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Neural Regeneration Research 2024年第8期19卷 1645-1646页

作者： Dmitry Lim Alexei Verkhratsky Department of Pharmaceutical Sciences Universitàdel Piemonte Orientale“Amedeo Avogadro”NovaraItaly Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Achucarro Center for Neuroscience IKERBASQUEBasque Foundation for ScienceBilbaoSpain&Department of NeurosciencesUniversity of the Basque Country UPV/EHU and CIBERNEDLeioaSpain Department of Stem Cell Biology State Research Institute Centre for Innovative MedicineVilniusLithuania Department of forensic Analytical Toxicology School of Forensic MedicineChina Medical UniversityShenyangLiaoning ProvinceChina

Alzheimer’s disease(AD)is a major age-related form of dementia with a number of cases exponentially growing,causing enormous social and economic impact on individuals and *** hallmarks of AD,evident in postmortem AD brains,include a massive loss of the grey matter in the neocortex,extracellular deposition of amyloid-β(Aβ)in the form of senile plaques and cerebrovascular amyloid angiopathy,and intra-neuronal accumulation of neurofibrillary tangles,formed by hyper-phosphorylated tau protein.

关键词： Alzheimer homeostasis cortex

Evaluation of a Novel 32 X-STR Loci Multiplex System in the forensic Application

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刑事技术 2024年第5期49卷 456-463页

作者： ZHANG Juntao YANG Xingyi YU Zhengliang ZHAO Peng LIU Dayu HAN Xiaolong SUN Hongyu LIU Chao Faculty of forensic Medicine Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510089China Guangzhou forensic Science Institute Guangzhou 510080China Institute of forensic Science Ministry of Public SecurityBeijing 100038China AGCU ScienTech Incorporation Wuxi 214174JiangsuChina National Anti-Drug Laboratory Guangdong Regional Center Guangzhou 510230China

The AGCU X Plus STR system is a newly developed multiplex PCR kit that detects 32 X-chromosomal STR loci *** are DXS6807,DXS9895,linkage group 1(DXS10148,DXS10135,DXS8378),DXS9902,DXS6795,DXS6810,DXS10159,DXS10162,DXS10164,DXS7132,linkage group 2(DXS10079,DXS10074,DXS10075),DXS981,DXS6800,DXS6803,DXS6809,DXS6789,DXS7424,DXS101,DXS7133,GATA172D05,GATA165B12,linkage group 3(DXS10103,HPRTB,DXS10101),GATA31E08 and linkage group 4(DXS8377,DXS10134,DXS7423).A major advantage of this kit is that it takes into account linkage between loci,in addition to detecting more X-STR *** order to evaluate the forensic application of 32 X-STR fl uorescence amplifi cation system,PCR settings,sensitivity,species specifi city,stability,DNA mixtures,concordance,stutter,sizing precision,and population genetics investigation were evaluated according to the Scientific Working Group on DNA Analysis Methods(SWGDAM)developmental validation *** study showed that the genotyping results of each locus were signifi cantly accurate when the DNA template was at least 62.5 *** profi les were obtained for the 1∶1 and 1∶3 combinations.A total of 209 unrelated individuals from Southern Chinese Han community,consisting of 84 females and 125 males,were selected for population studies,and 285 allele profi les were detected from 32 X-STR *** polymorphism information content(PIC)ranged from 0.2721 in DXS6800,to 0.9105 in DXS10135,with an average of ***10135(PIC=0.9105)was the most polymorphic locus,with discrimination power(DP)of 0.9164 and 0.9871 for the male and *** cumulative PD_(F),PD_(M),MEC_(trio) and MEC_(duo) valu es were all greater than *** were 78 different DXS10103-HPRTB-DXS10101 haplotypes among the 125 males,and the haplotype diversity was *** was no signifi cant difference in the cumulative PD_(F),PD_(M),MEC_(trio) and MEC_(duo) values whether considering linkage or *** summary,the new X-STR multiplex typing sys

关键词： forensic genetics X-STR loci kinship analysis evaluation

Isobavachromene ameliorates insulin resistance via inactivating the MAPK/NF-κB signaling pathway

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Food Science and Human Wellness 2024年

