKlagenfurt am Wörthersee 9020Austria Department of Human Motion Science and Exercise Physiology Friedrich Schiller UniversityJena 07749Germany Department Sport Exercise and HealthUniversity of BaselBasel 4052Switzerland Department of Health Sciences and Technology ETH ZurichZurich 8092Switzerland School of Human Kinetics and Recreation Memorial University of NewfoundlandSt.JohnsNL A1C 5S7Canada

Background:Acute improvement in range of motion(ROM)is a widely reported effect of stretching and foam rolling,which is commonly explained by changes in pain threshold and/or musculotendinous ***,these effects were also reported in response to various other active and passive interventions that induce responses such as enhanced muscle ***,we hypothesized that acute ROM enhancements could be induced by a wide variety of interventions other than stretching or foam rolling that promote an increase in muscle ***:After a systematic search in PubMed,Web of Science,and SPORTDiscus databases,38 studies comparing the effects of stretching and foam rolling with several other interventions on ROM and passive properties were *** studies had 1134 participants in total,and the data analysis resulted in 140 effect sizes(ESs).ES calculations were performed using robust variance estimation model with ***:Study quality of the included studies was classified as fair(PEDro score=4.58)with low to moderate certainty of *** showed no significant differences in ROM(ES=0.01,p=0.88),stiffness(ES=0.09,p=0.67),or passive peak torque(ES=-0.30,p=0.14)between stretching or foam rolling and the other identified *** plots revealed no publication ***:Based on current literature,our results challenge the established view on stretching and foam rolling as a recommended component of warm-up *** lack of significant difference between interventions suggests there is no need to emphasize stretching or foam rolling to induce acute ROM,passive peak torque increases,or stiffness reductions.

关键词： Range of motion Passive properties Muscletendon unit Muscle tissue

Revisiting the stretch-induced force deficit:A systematic review with multilevel meta-analysis of acute effects

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Journal of Sport and Health Science 2024年第6期13卷 805-819页

作者： Konstantin Warneke Lars Hubertus Lohmann Institute of Human Movement Science Sport and HealthUniversity of GrazGraz 8010Austria Institute of Sport Science Alpen-Adria University of KlagenfurtKlagenfurt am Worthersee 9020Austria Institute of Human Movement and Exercise Physiology University of JenaJena 07749Germany

Background:When recommending avoidance of static stretching prior to athletic performance,authors and practitioners commonly refer to available systematic ***,effect sizes(ES)in previous reviews were extracted in major part from studies lacking control conditions and/or prepost testing ***,currently available reviews conducted calculations without accounting for multiple study outcomes,with ES:0.03 to 0.10,which would commonly be classified as ***:Since new meta-analytical software and controlled research articles have appeared since 2013,we revisited the available literatures and performed a multilevel meta-analysis using robust variance estimation of controlled prepost trials to provide updated ***,previous research described reduced electromyography activity—also attributable to fatiguing training routines—as being responsible for decreased subsequent *** second part of this study opposed stretching and alternative interventions sufficient to induce general fatigue to examine whether static stretching induces higher performance losses compared to other exercise ***:Including 83 studies with more than 400 ES from 2012 participants,our results indicate a significant,small ES for a static stretch-induced maximal strength loss(ES=0.21,p=0.003),with high magnitude ES(ES=0.84,p=0.004)for stretching durations≥60 s per bout when compared to passive *** opposed to active controls,the maximal strength loss ranges between ES:0.17 to0.28,p<0.001 and 0.040 with mostly no to small ***,stretching did not negatively influence athletic performance in general(when compared to both passive and active controls);in fact,a positive effect on subsequent jumping performance(ES=0.15,p=0.006)was found in ***:Regarding strength testing of isolated muscles(e.g.,leg extensions or calf raises),our results confirm previous ***,since no(or even positive)e

关键词： Static stretching Maximal strength Athletic performance Performance testing

Optical probing of ultrafast laser-induced solid-to-overdense-plasma transitions

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Light(Science & Applications) 2024年第5期13卷 973-984页

作者： Yasmina Azamoum Georg Alexander Becker Sebastian Keppler Guillaume Duchateau Stefan Skupin Mickael Grech Fabrice Catoire Sebastian Hell Issa Tamer Marco Hornung Marco Hellwing Alexander Kessler Franck Schorcht Malte Christoph Kaluza GSI Helmholtzzentrum für Schwerionenforschung Planckstr.164291 DarmstadtGermany. Helmholtz Institute jena Fröbelstieg 307743 JenaGermany. Institute of Optics and Quantum Electronics Friedrich-SchillerUniversität JenaMax-Wien-Platz 107743 JenaGermany. CEA-CESTA 15 Avenue des SablièresCS6000133116 Le BarpCedexFrance Institut Lumière Matière UMR 5306-CNRSUniversitéde Lyon 169622 VilleurbanneFrance. LULI CNRSCEASorbonne UniversitéInstitut Polytechnique de ParisPalaiseauFrance. Universitéde Bordeaux-CNRS-CEA CELIAUMR 5107 TalenceFrance

