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food Bioscience 2022年第2期46卷 330-337页

作者： Xiaojiang Wu Guiming Fu Ziwen Xu Biao Dong Ruyi Li Yin Wan Guofu Jiang Chengmei Liu State Key laboratory of food Science and Technology College of Food Science and TechnologyNanchang UniversityNanchang330047JiangxiPR China Jiangxi Chunsi foods Co. Ltd.Zhangshu331200JiangxiPR China

Dietary interventions play an important role in the prevention and treatment of type 2 diabetes(T2D).This study aims to evaluate the in vitro nutrition properties of whole Tartary buckwheat straight noodles(TSNw)and investigate its amelioration effect on T2D *** buckwheat straight noodles(TSNs),including TSNw and TSNc(made by TB core flour),were prepared using extrusion technology,with characteristic of two times *** showed that TSNw presented higher in vitro antioxidant abilities and lower in vitro digestibility than TSNc(Pfood for treating T2D.

关键词： Tartary buckwheat Straight noodles Type 2 diabetes Whole grains

Bisphenol A disrupts glucose transport and neurophysiological role of IR/IRS/AKT/GSK3β axis in the brain of male mice

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Bisphenol A disrupts glucose transport and neurophysiologica...

Retrieval of original signals for superconducting quantum interference device operating in flux locked mode

中国毒理学会第七次全国毒理学大会暨第八届湖北科技论坛

作者： Fangfang Fang Jun wang Hang Xiao Key Lab of Modern toxicology（NJMU） Ministry of Education.Department of ToxicologySchool of Public HealthNanjing Medical University

Bisphenol A（BPA）,a kind of environmental endocrine disrupting chemicals（EDCs）,is present ubiquitously in our *** is used commercially in products containing polycarbonate plastics such as food and drink packaging materials and infusion bags which sometimes may be boiled,microwave heated,autoclaved and brushed,and is recently reported to disturb the homeostasis of energy metabolism and insulin signaling pathways,which might contribute to the increased prevalence rate of mild cognitive impairment（MCI）.However,the underlying mechanisms are still remained poorly ***,the present work was undertaken to investigate the effect of low doses of BPA on glucose transport and the IR/IRS/AKT/GSK3β axis in adult male mice with the aim to delineate the associations between insulin signaling disruption and neurotoxicity mediated by *** mice were treated with subcutaneous injection of 100 μg/kg/d BPA or vehicle for 30 days,then the insulin signaling and glucose transporters in the hippocampus and prefrontal cortex were detected by western *** results showed mice treated with BPA displayed a significant decrease of insulin sensitivity,and in the mouse brain the protein levels of glucose transporter 1,3（GLUT1,3）were significantly ***,hyperactivation of IR/IRS/AKT/GSK3β axis was displayed in the brain of BPA treated ***,a significant increase of phosphorylated tau and β-APP was observed in BPA treated *** results,taken together,strongly suggest that BPA exposure significantly disrupts brain insulin signaling and BPA exposure might be considered as a potential risk factor for neurodegenerative disease.

关键词： BPA insulin signaling neurodegenerative diseases

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Chinese Physics B 2015年第4期24卷 421-424页

作者：刘当婷田野赵士平任育峰陈赓华 Beijing National laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences

We discuss a simple relation between the input and output signals of a superconducting quantum interference device magnetometer operating in flux locked mode in a cosine curve approximation. According to this relation, an original fast input signal can be easily retrieved from its distorted output response. This technique can be used in some areas such as sensitive and fast detection of magnetic or metallic grains in medicine and food security checking.

关键词： SQUID magnetometer signal retrieval

Delineation of biomarkers and molecular pathways of residual effects of fluoxetine treatment in juvenile rhesus monkeys by proteomic profiling

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Zoological Research 2023年第1期44卷 30-42页

作者： Yu Yan Dong Ik Park Anja Horn Mari Golub Christoph W.Turck Proteomics and Biomarkers Max Planck Institute of PsychiatryMunich 80804Germany Ludwig-Maximilians-Universität Chair of Vegetative AnatomyInstitute of AnatomyFaculty of MedicineMunich 80336Germany Department of Environmental toxicology University of CaliforniaDavisCA 95616USA

