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Food Science and Human Wellness 2024年第1期13卷 339-348页

作者： Yao Liu Songyi Lin Kexin Liu Shan Wang Wang Li Na Sun National Engineering research Center of Seafood School of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China Collaborative innovation Center of Seafood Deep Processing Dalian Polytechnic UniversityDalian 116034China

Shrimp(Penaeus vannamei)proteins have been shown an allergenic potential;however,little information is available on the sensitizing and eliciting capacity of shrimp protein digestion *** this study,a BALB/c mice model was used to explore the allergenicity of shrimp protein sample(SPS)and their gastric and gastrointestinal digestion products(GDS/GIDS).As compared with the SPS groups,the GDS/GIDS groups caused lower specific immunoglobulins(Ig E/Ig G1)levels(P<0.05),but higher than the control groups,indicating that the digestion products sensitized the ***,spleen index,mouse mast cell protease-1(m MCP-1)concentration and proportion of degranulated mast cells were significantly reduced in the GDS/GIDS groups(P<0.05);simultaneously,allergic symptoms,vascular permeability and histopathological changes of tissues were ***,the allergenicity of digestion products cannot be eliminated and still cause systemic allergic reactions in *** study showed that the digestion products of shrimp still had high sensitizing and eliciting capacity.

关键词： Penaeus vannamei Allergenicity Digestion BALB/c mice model

Unveiling the secrets of diatom-mediated calcification: Implications for the biological pump

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Science China Earth Sciences 2024年第9期67卷 2895-2909页

作者： Yiwen PAN Yifan LI Chen-Tung Arthur CHEN Zong-Pei JIANG Wei-Jun CAI Yunwen SHEN Zesheng DING Qixian CHEN Yanan DI Wei FAN Chenba ZHU Ying CHEN Ocean College Zhejiang University Hainan Institute of Zhejiang University Department of Oceanography Sun Yat-Sen University School of Marine Science and Policy University of Delaware Carbon Neutral innovation research Center Xiamen University

Siliceous diatoms are one of the most prominent actors in the oceans, and they account for approximately 40% of the primary production and particulate organic carbon export flux. It is believed that changes in carbon flux caused by variations in diatom distribution can lead to significant climate shifts. Although the fundamental pathways of diatom-driven carbon sequestration have long been established, there are no reports of CaCO3precipitation induced by marine diatom species. This manuscript introduces novel details regarding the enhancement of aragonite precipitation during photosynthesis in Skeletonema costatum in both artificial and natural seawater. Through direct measurements of cell surfaces via a pH microelectrode and zeta potential analyzer, it was determined that the diatom-mediated promotion of CaCO3precipitation is achieved through the creation of specific microenvironments with concentrated [CO32–] and [Ca2+] and/or the dehydrating effect of adsorbed Ca2+.Based on this mechanism, it is highly plausible that diatom-mediated calcification could occur in the oceans, an assertion that was supported by the significant deviation of total alkalinity（TA） from the conservative TA-salinity mixing line during a Skeletonema costatum bloom in the East China Sea and other similar occurrences. The newly discovered calcification pathway establishes a link between particulate inorganic and organic carbon flux and thus helps in the reassessment of marine carbon export fluxes and CO2sequestration efficiency. This discovery may have important ramifications for assessing marine carbon cycling and predicting the potential effects of future ocean acidification.

关键词： Diatom bloom Skeletonema costatum Calcification Biological carbon pump Counter carbonate pump

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WavEnhancer: Unifying Wavelet and Transformer for Image Enhancement

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Journal of Computer Science & Technology 2024年第2期39卷 336-345页

作者：李梓诺陈绪行郭淑娜王书强潘治文 Department of Computer and Information Science University of MacaoMacao 999078China research Center for biomedical Information Technology Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Image enhancement is a widely used technique in digital image processing that aims to improve image aesthetics and visual quality. However, traditional methods of enhancement based on pixel-level or global-level modifications have limited effectiveness. Recently, as learning-based techniques gain popularity, various studies are now focusing on utilizing networks for image enhancement. However, these techniques often fail to optimize image frequency domains. This study addresses this gap by introducing a transformer-based model for improving images in the wavelet domain. The proposed model refines various frequency bands of an image and prioritizes local details and high-level features. Consequently, the proposed technique produces superior enhancement results. The proposed model’s performance was assessed through comprehensive benchmark evaluations, and the results suggest it outperforms the state-of-the-art techniques.

