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food Science and Human Wellness 2025年第1期14卷 154-160页

作者： Haizhen Ding Shuai Hou Siqi Zhao Liping Guo Ao Sun Qiuhui Hu Leiqing Pan Qiang Liu Chao Ding Collaborative Innovation Center for Modern Grain Circulation and Safety Key Laboratory of Grains and Oils Quality Control and ProcessingCollege of Food Science and EngineeringNanjing University of Finance and EconomicsNanjing 210023China College of food Science and Technology Nanjing Agricultural UniversityNanjing 210095China

Cadmium ion(Cd^(2+))detection technology plays a prominent role in food safety and human ***,we designed and constructed an 2-aminoethyl dihydrogen phosphate(AEP)@upconversion nanoparticles(UCNPs)fluorescence sensor for quantitative detection of Cd^(2+)in paddy rice based on inner filter effect(IFE)combined with enzyme inhibition *** AEP modification UCNPs can offer a stable fluorescence donor at 658 nm and be quenched by the oxidized tetramethylbenzidine(oxTMB)catalyzed by horseradish peroxidase(HRP)*** addition of Cd^(2+),the fluorescence of AEP@UCNPs fluorescence sensor was weaken due to the IFE between AEP@UCNPs and *** addition of Cd^(2+),HRP enzyme activity was inhibited by Cd^(2+),leading to the decreased oxTMB,resulting in the enhance upconversion fluorescence *** a result,the fluorescence intensity signal at 658 nm of the IFE-based AEP@UCNPs fluorescence sensor increased linearly with the increase in Cd^(2+)in a wide range from 0.5μmol/L to 6μmol/L and the limit of detection(LOD)was 24.6 n mol/*** addition,our proposed IFE-based AEP@UCNPs fluorescence sensor can achieve Cd^(2+)detection in paddy rice in 30 min.

关键词： Paddy rice Cd^(2+) Enzyme inhibition Upconversion nanoparticles(UCNPs) Inner filter effect(IFE)

Acrylamide drives amidase-mediated gut dysbiosis to aggravate colitis

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Science Bulletin 2025年第2期70卷 157-161页

作者： Daotong Li Yinghua Luo Huimin Fan Li Dong Xiaoying Zhang Yu Feng Meiling Tian Shuqing Zhang Wenjing Chen Lujia Zhang Jianwei Gao Xiangning Ma Xiaofei Wang Chen Ma Ruimao Zheng Xiaosong Hu Jinfeng Wang Fang Chen College of food Science and Nutritional Engineering National Engineering Research Center for Fruit and Vegetable ProcessingKey Laboratory of Fruits and Vegetables ProcessingMinistry of AgricultureEngineering Research Centre for Fruits and Vegetables ProcessingMinistry of EducationChina Agricultural UniversityBeijing 100083China College of food Science and Nutritional Engineering China Agricultural UniversityBeijing 100083China Department of Anatomy Histology and EmbryologyHealth Science CenterPeking UniversityBeijing 100191China

Inflammatory bowel diseases(IBDs)are chronic intestinal inflammatory disorders that have emerged as a global public health challenge[1].Increased availability and consumption of processed foods is considered as a crucial environmental factor underlying the worldwide prevalence of IBD[2].Nevertheless,how specific components in processed foods contribute to increased risk of IBD has not been ***(AA)is a ubiquitous food-related contaminant formed during thermal processing[3,4].

关键词： diseases prevalence clarified

Preparations of Mytilus edulis protein hydrolysate-iron complexes and their ameliorative effects on mice with iron deficiency anemia

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food Science and Human Wellness 2025年

作者： Guang Li Xuening Yu Shuling Zhou Xiaoyang Liu Fawen Yin Deyang Li Baocai Xu Dayong Zhou School of food and Biological Engineering， Hefei University of Technology SKL of Marine food processing & Safety Control， National Engineering Research Center of Seafood， Collaborative Innovation Center of Seafood Deep processing， Liaoning Province Key Laboratory for Marine food Science and Technology， School of food Science and Technology， Dalian Polytechnic University

Iron is a fundamental trace element essential for the immune system， and current research on iron supplements is increasingly focusing on food-derived peptides capable of binding iron ions. The objectives of this study were to characterize the iron-chelating peptide (MEPH) derived from Mytilus edulis and to investigate the effects of MEPH-Fe complexes on mice with iron deficiency-induced anemia (IDA). MEPH and iron(II) sulfate heptahydrate successfully formed MEPH-Fe complexes under conditions of 4.5 mg/mL concentration， 45 ℃ temperature， and 60 minutes of incubation， utilizing both carboxyl and amino binding sites. Compared to MEPH alone， the MEPH-Fe complexes exhibited fluorescence quenching， ultraviolet shifts， reduced X-ray diffraction peak intensities， stabilization during in vitro digestion， microstructural changes， increased particle size， and decreased absolute values of zeta potential. In the IDA mouse model， the MEPH-Fe complexes were able to restore body weight， hematological indices， organ coefficients， iron content in organs， and antioxidant capacity to normal levels. Additionally， they demonstrated beneficial effects on IDA-induced colonic inflammation by normalizing tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) levels. The results indicated that MEPH-Fe complexes had more positive effects on IDA mice compared to ferrous sulfate. In conclusion， this study provides valuable insights into the potential of MEPH-Fe complexes as iron supplements.