作者： Zhenhua Liu Zhenhua Liang Lanting Xu Jiajia Yuan Yiqi Li Wenyi Kang Yan Zhang Bin Cong National R & D Center for Edible Fungus Processing Technology， Henan University Joint International Research Laboratory of Food & Medicine Resource Function College of Agriculture， Henan University Shenzhen Research Institute of Henan University Hebei Key Laboratory of forensic Medicine， College of forensic Medicine， Hebei Medical University Hebei Food Safety Key Laboratory， Hebei Food Inspection and Research Institute

Inflammation caused by obesity， particularly in adipose tissue and the liver， can lead to insulin resistance (IR) and trigger type 2 diabetes (T2DM). It is crucial to identify therapeutic agents that alleviate IR by reducing inflammation. Here， we report that isobavachromene (IB)， a flavonoid derived from Psoralea corylifolia Linn.， ameliorates IR in 3T3-L1 adipocytes by inhibiting the MAPK/NF-κB signaling pathway. We first found that IB could promote glucose uptake in 3T3-L1 adipocytes by activating the PI-3K/Akt signaling pathway and was more effective than the positive control sodium orthovanadate at concentrations ranging from 25 to 100 μmol/L. Additionally， IB inhibited RAW264.7 macrophage infiltration into 3T3-L1 adipocytes and suppressed the secretion of inflammatory factors from RAW264.7 macrophages， as well as the phosphorylation levels of key proteins (NF-κB P65， ERK1/2， JNK， and P38) in the NF-κB and MAPK signaling pathways. In summary， IB improves glucose uptake in IR adipocytes， activates the PI-3K/Akt signaling pathway， inhibits the JNK and NF-κB inflammatory signaling pathways， and reduces adipocyte inflammation， thereby improving of IR in 3T3-L1 adipocytes.

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Crucial role played by CK8^(+)cells in mediating alveolar injury remodeling for patients with COVID-19

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Virologica Sinica 2024年第3期39卷 390-402页

作者： Yufeng Li Hengrui Hu Jia Liu Longda Ma Xi Wang Liang Liu Qian Liu Liang Ren Jiang Li Fei Deng Zhihong Hu Yiwu Zhou Manli Wang State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430071China Department of forensic Medicine Tongji Medical College of Huazhong University of Science and TechnologyWuhan430010China University of the Chinese Academy of Sciences Beijing100049China

The high risk of SARS-CoV-2 infection and reinfection and the occurrence of post-acute pulmonary sequelae have highlighted the importance of understanding the mechanism underlying lung repair after *** address this concern,comparative and systematic analyses of SARS-CoV-2 infection in COVID-19 patients and animals were *** the lungs of nine patients who died of COVID-19 and one recovered from COVID-19 but died of unrelated disease in early 2020,damage-related transient progenitor(DATP)cells expressing CK8 marker proliferated *** CK8^(+)DATP cells were derived from bronchial CK5^(+)basal ***,they showed different cell fate toward differentiation into type I alveolar cells in the deceased and convalescent patients,*** using a self-limiting hamster infection model mimicking the dynamic process of lung injury remodeling in mild COVID-19 patients,the accumulation and regression of CK8t cell marker were found to be closely associated with the disease ***,we examined the autopsied lungs of two patients who died of infection by the recent Omicron variant and found that they only exhibited mild pathological injury with no CK8^(+)cell *** results indicate a clear pulmonary cell remodeling route and suggest that CK8^(+)DATP cells play a primary role in mediating alveolar remodeling,highlighting their potential applications as diagnostic markers and therapeutic targets.