Understanding the solid target dynamics resulting from the interaction with an ultrashort laser pulse is a challenging fundamental multi-physics problem involving atomic and solid-state physics,plasma physics,and laser *** of the initial interplay of the underlying processes is essential to many applications ranging from lowpower laser regimes like laser-induced ablation to high-power laser regimes like laser-driven ion *** the properties of the so-called pre-plasma formed as the laser pulse’s rising edge ionizes the target is complicated from the theoretical and experimental point of view,and many aspects of this laser-induced transition from solid to overdense plasma over picosecond timescales are still open *** the one hand,laser-driven ion acceleration requires precise control of the pre-plasma because the efficiency of the acceleration process crucially depends on the target properties at the arrival of the relativistic intensity peak of the *** the other hand,efficient laser ablation requires,for example,preventing the so-called“plasma shielding”.By capturing the dynamics of the initial stage of the interaction,we report on a detailed visualization of the pre-plasma formation and ***-thin diamond-like carbon foils are shown to transition from solid to plasma during the laser rising edge with intensities<10^(16)W/cm^(2).Single-shot near-infrared probe transmission measurements evidence sub-picosecond dynamics of an expanding plasma with densities above 10^(23)cm^(−3)(about 100 times the critical plasma density).The complementarity of a solid-state interaction model and kinetic plasma description provides deep insight into the interplay of initial ionization,collisions,and expansion.

关键词： laser acceleration solid

Electron vortices generation of photoelectron of H_(2)^(+) by counter-rotating circularly polarized attosecond pulses

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Chinese Physics B 2024年第1期33卷 362-367页

作者：杨浩婧刘晓煜朱风筝焦利光刘爱华 Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China School of Mathematics and Physics Hubei Polytechnic UniversityHuangshi 435003China College of Physics Jilin UniversityChangchun 130012China Helmholtz-Institut jena D-07743 JenaGermany State Key Laboratory of Transient Optics and Photonics Chinese Academy of SciencesXi'an 710119China

Molecular-frame photoelectron momentum distributions(MF-PMDs) of an H_(2)^(+) molecule ion in the presence of a pair of counter-rotating circularly polarized attosecond extreme ultraviolet laser pulses is studied by numerically solving the two-dimensional time-dependent Schrodinger equation within the frozen-nuclei approximation. At small time delay, our simulations show that the electron vortex structure is sensitive to the time delay and relative phase between the counterrotating pulses when they are partially overlapped. By adjusting time delay and relative phase, we have the ability to manipulate the MF-PMDs and the appearance of spiral arms. We further show that the internuclear distance can affect the spiral vortices due to its different transition cross sections in the parallel and perpendicular geometries. The lowest-order perturbation theory is employed to interpret these phenomena qualitatively. It is concluded that the internuclear distancedependent transition cross sections and the confinement effect in diatomic molecules are responsible for the variation of vortex structures in the MF-PMDs.

关键词： photoelectron momentum distribution attosecond pulse vortex

Electron vortex generations in photoionization of hydrogen atoms by circularly-polarized chirped attosecond pulses

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Communications in Theoretical Physics 2024年第1期76卷 111-118页

作者： Bingshuang Zhang Xiaoyu Liu Fengzheng Zhu Liguang Jiao Aihua Liu Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China School of Mathematics and Physics Hubei Polytechnic UniversityHuangshi 435003China College of Physics Jilin UniversityChangchun 130012China Helmholtz-Institut jena D-07743 JenaGermany State Key Laboratory of Transient Optics and Photonics Chinese Academy of SciencesXi'an 710119China

By numerically solving the time-dependent Schr?dinger equation and employing the analytical perturbative model,we investigated the chirp-induced electron vortex in the photoionization of hydrogen atoms by a pair of counter-rotating circularly polarized chirped attosecond extremely ultraviolet *** demonstrated that single-photon ionization of hydrogen atoms generates photoelectron momentum distributions(PMDs)with distinct helical vortex structures either with or without a time delay between two counter-rotating circularly polarized laser *** structures are highly sensitive to both the time delay between the pulses and their chirp *** analytical model reveals that the splitting of vortex spirals is caused by the sign changing of the chirp-induced frequency-dependent time *** showed that to obtain the counterpart of the PMD under a pair of counter-rotating circularly polarized chirped pulses,both chirp parameters and ordering of pulses need to be reversed.

