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A visual analytics workflow for probabilistic modeling

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Visual Informatics 2023年第2期7卷 72-84页

作者： Julien Klaus Mark Blacher Andreas Goral Philipp Lucas Joachim Giesen friedrich schiller university jena Germany

Probabilistic programming is a powerful means for formally specifying machine learning *** inference engine of a probabilistic programming environment can be used for serving complex queries on these *** of the current research in probabilistic programming is dedicated to the design and implementation of highly efficient inference *** less research aims at making the power of these inference engines accessible to non-expert *** programming means writing *** many potential users from promising application areas such as the social sciences lack programming *** prompted recent efforts in synthesizing probabilistic programs directly from ***,working with synthesized programs still requires the user to read,understand,and write some code,for instance,when invoking the inference engine for answering ***,we present an interactive visual approach to synthesizing and querying probabilistic programs that does not require the user to read or write code.

关键词： Probabilistic inference Bayesian network Structured query language Table-based visualization

Tissue-specific Gene Expression Changes Are Associated with Aging in Mice

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Genomics, Proteomics & Bioinformatics 2020年第4期18卷 430-442页

作者： Akash Srivastava Emanuel Barth Maria A.Ermolaeva Madlen Guenther Christiane Frahm Manja Marz Otto W.Witte Hans-Berger Department of Neurology University Hospital JenaFriedrich Schiller University Jena07747 JenaGermany Bioinformatics/High Throughput Analysis Friedrich Schiller University Jena07743 JenaGermany FLI Leibniz Institute for Age Research 07745 JenaGermany

Aging is a complex process that can be characterized by functional and cognitive decline in an individual. Aging can be assessed based on the functional capacity of vital organs and their intricate interactions with one another. Thus, the nature of aging can be described by focusing on a specific organ and an individual itself. However, to fully understand the complexity of aging,one must investigate not only a single tissue or biological process but also its complex interplay and interdependencies with other biological processes. Here, using RNA-seq, we monitored changes in the transcriptome during aging in four tissues(including brain, blood, skin and liver) in mice at9 months, 15 months, and 24 months, with a final evaluation at the very old age of 30 *** identified several genes and processes that were differentially regulated during aging in both tissue-dependent and tissue-independent manners. Most importantly, we found that the electron transport chain(ETC) of mitochondria was similarly affected at the transcriptome level in the four tissues during the aging process. We also identified the liver as the tissue showing the largest variety of differentially expressed genes(DEGs) over time. Lcn2(Lipocalin-2) was found to be similarly regulated among all tissues, and its effect on longevity and survival was validated using its orthologue in Caenorhabditis elegans. Our study demonstrated that the molecular processes of aging are relatively subtle in their progress, and the aging process of every tissue depends on the tissue’s specialized function and environment. Hence, individual gene or process alone cannot be described as the key of aging in the whole organism.

关键词： Aging RNA-seq analysis Inflammaging Electron transport chain Tissue aging

Magnetic resonance imaging in children and adolescents with chronic inflammatory bowel disease

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World Journal of Gastroenterology 2014年第5期20卷 1180-1191页

作者： Hans-Joachim Mentzel Steffen Reinsch Monika Kurzai Martin Stenzel Section of Pediatric Radiology Department of Radiology University Hospital Jena- Friedrich-Schiller-University Jena Section of Pediatric Gastro-enterology Department of Pediatrics University Hospital Jena Friedrich-Schiller-University Jena

Inflammatory bowel diseases(IBD) represent challenges, both from a diagnostic, and therapeutic point of view. Deep-seated anatomic structures are difficult to assess by ultrasound technique alone. As radiation-free alternative cross-sectional imaging method, magnetic resonance imaging of the intestinal structures is costly and time-consuming. Examination of pediatric patients imply additional considerations: reduction of body motions in younger children and consideration of the most appropriate preparation, and examination technique. The demanding Sellink technique is the only means for appropriately distending the lesser intestine in order to detect small bowel strictures. Oral intake of contrast medium(CM) alone shows its limitations regarding distensibility. The need for intravenous contrast media application needs to be considered, too. Active inflammation of both intestinal wall, and mesentery can be demonstrated accurately. Nevertheless, viable alternatives to CM application is desirable, considering non-negligible adverse reactions. Recent data suggest diffusion weighted imaging might fill this diagnostic gap. Irrespective of sequence technique chosen, bowel movement remains a major obstacle. Antispasmolytics in their function as smooth muscle relaxants help in improving image quality, however, their use in children might be off-label. Optimal preparation for the examination and appropriate imaging technique allow for diagnosing typical patterns of changes in IBD, such as bowel wall thickening, ulcers, mural stratification, strictures, creeping fat, and comb sign, and lymphadenopathy. The article gives a detailed overview of current significance of magnetic resonance imaging pediatric patients suffering from IBD, considering indications, limitations, and safety aspects.

关键词： Children, Adolescents, Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Magnetic resonance imaging, Enterography

Embolization of an unusual metastatic site of hepatocellular carcinoma in the humerus

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World Journal of Gastroenterology 2009年第18期15卷 2280-2282页

作者： Andreas Hansch Rotraud Neumann Alexander Pfeil Ivan Marintchev Stefan Pfleiderer Mieczyslaw Gajda Werner A Kaiser Institute of Diagnostic and Interventional Radiology Friedrich Schiller University JenaErlanger Allee 101D-07747 JenaGermany Department of Traumatology Hand and Reconstructive SurgeryFriedrich Schiller University JenaErlanger Allee 101D-07740 JenaGermany Institute of Pathology Friedrich Schiller University JenaZiegelmuehlenweg 1D-07740 JenaGermany

Hepatocellular carcinoma （HCC） is the fish most common cancer in the world. This case documents an unusual metastatic presentation of HCC in the humerus. Preoperative palliative arterial embolization of the tumor was performed to arrest severe tumor bleeding caused by the biopsy. Embolization turned out to be useful also in limiting/preventing potential uncontrolled bleeding during subsequent amputation.