关键词： SARS-CoV-2 CK8t DATP cells Cell proliferation Lung injury-remodeling Autopsy Hamster infection model

The role and applications of extracellular vesicles in osteoporosis

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Bone Research 2024年第1期12卷 62-77页

作者： Fei Fang Jie Yang Jiahe Wang Tiantian Li Erxiang Wang Demao Zhang Xiaoheng Liu Chenchen Zhou Institute of Biomedical Engineering West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu 610041China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041China

Osteoporosis is a widely observed condition characterized by the systemic deterioration of bone mass and microarchitecture,which increases patient susceptibility to fragile *** intricate mechanisms governing bone homeostasis are substantially impacted by extracellular vesicles(EVs),which play crucial roles in both pathological and physiological *** derived from various sources exert distinct effects on ***,EVs released by osteoblasts,endothelial cells,myocytes,and mesenchymal stem cells contribute to bone formation due to their unique cargo of proteins,miRNAs,and ***,EVs secreted by osteoclasts and immune cells promote bone resorption and inhibit bone ***,the use of EVs as therapeutic modalities or biomaterials for diagnosing and managing osteoporosis is ***,we review the current understanding of the impact of EVs on bone homeostasis,including the classification and biogenesis of EVs and the intricate regulatory mechanisms of EVs in ***,we present an overview of the latest research progress on diagnosing and treating osteoporosis by using ***,we discuss the challenges and prospects of translational research on the use of EVs in osteoporosis.

关键词： osteoporosis homeostasis biomaterials

A systematic review of salivary biomarkers in Parkinson's disease

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Neural Regeneration Research 2024年第12期19卷 2613-2625页

作者： Maria Ilenia De Bartolo Daniele Belvisi Romina Mancinelli Matteo Costanzo Claudia Caturano Giorgio Leodori Alfredo Berardelli Giovanni Fabbrini Giorgio Vivacqua IRCCS Neuromed PozzilliItaly Department of Human Neurosciences Sapienza University of RomeRomeItaly Department of Anatomical HistologicalForensic Medicine and Orthopedics SciencesSapienza University of RomeRomeItaly Department of Experimental Morphology and Microscopy-Integrated Research Center(PRAAB)-Campus Biomedico University of Rome RomeItaly

The search fo r reliable and easily accessible biomarkers in Parkinson's disease is receiving a growing emphasis,to detect neurodegeneration from the prodromal phase and to enforce disease-modifying *** the need for non-invasively accessible biomarke rs,the majo rity of the studies have pointed to cerebrospinal fluid or peripheral biopsies biomarkers,which require invasive collection *** represents an easily accessible biofluid and an incredibly wide source of molecular *** the present study,after presenting the morphological and biological bases for looking at saliva in the search of biomarkers for Parkinson's disease,we systematically reviewed the results achieved so far in the saliva of different cohorts of Parkinson's disease patients.A comprehensive literature search on PubMed and SCOPUS led to the discovery of *** screening and exclusion,34 relevant articles were derived fo r systematic ***-synuclein,the histopathological hallmark of Parkinson's disease,has been the most investigated Parkinson's disease biomarker in saliva,with oligomeric alphasynuclein consistently found increased in Parkinson's disease patients in comparison to healthy controls,while conflicting results have been reported regarding the levels of total alpha-synuclein and phosphorylated alpha-synuclein,and few studies described an increased oligomeric alpha-synuclein/total alpha-synuclein ratio in Parkinson's *** alpha-synuclein,other biomarkers to rgeting diffe rent molecular pathways have been explored in the saliva of Parkinson's disease patients:total tau,phosphorylated tau,amyloid-β1-42(pathological protein aggregation biomarkers);DJ-1,heme-oxygenase-l,metabolites(alte red energy homeostasis biomarkers);MAPLC-3beta(aberrant proteostasis biomarker);cortisol,tumor necrosis factor-alpha(inflammation biomarkers);DNA methylation,miRNA(DNA/RNA defects biomarkers);acetylcholinesterase activity(synaptic and neuronal network

关键词： alpha-synuclein amyloid-beta autophagy DJ-1 neurodegeneration neuroinflammation Parkinson's disease salivary biomarkers tau

Fibroblast-localized lncRNA CFIRL promotes cardiac fibrosis and dysfunction in dilated cardiomyopathy

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Science China(Life Sciences) 2024年第6期67卷 1155-1169页

作者： Shuai Yuan Xudong Zhang Jiabing Zhan Rong Xie Jiahui Fan Beibei Dai Yanru Zhao Zhongwei Yin Qian Liu Dao Wen Wang Huaping Li Chen Chen Division of Cardiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan 430030China Department of forensic Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

