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Peptidomimetic-liganded gold nanoclusters for controlled iron delivery and synergistic suppression of tumor growth

Nano Research 2023年第10期16卷 12066-12075页

作者： Xiqi Ma Duo Cai Zhixiong Zhang Qi Dai Xinyu Li Biao Yu Baosheng Ge Shihai Liu Xiaojuan Wang Fang Huang College of Chemical engineering State Key Laboratory of Heavy Oil ProcessingChina University of Petroleum(East China)Qingdao 266580China Medical Animal Laboratory Affiliated Hospital of Qingdao UniversityQingdao 266500China

A novel peptidomimetic-liganded gold nanocluster(CDp-AuNC)is proposed for the synergistic suppression of tumor *** advantages of the multi-capabilities offered by the surface ligands,including iron chelation,glutathione peroxidases-1(GPx-1)binding,and tumor cells recognition,CDp-AuNCs are able to function as the nanocarriers to deliver iron in a controlled manner for the ferroptosis therapy and as the inhibitors for GPx-1 to induce the apoptosis of tumor *** Fe2+@CDp-AuNC nanocomplexes are fabricated through a facile self-assembly *** experimental data verify that the nanocomplexes are internalized specifically by tumor cells with high *** acidic microenvironment in endosomes triggers the collapse of the nanocomplexes and thereby releases Fe2+to induce ferroptosis and CDp-AuNCs to inhibit the enzyme activity of *** from the H_(2)O_(2)-depleted pathway inhibition and ferroptosis acceleration,the intracellular reactive oxygen species(ROS)level could be enhanced *** a consequence,the apoptosis/ferroptosis of 4T1 cells as well as the tumor elimination in vivo are observed after treatment with the Fe2+@CDp-AuNC nanocomplexes at a relatively low *** facile iron loading method,simple construction procedure,and outstanding tumor suppression performance,provide CDp-AuNCs great application *** importantly,the strategy of peptidomimetic ligands design provides a transferable approach to building multifunctional nanomaterials.

关键词： self-assembly drug delivery ferroptosis peptidomimetics gold nanocluster

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Influence of original microstructure on the transformation behavior and mechanical properties of ultra-high-strength TRIP-aided steel

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International Journal of Minerals,Metallurgy and Materials 2015年第3期22卷 262-271页

作者： Hong-xiang Yin Ai-min Zhao Zheng-zhi Zhao Xiao Li Shuang-jiao Li Han-jiang Hu Wei-guang Xia Metallurgical engineering Research Institute University of Science and Technology Beijing Beijing Laboratory of Metallic Materials and processing for Modern Transportation Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of Mechanics Chinese Academy of Sciences

The transformation behavior and tensile properties of an ultra-high-strength transformation-induced plasticity （TRIP） steel （***） were investigated by different heat treatments for automobile applications. The results show that F-TRIP steel, a tradi- tional TRIP steel containing as-cold-rolled ferfite and pearlite as the original microstructure, consists of equiaxed grains of intercritical ferrite surrounded by discrete particles of M/RA and B. In contrast, M-TRIP steel, a modified TRiP-aided steel with martensite as the original mi- crostlucture, containing full martensite as the original microstructure is comprised of lath-shaped grains of ferrite separated by lath-shaped martensite/retained austenite and bainite. Most of the austenite in F-TRIP steel is granular, while the austenite in M-TRIP steel is lath-shaped. The volume fraction of the retained austenite as well as its carbon content is lower in F-TRIP steel than in M-TRIP steel, and austenite grains in M-TRIP steel are much finer than those in F-TRIP steel. Therefore, M-TRIP steel was concluded to have a higher austenite stability, re- sulting in a lower transformation rate and consequently contributing to a higher elongation compared to F-TRIP steel. Work hardening be- havior is also discussed for both types of steel.

