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Journal of Animal Science and Biotechnology 2024年第5期15卷 1761-1777页

作者： Kaiqi Li Xiangyu Xiao Yuling Li Sichen Lu Jianghang Zi Xiaoqiang Sun Jia Xu Hao‑Yu Liu Xiaoqiong Li Tongxing Song Demin Cai Laboratory of Animal Physiology and Molecular Nutrition Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular DesignCollege of Animal Science and TechnologyYangzhou UniversityYangzhou 225009China College of Animal Science and Technology Huazhong Agricultural UniversityWuhan 430070China School of Life Science and Engineering Foshan UniversityFoshan 528231China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and safety of Agro‑Products Institute of Food ScienceZhejiang Academy of Agricultural SciencesHangzhouZhejiang 310021People’s Republic of China College of Agriculture Jinhua PolytechnicJinhua 321017China

Obesity is a prevalent chronic disease that has significant negative impacts on humans and our companion animals,including dogs and *** occurs with multiple comorbidities,such as diabetes,hypertension,heart disease and osteoarthritis in dogs and cats.A direct link between lipid metabolism dysregulation and obesity-associated diseases has been ***,the understanding of such pathophysiology in companion animals is *** review aims to address the role of lipid metabolism in various metabolic disorders associated with obesity,emphasizing the involvement of the gut ***,we also discuss the management of obesity,including approaches like nutritional interventions,thus providing novel insights into obesity prevention and treatment for canines and felines.

关键词： Cat Dog Gut microbiota Lipid metabolism Obesity Management

Moringa oleifera Lam. isothiocyanate inhibits lipid accumulation in high-fat diet mice by promoting lipid metabolism and modulating appetite

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food Science and Human Wellness 2024年

作者： Jing Xie Zishan Hong Jiaying Mao Linjie Peng Yuying Bai Jun Sheng Yang Tian College of food Science and Technology， Yunnan Agricultural University Yunnan Provincial Key Laboratory of Precision Nutrition and Personalized food Manufacturing， Yunnan Agricultural University National Research and Development Professional Center for Moringa Processing Technology， Yunnan Agricultural University Engineering Research Center of Development and Utilization of food and Drug Homologous Resources， Ministry of Education， Yunnan Agricultural University Yunnan Provincial Engineering Research Center for Edible and Medicinal Homologous Functional food， Yunnan Agricultural University School of Tea and Coffee， Puer University

Obesity has brought great challenges to global human health， and how to effectively prevent and control the occurrence and development of obesity has become an urgent problem. The role and mechanism of 4-[(α-L-Rhamnosyloxy) benzyl] isothiocyanate (MITC)， an active ingredient of Moringa oleifera Lam.， in the regulation of lipid metabolism have not been comprehensively investigated. In the present study， we investigated the mechanism of MITC in inhibiting lipid accumulation in mice fed with a high-fat diet (HFD) in terms of both lipolysis and central appetite regulation mediated by the gut microbe–gut–brain axis. MITC enhanced the characteristic indices associated with HFD mice and also promoted adipocytolysis and brown fat thermogenesis. Moreover， MITC was observed to improve leptin resistance， modulate the composition of gut microbiota such as Ruminococcaceae， Parasutterella， and Acetatifactor， promote 5-HT secretion， further enhance the secretion of glucagon-like peptide-1 (GLP-1) and peptide tyrosine-tyrosine (PYY) to activate peroxisome proliferator-activated receptor (PPAR) signaling in the hypothalamus， and modulate feeding behavior to inhibit lipid accumulation in HFD mice. These data suggest that MITC supplementation can help to alleviate obesity or obesity-related diseases.