CFIRL is a long noncoding RNA(lnc RNA),we previously identified as the most significantly upregulated lnc RNA in the failing hearts of patients with dilated cardiomyopathy(DCM).In this study,we determined the function of CFIRL and its role in ***-time polymerase chain reaction and in situ hybridization assays revealed that CFIRL was primarily localized in the nucleus of cardiac fibroblasts and robustly increased in failing *** knockdown or fibroblast-specific knockout of CFIRL attenuated transverse aortic constriction(TAC)-induced cardiac dysfunction and fibrosis in *** of CFIRL in vitro promoted fibroblast proliferation and aggravated angiotensin II-induced differentiation to *** knockdown attenuated these ***,RNA pull-down assay and gene expression profiling revealed that CFIRL recruited ENO1,a newly identified noncanonical transcriptional factor,to activate ***-6 exerted a paracrine effect on cardiomyocytes to promote cardiac hypertrophy,which can be prevented by CFIRL *** findings uncover the critical role of CFIRL,a fibroblast-associated lnc RNA,in heart failure by facilitating crosstalk between fibroblasts and *** knockdown might be a potent strategy to prevent cardiac remodeling in heart failure,particularly in DCM.

关键词： lncRNA fibroblast fibrosis dilated cardiomyopathy heart failure

The value of toxicological analysis in acute poisoning patients with uncertain exposure histories:a retrospective and descriptive study from an institute of poisoning

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World Journal of Emergency Medicine 2024年第2期15卷 98-104页

作者： Qifang Shi Gen Ba Zhenyu Xia Zhengsheng Mao Hao Sun Jinsong Zhang Institute of Poisoning Nanjing Medical UniversityNanjing 211100China Department of Emergency Medicine the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of forensic Medicine Nanjing Medical UniversityNanjing 211166China The Key Laboratory of Modern Toxicology of Ministry of Education Nanjing Medical UniversityNanjing 211166China

BACKGROUND:In clinical practice,some patients might not be able or unwilling to provide a thorough history of medication and poison *** aim of this study was to use toxicological analysis to examine the clinical characteristics of patients with acute poisoning whose exposure history was uncertain from a toxicological analysis ***:This was a retrospective and descriptive study from an institute of *** registration information and test reports spanning the period from April 1,2020 to March 31,2022,were *** with uncertain exposure histories and who underwent toxicological analysis were *** manifestations and categories of toxics were ***:Among the 195 patients with positive toxicological analysis results,the main causes of uncertain exposure history was disturbance of consciousness(62.6%),unawareness(23.6%)and unwillingness or lack of cooperation(13.8%).The predominant clinical manifestations were disturbed consciousness(62.6%),followed by vomiting and nausea(14.4%)and liver function abnormalities(8.7%).A comparison of clinical manifestations between patients with positive and negative(n=99)toxicological analyses results revealed significantly different proportions of disturbances in consciousness(63%vs.21%),dizziness(1.5%vs.5.1%),multi-organ failure(1.5%vs.7.1%),and local pain(0 vs 4%).The main categories of substances involved were psychiatric medications(23.1%),sedatives(20.5%),insecticides(13.8%),and herbicides(12.8%).CONCLUSION:The clinical manifestations of acute poisoning in patients with an uncertain exposure history are diverse and nonspecific,and toxicological analysis plays a pivotal role in the diagnosis and differential diagnosis of such patients.

关键词： Acute poisoning Toxic exposure Toxicological analysis Clinical manifestation

Sociodemographic Background and Psychosocial Behaviors of Perpetrators of Intimate Partner Violence: A Hospital-based Retrospective Study

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Journal of forensic Science and Medicine 2024年第3期10卷 176-183页

作者： Amal Nishantha Vadysinghe Tharanga Bandara Nayakarathne Y.M.G.Ilangarathna Banda Kasun Bandara Ekanayake Isuru Perera Yomal Wijesiriwardena Department of forensic Medicine Faculty of MedicineUniversity of PeradeniyaPeradeniyaSri Lanka Teaching Hospital Kurunegala KurunegalaSri Lanka