关键词： photoionization ultrafast processes ultrafast dynamics electron vortex

Two-photon polymerization lithography for imaging optics

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International Journal of Extreme Manufacturing 2024年第4期6卷 21-60页

作者： Hao Wang Cheng-Feng Pan Chi Li Kishan S Menghrajani Markus A Schmidt Aoling Li Fu Fan Yu Zhou Wang Zhang Hongtao Wang Parvathi Nair Suseela Nair John You En Chan Tomohiro Mori Yueqiang Hu Guangwei Hu Stefan A Maier Haoran Ren Huigao Duan Joel K W Yang College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082People's Republic of China Engineering Product Development Singapore University of Technology and DesignSingapore 487372Singapore Greater Bay Area Institute for Innovation Hunan UniversityGuangzhou 511300People's Republic of China Department of Electrical and Computer Engineering National University of Singapore4 Engineering Drive 3Singapore 117576Singapore School of Physics and Astronomy Faculty of ScienceMonash UniversityMelbourneVictoria 3800Australia Leibniz Institute of Photonic Technology 07745 JenaGermany Abbe Center of Photonics and Faculty of Physics FSU Jena07745 JenaGermany Otto Schott Institute of Material Research FSU Jena07745 JenaGermany Institute of Materials Research and Engineering A*STAR(Agency for Science Technology and Research)Singapore 138634Singapore Industrial Technology Center of Wakayama Prefecture Wakayama 6496261Japan School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore639798Singapore Department of Physics Imperial College LondonLondon SW72AZUnited Kingdom

Optical imaging systems have greatly extended human visual capabilities,enabling the observation and understanding of diverse *** technologies span a broad spectrum of wavelengths from x-ray to radio frequencies and impact research activities and our daily *** glass lenses are fabricated through a series of complex processes,while polymers offer versatility and ease of ***,modern applications often require complex lens assemblies,driving the need for miniaturization and advanced designs with micro-and nanoscale features to surpass the capabilities of traditional fabrication ***-dimensional(3D)printing,or additive manufacturing,presents a solution to these challenges with benefits of rapid prototyping,customized geometries,and efficient production,particularly suited for miniaturized optical imaging *** 3D printing methods have demonstrated advantages over traditional counterparts,yet challenges remain in achieving nanoscale ***-photon polymerization lithography(TPL),a nanoscale 3D printing technique,enables the fabrication of intricate structures beyond the optical diffraction limit via the nonlinear process of two-photon absorption within liquid *** offers unprecedented abilities,***-free fabrication,micro-and nanoscale capabilities,and rapid prototyping of almost arbitrary complex 3D *** this review,we emphasize the importance of the criteria for optical performance evaluation of imaging devices,discuss material properties relevant to TPL,fabrication techniques,and highlight the application of TPL in optical *** the first panoramic review on this topic,it will equip researchers with foundational knowledge and recent advancements of TPL for imaging optics,promoting a deeper understanding of the *** leveraging on its high-resolution capability,extensive material range,and true 3D processing,alongside advances in materials,fabrication,and design,we en

关键词： two-photon polymerization lithography 3D printing additive manufacturing imaging optics and nanophotonics

The relaxin peptide family–potential future hope for neuroprotective therapy? A short review

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Neural Regeneration Research 2018年第3期13卷 402-405页

作者： Marius Nistor Martin Schmidt René Schiffner Department of Neurology Jena University Hospital Friedrich Schiller University Jena Germany Orthopaedic Department Jena University Hospital Friedrich Schiller University Jena Germany Institute for Biochemistry II Jena University Hospital Friedrich Schiller University Jena Germany

Since its discovery in the 1920’s the relaxin peptide hormone family has not only grown in number to now seven members （relaxin-1, relaxin-2, relaxin-3, insulin-like peptide （INSL） 3, INSL4, INSL5 and INSL6）, but ever more effects, suchs as vasodilatory, angiogenic, anti-apoptopic, anti-fibriotic and anti-inflammatory, have been linked to them. While relaxin-2 has mainly been investigated in the context of cardiac protection, most comprehensively in the RELAX-AHF and RELAX AHF2 studies, a small number of studies have furthermore assessed the potential neuroprotective effects of especially relaxin-2 and other members of the relaxin family. In this short review we summarise and discuss recent efforts to utilize relaxin hormones for neuroprotection and point out potential future fields of research and translational applications. While many questions still need to be answered, the promising results of the available studies definitely warrant future well-designed studies on neuroprotection by relaxin peptides.

关键词： relaxin relaxin-2 neuroprotection stroke hemorrhagic shock cerebral