关键词： Hepatocellular carcinoma Humerus Upperarm Metastasis Embolization

Digital topics on cultural heritage investigated:how can data-driven and data-guided methods support to identify current topics and trends in digital heritage?

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Built Heritage 2021年第3期5卷 171-183页

作者： Sander Münster Ronja Utescher Selda Ulutas Aydogan Digital Humanities Friedrich Schiller University JenaJenaGermany

In research and policies,the identifcation of trends as well as emerging topics and topics in decline is an important source of information for both academic and innovation *** at present policy analysis mostly employs qualitative research methods,the following article presents and assesses diferent approaches–trend analysis based on questionnaires,quantitative bibliometric surveys,the use of computer-linguistic approaches and machine learning and qualitative *** this backdrop,this article examines digital applications in cultural heritage and,in particular,built heritage via various investigative frameworks to identify topics of relevance and trendlines,mainly for European Union(EU)-based research and ***,this article exemplifes and assesses the specifc opportunities and limitations of the diferent methodical approaches against the backdrop of data-driven ***-guided analytical *** its major fndings,our study shows that both research and policies related to digital applications for cultural heritage are mainly driven by the availability of new *** policies focus on meta-topics such as digitisation,openness or automation,the research descriptors are more *** general,data-driven approaches are promising for identifying topics and trendlines and even predicting the development of near future ***,qualitative approaches are able to answer“why”questions with regard to whether topics are emerging due to disruptive innovations or due to new terminologies or whether topics are becoming obsolete because they are common knowledge,as is the case for the term“internet”.

关键词： Digital heritage Research topics Policies Survey Bibliometrics NLP Qualitative assessment

Psychological Resilience Building in Disaster Risk Reduction:Contributions from Adult Education

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International Journal of Disaster Risk Science 2014年第1期5卷 33-40页

作者： Martha Hofler Institute of Education and Culture Chair of Adult EducationFriedrich Schiller University Jena07743 JenaGermany

This article discusses three What opportunities exist to enhance psychological resilience in adults?Why should psychological resilience promotion be considered an important disaster risk reduction strategy?What contribution can adult education make to such a strategy?Psychological resilience is presented as relational and somewhat malleable,even in *** psychological resilience building is often overlooked in sociallevel disaster risk reduction efforts,it is a key strategy for social resilience *** regarding the extent to which mental resilience can be improved and the techniques with which to do so may be answered by research in the field of adult *** learning and teaching research fundamentals are suggested to create psychological resilience-building strategies in adults.

关键词： Adult education Disaster risk reduction Mental health Psychological resilience Resilience building

Morrey smoothness spaces:A new approach

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Science China Mathematics 2023年第6期66卷 1301-1358页

作者： Dorothee D.Haroske Hans Triebel Institute of Mathematics Faculty of Mathematics and Computer ScienceFriedrich Schiller University JenaJena 07743Germany

In the recent years,the so-called Morrey smoothness spaces attracted a lot of *** can(also)be understood as generalisations of the classical spaces A_(p,q)^(s)(R^(n))with A∈{B,F}in R^(n),where the parameters satisfy ... 详细信息

关键词： Morrey space smoothness space of Morrey type Besov-Morrey space Triebel-Lizorkin-Morrey space Besov-type space Triebel-Lizorkin-type space

Pointwise multipliers for Besov spaces of dominating mixed smoothness-Ⅱ

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Science China Mathematics 2017年第11期60卷 2241-2262页

作者： NGUYEN Van Kien SICKEL Winfried Institute of Mathematics Friedrich-Schiller-University Jena Department of Mathematics University of Transport and Communications

We continue our investigations on pointwise multipliers for Besov spaces of dominating mixed smoothness. This time we study the algebra property of the classes S_(p,q)~rB(R^d) with respect to pointwise multiplication.... 详细信息

关键词： pointwise multipliers algebras with respect to pointwise multiplication Besov spaces of dominating mixed smoothness characterization by differences localization property

Debris disks: seeing dust, thinking of planetesimals and planets

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Research in Astronomy and Astrophysics 2010年第5期10卷 383-414页

作者： Alexander V. Krivov Astrophysical Institute and university Observatory Friedrich Schiller University JenaSchillergchen 2-3 07745 Jena Germany

Debris disks are optically thin, almost gas-free dusty disks observed arounda significant fraction of main-sequence stars older than about 10 Myr. Since the circumstellar dust is short-lived, the very existence of these disks is considered as evi-dence that dust-producing planetesimals are still present in mature systems, in whichplanets have formed – or failed to form – a long time ago. It is inferred that theseplanetesimals orbit their host stars at asteroid to Kuiper-belt distances and continuallysupply fresh dust through mutual collisions. This review outlines observational techniques and results on debris disks, summarizes their essential physics and theoreticalmodels, and then places them into the general context of planetary systems, uncovering interrelations between the disks, dust parent bodies, and planets. It is shownthat debris disks can serve as tracers of planetesimals and planets and shed light onthe planetesimal and planet formation processes that operated in these systems in thepast.

关键词： planetary systems: formation — circumstellar matter