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Broadband mid-infrared supercontinuum generation in dispersion-engineered As_(2)S_(3)-silica nanospike waveguides pumped by 2.8 μm femtosecond laser

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Photonics Research 2021年第4期9卷 630-636页

作者： Pan Wang Jiapeng Huang Shangran Xie Johann Troles and Philip St.J.Russell Max Planck Institute for the Science of Light 91058 ErlangenGermany Universitéde Rennes I Sciences Chimiques de Rennes35042 RennesFrance friedrich-alexander-Universität 91058 ErlangenGermany

Broadband mid-infrared(IR)supercontinuum laser sources are essential for spectroscopy in the molecular fingerprint ***,we report generation of octave-spanning and coherent mid-IR supercontinua in As_(2)S_(3)-silica nanospike hybrid waveguides pumped by a custom-built 2.8μm femtosecond fiber *** waveguides are formed by pressure-assisted melt-filling of molten As_(2)S_(3) into silica capillaries,allowing the dispersion and nonlinearity to be precisely *** coherent spectra spanning from 1.1μm to 4.8μm(30 dB level)are observed when the waveguide is designed so that 2.8μm lies in the anomalous dispersion ***,linearly tapered millimeter-scale As_(2)S_(3)-silica waveguides are fabricated and investigated for the first time,to the best of our knowledge,showing much broader supercontinua than uniform waveguides,with improved spectral *** waveguides are demonstrated to be long-term stable and water-resistant due to the shielding of the As_(2)S_(3) by the fused silica *** offer an alternative route to generating broadband mid-IR supercontinua,with applications in frequency metrology and molecular spectroscopy,especially in humid and aqueous environments.

关键词： pumped millimeter waveguide

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Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function variants in TMEM141,DDHD2,and LHFPL5

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Frontiers of Medicine 2024年第1期18卷 81-97页

作者： Liwei Sun Xueting Yang Amjad Khan Xue Yu Han Zhang Shirui Han Xiaerbati Habulieti Yang Sun Rongrong Wang Xue Zhang McKusick-Zhang Center for Genetic Medicine State Key Laboratory for Complex Severe and Rare DiseasesInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing100005China Chongqing Key Laboratory of Human Embryo Engineering Center for Reproductive MedicineNational Key Clinical Speciality Construction Project(Obstetrics and Gynecology)Chongqing Health Center for Women and ChildrenChongqing400013China Chongqing Clinical Research Center for Reproductive Medicine Women and Children’s Hospital of Chongqing Medical UniversityChongqing400013China Faculty of Biological Sciences Department of ZoologyUniversity of Lakki MarwatKhyber Pakhtunkhwa28420Pakistan Institute for Medical Genetics and Applied Genomics University of TübingenTübingen72076Germany alexander von Humboldt fellowship Foundation Berlin10117Germany Department of Pediatrics The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Department of Laboratory Medicine State Key Laboratory for Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing100730China

Highly clinical and genetic heterogeneity of neurodevelopmental disorders presents a major challenge in clinical genetics and *** variation analysis is imperative to analyze the disease phenotypes resulting from multilocus genomic ***,a Pakistani family with parental consanguinity was presented,characterized with severe intellectual disability(ID),spastic paraplegia,and *** mapping,integrated single nucleotide polymorphism(SNP)array,whole-exome sequencing,and whole-genome sequencing were performed,and homozygous variants in TMEM141(c.270G>A,***90^(*)),DDHD2(c.411+767_c.1249-327del),and LHFPL5(c.250delC,***84^(*))were identified.A Tmem141^(***90^(*)/***90^(*))mouse model was *** studies showed impairments in learning ability and motor *** slice electrophysiology and Golgi staining demonstrated deficient synaptic plasticity in hippocampal neurons and abnormal dendritic branching in cerebellar Purkinje *** electron microscopy showed abnormal mitochondrial ***,studies on a human in vitro neuronal model(SH-SY5Y cells)with stable shRNA-mediated knockdown of TMEM141 showed deleterious effect on bioenergetic function,possibly explaining the pathogenesis of replicated phenotypes in the cross-species mouse ***,panoramic variation analysis revealed that multilocus genomic variations of TMEM141,DDHD2,and LHFPL5 together caused variable phenotypes in ***,the biallelic loss-of-function variants of TMEM141 were responsible for syndromic ID.