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Puerariae Radix protects against ulcerative colitis in mice by inhibiting NLRP3 inflammasome activation

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food Science and Human Wellness 2024年第4期13卷 2266-2276页

作者： Yu Ga Yuanyuan Wei Qingyu Zhao Yimeng Fan Yannan Zhang Zhifang Zhang Sijia Hao Lixia Wang Zhifen Wang Jinlong Han Shuang Wu Zhihui Hao Innovation Centre of Chinese Veterinary Medicine College of Veterinary MedicineChina Agricultural UniversityBeijing 100086China National Center of Technology Innovation for Medicinal Function of food National Food and Strategic Reserves AdministrationBeijing 100193China Inner Mongolia Medical University Hohhot 010059China China Agricultural University Yantai Institute Yantai 264670China Shandong Academy of Agricultural Sciences Jinan 250100China

Ulcerative colitis(UC)is a common inflammatory disease of the gastrointestinal *** Chinese medicine(TCM)has long been used in Asia as a treatment for UC and Puerariae Radix(PR)is a reliable anti-diarrheal *** aims of this study were to investigate the protective effect of PR using the dextran sulfate sodium salt(DSS)-induced UC model in mice and identify molecular mechanisms of PR *** chemical constituents of PR via ultra-performance liquid chromatography/tandem mass spectrometry and identified potential PR and UC targets using a network pharmacology(NP)approach were obtained to guide mouse experiments.A total of 180 peaks were identified from PR including 48 flavonoids,46 organic acids,14 amino acids,8 phenols,8 carbohydrates,7 alkaloids,6 coumarins and 43 other *** results showed that caspase-1 was the most dysregulated of the core genes associated with UC.A PR dose of 0.136 mg/g administered to DSS treated mice reversed weight loss and decreased colon lengths found in UC *** also alleviated intestinal mucosal shedding,inflammatory cell infiltration and mucin *** treatment suppressed upregulation of NOD-like receptor protein 3(NLRP3),cysteinyl aspartate-specific proteases-1(caspase-1),apoptosis-associated speck-like(ASC)and gasdermin D(GSDMD)at both the protein and m RNA expression *** addition of a small molecule dual-specificity phosphatase inhibitor NSC 95397 inhibited the positive effects of *** results indicated that PR exerts a protective effect on DSS-induced colitis by inhibiting NLRP3 inflammasome activation in mice.

关键词： Puerariae Radix Ulcerative colitis Molecular mechanisms Pyroptosis NOD-like receptor protein 3 inflammasome

A new iterative algorithm for geolocating a known altitude target using TDOA and FDOA measurements in the presence of satellite location uncertainty

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Chinese Journal of Aeronautics 2015年第5期28卷 1510-1518页

作者： Cao Yalu Peng Li Li Jinzhou Yang Le Guo Fucheng School of Internet of Things (Io T) Engineering Jiangnan University College of Electronic Science and Engineering National University of Defense Technology Synergetic Innovation Center of food safety and Nutrition

This paper considers the problem of geolocating a target on the Earth surface whose altitude is known previously using the target signal time difference of arrival （TDOA） and frequency difference of arrival （FDOA） measurements obtained at satellites. The number of satellites available for the geolocation task is more than sufficient and their locations are subject to random errors. This paper derives the constrained Cramor-Rao lower bound （CCRLB） of the target position, and on the basis of the CCRLB analysis, an approximately efficient constrained maximum likelihood estimator （CMLE） for geolocating the target is established. A new iterative algorithm for solving the CMLE is then proposed, where the updated target position estimate is shown to be the globally optimal solution to a generalized trust region sub-problem （GTRS） which can be found via a simple bisection search. First-order mean square error （MSE） analysis is conducted to quantify the performance degradation when the known target altitude is assumed to be precise but indeed has an unknown but deterministic error. Computer simulations are used to compare the performance of the proposed iterative geolocation technique with those of two benchmark algorithms. They verify the approximate efficiency of the proposed algorithm and the validity of the MSE analysis.