Background:Intimate partner violence(IPV)is a worldwide issue with a high prevalence rate seen *** and Objectives:To plan and implement preventive measures,it is important to understand the characteristics,background,and medico-legal significance,especially from the perspective of *** and Methods:This study is a questionnaire-based retrospective study conducted among perpetrators of IPV who presented to a tertiary care hospital in Sri ***:Out of 325 subjects,97.2%were males and 64.0%were aged 26–45 ***(80.9%)perpetrators were older than the victimized partner,with a mean age gap of 4.3 *** 2.8%had achieved higher education and 78.5%had been married to the victim for more than5 *** and/or other substances were abused by 75.4%and 11.1%of them were diagnosed with a psychiatric *** have been exposed to child abuse(CA)as minors(50.1%),with physical CA being the most common,whereas 42.5%had witnessed IPV during their ***-treatment by the spouse(odds ratio[OR]=24[95%confidence interval(CI):5.6,99.9])and substance use(OR=22[95%CI:5.1,91.5])were significantly associated with perpetrating emotional violence.A victim having an extramarital affair was 5.1 times more likely to be subjected to sexual IPV,whereas previous IPV,parental deprivation,and affairs of perpetrator were proved to be protective *** had negatively affected the economy of 71.3%of *** procedures were expected by 22.4%,whereas 60%wanted to negotiate with their ***:Families having low income and alcohol/substance abuse should be targeted to plan preventive programs at the community *** counseling and follow-up of victims of CA can be used as a primary preventive measure of IPV.

关键词： Domestic violence intimate partner violence physical abuse sexual harassment

Landscape of human organoids:Ideal model in clinics and research

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The Innovation 2024年第3期5卷 146-164页

作者： Xinxin Han Chunhui Cai Wei Deng Yanghua Shi Lanyang Li Chen Wang Jian Zhang Mingjie Rong Jiping Liu Bangjiang Fang Hua He Xiling Liu Chuxia Deng Xiao He Xin Cao Organ Regeneration X Lab Lisheng East China Institute of BiotechnologyPeking UniversityJiangsu 226200China Shanghai Lisheng Biotech Shanghai 200092China LongHua Hospital Shanghai University of Traditional Chinese Medicine725 Wanping South RoadXuhui DistrictShanghai 200032China Department of Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China Department of Neurosurgery Third Affiliated HospitalNaval Medical UniversityShanghai 200438China Shanghai Key Laboratory of forensic Medicine Shanghai Forensic Service PlatformAcademy of Forensic ScienceMinistry of JusticeShanghai 200063China Cancer Center Faculty of Health SciencesUniversity of MacaoTaipaMacao SARChina Ministry of Education Frontiers Science Center for Precision Oncology University of MacaoTaipaMacao SAR 999078China CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Zhongshan Hospital Institute of Clinical Science Fudan University Shanghai Medical CollegeShanghai 200032China

In the last decade,organoid research has entered a golden era,signifying a pivotal shift in the biomedical *** year 2023 marked a milestone with the publication of thousands of papers in this arena,reflecting exponential ***,amid this burgeoning expansion,a comprehensive and accurate overview of the field has been conspicuously *** review is intended to bridge this gap,providing a panoramic view of the rapidly evolving organoid *** meticulously analyze the organoid field from eight distinctive vantage points,harnessing our rich experience in academic research,industrial application,and clinical *** present a deep exploration of the advances in organoid technology,underpinned by our long-standing involvement in this *** narrative traverses the historical genesis of organoids and their transformative impact across various biomedical sectors,including oncology,toxicology,and drug *** delve into the synergy between organoids and avant-garde technologies such as synthetic biology and single-cell omics and discuss their pivotal role in tailoring personalized medicine,enhancing high-throughput drug screening,and constructing physiologically pertinent disease *** comprehensive analysis and reflective discourse provide a deep dive into the existing landscape and emerging trends in organoid *** spotlight technological innovations,methodological evolution,and the broadening spectrum of applications,emphasizing the revolutionary influence of organoids in personalized medicine,oncology,drug discovery,and other *** ahead,we cautiously anticipate future developments in the field of organoid research,especially its potential implications for personalized patient care,new avenues of drug discovery,and clinical *** trust that our comprehensive review will be an asset for researchers,clinicians,and patients with keen interest in personalized medical *** offer a broad view of the

关键词： landscape intended advances