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Multi-interface structure design of bamboo-based carbon/Co/CoO composite electromagnetic wave absorber based on biomimetic honeycomb-shaped superstructure

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International Journal of Minerals,Metallurgy and Materials 2025年第3期32卷 631-644页

作者： Yanting Wang He Han Huiyang Bian Yanjun Li Zhichao Lou Jiangsu Co-Innovation Center of Efficient processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China College of Light Industry and food Engineering Nanjing Forestry UniversityNanjing 210037China

The rapid development of 5G communication technology and smart electronic and electrical equipment will inevitably lead to electromagnetic radiation *** heterointerface polarization relaxation through nanostructure design and interface modifica-tion has proven to be an effective strategy to obtain efficient electromagnetic wave ***,this work implements an innovative method that combines biomimetic honeycomb superstructure to constrain hierarchical porous heterostructure composed of Co/CoO nano-particles to improve the interfacial polarization *** method effectively controlled the absorption efficiency of Co^(2+)through de-lignification modification of bamboo,and combined with the bionic carbon-based natural hierarchical porous structure to achieve uniform dispersion of nanoparticles,which is conducive to the in-depth construction of heterogeneous *** addition,the multiphase struc-ture brought about by high-temperature pyrolysis provides the best dielectric loss and impedance matching for the ***,the obtained bamboo-based Co/CoO multiphase composite showed excellent electromagnetic wave absorption performance,achieving excel-lent reflection loss(RL)of-79 dB and effective absorption band width of 4.12 GHz(6.84-10.96 GHz)at low load of 15wt%.Among them,the material’s optimal radar cross-section(RCS)reduction value can reach 31.9 dB·m^(2).This work provides a new approach to the micro-control and comprehensive optimization of macro-design of microwave absorbers,and offers new ideas for the high-value utiliza-tion of biomass materials.

关键词： biomass honeycomb porous heterojunction structure interfacial polarization electromagnetic wave absorption

Anti-fibrotic effects of marein-enriched Coreopsis tinctoria flavonoids on CCl4-induced hepatic fibrosis in rats via blocking the TGF-β1/Smad signaling pathway

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food Science and Human Wellness 2025年

作者： Limin Guo Wenyu Zhang Liwen Wang Junfeng Shen Chi-Tang Ho Shiming Li Institute of Agro-Products Storage and processing， Xinjiang Academy of Agricultural Sciences Xinjiang Key Laboratory of Agro-Products processing and Storage College of food Science and Technology， Hebei Agricultural University College of Biology and Agricultural Resources， Huanggang Normal University Department of food Science， Rutgers University(New Brunswick)

Coreopsis tinctoria Nutt. (C. tinctoria)， an edible flowering plant， belongs to the Chrysanthemum family and is mainly grown at high altitudes in northwestern China. It is rich in polyphenolic compounds， particularly marein and flavomarein， and possesses multiple health-promoting properties， such as antioxidant， hypoglycemic and vasorelaxant effects. Previous bioactivity investigations majorly focused on C. tinctoria and its crude extract. The aim of the present study was to prepare marein-dominant C. tinctoria flavonoids (CF)， further investigate the CF protective effects of liver fibrosis induced by carbon tetrachloride and elucidate the associated molecular mechanisms. Results have demonstrated that CF effectively attenuated hepatofibrogenesis by increasing the activity of GSH and SOD; suppressing the HSC activation， inhibiting TGF-β activation and the production of α-SMA， alleviating the phosphorylation of ERK1/2 and Smad1/2， thus maintaining the collagen metabolic homeostasis in the liver. Our study revealed that CF possesses an efficacious protective effect against chronic hepatic fibrosis due to their strong inhibitory effects of oxidative stress and chronic inflammation.