关键词： Constrained Cram6r-Raolower bound (CCRLB):Frequency difference ofarrival (FDOA) Generalized trust regionsub-problem (GTRS):Performance analysis:Time difference of arrival(TDOA)

Herb pair of Huangqi-Danggui exerts anti-tumor immunity to breast cancer by upregulating PIK3R1

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Animal Models and Experimental Medicine 2024年第3期7卷 234-258页

作者： Hai-Xin Liu Li Lian Li-Li Hou Cai-Xia Liu Jin-Hong Ren Yuan-Biao Qiao Shi-Yuan Wen Qing-Shan Li College of Traditional Chinese Medicine and food Engineering Shanxi University of Chinese MedicineTaiyuanChina Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation College of Traditional Chinese Medicine and Food EngineeringShanxi University of Chinese MedicineTaiyuanChina College of Basic Medical Sciences Shanxi Medical UniversityTaiyuanChina

Background:According to traditional Chinese medicine(TCM),drugs supplementing the vital energy,Qi,can eliminate tumors by restoring host *** objective of this study is to investigate the underlying immune mechanisms of anti-tumor activity associated with Qi-supplementing herbs,specifically the paired use of Huangqi and ***:Analysis of compatibility regularity was conducted to screen the combination of Qi-supplementing *** the MTT assay and a transplanted tumor mice model,the anti-tumor effects of combination TCMs were investigated in vitro and in *** content analysis and flow cytometry were then used to evaluate cellular immunity,followed by network pharmacology and molecular docking to dissect the significant active compounds and potential ***,the anti-tumor activity and the mechanism of the active ingredients were verified by molecular ***:There is an optimal combination of Huangqi and Danggui that,administered as an aqueous extract,can activate immunity to suppress tumor and is more effective than each drug on its own in vitro and in *** on network pharmacology analysis,PIK3R1 is the core target for the anti-tumor immunity activity of combined Huangqi and *** docking analysis shows 6 components of the combined Danggui and Huangqi extract(quercetin,jaranol,isorhamnetin,kaempferol,calycosin,and suchilactone)that bind to *** is the most important component against breast *** suchilactone/jaranol combination and,especially,the suchilactone/kaempferol combination are key for immunity enhancement and the anti-tumor effects of the ***:The combination of Huangqi and Danggui can activate immunity to suppress breast cancer and is more effective than the individual drugs alone.

关键词： anti-tumor Danggui Huangqi immunity

Sturgeon Cartilage-Derived Chondroitin Sulfate Exhibited Anti-inflammatory Activity against DSS-induced Colitis via Modification of Gut Microbiota

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food Science and Human Wellness 2024年

作者： Ruiyun Wu Zixin Han Zhenyu Wang Pinglan Li Nan Shang Institute of food Science and Technology， Chinese Academy of Agricultural Sciences， Integrated Laboratory of Processing Technology for Chinese Meat and Dish Products， Ministry of Agriculture and Rural Affairs College of food Science and Nutritional Engineering， China Agricultural University College of Engineering， China Agricultural University

Chondroitin sulfate (CS) is one of the main bioactive compounds in animal cartilage. In this study， the anti-inflammatory activity of sturgeon-derived chondroitin sulfate (SCS) was evaluated in the DSS-induced BALB/c mice model. Orally administration of SCS significantly alleviated the DSS-induced colitis symptoms， including the reduction of crypt depth， inhibition of the abnormal crypt foci formation， down-regulation of the proinflammatory biomarkers (NO， IL-6， IL-1β and TNF-α) and up-regulation of the anti-inflammatory biomarkers (IL-10 and IL-4). The gut microbiota analysis revealed that SCS alters the intestinal microbiota composition in colitis mice， especially the increase of the relative abundance of Ruminococcaceae and Lachnospiracea. This alternation further induced primary bile acids convert into secondary bile acids. With SCS administration， the levels of deoxycholic acid (DCA) and litho cholic acid (LCA) were increased by ～1.5 and ～2.5-fold， respectively. The stimulated secretion of DCA and LCA showed further activation of the NF-κB signaling pathway， thereby suppressing the inflammatory response and attenuating IBD in mice. This study provided a valuable strategy for colitis prevention and treatment with sturgeon cartilage by-products.

