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Self-Powered Absorptive Reconfigurable Intelligent Surfaces for Securing Satellite-Terrestrial Integrated Networks

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China Communications 2024年第9期21卷 276-291页

作者： Lin Zhi Niu Hehao He Yuanzhi An Kang Zhong Xudong Chu Zheng Xiao Pei College of Electronic Engineering National University of Defense TechnologyHefei 230037China Sixty-Third research institute National University of Defense TechnologyNanjing 210007China institute of Systems Engineering Academy of Military ScienceBeijing 100141China Department of Electrical and Electronic Engineering University of Nottingham Ningbo ChinaNingbo 315100China institute for Communication Systems University of SurreyGuildford GU27XHU.K.

Satellite communications have attracted significant interests due to its advantages of large footprint and massive ***,the commonly used onboard beamforming is hard to achieve reliable security because of the highly correlated legitimate and wiretap downlink *** exploit the benefits of satellite-terrestrial integrated network(STIN)and a novel absorptive reconfigurable intelligent surface(RIS)for improving the security of satellite downlink communications(SDC)in the presence of eavesdroppers(Eves).This paper aims to maximize the achievable secrecy rate of the earth station(ES)while satisfying the signal reception constraints,harvested power threshold at the RIS,and total transmit power *** solve this nonconvex problem,we propose a penalty-function based dual decomposition scheme,which firstly transforms the original problem into a two-layer optimization ***,the outer layer and inner problems are solved by utilizing the successive convex approximation,Lagrange-dual and Rayleigh quotient methods to obtain the beamforming weight vectors and the reflective coefficient ***,simulation results verify the effectiveness of the proposed scheme for enhancing the SDC security.

关键词： absorptive RIS beamforming design secure communications STIN

A semi-analytical multi-harmonic balance method on full-3D contact model for dynamic analysis of dry friction systems

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Chinese Journal of Aeronautics 2024年第2期37卷 309-329页

作者： He SuN Dayi ZHANG Yaguang Wu Qingyang SHEN Dianyin Hu research institute of Aero-Engine Beihang UniversityBeijing 100191China School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Key Laboratory of Aero-Engine Structure and Strength Beijing 100191China Sino-french Engineering School Beihang UniversityBeijing 100191China AECC Sichuan Gas Turbine research Establishment Chengdu 610500China

Dry friction damping structures are widely-used in aero-engines to mitigate *** nonlinear nature of friction and the two-dimensional in-plane motion on the contact interface bring challenges to accurately and efficiently predict the forced response of frictionally damped *** state-of-the-art Multi-Harmonic Balance Method(MHBM)on quasi-3D contact model in engineering cannot precisely capture the kinematics on the friction interface although the efficiency is *** full-3D contact model can describe the constitutive relationship of the interface in a more accurate manner;however,the efficiency and convergence are not guaranteed for large-scale *** this paper,a semi-analytical MHBM on full-3D contact model is *** original Trajectory Tracking Method(TTM)for evaluating the contact force is reformulated to make the calculation more concise and the derivation of the Analytical Jacobian Matrix(AJM)*** on the chain rule of derivation,the AJM which is the core to upgrade the performance is *** a shrouded blade finite element model,the accuracy and efficiency of the proposed method are compared with both the MHBM on full-3D contact model with numerical Jacobian matrix and the MHBM on quasi-3D contact model with *** results show that the AJM improves significantly the efficiency of the MHBM on full-3D contact *** time cost of the proposed method is in the same order of magnitude as that of the MHBM on quasi-3D contact *** also confirm that the full-3D contact model is necessary for the dynamic analyses of shrouded *** one uses the quasi-3D model,the estimation relative error of damping can even reach 31.8%in some *** addition,the AJM also brings benefits for stability *** is highly recommended that engineers use the MHBM on full-3D contact model for the dynamic analysis and design of shrouded blades.

