检索结果-南通市图书馆

China CDC weekly 2024年第18期6卷 385-389,I0001-I0004页

作者： Penghang Zhang Xiaochen Ma Yuzhu Liu Tongyu Wang Shuning Huo Xiaoai Zhang Beijing Key Laboratory of Diagnostic and Traceability Technologies for food Poisoning Institute for Nutrition and Food HygieneBeijing Center for Disease Prevention and ControlBeijingChina Yanjing Medical College of Capital Medical University BeijingChina

Summary What is already known on this topic?foodborne diseases present a substantial global health *** diagnostic methods have constraints,but advancements in molecular techniques,like quantitative polymerase chain reaction(qPCR),provide a hopeful *** is added by this report?We examined 1,011 stool samples from individuals suspected of foodborne illnesses.

关键词： solution. constraints advancement

Cellular precision modulation of JAK1:tailoring therapies for allergic lung inflammation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第7期9卷 2843-2844页

作者： Xiaocheng Yan Siegfried Ussar research Unit Adipocytes&Metabolism(ADM) Helmholtz Diabetes CenterHelmholtz Zentrum MünchenGerman Research Center for Environmental Health GmbH85764 NeuherbergGermany German center for Diabetes research(DZD) 85764 NeuherbergGermany

In a recent publication published in Cell,Tamari et *** a previously unrecognized role of JAK1 signaling in vagal sensory neurons regulating the immune response to allergic lung inflammation.1 The authors show that sensory neuromodulation could be an important therapeutic avenue for the treatment of lung *** is now well established that the number of patients suffering from allergic disorders,like those suffering from obesity and the metabolic syndrome,is rapidly increasing world-wide,accelerating the burden on individual health and healthcare ***,basic and clinical researchers urgently need to develop novel therapeutics and approaches to limit or prevent disease development or progression.

关键词： JAK1 allergic lung

Effect of sodium starch octenyl succinate-based Pickering emulsion on the physicochemical properties of hairtail myofibrillar protein gel subjected to multiple freeze-thaw cycles

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

food Science and Human Wellness 2024年第2期13卷 1018-1028页

作者： Huinan Wang Jiaxin Zhang Xinran Liu Jinxiang Wang Xuepeng Li Jianrong Li Key Laboratory of food Nutrition and Safety Ministry of EducationCollege of Food Science and EngineeringTianjin University of Science and TechnologyTianjin 300457China College of food Science and Technology Bohai UniversityNational R&D Branch Center of Surimi and Surimi Products ProcessingJinzhou 121013China

A Pickering emulsion based on sodium starch octenyl succinate(SSOS)was prepared and its effects on the physicochemical properties of hairtail myofibrillar protein gels(MPGs)subjected to multiple freeze-thaw(F-T)cycles were *** whiteness,water-holding capacity,storage modulus(G')and texture properties of the MPGs were significantly improved by adding 1%-2%Pickering emulsion(P<0.05).Meanwhile,Raman spectral analysis demonstrated that Pickering emulsion promoted the transformation of secondary structure,enhanced hydrogen bonds and hydrophobic interactions,and promoted the transition of disulfide bond conformation from g-g-g to g-g-t and *** an emulsion concentration of 2%,theα-helix content decreased by 10.37%,while theβ-sheet content increased by 7.94%,compared to the *** F-T cycles,the structure of the MPGs was destroyed,with an increase in hardness and a decrease in whiteness and water-holding capacity,however,the quality degradation of MPGs was reduced with 1%-2%Pickering *** findings demonstrated that SSOS-Pickering emulsions,as potential fat substitutes,can enhance the gel properties and the F-T stability of MPGs.

关键词： Pickering emulsion Myofibrillar protein Gel properties Freeze-thaw stability Intermolecular interactions

An approximate Kerr–Newman-like metric endowed with a magnetic dipole and mass quadrupole

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2024年第8期76卷 126-140页

作者： Francisco Frutos-Alfaro Space research center and School of Physics University of Costa Rica

Approximate all-terrain spacetimes for astrophysical applications are presented. The metrics possess five relativistic multipole moments, namely, mass, rotation, mass quadrupole, charge,and magnetic dipole moment. All these spacetimes approximately satisfy the Einstein–Maxwell field equations. The first metric is generated using the Hoenselaers–Perjés method from given relativistic multipoles. The second metric is a perturbation of the Kerr–Newman metric, which makes it a relevant approximation for astrophysical calculations. The last metric is an extension of the Hartle–Thorne metric that is important for obtaining internal models of compact objects perturbatively. The electromagnetic field is calculated using Cartan forms for locally non-rotating observers. These spacetimes are relevant for inferring properties of compact objects from astrophysical observations. Furthermore, the numerical implementations of these metrics are straightforward, making them versatile for simulating potential astrophysical applications.