关键词： neurodevelopmental disorder autosomal recessive intellectual disability consanguinity spastic paraplegia hearing loss TMEM141

Correction:The interplay between dendritic cells and CD8 T lymphocytes is a crucial component of SARS-CoV-2 immunity

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Cellular & Molecular Immunology 2022年第12期19卷 1441-1441页

作者： Jonas Buttenschon Jochen Mattner Mikrobiologisches Institut - Klinische Mikrobiologie Immunologie und Hygiene Universitätsklinikum Erlangen and Friedrich-Alexander Universität (FAU) Erlangen-Nürnberg Erlangen Germany Medical Immunology Campus erlangen FAU Erlangen-Nürnberg Erlangen Germany

Correction to:Cellular&Molecular Immunology https://***/10.1038/s41423-020-00624-1,published online 08 January 2021 The licence information was missing from this article and should *** original article has been correc... 详细信息

关键词： immunity lymphocytes Immunology

Gallium containing bioactive materials: A review of anticancer, antibacterial, and osteogenic properties

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Bioactive Materials 2022年第11期7卷 125-146页

作者： Fatih Kurtuldu Nurshen Mutlu Aldo R.Boccaccini Dusan Galusek FunGlass Alexander Dubcek University of TrencínStudentska 291150TrencínSlovakia Institute of Biomaterials Department of Material Science and EngineeringUniversity of Erlangen-Nuremberg91058ErlangenGermany Joint Glass Centre of the IIC SAS TnUAD and FChFT STUStudentska 291150TrencínSlovakia

The incorporation of gallium into bioactive materials has been reported to enhance osteogenesis,to influence blood clotting,and to induce anti-cancer and anti-bacterial ***-doped biomaterials prepared by various techniques include melt-derived and sol-gel-derived bioactive glasses,calcium phosphate bioceramics,metals and *** this review,we summarize the recently reported developments in antibacterial,anti-cancer,osteogenesis,and hemostasis properties of Ga-doped biomaterials and briefly outline the mechanisms leading to Ga biological *** key finding is that gallium addition to biomaterials has great potential for treating bone-related diseases since it can be efficiently transferred to the desired region at a controllable ***,it can be used as a potential substitute for antibiotics for the inhibition of infections during the initial and advanced phases of the wound healing *** is also used as an anticancer agent due to the increased concentration of gallium around excessive cell proliferation(tumor)***,we highlight the possibility to design different therapeutic approaches aimed at increasing the efficiency of the use of gallium containing bioactive materials for multifunctional applications.

关键词： Antibacterial Bioactive materials Cancer treatment Hemostasis Osteogenesis

Catalyzing Singlet Fission by Transition Metals:Second versus Third Row Effects

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Precision Chemistry 2023年第9期1卷 555-564页

作者： Yuxuan Hou Ilias Papadopoulos Yifan Bo Anna-Sophie Wollny Michael J.Ferguson Lukas A.Mai Rik R.Tykwinski Dirk M.Guldi Department of Chemistry University of AlbertaEdmontonAlberta T6G 2G2Canada Department of Chemistry and Pharmacy&Interdisciplinary Center for Molecular Materials(ICMM) Friedrich-Alexander-University Erlangen-Nuremberg91058 ErlangenGermany Department of Applied Chemistry Graduate School of EngineeringCenter for Molecular Systems(CMS)Kyushu University744 Moto-okaNishi-kuFukuoka 819-0395Japan

The synthesis and characterization of platinum(II)and palladium(II)complexes bearing two(dimers Pt(L_(pc))_(2)Cl_(2)and Pd(L_(pc))_(2)Cl_(2)),one(monomers Pt(L_(pc))(L_(ref))Cl_(2)and Pd(L_(pc))(L_(ref))-Cl_(2)),or no(reference compounds Pt(L_(ref))_(2)Cl_(2)and Pd(L_(ref))_(2)Cl_(2))pentacene-based pyridyl ligands are *** properties of the dimers are probed by means of steady-state and time-resolved transient absorption measurements in compar-ison to the monomer and model *** results document that despite enhanced spin−orbit coupling from the presence of heavy atoms,intramolecular singlet fission(iSF)is not challenged by intersystem *** thus yields correlated triplet pairs and even uncorrelated triplet excited states upon ***,significant separation of the two pentacenyl groups facilitates decoupling of the two ***,the mechanism of iSF is altered depending on the respective metal center,that is,Pt(II)versus Pd(II).The dimer based on Pt(II),Pt(L_(pc))2Cl_(2),exhibits a direct pathway for the iSF and forms a correlated triplet pair with singlet−quintet spin-mixing within 10 ns in variable *** the other hand,the dimer based on Pd(II),Pd(L_(pc))_(2)Cl_(2),leads to charge transfer mixing during the population of the correlated triplet pair that is dependent on solvent ***,Pd(L_(pc))_(2)Cl_(2)gives rise to a stable equilibrium between singlet and quintet correlated triplet pairs with lifetimes of up to 170 *** differences in the size and polarizability,when contrasting platinum(II)with palladium(II),are the most likely rationale for the underlying trends.