关键词： Dry friction damping Multi-harmonic balance method Trajectory tracking method Jacobian matrix Shrouded blade

Design and optimization of piperidinesubstituted thiophene[3,2-d]pyrimidine-based HIV-1 NNRTIs with improved drug resistance and pharmacokinetic profiles

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3110-3124页

作者： Yanying Sun Zhenzhen Zhou Zhongling Shi Fabao Zhao Minghui Xie Zongji Zhuo Erik De Clercq Christophe Pannecouqueb Dongwei Kang Peng Zhan Xinyong Liu Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJinan 250012China Rega institute for medical research Laboratory of Virology and ChemotherapyK.U.LeuvenLeuven B-3000Belgium China-Belgium Collaborative research Center for Innovative Antiviral Drugs of Shandong Province Jinan 250012China

HIV-1 reverse transcriptase(RT)has received great attention as an attractive therapeutic target for acquired immune deficiency syndrome(AIDS),but the inevitable drug resistance and side effects have always been major challenges faced by non-nucleoside reverse transcriptase inhibitors(NNRTIs).This work aimed to identify novel chemotypes of anti-HIV-1 agents with improved drugresistance profiles,reduced toxicity,and excellent druggability.A series of diarylpyrimidine(DAPY)derivatives were prepared via structural modifications of the leads K-5a2 and *** them,15a with dimethylphosphine oxide moiety showed the most prominent antiviral potency against all of the tested viral panel,being 1.6-fold(WT,EC_(50) Z 1.75 nmol/L),3.0-fold(L100I,EC_(50) Z 2.84 nmol/L),2.4-fold(K103N,EC_(50) Z 1.27 nmol/L),3.3-fold(Y181C,EC50 Z 5.38 nmol/L),2.9-fold(Y188L,EC_(50) Z 7.96 nmol/L),2.5-fold(E138K,EC_(50) Z 4.28 nmol/L),4.8-fold(F227L/V106A,EC_(50) Z 3.76 nmol/L)and 5.3-fold(RES056,EC_(50) Z 15.8 nmol/L)more effective than that of the marketed drug *** docking results illustrated the detailed interactions formed by compound 15a and WT,F227L/V106A,and RES056 ***,15a-HCl carried outstanding pharmacokinetic(t1/2 Z 1.32 h,F Z 40.8%)and safety profiles(LD_(50)>2000 mg/kg),which demonstrated that 15a HCl is a potential anti-HIV-1 drug candidate.

关键词： HIV-1 NNRTIs NNIBP Structural alert Anti-HIV-1 drug candidate

Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

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Infectious Diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders Joseph Nelson Siewe Fodjo Olivia Kamoen Luis-Jorge Amaral Amber Hadermann Chiara Trevisan Mark J.Taylor Julia Gauglitz Achim Hoerauf Yasuaki Sato Katja Polman Maria-Gloria Basanez Dan Bhwana Thomson Lakwo Gasim Abd-Elfarag Sebastien D.Pion Global health institute University of AntwerpAntwerpBelgium Department of Neurology Heilig Hart ZiekenhuisLierBelgium Department of Public health Institute of Tropical MedicineAntwerpBelgium Liverpool School of Tropical Medicine LiverpoolUK Department of Computer Science University of AntwerpAntwerpBelgium institute of medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection research(DZIF) Partner Site Bonn-CologneBonnGermany School of Global Humanities and Social Sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected TropicalDisease research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK national institute for medical research TangaTanzania Vector Control Division Ministry of HealthKampalaUganda School of Public health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan french national research institute for Sustainable Development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World health Organization how to address this public health *** text During the 2nd International Workshop on OAE held on 19-21 September, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-Saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (ASMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. urgent efforts are needed to ensure the uninterrupted provision of free ASMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease Prevention Ivermectin Epilepsy Nodding syndrome Treatment Children Policy

Targeting complement hyperactivation:a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection

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Signal Transduction and Targeted Therapy 2024年第1期9卷 51-54页

作者： Leili Jia Haihua Luo Lizhong Li Mingyao Wang Jiangfeng Liu Yuan Liang Shan Li Yong Jiang Juntao Yang Hongbin Song institute for Disease Control and Prevention of PLA BeijingChina Guangdong Provincial Key Laboratory of Proteomics State Key Laboratory of Organ Failure ResearchSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Common Mechanism research for Major Diseases Institute of Basic Medical SciencesChinese Academy of Medical Science and Peking Union Medical College100005 BeijingChina