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The potential mechanism of Isodon suzhouensis against COVID-19 via EGFR/TLR4 pathways

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food Science and Human Wellness 2024年

作者： Hong Duan Wei Wang Shu Li Han Li Ghulam Jilany Khan Fawang Liu Kefeng Zhai Lili Li Zhaojun Wei General Clinical Research Center， Anhui Wanbei Coal-Electricity Group General Hospital Department of Pharmacology and Therapeutics， Faculty of Pharmacy， University of Central Punjab College of Biological and food Engineering， Anhui Polytechnic University School of Biological and food Engineering， Engineering Research Center for Development and High Value Utilization of Genuine Medicinal Materials in North Anhui Province， Suzhou University School of food and Biological Engineering， Hefei University of Technology

Corona Virus Disease 2019 (COVID-19) has brought the new challenges to scientific research. Isodon suzhouensis has good anti-inflammatory and antioxidant stress effects， which is considered as a potential treatment for COVID-19. The possibility for the treatment of COVID-19 with suzhouensis and its potential mechanism of action were explored by employing molecular docking and network pharmacology. Network pharmacology and molecular docking were used to screen drug targets， and Lipopolysaccharide (LPS) induced RAW264.7 and NR8383 cells inflammation model was used for experimental verification. Collectively a total of 209 possible linkages against 18 chemical components from suzhouensis and 1194 COVID-19 related targets were selected. Among these， 164 common targets were obtained from the intersection of suzhouensis and COVID-19. GO and KEGG enriched 582 function targets and 87 target proteins pathways， respectively. The results from molecular docking studies revealed that rutin， vitexin， isoquercitrin and quercetin had significant binding ability with SARS-CoV-23CLpro and ACE2. In vitro studies showed that Isodon suzhouensis extract (ISE) may inhibit the activation of PI3K/Akt pathway and the expression level of downstream pro-inflammatory factors by inhibiting the activation of EGFR in RAW264.7 cells induced by LPS. In addition， ISE was able to inhibit the activation of TLR4/NF-κB signaling pathway in NR8383 cells exposed to LPS. Overall， the network pharmacology and in vitro studies conclude that active components from suzhouensis have strong therapeutic potential against COVID-19 through multi-target， multi-pathway dimensions and can be a promising candidate against COVID-19.

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Unsaponifiable matter from walnut oil ameliorate memory deficits and mitochondrial dysfunction in aging mice via activating Nrf2 signaling pathway

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food Science and Human Wellness 2024年

作者： Dan Hong Xiao Xiao Aijin Ma Zhou Chen SiTing Li JunXia Xia YiLing Tian Yingmin Jia Hebei Yangyuan ZhiHui Beverage Co.， Ltd. Institution of Chinese Walnut Industry College of food Science and Technology， Hebei Agricultural University Hebei Key Laboratory of Walnut Nutritional Function and Processing Technology School of food and Health， Beijing Technology and Business University

Aging is an inevitable biological phenomenon that involves a multitude of physiological alterations. Dietary interventions are being considered as potential strategies for delaying age-related dysfunction. Unsaponifiable matter (USM)， a composition of highly active ingredients found in walnut oil， has demonstrated antioxidant effects. This study aims to explore the neuroprotective effects of USM on D-galactose-treated C57BL/6 mice and elucidate its underlying mechanism， which was validated in PC12 cells treated with D-galactose. The results of behavioral tests demonstrated that USM significantly improved cognitive deficits associated with aging. The morphological analysis demonstrated that USM effectively alleviated hippocampal neuronal damage， synaptic impairment， and mitochondrial dysfunction induced by D-galactose. Furthermore， USM significantly increases the antioxidant enzymes activity while reducing the malondialdehyde (MDA) andreactive oxygen species (ROS) levels. The results suggest that USM can mitigate age-related symptoms caused by D-galactose by activating the Nrf2 signaling pathway， which enhances the expression of antioxidant enzymes， restore redox balance， and improves synaptic and mitochondrial functions. This has a positive on improving cognition and memory disorders in elderly mice.