关键词： Compact objects Einstein-Maxwell equations Gravitation

Global analysis of basic leucine zipper transcription factors in trifoliate orange and the function identification of PtbZIP49 in salt tolerance

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Horticultural Plant Journal 2024年第1期10卷 115-130页

作者： Yuanyuan Xu Qiuling Hui Meng Li Hongxian Peng Yizhong He Changpin Chun Liangzhi Peng Xingzheng Fu National Citrus Engineering research center Citrus Research InstituteSouthwest UniversityChongqing 400712China

As one of the most widely distributed and highly conserved transcription factors in eukaryotes,basic leucine zipper proteins(bZIPs)are involved in a variety of biological processes in plants,but they are largely unknown in *** this study,56 bZIP family members were identified genome-wide from an important citrus rootstock,namely trifoliate orange(Poncirus trifoliata ***.),and these putative bZIPs were named PtbZIP1—*** PtbZIPs were classified into 13 subgroups by phylogenetic comparison with Arabidopsis thaliana bZIPs(AtbZIPs),and they were randomly distributed on nine known(50 genes)chromosomes and one unknown(6 genes)*** analysis revealed the detailed characteristics of PtPZIPs,including their amino acid length,isoelectric point(pI),molecular weight(MW),predicted subcellular localization,gene structure,and conserved *** of promoter elements suggested the presence of drought,low-temperature,wound,and defense and stress responsive elements,as well as multiple hormone-responsive cis-acting *** expression analysis showed the transcriptional patterns of PtbZIPs in different tissues and under dehydration,high salt,ABA,and IAA *** addition,21 PtbZIPs were predicted to have direct or indirect protein—protein *** these,PtbZIP49 was experimentally proven to interact with PtbZIP1 or PtbZIP11 by using a yeast two-hybrid assay and bimolecular fluorescence complementation(BiFC).Subcellular localization analysis further revealed that PtbZIP1,PtbZIP11,and PtbZIP49 were localized in the ***,PtbZIP49 was functionally identified as having an important role in salt stress via ectopic expression in *** and silenced in trifoliate orange using virus-induced gene silencing(VIGS).This study provided comprehensive information on PtbZIP transcription factors in citrus and highlights their potential functions in abiotic stress.

关键词： bZIP Citrus Trifoliate orange Abiotic stress Expression pattern

Assessment of corrected time-step method for nominal ionospheric gradient calculation: A comparative analysis with spatial approaches

在线全文

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2024年第4期8卷 641-649页

作者： Slamet Supriadi Prayitno Abadi Susumu Saito Harry Bangkit Dwiko Unggul Prabowo Adi Purwono Ginaldi Ari Nugroho research center for Smart Mechatronics National Research and Innovation Agency(BRIN)BandungIndonesia research center for Climate and Atmosphere BRINBandungIndonesia School of Electrical Engineering Telkom UniversityKab.BandungIndonesia Electronic Navigation research Institute National Institute of MaritimePort and Aviation TechnologyTokyoJapan research center for Space BRINBandungIndonesia

The effect of ionospheric delay on the ground-based augmentation system under normal conditions can be mitigated by determining the value of the nominal ionospheric gradient(σvig).The nominal ionospheric gradient is generally obtained from Continuously Operating Reference Stations data by using the spatial single-difference method(mixed-pair,station-pair,or satellite-pair)or the temporal single-difference method(time-step).The time-step method uses only a single receiver,but it still contains ionospheric temporal *** introduce a corrected time-step method using a fixed-ionospheric pierce point from the geostationary equatorial orbit satellite and test it through simulations based on the global ionospheric *** also investigate the effect of satellite paths on the corrected time-step method in the region of the equator,which tends to be in a more north–south direction and to have less coverage for the east–west ionospheric *** study also addresses the limitations of temporal variation correction coverage and recommends using only the correction from *** processes are developed under simulations because observational data are still difficult to *** findings demonstrate that the corrected time-step method yieldsσvig values consistent with other approaches.

关键词： ground-based augmentation system nominal ionospheric gradient time-step correction global ionospheric model

Recent progress in functional modification and crosslinking of bioprosthetic heart valves

在线全文

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2024年第1期3卷 1-16页

作者： Cheng Zheng Li Yang Yunbing Wang National Engineering research center for Biomaterials Sichuan UniversityChengdu 610064China

Valvular heart disease(VHD),clinically manifested as stenosis and regurgitation of native heart valve,is one of the most prevalent cardiovascular diseases with high *** valve replacement surgery has been recognized as golden standard for the treatment of *** to the clinical application of transcatheter heart valve replacement technic and the excellent hemodynamic performance of bioprosthetic heart valves(BHVs),implantation of BHVs has been increasing over recent years and gradually became the preferred choice for the treatment of ***,BHVs might fail within 10-15 years due to structural valvular degeneration(SVD),which was greatly associated with drawbacks of glutaraldehyde crosslinked BHVs,including cytotoxicity,calcification,component degradation,mechanical failure,thrombosis and immune *** prolong the service life of BHVs,much effort has been devoted to overcoming the drawbacks of BHVs and reducing the risk of *** this review,we summarized and analyzed the research and progress on:(i)modification strategies based on glutaraldehyde crosslinked BHVs and(ii)nonglutaraldehyde crosslinking strategies for BHVs.