Dear Editor,Infections by the influenza virus are a significant and widespread global health threat,as these infections have an annual death toll ranging from 290,000 to 650,000.1 A significant proportion of these fatalities are attributed to secondary bacterial pneumonia,a severe complication commonly caused by ubiquitous respiratory pathogens such as Staphylococcus aureus(***).2 Of particular concern is the increased morbidity and mortality rates in individuals infected simultaneously with influenza virus and methicillin-resistant ***(MRSA).3 The concurrent presence of bacteria and influenza virus usually causes acute respiratory distress syndrome(ARDS),which is associated with acute lung injury(ALI),severe lung tissue edema,and widespread ***,determining the complex mechanisms underlying the synergistic interplay will require further investigation with a suitable coinfection mouse *** our previous study,we utilized different sequential coinfections at various time points to model influenza A virus and MRSA coinfection.

关键词： influenza pneumonia lung

Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis

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Signal Transduction and Targeted Therapy 2024年第2期9卷 738-750页

作者： Yun Zhang Lijun Du Chenxi Wang Zhangsheng Jiang Qingchi Duan Yiping Li Zhijun Xie Zhixing He Yi Sun Lin Huang Liwei Lu Chengping Wen Key Laboratory of Chinese medicine rheumatology of Zhejiang Province Research Institute of Chinese Medical Clinical Foundation and ImmunologyCollege of Basic Medical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Cancer institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang university Hangzhou 310029China Department of Pathology and Shenzhen institute of research and Innovation The University of Hong KongHong KongChina Chongqing International institute for Immunology Chongqing 400038China

Systemic lupus erythematosus(SLE),a severe autoimmune disorder,is characterized by systemic inflammatory response,autoantibody accumulation and damage to *** dysregulation of double-negative(DN)T cells is considered as a crucial commander during ***,a significant type of protein post-translational modification(PTM),has been well-proved to regulate T cell-mediated immune ***,the function of neddylation in SLE is still ***,we reported that neddylation inactivation with MLN4924,a specific inhibitor of NEDD8-activating enzyme E1(NAE1),or genetic abrogation of ube2m in T cells decreased DN T cell accumulation and attenuated murine lupus *** investigations revealed that inactivation of neddylation blocked Bim ubiquitination degradation and maintained Bim level in DN T cells,contributing to the apoptosis of the accumulated DN T cells in lupus *** double knockout(KO)lupus-prone mice(ube2m-/-Bim-/-lpr)were generated and results showed that loss of Bim reduced ube2m deficiency-induced apoptosis in DN T cells and reversed the alleviated lupus *** findings identified that neddylation inactivation promoted Bim-mediated DN T cell apoptosis and attenuated lupus ***,we also found that in SLE patients,the proportion of DN T cells was raised and their apoptosis was ***,compared to healthy groups,SLE patients exhibited decreased Bim levels and elevated Cullin1 neddylation ***,the inhibition of neddylation induced Bim-dependent apoptosis of DN T cells isolated from SLE ***,our findings provide the direct evidence about the function of neddylation during lupus,suggesting a promising therapeutic approach for this disease.

关键词： inactivation double finding

Variability of urban fractional vegetation cover and its driving factors in 328 cities in China

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Science China Earth Sciences 2024年第2期67卷 466-482页

作者： Fei FENG Xin YANG Baoquan JIA Xiaoting LI Xianwen LI Chengyang Xu Kaicun WANG research Centre of urban Forestry Key Laboratory for Silviculture and Forest Ecosystem of State Forestry and Grassland AdministrationBeijing Forestry UniversityBeijing100083China State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing100875China research institute of Forestry Chinese Academy of ForestryBeijing100091China School of Architecture Tsinghua UniversityBeijing100084China College of urban and Environmental Sciences Sino-French Institute for Earth System ScienceInstitute of Carbon NeutralityPeking UniversityBeijing100871China