关键词： high strength steels transformation-induced plasticity phase transformations mechanical properties original microstructure work hardening

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A novel scheme for processing FMCW-ladar data acquired with low sampling rate

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Geo-Spatial Information Science 2022年第3期25卷 489-499页

作者： Sujuan Fang Guangzuo Li Fei Zhang Bing Han Wen Hong School of Electronic Information and Electrical engineering Shanghai Jiao Tong UniversityShanghaiChina Key lab of Geospatial Information processing Aerospace Information Research InstituteChinese Academy of Sciences(AIR-CAS)BeijingChina

The frequency-modulated continuous wave(FMCW)ladar is a useful sensor for remote sensing applications and has been widely used in both the military and civilian fields for precise geospatial data ***,the FMCW-ladar signal is collected by use of the hetero-dyne detection through the dechirping so as to decrease the sampling rate commensurate with the *** this manuscript,we proposed a novel scheme for processing the FMCW-ladar signal acquired through the simplified heterodyne detection,and the sampling rate was the same as that in the dechirp *** on the time-frequency relation of the FMCW-ladar signal,two algorithms were proposed to post-process the echo acquired by the simplified heterodyne detection with the sub-Nyquist sampling *** the FMCW-ladar echo data acquired by the simplified heterodyne detection with the same sampling rate as in the traditional dechirp detection,the algorithms can achieve the unambiguous range image retaining the range resolution commensurate with the transmitted chirp *** effectiveness of the scheme was validated by simulation and real data processing *** capability of the proposed scheme provides an alternative for the FMCW-ladar system without use of the dechirp detection,which can benefit the future FMCW-ladar and microwave photonics radar applications in the remote sensing.

关键词： Frequency modulated continuous wave(FMCW)-ladar range imaging remote sensing time-frequency mapping

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Molecular Dynamics Simulations of the Interactions Between Konjac Glucomannan and Soy Protein Isolate

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Agricultural Sciences in China 2010年第10期9卷 1538-1542页

作者： WANG Meng YAO Min-na JIAN Wen-lie SUN Yu-jing PANG Jie College of food Science Fujian Agriculture and Forestry University Fuzhou 350002 P.R.China College of Biosystem engineering and food Science Zhejiang University Hangzhou 310029 P.R.China

The interactions between konjac glucomannan（KGM） and soy protein isolate （SPI） were studied with the method of molecular dynamics simulation. Part representative structures segments of KGM and SPI were used as mode, and the force-field was FF03. The stability and sites of KGM/SPI interactions in water were researched at 363 K with the following results： the potential energy （EPOT） of the mixed gel dropped, while that of single KGM gel increased. The surface area （SA） of KGM in the mixed system was decreased to 401.41 from 1 267.54 Az, and that of SPI to 484.94 from 1 943.28 A2. The sum potential energy of KGM and soy protein in the mixed system was decreased to -13 402.41 from -5 768.56 kcal mol^-1. The variations of two parameters showed that the stability of compound gel KGM/SPI was improved, which was consistent with the previous studies. The sites of interactions in the mixed gel were the -OH groups on C（2） in KGM mannose and glucose, and the amide linkage group on Histidine, Asparagine and Leucine in SPI. The hydrogen bond was formed directly or indirectly by the bridge of waters.

关键词： KGM SPI molecular dynamics simulation interaction

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Eco-friendly preparation of chitooligosaccharides with different degrees of deacetylation from shrimp shell waste and their effects on the germination of wheat seeds

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Marine Life Science & Technology 2019年第1期1卷 95-103页

作者： Xiaodan Fu Lin Zhu Li Li Tan Zhang Meng Li Haijin Mou College of food Science and engineering Ocean University of ChinaNo.5 Yushan RoadQingdao 266003China

Production of chitosan and its derivatives by traditional methods involves the excessive use of a reaction solution comprisedof sodium hydroxide and hydrochloric acid. Waste water resulting from this process has lim让ed the application of chitosanas a fertilizer as the process causes serious environmental pollution. Specifically, the resulting waste water contains highlevels of dissolved nitrogen and minerals from shrimp shells. In this study, an eco-friendly method was established to produce chitooligosaccharides (COS) with different degrees of deacetylation (DDAs) from shrimp shell waste. At a solid-tosolventratio of 1:6, the degree of demineralization was above 90% with the treatment of 30 g-L_1 H3PO4, and the degree ofdeproteinization was above 80% when treated with 30 g-L_1 KOH at 70 °C. Chitosans with different DDAs were obtainedby microwave-assisted KOH metathesis and the COS with Mw approximately 1500 Da were then prepared by oxidativedegradation. In summary, 33.73 kg H3PO4,12.77 kg, and 241.31 kg KOH were supplied during the processes of demineralization,deproteinization, and deacetylation of 100 kg shrimp shell waste, respectively. The process water was totally recycled,demonstrating that the shrimp shell could be wholly transformed into fertilize The entire process created a product withthe fractions of N:P2O5:K2O:COS = 7.94:24.44:10.72:1 &27. The test on the germination promotion of wheat seeds revealedthat the COS with 72」2% DDA significantly promoted germination. This work demonstrated the use of an eco-friendlypreparation method of COS with a specific degree of deacetylation that can be applied as a fertilizer.