关键词： transformer wavelet transform image enhancement

Dynamic asymmetric mechanical responsive carbon nanotube fiber for ionic logic gate

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Chinese Chemical Letters 2024年第6期35卷 249-253页

作者： Pei Cao Yilan Wang Lejian Yu Miao Wang Liming Zhao Xu Hou State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China The Higher Educational Key Laboratory for biomedical Engineering of Fujian Province Department of BiomaterialsResearch Center of Biomedical Engineering of XiamenCollege of MaterialsXiamen UniversityXiamen 361005China Key Laboratory of Multifunctional Nanomaterials and Smart Systems Advanced Materials DivisionSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Institute of Artificial Intelligence Xiamen UniversityXiamen 361005China Department of Physics Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Functional Materials ResearchJiujiang Research InstituteCollege of Physical Science and TechnologyXiamen UniversityXiamen 361005China Engineering research Center of Electrochemical Technologies of Ministry of Education Xiamen UniversityXiamen 361005China

Inspired by biological ion channels,numerous artificial asymmetric ion channels have been synthesized to facilitate the fabrication of ionic ***,the creation of biomimetic asymmetric ion channels necessitates expensive scientific apparatus and intricate material processing procedures,which constrains its advancement within the realm of ionic *** this study,we have devised dynamic asymmetric ion channels with mechanical responsiveness by combining polymers of varying elastic modulus along the longitudinal axis of carbon nanotube fiber(CNTF).The ion rectification can be modulated via the disparate response of CNTF-based ion channels to mechanical *** have effectively employed these asymmetric ion channels with mechanical sensitivity in the design of a logic gate device,achieving logic operations such as“AND”and“OR”.The conception of these dynamic asymmetric ion channels with mechanical sensitivity offers a straightforward,cost-effective,and versatile approach for generating ion channels,highlighting their potential application in intricate,highly integrated ionic circuits.

关键词： Carbon nanotubes fibers Mechanical response Rectification effect Ionic logic gate

Multiple types of disease-associated RNAs identification for disease prognosis and therapy using heterogeneous graph learning

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Science China(Information Sciences) 2024年第8期67卷 341-342页

作者： Wenxiang ZHANG Hang WEI Wenjing ZHANG Hao WU Bin LIU School of Computer Science and Technology Beijing Institute of Technology School of Computer Science and Technology Xidian University Department of Teaching and research Shenzhen University General Hospital Guangdong Key Laboratory for biomedical Measurements and Ultrasound Imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical Engineering Shenzhen University Medical School Advanced research Institute of Multidisciplinary Science Beijing Institute of Technology

Identifying disease-associated RNAs is crucial in revealing the pathogenic mechanisms of diseases [1], and biologists have made notable progress in this field [2]. However, more effective computational methods are needed to provide reference disease-associated RNAs, reducing the manpower and material resources required for biological experiments.

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Near resonance vibration isolation on a levered-dual response(LEDAR)Coulomb-damped system by differential preloads/offsets in linear springs

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1033-1050页

作者： T.I.TOLUWALOJU C.K.THEIN D.HALIM Department of Mechanical Materials and Manufacturing EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100Zhejiang ProvinceChina Nottingham Ningbo China Beacons of Excellence research and innovation Institute University of Nottingham Ningbo ChinaNingbo 315048Zhejiang ProvinceChina

The levered-dual response(LEDAR)Coulomb-damped system attains near resonant vibration isolation by differential preloads/offsets in linear *** takes the advantages of both the preloads/offsets in linear springs and the guiderail friction for realizing different levels of vibration *** isolation capacities are investigated on the strategies with both the horizontal and vertical guiderails,with the horizontal rail only,and without *** compressive preloads generally result in the consumption of most of the initial excitation energy so as to overcome the potential *** isolation onsets at the frequency ratio of 1∓0.095 on the left-hand side(LHS)and the right-hand side(RHS)of the lever are relative to the load plate *** observed near resonant isolation thus makes the LEDAR system a candidate for the isolation of the mechanical systems about resonance while opening a path for simultaneous harvesterisolation functions and passive functions at extreme frequencies.

关键词： lever ratio Coulomb damping preload tension/compression isolation band/depth offset potential

A new method for identifying flow pattern of spouted fluidized bed by coupling Hilbert-Huang transform characteristics of differential pressure signals in different zones

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Particuology 2024年第6期89卷 67-78页

作者： Yongzhi Mei Yang Wang Lihui Zhang Feng Duan School of Energy and Environment Anhui University of TechnologyMaanshan243002China Wuhu Technology and innovation research Institute Wuhu241000China Wuhu Cigarette Factory of China Tobacco Anhui Industrial Co. Ldt.Wuhu241002China

On a cold spouted fluidized bed,this study compares the characteristic differences in intrinsic mode function(IMF)energy and Hilbert–Huang spectrum between the spout zone and annulus zone under different combinations of spouted gas and fluidized gas flow rates for five typical flow *** energy distribution characteristics under different flow patterns are also *** Hilbert–Huang spectrum and IMF energy of pressure difference signals exhibit distinct variations in different zones as the flow pattern ***,there exists a correlation between the energy in the middle-frequency range and the flow *** the K-means algorithm,the middle-frequency range energy of IMFs in the spout zone and annulus zone is subjected to clustering analysis,leading to the identification of partition boundaries for each flow *** on this,a flow pattern identification method of spouted fluidized bed coupled with middle-frequency range energy in spout zone and annulus zone is proposed,which has very high identification accuracy.