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Sea cucumber intestinal hydrolysates alleviate insulin resistance through regulating IRS1/PI3K/AKT signaling pathway mediated by glutamine metabolism in high-fat and high-sucrose diet-induced mice

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food Science and Human Wellness 2025年

作者： Meng Wang Man Yao Hao Yue Yingying Tian Zifang Zhao Changhu Xue Tiantian Zhang Yuming Wang SKL of Marine food processing & Safety Control， College of food Science and Engineering， Ocean University of China Institute of food & Nutrition Science and Technology， Shandong Academy of Agricultural Sciences Hainan Huayan Collagen Technology Co. Sanya Institute of Oceanography， Ocean University of China

It has been reported that sea cucumber intestine hydrolysates (SCIH) could promote glutamine metabolism in mice， while there is a close connection between glutamine metabolism and insulin sensitivity. However， the effect of SCIH on insulin resistance is still unclear. The results showed that SCIH hydrolyzed by flavor protease had significant activity using the insulin-induced HepG2 cell model. Animal experiments exhibited that SCIH supplementation significantly improved the high-fat and high-sucrose diet-induced impaired glucose tolerance， reduced fasting serum glucose and glycosylated serum protein. Besides， SCIH ameliorated islet vacuolization and decreased the pancreas TNF-α and IL-6 by 32.1% and 36.2%， respectively. Immunofluorescence staining results showed that SCIH promoted insulin secretion. Interestingly， SCIH significantly increased the liver glutamine levels and upregulated the expression of glutaminase1 (GLS1) and glutamate dehydrogenase 1 (GLUD1). Furthermore， SCIH increased liver acetyl-CoA levels to enhance histone acetylation and activate the gene transcription and translation on glucose metabolism-related IRS/PI3K/AKT signaling pathway， thereby attenuating insulin resistance. The present findings proposed the potential value for developing functional foods in SCIH utilization.

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Mitochondria-targeted nanoparticles for encapsulating astaxanthin:exploring the reason for alleviating oxidative damage

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food Science and Human Wellness 2025年第1期14卷 124-133页

作者： Yannan Chen Siyuan Fei Lijuan Zhang Mingqian Tan Academy of food Interdisciplinary Science School of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China National Engineering Research Center of Seafood Dalian Polytechnic UniversityDalian 116034China Collaborative Innovation Center of Seafood Deep processing Dalian Polytechnic UniversityDalian 116034China

Oxidative stress is considered as a critical factor in the process of pathological diseases,and mitochondria are considered as vital target organelles for disease *** purpose of this study was aimed to evaluate the antioxidant efficacy of mitochondria-targeted astaxanthin nanoparticle on hydrogen peroxideinduced oxidative *** expected,mitochondria-targeted nanoparticle showed excellent mitochondria co-localization ability with higher Pearson's correlation coefficient(r=0.88).In vitro experiments suggested that the mitochondria-targeted astaxanthin nanoparticle could promote cell viability and increase antioxidantrelated enzyme ***,metabolomics analysis indicated that mitochondria-targeted astaxanthin nanoparticle could alleviate oxidative stress by regulating amino acid metabolism and energy ***,all these results strongly confirmed the mitochondria-targeted strategy for astaxanthin delivery could relieve oxidative stress and had great promise in the application of disease intervention.

关键词： Oxidative stress Mitochondria-targeted Astaxanthin Antioxidant Metabolism

Beneficial effects of lacquer seed oil on bromocriptine-induced postpartum hypogalactia in rats

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food Science and Human Wellness 2025年第1期14卷 144-153页

作者： Mengting Li Xiaoyu Song Lin Shi Jie Li Mayira Ahat Yaojie Liu Chen Hou Jianke Li College of food Engineering and Nutritional Science Shaanxi Normal UniversityXi’an 710119China University Key Laboratory of food processing Byproducts for Advanced Development and High Value Utilization Shaanxi Normal UniversityXi’an 710119China

The high incidence of postpartum hypogalactia hinders the healthy development of postpartum women and the next *** seed oil(LSO),extracted from the seeds of the lacquer tree,has been traditionally used as a dietary supplement for promoting postpartum lactation and recovery in some districts of ***,its physiological effects have not been verified,and the mechanism and active components of LSO have not been ***,we applied LSO to bromocriptine-induced postpartum hypogalactia *** results showed that LSO supplement effectively improves bromocriptine-induced postpartum *** also increased prolactin levels reduced by bromocriptine,promoted JAK2/STAT5 and PI3K/AKT pathways and several gene expression levels of milk synthesis in mammary ***,metabolomic and network pharmacological analysis further revealed that JAK2/STAT5,PI3K/AKT,and estrogen signaling pathway are the potential main regulatory sites for the beneficial effects of LSO on postpartum hypogalactia,and that quercetin,kaempferol,arachidonic acid,epicatechin,and β-sitosterol are the top 5 main active ingredients of *** results suggested that LSO has great potential in the application of the improvement of postpartum hypogalactia.