urban green space promotes the health of urban residents,enhances urban ecosystem biodiversity,mitigates environmental pollution,and attenuates urban heat island ***,urban vegetation cover is highly heterogeneous and difficult to *** this study,the variation of urban fractional vegetation cover(FVC)in 328 cities in China from 1990 to2022 was quantified based on Landsat satellite data at a 30-m *** was found that from 1990 to 2005,due to increases in building density and impervious surfaces in cities,the national mean urban vegetation cover decreased from 0.38 to ***2005,urban vegetation cover began to reverse,reaching 0.45 in *** increasing trend was most pronounced in newly built urban *** decrease in average urban vegetation cover before 2005 was mainly due to the expansion of low vegetation cover areas,while the increase in urban vegetation cover after 2005 manifested as the expansion of high vegetation cover *** reversal in the trend of urban vegetation cover change after 2004 is related to the gradual implementation of national policies requiring increased urban green space *** urban gross domestic product(GDP)showed the highest correlation with changes in urban vegetation *** large and medium-sized cities,the top three factors influencing vegetation cover were GDP,urban population,and ***,for cities in arid/semi-arid regions,changes in vegetation cover were more sensitive to climatic factors(such as precipitation).Although the urban vegetation cover in China has substantially increased in recent years,the urban green space in small-sized cities and in the old urban districts of large-sized cities still have room to improve.

关键词： urban vegetation urban vegetation cover urbanization Remote sensing

Intelligent representation method of image flatness for cold rolled strip

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Journal of Iron and Steel research International 2024年第5期31卷 1177-1195页

作者： Yang-huan Xu Dong-cheng Wang Hong-min Liu Bo-wei Duan national Engineering research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao066004HebeiChina national Key Laboratory of Metal Forming Technology and Heavy Equipment China National Heavy Machinery Research Institute Co.Ltd.Xi’an710018ShaanxiChina State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004HebeiChina

Real flatness images are the bases for flatness detection based on machine vision of cold rolled *** characteristics of a real flatness image are analyzed,and a lightweight strip location detection(SLD)model with deep semantic segmentation networks is *** interference areas in the real flatness image can be eliminated by the SLD model,and valid information can be *** this basis,the concept of image flatness is proposed for the first *** image flatness representation(IFAR)model is established on the basis of an autoencoder with a new *** optimal structure of the bottleneck layer is 16×16×4,and the IFAR model exhibits a good representation ***,interpretability analysis of the representation factors is carried out,and the difference and physical meaning of the representation factors for image flatness with different categories are *** flatness with new defect morphologies(bilateral quarter waves and large middle waves)that are not present in the original dataset are generated by modifying the representation factors of the no wave ***,the SLD and IFAR models are used to detect and represent all the real flatness images on the test *** average processing time for a single image is 11.42 ms,which is suitable for industrial *** research results provide effective methods and ideas for intelligent flatness detection technology based on machine vision.

关键词： Cold rolled strip Image flatness Location detection Representation learning Bottleneck layer

A Novel Anti-Collision Algorithm for Large Scale of uHF RFID Tags Access Systems

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Computers, Materials & Continua 2024年第7期80卷 897-912页

作者： Xu Zhang Yi He Haiwen Yi Yulu Zhang Yuan Li Shuai Ma Gui Li Zhiyuan Zhao Yue Liu Junyang Liu Guangjun Wen Jian Li School of Information and Communication Engineering/Yibin institute University of Electronic Science and Technology of ChinaChengdu611731China Department of IoT Technology research China Mobile Research InstituteBeijing100053China The 10th research institute of China Electronics Technology Group Corporation Chengdu611731China College of Information and Communication National University of Defense TechnologyWuhan430019China

When the radio frequency identification(RFID)system inventories multiple tags,the recognition rate will be seriously affected due to *** on the existing dynamic frame slotted Aloha(DFSA)algorithm,a sub-frame observation and cyclic redundancy check(CRC)grouping combined dynamic framed slotted Aloha(SuBF-CGDFSA)algorithm is *** algorithm combines the precise estimation method of the quantity of large-scale tags,the large-scale tags grouping mechanism based on CRC pseudo-randomcharacteristics,and the Aloha anti-collision optimization mechanism based on sub-frame *** grouping tags and sequentially identifying themwithin subframes,it accurately estimates the number of remaining tags and optimizes frame length accordingly to improve efficiency in large-scale RFID *** outcomes demonstrate that this proposed algorithmcan effectively break through the system throughput bottleneck of 36.8%,which is up to 30%higher than the existing DFSA standard scheme,and has more significant advantages,which is suitable for application in largescale RFID tags scenarios.

关键词： Radio frequency identification anti-collision tags grouping dynamic framed slotted Aloha