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Artificial intelligence in cancer target identification and drug discovery

Signal Transduction and Targeted Therapy 2022年第6期7卷 1951-1974页

作者： Yujie You Xin Lai Yi Pan Huiru Zheng Julio Vera Suran Liu Senyi Deng Le Zhang College of Computer Science Sichuan UniversityChengdu 610065China Laboratory of Systems Tumor Immunology Friedrich-Alexander-Universität Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenErlangen 91052Germany Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesRoom D5131068 Xueyuan AvenueShenzhen University TownShenzhen 518055China School of Computing Ulster UniversityBelfast BT151EDUK Institute of Thoracic Oncology Department of Thoracic SurgeryWest China HospitalSichuan UniversityChengdu 610065China Key Laboratory of Systems Biology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesChinese Academy of SciencesHangzhou 310024China Key Laboratory of Systems Health Science of Zhejiang Province Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Artificial intelligence is an advanced method to identify novel anticancer targets and discover novel drugs from biology networks because the networks can effectively preserve and quantify the interaction between components of cell systems underlying human diseases such as ***,we review and discuss how to employ artificial intelligence approaches to identify novel anticancer targets and discover ***,we describe the scope of artificial intelligence biology analysis for novel anticancer target ***,we review and discuss the basic principles and theory of commonly used network-based and machine learning-based artificial intelligence ***,we showcase the applications of artificial intelligence approaches in cancer target identification and drug *** together,the artificial intelligence models have provided us with a quantitative framework to study the relationship between network characteristics and cancer,thereby leading to the identification of potential anticancer targets and the discovery of novel drug candidates.

关键词： drugs cancer drug

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Longitudinal Changes in Sarcopenia Criteria in Older Men with Low Skeletal Muscle Mass Index:A 2-Year Observational Study

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Journal of Science in Sport and Exercise 2019年第1期1卷 59-68页

作者： Wolfgang Kemmler Simon von Stengel Stephanie Kast Cornel Sieber Ellen Freiberger Institute of Medical Physics Friedrich-Alexander University Erlangen-NürnbergHenkestrasse 9191052 ErlangenGermany Institute of Biomedicine of Aging University of Erlangen-Nürnberg90408 NürnbergGermany

Purpose Declines in muscle mass and function are inevitable during the aging ***,what is the“normal age appropriate”decline of muscle mass and function?Further,is this decline uniform for muscle mass versus functions or between different functional abilities?Using recognized Sarcopenia criteria[*** muscle mass index(SMI)defined as appendicular skeletal muscle mass/height(kg/m^(2)),handgrip strength,gait velocity],the aim of the present project was to determine corresponding changes in community-dwelling men 70 years+with low SMI over a 2-year *** One hundred and seventy-seven(177)men within the lowest SMI quartile of a recent epidemiologic study(n=965)were included in the 2-year follow-up *** mass was determined via direct-segmental,multi-frequency Bio-Impedance-Analysis,handgrip strength was tested with a Jamar hand-dynamometer and habitual gait speed was assessed with photo sensors applying the 10 m *** SMI,handgrip strength and gait velocity all declined significantly(P<0.001;effect size,d′0.39-1.17),however,with significantly higher reductions(P<0.001)in functional compared with morphologic Sarcopenia criteria(P≤0.006).Less expected,handgrip strength featured a fourfold higher decline compared with gait velocity(−12.8±10.9%versus−3.5±9.0%).Conclusion We provided evidence for significant non-uniform changes of Sarcopenia criteria in a cohort of community dwell-ing men 70 years+with low *** doubt that this result might be a particularity of the selected cohort;however,studies with other(older)cohorts should address this issue in more *** practical relevance,our data further give implications for the prioritization of interventions that address Sarcopenia criteria in older community-dwelling men.