关键词： Lacquer seed oil Metabolomics Network pharmacology Postpartum hypogalactia

Punicalagin alleviates hypercholesterolemia in mice through modulating farnesoid X receptor signaling and modulating gut microbiota

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food Science and Human Wellness 2025年第1期14卷 175-189页

作者： Huanhuan Liu Hongli Liu Chunhong Yan Jiaxiu Liu Yu Cao Guopeng Li Xiaodong Xia State Key Laboratory of Marine food processing and Safety Control National Engineering Research Center of SeafoodSchool of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China Beijing Advanced Innovation Center for food Nutrition and Human Health College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China

Punicalagin has been demonstrated to exhibit anti-oxidant and anti-inflammatory properties,but whether and how it could impact hypercholesterolemia remains not fully *** aim of this study was to investigate the influence of punicalagin on hypercholesterolemia in mice and its related *** 6 weeks'intervention,punicalagin significantly reduced serum total cholesterol and low-density lipoprotein cholesterol(LDL-C)levels in mice fed a high-fat high-cholesterol(HFHC)***,punicalagin supplementation lowered hepatic cholesterol level,which corresponded to the down-regulation of cholesterol synthesis genes(Fdps,Cyp51)and up-regulated bile acid synthesis genes(Cyp7a1,Cyp27a1).In addition,bile acid reabsorption was retarded in punicalagin-fed mice through down-regulating ileal apical sodium-dependent BA transporter(ASBT).Furthermore,intestinal farnesoid X receptor(FXR)-fibroblast growth factor 15(Fgf15)pathway was inhibited while hepatic FXR-small heterodimeric partner(SHP)pathway was activated in punicalagin *** analysis and targeted metabolomics showed that punicalagin decreased the abundance of bile-salt hydrolase(BSH)-producing bacteria(Clostridiaceae and Bifidobacteriaceae)and the ratio of primary BAs to secondary *** conclusion,the cholesterol-lowering effect of punicalagin partly through down-regulating cholesterol synthesis and increasing cholesterol catabolism,which could be achieved by regulating gut microbiota,altering bile acid composition and modulating FXR signaling *** findings indicate the potential application of punicalagin-related products as an alternative strategy for hypercholesterolemia prevention and mitigation.

关键词： Punicalagin Hypercholesterolemia Farnesoid X receptor Bile acid metabolism Gut microbiota

Oil Palm Particleboard: Properties and Fungi Susceptibility

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Journal of Renewable Materials 2025年第1期13卷 163-180页

作者： Nur Azreena Idris Madihah Ahmad Zairun Aisyah Humaira Alias Zawawi Ibrahim Noorshamsiana Abdul Wahab Biomass Technology Unit Engineering and Processing DivisionMalaysian Palm Oil BoardNo.6Persiaran InstitusiBandar Baru BangiKajang43000Malaysia Plant Pathology&Biosecurity Unit Biology Research division Malaysian Palm Oil BoardNo.6Persiaran InstitusiBandar Baru BangiKajang43000Malaysia

The utilization of oil palm biomass in the production of high-value products has increased *** to the presence of sugars and starches in their tissues,oil palms have an exceptionally low natural resistance to fungi,making them susceptible to *** this study,the properties of particleboard made from oil palmﬁbers,namely empty fruit bunches(EFB),oil palm trunks(OPT),and oil palm fronds(OPF)ﬁbers and its poten-tial for fungal attack were *** chemical composition,spectroscopic characterization,morphological features,and elemental analysis of oil palm biomassﬁbers were identiﬁed and thoroughly *** mechan-ical properties and dimensional stability of the boards were assessed based on Japanese Industrial Standards(JIS)and American National Standards Institute(ANSI)*** density,strength,and moisture resistance of particleboard made from OPTﬁbers may vary from those made from OPF and EFB due to inherent changes in chemical composition andﬁber *** differences have an impact on the overall performance of the *** on the ANOVA and Tukey’s test results,signiﬁcant differences in elasticity properties were observed mainly between OPT and otherﬁbers,while bending strength revealed notable differences between various pairs of *** evaluation also highlighted variations in dimensional stability and water absorption ***,bending strength properties did not demonstrate any signiﬁcant *** the fungi test,fungal activity on the boards was observed over a two-week period in a controlled *** study revealed that oil palm-based particleboard exhibited susceptibility to fungal attacks,particularly from Aspergillus sp.,Trichoderma sp.,and Paecilomyces ***ﬁndings highlight the necessity for additional treatments to control or prevent fungal growth,thereby enhancing the commercial value of the particleboards.

关键词： Particleboard medium densityﬁberboard(MDF) empty fruit bunches(EFB) oil palm trunks(OPT) and oil palm fronds(OPF)