关键词： bioprosthetic heart valves modification crosslinking anticalcification antithrombosis

Rice bran oil rescues cognitive decline in D-galactose-induced aging mice by inhibiting Aβ accumulation and Tau hyperphosphorylation induced oxidative stress and neuroinflammation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

food Science and Human Wellness 2024年

作者： Yadan Zhang Diya Xu Xiaoyu Zhang Wenhua Zhou Lin Zhang Qinlu Lin College of food Science and Engineering National Engineering research center of Rice and Byproduct Deep Processing Hunan Key Laboratory of Processed food for Special Medical Purpose Central South University of Forestry and Technology

Alzheimer's disease (AD) is a neurodegenerative disorder associated with brain aging， and the accumulation of amyloid-beta (Aβ) and hyperphosphorylated Tau proteins are key pathological features. Currently， drugs for the treatment of AD are mainly single-targeted， but the complex pathogenesis of AD makes it difficult to achieve the desired results. Therefore， the development of multitargeted therapies is crucial for future interventions. Rice bran oil (RBO) has been recognized as an edible oil with several health benefits， but its effects on AD caused by brain aging remain underexplored. In this study， the effects of RBO on memory dysfunction in D-galactose (D-gal) mice and its molecular mechanisms were investigated via in vivo and in silico methods from the perspective of AD pathologies. Our results suggested that compounds in RBO could modulate the activities of β-site amyloid precursor protein cleaving enzyme 1 (BACE1)， mitogen-activated protein kinase 3 (MAPK3)， matrix metalloproteinase 3 (MMP3)， and intercellular adhesion molecule 1 (ICAM1)， leading to inhibition of Aβ accumulation and Tau protein hyper-phosphorylation. Moreover， RBO reduced Aβ-induced oxidative stress by inhibiting the activity of mouse double minute 2 homolog (MDM2) and cyclic adenosine monophosphate response element binding protein binding protein (CREBBP)， and attenuated neuroinflammation by inhibiting the activity of nitric oxide synthase 2 (NOS2) and reducing Aβ accumulation and Tau protein hyperphosphorylation. Additionally， α-linolenic acid in RBO exhibited inhibitory effects on D-gal-induced apoptosis in PC12 cells through modulation of NOS2， MDM2， ICAM1， and phospho-extracellular signal-regulated kinase 1/2 (p-ERK1/2). Similarly， stigmastanol inhibited apoptosis in D-gal-induced PC12 cells through the regulation of NOS2. Thus， RBO can be considered as a potential functional food to attenuate AD owing to its multicomponent and multitarget effects.

关键词：

An impact sensitivity assessment method of spacecraft based on virtual exterior wall

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第1期31卷 142-157页

作者： Runqiang Chi Yuyan Liu Diqi Hu Baojun Pang Hypervelocity Impact research center Harbin Institute Of TechnologyHarbin150080China

The impact sensitivity assessment of spacecraft is to obtain the probability of spacecraft encountering the OD/M(orbital debris or meteoroid),which is a prerequisite for survivability assessment of on-orbit *** impact sensitivity assessment method of spacecraft based on virtual exterior wall was proposed to improve the computational *** method eliminates determination of the outermost surface elements of the spacecraft before generating the debris rays,which are assumed to originate from a non-concave virtual wall that completely wraps the *** Dist Mesh method was adopted for the generating of the virtual wall to ensure its mesh *** influences of the sizes,mesh densities,shapes of the virtual wall on the efficiency and accuracy were considered to obtain the best combination of the size and mesh density of the wall and *** results of this method were compared with those of S3DE(Survivability of Spacecraft in Space Debris Environment),BUMPER,MDPANTO,ESABASE2/Debris to verify the feasibility of the *** PCHIP(Piecewise Cubic Hermite Interpolating Polynomial)was used to fit the size *** relationship of the space debris to acquire the impact probability of OD/M with arbitrary size on the spacecraft.

关键词： Sensitivity OD/M Spacecraft Virtual exterior wall

On-surface synthesis and characterization of polyynic carbon chains

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第3期11卷 192-199页

作者： Wenze Gao Wei Zheng Luye Sun Faming Kang Zheng Zhou Wei Xu Interdisciplinary Materials research center School of Materials Science and Engineering Tongji University

Carbyne, an elusive sp-hybridized linear carbon allotrope, has fascinated chemists and physicists for decades. Due to its high chemical reactivity and extreme instability, carbyne was much less explored in contrast to the sp2-hybridized carbon allotropes such as graphene. Herein, we report the on-surface synthesis of polyynic carbon chains by demetallization of organometallic polyynes on the Au（111） surface;the longest one observed consists of ～60 alkyne units（120 carbon atoms）. The polyynic structure of carbon chains with alternating triple and single bonds was unambiguously revealed by bond-resolved atomic force microscopy. Moreover, an atomically precise polyyne, C14, was successfully produced via tip-induced dehalogenation and ring-opening of the decachloroanthracene molecule(C14Cl10) on a bilayer NaCl/Au（111） surface at 4.7 K, and a band gap of 5.8 eV was measured by scanning tunnelling spectroscopy,in a good agreement with the theoretical HOMO–LUMO gap（5.48 eV）.

关键词： polyyne scanning probe microscopy carbon allotrope on-surface synthesis organometallic polyyne