Fluoxetine(Prozac^(TM))is the only antidepressant approved by the US food and Drug Administration(FDA)for the treatment of major depressive disorder(MDD)in *** its considerable efficacy as a selective serotonin reuptake inhibitor,the possible long-term effects of fluoxetine on brain development in children are poorly *** the current study,we aimed to delineate molecular mechanisms and protein biomarkers in the brains of juvenile rhesus macaques(Macaca mulatta)one year after the discontinuation of fluoxetine treatment using proteomic and phosphoproteomic *** identified several differences in protein expression and phosphorylation in the dorsolateral prefrontal cortex(DLPFC)and cingulate cortex(CC)that correlated with impulsivity in animals,suggesting that the GABAergic synapse pathway may be affected by fluoxetine *** in combination with the identified pathways contribute to a better understanding of the mechanisms underlying the chronic effects of fluoxetine after discontinuation in children.

关键词： Major depressive disorder Fluoxetine Rhesus monkeys Proteomics GABAergic synapse

Low-levels of graphene inhibit cellular xenobiotic defense system mediated by efflux transporters Abstract

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Low-levels of graphene inhibit cellular xenobiotic defense s...

Strategies to improve aerobic granular sludge stability and nitrogen removal based on feeding mode and substrate

全国环境纳米技术及生物效应学术研讨会

作者： Su Liu Wei Jiang Bing Wu Jing Yu Haiyan Yu Xu-Xiang Zhang Cristina Torres-Duarte Gary N.Cherr State Key laboratory of Pollution Control and Resource Reuse School of the Environment Nanjing University Bodega Marine laboratory University of CaliforniaDavis California USA Departments of Environmental toxicology and Nutrition University of CaliforniaDavis California USA

Dose is one of the most important factors of nanomaterial（NM） toxicity. Low levels of NMs are considered to be safe[1]. In this study, we analyzed the potential toxicity of Graphene at relatively low concentration on plasma membrane ABC transporter activity of Human cell line HepG2. In the cell membrane, ABC transporters are common and are known to play a crucial role in multidrug resistance（MDR） [2, 3], where they function as efflux pumps and are responsible for chemotherapeutic drug resistance in cancer cells. ABC transporters can also pump xenobiotics out of the cell using an ATPdependent mechanism, thus reducing potential toxic effects. The results showed that Graphene（＜0.5 μg/mL） did not decrease cell viability, generate reactive oxygen species（ROS） and cause cell apoptosis. However, Graphene at non-toxic concentration could increase Calcein-AM（CAM, an indicator of membrane ABC transporter activities） accumulation, indicating inhibition of ABC transporters’ activities. This inhibition could be observed even at 0.005μg/mL, which is 100-times and lower than its lowest toxic concentration from cytotoxicity experiments. The inhibition of ABC transporters significantly sensitized the toxicity of paraquat, a toxic and widely used herbicide and a known substrate of ABC transporters. The potential mechanism of inhibition of membrane transporter activities caused by Graphene was further analyzed by gene expression, protein expression and membrane integrity and function. Based on above results, we assume that Graphene can damage cell membrane functions, and thus causing an inhibition of potentially all plasma membrane transporter（P-gp/MRP/BCRP） activity. This study shows the amplification of environmental effects of Graphene at non-toxic concentrations, which could significantly cause the inhibition of ABC transporters’ activities.

关键词： Graphene ABC transporter Cytotoxicity Chemosensitizer

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Journal of Environmental Sciences 2019年第10期31卷 144-154页

作者： Quan Yuan Hui Gong Hao Xi Heng Xu Zhengyu Jin Nasir Ali Kaijun Wang State Key Joint laboratory of Environment Simulation and Pollution Control School of EnuironmentTsinghua Uniuersity

A systemic strategy was proposed to improve aerobic granular sludge(AGS)stability and nitrogen(N)removal efficiency by optimizing feeding mode and substrate aiming at complicated wastewater *** functional groups at the genus level identified by high-throughput sequencing were evaluated as *** results showed that anaerobic feeding mode and acetate promoted the compact AGS formation with excellent total nitrogen(TN)removal efficiency(averaging 91.7%±4.1%)at various dissolved oxygen *** the aerobic feeding mode led to a loose AGS structure with a vulnerable anaerobic core and poor TN removal efficiency(averaging58.8%±7.4%).Simultaneous nitrification and denitrification process played the dominant role in N removal in compact AGS over the alternating nitrification and denitrification ***-concentration glucose undermined feast-famine condition with filamentous bacteria growth out of granule and decreased TN removal efficiency to 67.3%±15.2%.Lower food to microorganism ratio may result in a lower N removal rate attributed to the sharply increased biomass concentration fed by ***-oxidizing bacteria,nitrite-oxidizing bacteria,denitrifying bacteria,and denitrifying phosphorus accumulation organisms enriched during AGS granulation also contributed to the efficient N *** proposed strategy provided insights into the relationship between various factors and stable AGS formation,and systemic operation methods for various complicated wastewater treatment.