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Exploring the taste presentation and receptor perception mechanism of salty peptides from Stropharia rugosoannulata based on molecular dynamics and thermodynamics simulation

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food Science and Human Wellness 2024年第4期13卷 2277-2288页

作者： Wen Li Shuai Sun Wanchao Chen Haile Ma Tingzhao Li Zhong Zhang Di Wu Mengqiu Yan Yan Yang Institute of Edible Fungi Shanghai Academy of Agricultural SciencesNational Engineering Research Center of Edible FungiKey Laboratory of Edible Fungi Resources and Utilization(South)Ministry of Agriculture and Rural AffairsShanghai 201403China School of food&Biological Engineering Institute of Food Physical ProcessingJiangsu UniversityZhenjiang 212013China Amway(Shanghai)Innovation&Science Co. Ltd.Shanghai 201203China Amway(China)Botanical R&D Center Wuxi 214115China

The taste presentation and receptor perception mechanism of the salty peptide of Stropharia rugosoannulata were predicted and verified using peptide omics and molecular interaction *** combination of aspartic acid(D)and glutamic acid(E),or peptide fragments composed of arginine(R),constitute the characteristic taste structural basis of salty peptides of *** taste intensity of the salty peptide positively correlates with its concentration within a specific concentration range(0.25–1.0 mg/mL).The receptor more easily recognizes the first amino acid residue at the N-terminal of salty peptides and the aspartic acid residue in the ***513,ASP707,and VAL508 are the critical amino acid residues for the receptor to recognize salty ***1 is specifically the receptor for recognizing salty *** bonds and electrostatic interactions are the main driving forces for the interactions between salty peptides and TRPV1 *** has the most potent binding capacity with the receptor and has tremendous potential for application in sodium salt *** study confirmed the taste receptor that specifically recognizes salty peptides,analyzed the receptor-peptide binding interaction,and provided a new idea for understanding the taste receptor perception of salty peptides.

关键词： Salty peptide Molecular docking Biolayer interferometry Isothermal titration calorimetry

Internet of Things Authentication Protocols: Comparative Study

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Computers, Materials & Continua 2024年第4期79卷 65-91页

作者： Souhayla Dargaoui Mourade Azrour Ahmad ElAllaoui Azidine Guezzaz Abdulatif Alabdulatif Abdullah Alnajim Engineering Science and Technology Laboratory IDMS TeamFaculty of Sciences and TechniquesMoulay Ismail University of MeknesErrachidia52000Morocco Higher School Essaouira Cadi Ayyad UniversityMarrakesh44000Morocco Department of Computer Science College of ComputerQassim UniversityBuraydah51452Saudi Arabia Department of Information Technology College of ComputerQassim UniversityBuraydah51452Saudi Arabia

Nowadays, devices are connected across all areas, from intelligent buildings and smart cities to Industry 4.0 andsmart healthcare. With the exponential growth of Internet of Things usage in our world, IoT security is still thebiggest challenge for its deployment. The main goal of IoT security is to ensure the accessibility of services providedby an IoT environment, protect privacy, and confidentiality, and guarantee the safety of IoT users, infrastructures,data, and devices. Authentication, as the first line of defense against security threats, becomes the priority ofeveryone. It can either grant or deny users access to resources according to their legitimacy. As a result, studyingand researching authentication issues within IoT is extremely important. As a result, studying and researchingauthentication issues within IoT is extremely important. This article presents a comparative study of recent researchin IoT security;it provides an analysis of recent authentication protocols from2019 to 2023 that cover several areaswithin IoT (such as smart cities, healthcare, and industry). This survey sought to provide an IoT security researchsummary, the biggest susceptibilities, and attacks, the appropriate technologies, and the most used simulators. Itillustrates that the resistance of protocols against attacks, and their computational and communication cost arelinked directly to the cryptography technique used to build it. Furthermore, it discusses the gaps in recent schemesand provides some future research directions.

关键词： Attacks cryptography Internet of Things security authentication