关键词： Chitooligosaccharide Deacetylation degree Phosphoric acid Potassium hydroxide Germination promotion

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Design and experiment evaluation of furrow compaction device with opener for maize

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International Journal of Agricultural and Biological engineering 2020年第2期13卷 123-131页

作者： Wenjun Wang Peisong Diao Honglei Jia Yulong Chen School of Agricultural engineering and food Science Shandong University of TechnologyZibo 255000China School of Biological and Agricultural engineering Jilin UniversityChangchun 130022China

The double-disc opener of maize precision seeder is an important component which affects sowing *** the double-disc opening operation,there will be many unfavorable phenomena such as a W-shaped bottom with pointed ridge,returning soil to furrow,loose and rough furrow sidewall,and large soil blocks in the furrow *** phenomena often cause the problems of poor sowing depth consistency and seed spacing *** order to solve the above problems,the furrow compaction device with opener was designed to compact and reshape the original seed furrow,eventually forming a smooth and flat V-shaped seed *** theoretical calculations and kinematic analysis,the main structural parameters of the device were limited to a small range:the spring stiffness coefficient k=0.96-4.19 N/mm and the angle of the furrow compaction wheelφ=30°-60°.In the soil-bin experiment,the rotary combination design was adopted to study the effects of the parameters of the furrow compaction device with opener on the seeds location *** regression model of two factors with respect to each indicator was established in the Design-Expert software,revealing the effects of two factors on the ***,the optimal structural parameters obtained were:the spring stiffness coefficient k=4.0 N/mm,and the angle of furrow compaction wheelφ=42.4°.The field test was carried out to verify the effect of the furrow compaction device with opener on the performance of precision *** results showed that the average values of the sowing depth variable coefficient,the lateral deviation and the seed spacing variable coefficient respectively were 5.77%,5.1 mm and 9.54%in the treatment of the furrow compaction device with *** indicators were superior to the traditional double-disc *** research can provide references for the design of furrow opening device and maize precision seeder.

关键词： furrow opener seed furrow compaction sowing depth variable coefficient lateral deviation seed spacing variable coefficient

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Influence of isochronal heat treatment on damping behavior of AZ61 alloy

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Journal of Central South University of Technology 2007年第3期14卷 315-318页

作者：刘楚明刘子娟朱秀荣胡必文王荣王孟君 School of Materials Science and engineering Central South University State Key Laboratory of Material processing and Die & Mould Technology Wuhan 430074 China Light Materials Institute Ningbo Branch of Enginery Science Academy of China Testing Technology Institute of Yichang State Key Laboratory of Material processing and Die & Mould Technology

Strain amplitude dependence of the logarithmic decrement was measured and studied on an AZ61 magnesium alloy at room temperature. Measurements were carried out before and after isochronal thermal treatment step by step with increasing temperature. For all specimens, the strain dependence of the logarithmic decrement exhibits two regions. At lower strains the logarithmic decrement is strain independent and in the higher strain region it depends strongly on strain amplitude. The strain-independent logarithmic decrement is mainly composed of thermoelastic damping and dislocation damping, which can be explained by Granato-Lticke theory. In addition, the strain-independent logarithmic decrement for the specimens annealed at higher temperatures is a little lower than that for as-cast specimen, and it increases with increasing temperature of heat treatment. Microstructure changes due to heat treatment are responsible for changes of the logarithmic decrement.

关键词： AZ61 magnesium alloy heat treatment damping dislocation

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Optimization of process conditions for drying of catfish(Clarias gariepinus)using Response Surface Methodology(RSM)

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food Science and Human Wellness 2019年第1期8卷 46-52页

作者： Elijah George Ikrang Kingsley Charles Umani Department of Agricultural and food engineering Faculty of EngineeringUniversity of UyoUyoAkwa Ibom StateNigeria Department of Agricultural engineering Faculty of EngineeringAkwa Ibom State UniversityMkpat EninAkwa Ibom StateNigeria

Drying is applied to lower the moisture content of fish to a level that can prevent the growth of mould and infestation of micro-organism and thus minimizes microbial *** goal of this work was to optimize the process conditions during electrical oven drying of *** content(MC)was quantitatively investigated during the drying process of catfish sizes using response surface methodology(RSM)to obtain minimum moisture *** independent process variables for the drying process were temperature(50–70◦C),product thickness(10–20 mm),salt concentration(0–20%)and drying time(480–600 min.).Two factorial interaction(2FI)regression model describing the effects of independent drying process variables on the moisture content was *** effects of temperature and drying time were more pronounced for MC than the thickness and salt *** optimum conditions were found to be temperature=63.43◦C,product thickness=14.81 mm,salt concentration=9.07%and drying time=600 *** these optimum conditions,moisture content was found to be 2.64%*** of experimental results with the empirical model was evaluated using coefficient of correlation(R2)which was found for the model equation as,R2=0.994.