关键词： Sarcopenia Muscle mass Handgrip strength Gait velocity Aging Older men

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Improvement of thickness deposition uniformity in nickel electroforming for micro mold inserts

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Journal of Central South university 2016年第10期23卷 2536-2541页

作者：蒋炳炎翁灿周明勇吕辉 DRUMMER Dietmar State Key Laboratory of High Performance Complex Manufacturing(Central South university) Changsha 410083China School of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China Institute of Polymer Technology(friedrich-alexander-Universitat erlangen-Numberg) Am weichselgarten 991058 ErlangenTennenloheGermany

Thickness deposition is a crucial issue on the application of electroformed micro mold inserts. Edge concentration effect is the main source of the non-uniformity. The techniques of adopting a non-conducting shield, a secondary electrode and a movable cathode were explored to improve the thickness deposition uniformity during the nickel electroforming process. Regarding these techniques, a micro electroforming system with a movable cathode was particularly developed. The thickness variation of a 16 mm×16 mm electroformed sample decreased respectively from 150% to 35%, 12% and 18% by these three techniques. Combining these validated methods, anickelmold insert for microlens array was electroformed with satisfactory mechanical properties and high replication precision. It could be applied to the following injection molding process.

关键词： deposition uniformity nickel electroforming secondary electrode non-conducting shield movable cathode micro mold insert

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Four-dimensional light shaping: manipulating ultrafast spatiotemporal foci in space and time

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Light(Science & Applications) 2017年第1期6卷 293-299页

作者： Bangshan Sun Patrick S Salter Clemens Roider alexander Jesacher Johannes Strauss Johannes Heberle Michael Schmidt Martin J Booth Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK Institute of Photonic Technologies Friedrich-Alexander-University Erlangen-NurembergKonrad-Zuse-Strasse 3/5Erlangen 91052Germany Division of Biomedical Physics Innsbruck Medical UniversityMullerstrasse 44Innsbruck 6020Austria Graduate School in Advanced Optical Technologies(SAOT) Friedrich-Alexander University Erlangen-NurembergPaul-Gordan-Strasse 6Erlangen 91052Germany Centre for Neural Circuits and Behaviour University of OxfordMansfield RoadOxford OX13SRUK

The spectral dispersion of ultrashort pulses allows the simultaneous focusing of light in both space and time,which creates socalled spatiotemporal *** space–time coupling may be combined with the existing holographic techniques to give a further dimension of control when generating focal light *** the present study,it is shown that a phase-only hologram placed in the pupil plane of an objective and illuminated by a spatially chirped ultrashort pulse can be used to generate threedimensional arrays of spatio-temporally focused *** exploiting the pulse front tilt generated at focus when applying simultaneous spatial and temporal focusing(SSTF),it is possible to overlap neighboring foci in time to create a smooth intensity *** resulting light field displays a high level of axial confinement,with experimental demonstrations given through two-photon microscopy and the non-linear laser fabrication of glass.

关键词： laser material processing light shaping spatiotemporal focusing ultrafast lasers

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MICROENDOSCOPIC SPECTRAL IMAGING AS A TOOL FOR SMALL DUCTUAL DIAGNOSTICS:PRELIMINARY EXPERIENCE

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Journal of Innovative Optical Health Sciences 2012年第3期5卷 64-70页

作者： A.DOUPLIK W.L.LEONG A.M.EASSON S.DONE B.C.WILSON A.SHAHMOON Z.ZALEVSKY Department of Physics Ryerson University 350 Victoria StreetToronto M5B 2K3Canada School of Advanced Optical Technologies(SAOT)friedrich-alexander erlangen-Nuremberg university ErlangenGermany Ontario Cancer Institute University Health Network TorontoCanada Xillix Ltd TorontoCanada Medical Photonics Engineering Group(MPEG)Chair of Photonics Technologies friedrich-alexander erlangen-Nuremberg university ErlangenGermany Department of Surgical Oncology Princess Margaret Hospital University Health Network TorontoCanada Department of Medical Biophysics university of Toronto TorontoCanada Faculty of Engineering Bar-Ilan university Ramat GanIsrael

A technical feasibility of autofluorescence ductoscopy in breast milk ducts as blood vessels phantoms has been assessed as *** tumor can be clearly identified through the milk *** also present the operation principle as well as the preliminary experimental results of a new type of microsize multicorefiber that enables imaging through blood vessel *** of a manipulated microwire through a drilled phantom is presented.