关键词： Spouted fluidized bed Flow pattern Zoning signal Flow pattern transition Hilbert-Huang transform

Design of a biomedical Device to Reduce Anxiety Experienced by Patients Diagnosed with Parkinson’s Disease

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Journal of biomedical Science and Engineering 2024年第3期17卷 57-71页

作者： Madhini Vigneswaran Anjali Menon research Department MEDIC Foundation Vancouver Canada

Parkinson’s disease (PD) is a neurodegenerative disease that occurs due to loss of nerve cells that produce dopamine in the brain, affecting approximately 4 million people worldwide. PD patients often feel an increase in anxiety levels daily. While there are medications/exercises to help relieve anxiety, there are limited methods to reduce anxiety without the help of a caretaker. As a result, MEDIC foundation, a non-profit organization in British Columbia, Canada, is designing an automated system that consists of a wristband and an application which uses vi-bration therapy to help reduce anxiety of PD patients. Literature reviews were conducted to document the project’s needs. Phase I of the project focused on de-veloping a prototype for the application and phase II on developing the wrist-band. The team developed prototypes of a wristband that automatically applies vibration near the median nerve as the heart rate variability (HRV) deviates away from the normal threshold of the user, and an application that displays real-time heart rate variability signals as well as provides for relaxation. The development of the prototype is still in early progress. By creating this automated system, we aim to provide a solution to senior PD patients to relieve anxiety independently. .

关键词： Vibration Therapy Healthcare Application Parkinson’s Disease Anxiety Wristband Heart Rate Variability

Aberration correction for deformable-mirror-based remote focusing enables high-accuracy whole-cell super-resolution imaging

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Photonics research 2024年第4期12卷 821-832页

作者： WEI SHI YINGCHUAN HE JIANLIN WANG LULU ZHOU JIANWEI CHEN LIWEI ZHOU ZEYU XI ZHEN WANG KE FANG YIMING LI Department of biomedical Engineering Southern University of Science and TechnologyShenzhen 518055China

Single-molecule localization microscopy(SMLM)enables three-dimensional(3D)investigation of nanoscale structures in biological samples,offering unique insights into their ***,traditional 3D super-resolution microscopy using high numerical aperture(NA)objectives is limited by imaging depth of field(DOF),restricting their practical application to relatively thin biological ***,we developed a unified solution for thick sample super-resolution imaging using a deformable mirror(DM)which served for fast remote focusing,optimized point spread function(PSF)engineering,and accurate aberration *** effectively correcting the system aberrations introduced during remote focusing and sample aberrations at different imaging depths,we achieved high-accuracy,large DOF imaging(~8μm)of the whole-cell organelles[i.e.,nuclear pore complex(NPC),microtubules,and mitochondria]with a nearly uniform resolution of approximately 35 nm across the entire cellular volume.

关键词： enable mirror resolution

The centrosymmetric to non-centrosymmetric transformation induced by alkaline-earth cations producing infrared nonlinear optical AeMn6Ga6S16（Ae = Ca, Sr）

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Science China Chemistry 2024年第9期67卷 2941-2948页

作者： Yang-Ping Zhang Shao-Min Pei Wen-Fa Chen Bin-Wen Liu Xiao-Ming Jiang Guo-Cong Guo State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Physical Science and Technology Shanghai Tech University Fujian Science & Technology innovation Laboratory for Optoelectronic Information of China

Non-centrosymmetric（NCS） structure is an indispensable prerequisite for second-order nonlinear optical（NLO） ***, the mainstream approach for designing new NCS structures still relies on chemical substitution, necessitating an urgent infusion of fresh ideas. In this work, two isomorphic sulfides AeMn6Ga6S16（Ae = Ca, 1; Sr, 2） are afforded by modifying the skeleton of centrosymmetric（CS） Mn2Ga2S5via introducing strong electropositive alkaline-earth cations. Concretely, the incorporation of Ca2+/Sr2+cations allows the elementary [MnGaS9]∞chains to reconfigure into bumpy [MnS6]-[GaS4] layers in a new engagement manner, thus enabling the conversion from CS to NCS structure. Such modifications cause not only strong second-harmonic generation（SHG） responses（～1.5 × benchmark AgGaS2@1,700 nm）, but also significantly feasible bandgaps（2.60–2.64 e V） compared to the sulfide Mn2Ga2S5（1.36 e V）, which ultimately facilitate ultrahigh laser-induced damage thresholds（4.4–6.6 × AgGaS2@1,064 nm for compounds 1 and 2）. The present study offers an ingenious approach for the transformation of CS to NCS structure.

关键词： second-harmonic generation non-centrosymmetrical structure NLO functional motif solid-state method