关键词： Optimization Oven drying Drying parameters Catfish Response surface methodology

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An Adaptive Hand Exoskeleton for Teleoperation System

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Chinese Journal of Mechanical engineering 2023年第3期36卷 123-134页

作者： Wei Wei Bangda Zhou Bingfei Fan Mingyu Du Guanjun Bao Shibo Cai College of Mechanical engineering Zhejiang University of TechnologyHangzhou 310023China Key Laboratory of Special Purpose Equipment and Advanced processing Technology Ministry of Education and Zhejiang ProvinceZhejiang University of TechnologyHangzhou 310023China

Teleoperation can assist people to complete various complex tasks in inaccessible or high-risk environments,in which a wearable hand exoskeleton is one of the key *** adaptability would be available to enable the master hand exoskeleton to capture the motion of human fingers and reproduce the contact force between the slave hand and its *** paper presents a novel finger exoskeleton based on the cascading four-link closed-loop kinematic *** finger has an independent closed-loop kinematic chain,and the angle sensors are used to obtain the finger motion including the flexion/extension and the adduction/*** cable tension is changed by the servo motor to transmit the contact force to the fingers in real *** on the finger exoskeleton,an adaptive hand exoskeleton is consequently *** addition,the hand exoskeleton is tested in a master-slave *** experiment results show that the adaptive hand exoskeleton can be worn without any mechanical constraints,and the slave hand can follow the motions of each human *** accuracy and the real-time capability of the force reproduction are *** proposed adaptive hand exoskeleton can be employed as the master hand to remotely control the humanoid five-fingered dexterous slave hand,thus,enabling the teleoperation system to complete complex dexterous manipulation tasks.

关键词： Hand exoskeleton Humanoid dexterous hand Teleoperation Motion capture Force-reproduction

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Stretchable polymer composites with ultrahigh piezoelectric performance

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National Science Review 2023年第8期10卷 203-210页

作者： Tongxiang Tang Zhonghui Shen Jian Wang Shiqi Xu Jiaxi Jiang Jiahui Chang Mengfan Guo Youjun Fan Yao Xiao Zhihao Dong Houbing Huang Xiaoyan Li Yihui Zhang Danyang Wang Long-Qing Chen Ke Wang Shujun Zhang Ce-Wen Nan Yang Shen State Key Lab of New Ceramics and Fine processing School of Materials Science and Engineering Tsinghua University State Key Laboratory of Advanced Technology for Materials Synthesis and processing Center of Smart Materials and Devices Wuhan University of Technology Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Applied Mechanics Laboratory Department of Engineering Mechanics Tsinghua University Center for Flexible Electronics Technology Tsinghua University School of Materials Science and engineering University of New South Wales Department of Materials Science and engineering The Pennsylvania State University State College Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of Wollongong

Flexible piezoelectric materials capable of withstanding large deformation play key roles in flexible electronics. Ferroelectric ceramics with a high piezoelectric coefficient are inherently brittle, whereas polar polymers exhibit a low piezoelectric coefficient. Here we report a highly stretchable/compressible piezoelectric composite composed of ferroelectric ceramic skeleton, elastomer matrix and relaxor ferroelectric-based hybrid at the ceramic/matrix interface as dielectric transition layers, exhibiting a giant piezoelectric coefficient of 250 picometers per volt, high electromechanical coupling factor keff of 65%,ultralow acoustic impedance of 3MRyl and high cyclic stability under 50% compression strain. The superior flexibility and piezoelectric properties are attributed to the electric polarization and mechanical load transfer paths formed by the ceramic skeleton, and dielectric mismatch mitigation between ceramic fillers and elastomer matrix by the dielectric transition layer. The synergistic fusion of ultrahigh piezoelectric properties and superior flexibility in these polymer composites is expected to drive emerging applications in flexible smart electronics.

关键词： polymer composites piezoelectric materials structure design flexible electronics

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