关键词： Cancer margin delineation endoscopy microendoscopy autofluorescence imaging surgical guidance multicorefibers

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Linear-fitting-based recursive filtering for nonlinear systems under encoding-decoding mechanism

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Science China(Information Sciences) 2024年第5期67卷 183-196页

作者： Bo JIANG Hongli DONG Zhiwei GAO Yuxuan SHEN Fan YANG Artificial Intelligence Energy Research Institute Northeast Petroleum University Heilongjiang Provincial Key Laboratory of Networking and Intelligent Control Sanya Offshore Oil & Gas Research Institute Northeast Petroleum University School of Electrical & Information Engineering Northeast Petroleum University

This paper deals with a recursive filtering problem for a class of discrete time-varying nonlinear networked systems with the encoding-decoding mechanism. The linear fitting method is introduced to handle the nonlinearity. An encoding-decoding mechanism is constructed to describe the data transmission process in wireless communication networks(WCNs). To be specific, the measurement outputs are mapped by a quantizer to unique codewords for transmission in WCNs. Then, the codewords are decoded by the decoder to recover the measurement outputs which are sent to the filter. The processing/encoding delay and network delay have been considered. Firstly, on the premise that the upper bound of the filtering error covariance is minimum, the appropriate filtering gain is calculated. Then, the mean square exponential boundedness of the filtering error is analyzed. Finally, two simulation examples are presented to verify the effectiveness of the proposed algorithm.

关键词： encoding-decoding mechanism uniform quantizer linear fitting networked systems recursive filtering

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Cooling rate calibration and mapping of ultra-short pulsed laser modifications in fused silica by Raman and Brillouin spectroscopy

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极端制造（英文） 2020年第3期2卷 161-172页

作者： Michael Bergler Kristian Cvecek Ferdinand Werr Martin Brehl Dominique De Ligny Michael Schmidt friedrich-alexander-Universitat erlangen-Nurnberg Institute of Photonic TechnologiesErlangenGermany friedrich-alexander-Universitat erlangen-Nurnberg Institute of Glass and CeramicsErlangenGermany friedrich-alexander-Universitat erlangen-Nurnberg SAOT-Erlangen Graduate School in Advanced Optical TechnologiesErlangenGermany

This paper focuses on the preparation of a new extended set of calibrations of cooling rate(fictive temperature)in fused silica determined by inelastic light scattering and its subsequent use to characterize the local cooling rate distribution in ultra-short pulsed(USP)laser *** order to determine the thermal history(*** rate and fictive temperature)of fused silica,high-resolution inelastic light-scattering experiments(Raman and Brillouin spectroscopy)were *** were performed and compared to the existing literature to quantify structural changes due to a change of fictive *** to existing calibrations,this paper provides an extension to lower and higher cooling *** this new set of calibrations,we characterized a USP laser modification in fused silica and calculated the local fictive temperature *** equation relating the fictive temperature(Tf)to cooling rates is given.A maximum cooling rate of 3000 K min-1 in the glass transition region around 1200℃ was deduced from the Raman *** Brillouin observations are sensitive to both the thermal history and the residual *** comparing the Raman and Brillouin observations,we extracted the local residual stress distribution with high spatial *** the first time,combined Raman and Brillouin inelastic light scattering experiments show the local distribution of cooling rates and residual stresses(detailed behavior of the glass structure)in the interior and the surrounding of an USP laser modified zone.

关键词： glass structure ultra-short pulsed laser fused silica cooling rate fictive temperature Raman spectroscopy Brillouin spectroscopy

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Rotating Lepton Model of Pions and Kaons: Mechanics at fm Distances

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Journal of Applied Mathematics and Physics 2022年第9期10卷 2805-2819页

作者： Constantinos G. Vayenas Dionysios Tsousis Dimitrios Grigoriou Konstantinos Parisis Elias C. Aifantis university of Patras Patras Greece Academy of Athens Athens Greece Stanford university Stanford USA Aristotle university of Thessaloniki Thessaloniki Greece Michigan Technological Institute Houghton USA friedrich-alexander university Erlangen-Nürnberg Germany