关键词： Aerobic granular sludge Feeding mode Substrate N removal Stability

TiO2 nanoparticles amplify the genotoxicity of arsenic in mammalian cells:new insights from physicochemical interactions and mitochondria

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TiO2 nanoparticles amplify the genotoxicity of arsenic in ma...

Molecular and genetic pathways for optimizing spikelet development and grain yield

第二届全国环境纳米技术及生物效应学术研讨会

作者： Xinan Wang Yun Liu Lijun Wu An Xu Key laboratory of High Magnetic Field and Ion Beam Physical Biology Chinese Academy of SciencesAnhui Province Key Laboratory of Environmental Toxicology and Pollution Control TechnologyHefei Institutes of Physical ScienceChinese Academy of Sciences

Titanium dioxide nanoparticles(TiO NPs) are one of the most important nanomaterials with a broad range of industrial and household *** of their unique properties,TiO NPs have shown great advantages in absorbing and concentrating chemical pollutants,which may eventually modify their fate,behavior,bioavailability, and toxicity to the ecosystem and human ***(As) is a naturally occurring heavy metal that is widely distributed in the *** term exposure to As has been associated with various cancers as well as other non-cancerous *** TiO,NPs and arsenic are ubiquitous in the environment and TiO NPs have shown great adsorption capacity for arsenic(As),it is of great interest to investigate the interaction of TiO,NPs and arsenic and their co-biological *** the toxicity of TiO NPs and As have been well studied individually,the potential impact of TiO NPs on the behavior and toxic responses of As and the underlying mechanisms remain largely *** the present study,we focused on the physicochemical interaction between TiO NPs and As(Ⅲ) to clarify the underlying mechanisms involved in their synergistic genotoxic effect on mammalian *** a series of physicochemical characterizations,Our data showed that As(Ⅲ) mainly interacted with TiO NPs by competitively occupying the sites of hydroxyl groups on the surface of TiO NP aggregates,resulting in more aggregation of TiO *** illustrate the interaction and genotoxic response of TiO NPs and As during their co-exposure process,human-hamster hybrid(AL) cells,which provide an attractive alternative in evaluating genotoxic compounds that induce mostly *** deletions were *** found that although TiO NPs at concentrations used here had no cytotoxic or gcnotoxic effects,they efficiently increased the genotoxicity of As(Ⅲ) in human-hamster hybrid(AL) *** synergistic genotoxicity of TiO NPs and As(Ⅲ) was partially inhibited by various endoc

关键词： TiO2 nanoparticles(TiO2 NPs) arsenic(As(Ⅲ)) human-hamster hybrid(AL) cells synergistic genotoxicity physicochemical interactions mitochondria

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aBIOTECH 2020年第4期1卷 276-292页

作者： Zheng Yuan Staffan Persson Dabing Zhang Joint International Research laboratory of Metabolic and Developmental Sciences Shanghai Jiao Tong University-University of Adelaide Joint Centre for Agriculture and HealthState Key Laboratory of Hybrid RiceSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China School of Biosciences University of MelbourneMelbourneParkvilleVIC 3010Australia Department for Plant and Environmental Sciences University of Copenhagen1871 Frederiksberg CDenmark School of Agriculture Food and WineUniversity of AdelaideWaite CampusUrrbraeSA 5064Australia

The spikelet is a unique structure of inflorescence in grasses that generates one to many flowers depending on its determinate or indeterminate meristem *** growth patterns and number of spikelets,furthermore,define inflorescence architecture and ***,understanding the molecular mechanisms underlying spikelet development and evolution are attractive to both biologists and *** on the progress in rice and maize,along with increasing numbers of genetic mutants and genome sequences from other grass families,the regulatory networks underpinning spikelet development are becoming *** is particularly evident for domesticated traits in *** review focuses on recent progress on spikelet initiation,and spikelet and floret fertility,by comparing results from Arabidopsis with that of rice,sorghum,maize,barley,wheat,Brachypodium distachyon,and Setaria *** progress may benefit genetic engineering and molecular breeding to enhance grain yield.