关键词： metal complexes singlet fission pentacene dimers ultrafast spectroscopy electronic coupling

Distributed generalized Nash equilibrium seeking:event-triggered coding-decoding-based secure communication

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Science China(Information Sciences) 2024年第7期67卷 271-284页

作者： Shaofu YANG Wenying XU Wangli HE Jinde CAO School of Computer Science and Engineering Southeast University School of Mathematics Southeast University Key Laboratory of Advanced Control and Optimization for Chemical Processes East China University of Science and Technology

In this paper, we consider the distributed generalized Nash equilibrium(GNE) seeking problem in strongly monotone games. The transmission among players is implemented through a digital communication network with limited bandwidth. For improving communication efficiency or/and security, an event-triggered coding-decoding-based communication is first proposed, where the data(decision variable) are first mapped to a series of finite-level codewords and, only when an event condition is satisfied, then sent to the neighboring agents. Moreover, a distributed communication-efficient GNE seeking algorithm is constructed accordingly,and the overrelaxation scheme is further taken into consideration. Through primal-dual analysis, the proposed algorithm is proven to converge to a variational GNE with fixed step-sizes by recasting it as an inexact forward-backward iteration. Finally, numerical simulations illustrate the benefit of the proposed algorithms in terms of saving communication resources.

关键词： noncooperative games event-triggered communication coding-decoding quantization

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A visual analytics workflow for probabilistic modeling

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Visual Informatics 2023年第2期7卷 72-84页

作者： Julien Klaus Mark Blacher Andreas Goral Philipp Lucas Joachim Giesen friedrich Schiller university Jena Germany

Probabilistic programming is a powerful means for formally specifying machine learning *** inference engine of a probabilistic programming environment can be used for serving complex queries on these *** of the current research in probabilistic programming is dedicated to the design and implementation of highly efficient inference *** less research aims at making the power of these inference engines accessible to non-expert *** programming means writing *** many potential users from promising application areas such as the social sciences lack programming *** prompted recent efforts in synthesizing probabilistic programs directly from ***,working with synthesized programs still requires the user to read,understand,and write some code,for instance,when invoking the inference engine for answering ***,we present an interactive visual approach to synthesizing and querying probabilistic programs that does not require the user to read or write code.

关键词： Probabilistic inference Bayesian network Structured query language Table-based visualization

On Exact Controllability of Networks of Nonlinear Elastic Strings in 3-Dimensional Space

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Chinese Annals of Mathematics,Series B 2012年第1期33卷 33-60页

作者： Gnter R.LEUGERING *** SCHMIDT Department of Mathematics Friedrich-Alexander University Department of Mathematics and Statistics McGill University

This paper concerns a system of nonlinear wave equations describing the vibrations of a 3-dimensional network of elastic *** authors derive the equations and appropriate nodal conditions,determine equilibrium solutions,and,by using the methods of quasilinear hyperbolic systems,prove that for tree networks the natural initial,boundary value problem has classical solutions existing in neighborhoods of the "stretched" equilibrium *** the local controllability of such networks near such equilibrium configurations in a certain specified time interval is ***,it is proved that,given two different equilibrium states satisfying certain conditions,it is possible to control the network from states in a small enough neighborhood of one equilibrium to any state in a suitable neighborhood of the second equilibrium over a suffciently large time interval.

关键词：三维网络精确可控性非线性弹性三维空间非线性波动方程拟线性双曲系统平衡状态时间间隔

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PARTICLE PROPERTIES——PROMISE AND NEGLECT

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China Particuology 2003年第1期1卷 13-19页

作者： Wolfgang PeukertInstitute of Particle Technology, friedrich-alexander-university erlangen-Nuremberg, Cauerstr. 4 , 91058 erlangen, GermanyE-mail: W. Peukert@mvt. uni-erlangen. de Institute of Particle Technology Friedrich-Alexander-University Erlangen-Nuremberg Cauerstr. 4 91058 Erlangen Germany

We see two major trends in Particie Technology. First, the focus is shifted from unit operations towards functional products, i.e. towards product engineering. Second, modeling will become more and more important. Proc-esses cannot yet be designed from basie molecular understanding. Nanotechnology, however, begins to bridge this gap between molecules and particles and may thus open new ways not only for the production and handling of particulate matter but also for the engineered design of advanced material properties. Starting from the concept of product engineering we investigate the basie preconditions for tailoring nanoparticulate properties, i.e. the control of the particie in-teractions. Nanotechnology can only be transferred to industrial production if the interactions are effectively controlled.Material and particie properties are essential for predictive models. Although strong tools like MD, DEM or population balance models are available, these models are only predictive if realistic material and particie properties are available which is often not the case. We show for selected examples how particie properties can be obtained by studying the physically relevant elementary processes. The impact breakage behavior of many different materials is described by a master curve. Particie adhesion can be modeled if the roughness of particie and substrate and the Hamaker constant are known. The latter is obtained from adsorption studies.

关键词： product engineering nanoparticles surface forces comminution adhesion

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