The present article is a continuation of a recently published paper [1] in which we have modeled the composition and structure of neutrons and other hadrons using the Rotating Lepton Model (RLM) which is a Bohr type model employing the relativistic gravitational attraction between three ultrafast rotating neutrinos as the centripetal force. The RLM accounts for special relativity and also for the De Broglie equation of quantum mechanics. In this way this force was shown to reach the value of the Strong Force while the values of the masses of the rotating relativistic neutrinos reach those of quarks. Masses computed for twelve hadrons and bosons are in very close (~2%) agreement with the experimental values. Here we use the same RLM approach to describe the composition and structure and to compute the masses of Pions and Kaons which are important zero spin mesons. Contrary to hadrons and bosons which have been found via the RLM to comprise the heaviest neutrino eigenmass m3, in the case of mesons the intermediate neutrino mass eigenstate m2 is found to play the dominant role. This can explain why the lowest masses of mesons are generally smaller than those of hadrons and bosons. Thus in the case of Pions it is found that they comprise three rotating m2 mass eigenstate neutrinos and the computed mass of 136.6 MeV/c2 is in good agreement with the experimental value of 134.977 MeV/c2. The Kaon structure is found to consist of six m2 mass eigenstate neutrinos arranged in two parallel pion-type rotating triads. The computed Kaon mass differs less that 2% from the experimental K± and K°values of 493.677 MeV/c2 and 497.648 MeV/c2 respectively. This, in conjunction with the experimentally observed decay products of the Kaons, provides strong support for the proposed K structure.

关键词： Pions and Kaons-Structure and Masses Gravitational Bohr-de Broglie-Newton-Einstein Type Models Rotating Lepton Model (RLM) Hadronization Neutrino Masses Special Relativity Gravitational Force Quantum Mechanics

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Ageing Behavior of LiNi0.80Co0.15Al0.05O2Cathode Based Lithium Ion Cells—Influence of Phase Transition Processes

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Materials Sciences and Applications 2018年第1期9卷 155-173页

作者： Christopher Betzin Holger Wolfschmidt Siemens AG ErlangenGermany friedrich-alexander-university ErlangenGermany

In this paper, commercial lithium ion battery cells consisting of graphite based anode and LiNi0.80Co0.15Al0.05O2 (NCA) oxide based cathode were investigated regarding their aging behavior. The capacity loss is dependent on the state of charge (SOC) whereas the battery is operated with partial cycles at defined SOCs. The structural change of the positive electrode material is identified as dominating aging process. Especially grid services such as primary control reserve are of economic interest for battery system operators. In this application, small charge and discharge cycles are the main operation mode. Considering the operation of single battery storage systems in a virtual storage power plant, different states of charges are much more of interest. Thus the battery aging behavior of lithium ion cells with NCA based cathode material with respect to cycling at specific state of charge with small depth of discharge (DOD) is investigated. The results in this paper provide understanding of small DOD cycling at given SOC behavior which is necessary for NCA lifetime prediction in this particular case, especially in virtual storage plant with various storage systems and thus various SOCs for delivery primary reserve the small DOD behavior which has an important impact on efficiency and economy. It is a key finding, which aging mechanisms are essential in order to optimize the cell operation and adapt it to system performance.

关键词： Cyclic Voltammetry NCA Fatigue of LiNCAO Primary Control Reserve

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Photonic properties and applications of multi-functional organo-lanthanide complexes:Recent advances

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Journal of Rare Earths 2024年第1期42卷 16-27,I0001页

作者： Virender Archana Chauhan Ashwani Kumar Gurjaspreet Singh alexander A.Solovev Jichuan Xiong Xuefeng Liu Brij Mohan Department of Chemistry Kurukshetra University KurukshetraKurukshetra136119India Aggarwal College Ballabhgarh121004Department of Higher EducationHaryanaIndia Department of Chemistry&Centre for Advanced Studies in Chemistry Panjab UniversityChandigarh160014India Department of Materials Science Fudan UniversityShanghai200433China School of Electronic and Optical Engineering Nanjing University of Science and TechnologyNanjing210094China College of Ocean Food and Biological Engineering Jimei UniversityXiamen361021China

Lanthanides(Ln(Ⅲ))based compounds as light-emitting materials have emerged as successful agents in high-performance defense and lighting systems,magnets,bio-markers,and ***,they have recently gained much attention as energy-saving and cost-effective luminescent materials and their applications in analyte *** present review summarizes powerful features and recent developments of organo-lanthanide complexes in lighting applications with a particular focus on visible light emitters,including Eu(Ⅲ),Tb(Ⅲ),Sm(Ⅲ),and Dy(Ⅲ)*** addition,this review discusses the most relevant aspects of photosensitization,such as the structure,property,functionalization of primary and secondary ligands,and molecular *** addition,coordination sites of organo-lanthanide complexes and their applications collectively contribute to the improved performance of innovative luminescent ***,the current challenges and key recommendations for advancing organolanthanides in material science are provided.

关键词： Lanthanides Organometallic Luminescent Lifetime OLED Rare earths

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