关键词： Yield improvement Inflorescence Spikelet Fertility Breeding

Toxicity detection of sodium nitrite,borax and aluminum potassium sulfate using electrochemical method

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Journal of Environmental Sciences 2013年第4期25卷 785-790页

作者： Dengbin Yu Daming Yong Shaojun Dong State Key laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of Sciences

Based on the inhibition effect on the respiratory chain activity of microorganisms by toxicants, an electrochemical method has been developed to measure the current variation of a mediator in the presence of microorganisms contacted with a toxicant. Microelectrode arrays were adopted in this study, which can accelerate the mass transfer rate of an anaiyte to the electrode and also increase the total current signal, resulting in an improvement in detection sensitivity. We selected Escherichia coli as the testee and the standard glucose- glutamic acid as an exogenous material. Under oxygen restriction, the experiments in the presence of toxicant were performed at optimum conditions （solution pH 7.0, 37℃ and reaction for 3 hr）. The resulting solution was then separated from the suspended microorganisms and was measured by an electrochemical method, using ferricyanide as a mediator. The current signal obtained represents the reoxidation of ferrocyanide, which was transformed to inhibiting efficiency, IC50, as a quantitative measure of toxicity. The IC50 values measured were 410, 570 and 830 mg/L for sodium nitrite, borax and aluminum potassium sulfate, respectively. The results show that the toxicity sequence for these three food additives is consistent with the value reported by other methods. Furthermore, the order of damage degree to the microorganism was also observed to be： sodium nitrite 〉 borax 〉 aluminum potassium sulfate 〉 blank, according to the atomic force microscopy images of E. coli after being incubated for 3 hr with the toxic compound in buffer solutions. The electrochemical method is expected to be a sensitive and simple alternative to toxicity screening for chemical food additives.

关键词： food additives sodium nitrite borax aluminum potassium sulfate microelectrode arrays

Automated Chinese medicinal plants classification based on machine learning using leaf morpho-colorimetry,fractal dimension and visible/near infrared spectroscopy

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International Journal of Agricultural and Biological Engineering 2019年第2期12卷 123-131页

作者： Jinru Xue Sigfredo Fuentes Carlos Poblete-Echeverria Claudia Gonzalez Viejo Eden Tongson Hejuan Du Baofeng Su College of Mechanical and Electronic Engineering Northwest A&F UniversityYangling 712100ShaanxiChina School of Agriculture and food.Faculty of Veterinary and Agricultural Sciences the University of Melbourne3010 Australia Faculty of AgriSciences Stellenbosch UniversityStellenbosch 7602South Africa Key laboratory of Agricultural Internet of Things Ministry of Agriculture and Rural AffairsYangling 712100ShaanxiChina Key laboratory of Agricultural Perception and Intelligent Services Shaanxi ProvinceYangling 712100ShaanxiChina College of Information Engineering Tibet Nationality UniversityXianyang 712089ShaanxiChina

The identification of Chinese medicinal plants was conducted to rely on ampelographic manual assessment by *** recently,machine learning algorithms for pattern recognition have been successfully applied to leaf recognition in other plant *** new tools make the classification of Chinese medicinal plants easier,more efficient and cost *** study showed comparative results between machine learning models obtained from two methods:i)a morpho-colorimetric method and ii)a visible(VIS)/Near Infrared(NIR)spectral analysis from sampled leaves of 20 different Chinese medicinal ***,the automated image analysis and VIS/NIR spectral based parameters obtained from leaves were used separately as inputs to construct customized artificial neural network(ANN)*** showed that the ANN model developed using the morpho-colorimetric parameters as inputs(Model A)had an accuracy of 98.3%in the classification of leaves for the 20 medicinal plants *** the case of the model based on spectral data from leaves(Model B),the ANN model obtained using the averaged VIS/NIR spectra per leaf as inputs showed 92.5%accuracy for the classification of all medicinal plants *** A has the advantage of being cost effective,requiring only a normal document scanner as measuring *** method can be adapted for non-destructive assessment of leaves in-situ by using portable wireless *** B combines the fast,non-destructive advantages of VIS/NIR spectroscopy,which can be used for rapid and non-invasive identification of Chinese medicinal plants and other applications by analyzing specific light spectra overtones from leaves to assess concentration of pigments such as chlorophyll,anthocyanins and others that are related active compounds from the medicinal plants.

关键词： ampelography computer vision artificial neural networks pattern recognition Chinese medicinal plants