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The amazing potential of fungi:50 ways we can exploit fungi industrially

Fungal Diversity 2019年第4期97卷 1-136页

作者： Kevin D.Hyde Jianchu Xu Sylvie Rapior Rajesh Jeewon Saisamorn Lumyong Allen Grace T.Niego Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahamanage Siraprapa Brooks Amornrat Chaiyasen K.W.Thilini Chethana Putarak Chomnunti Clara Chepkirui Boontiya Chuankid Nimali I.de Silva Mingkwan Doilom Craig Faulds Eleni Gentekaki Venkat Gopalan Pattana Kakumyan Dulanjalee Harishchandra Hridya Hemachandran Sinang Hongsanan Anuruddha Karunarathna Samantha C.Karunarathna Sehroon Khan Jaturong Kumla Ruvishika S.Jayawardena Jian-Kui Liu Ningguo Liu Thatsanee Luangharn Allan Patrick G.Macabeo Diana S.Marasinghe Dan Meeks Peter E.Mortimer Peter Mueller Sadia Nadir Karaba N.Nataraja Sureeporn Nontachaiyapoom Meghan O’Brien Watsana Penkhrue Chayanard Phukhamsakda Uma Shaanker Ramanan Achala R.Rathnayaka Resurreccion B.Sadaba Birthe Sandargo Binu C.Samarakoon Danushka S.Tennakoon Ramamoorthy Siva Wasan Sriprom T.S.Suryanarayanan Kanaporn Sujarit Nakarin Suwannarach Thitipone Suwunwong Benjarong Thongbai Naritsada Thongklang Deping Wei S.Nuwanthika Wijesinghe Jake Winiski Jiye Yan Erandi Yasanthika Marc Stadler Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.PaPaeA.Mae TaengChiang Mai 50150Thailand Aix Marseille Université INRAUMR1163 BBF13288 Marseille Cedex 09France Beijing Key Laboratory of Environment Friendly Management on Fruit Diseases and Pests in North China Center of Plant and Environment ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Center of Chemical Innovation for Sustainability Mae Fah Luang UniversityTasudMuangChiang Rai 57100Thailand Center of Excellence in Microbial Diversity and Sustainable Utilization Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Center for Mountain Ecosystem Studies Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China Institute of Fungal Research School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Department Microbial Drugs Helmholtz Centre for Infection Researchand German Centre for Infection Research(DZIF)partner site Hannover-BraunschweigInhoffenstrasse 738124 BrunswickGermany Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Chemistry and Biochemistry The Ohio State UniversityColumbusOH 43210USA Department of Chemistry University of Science and TechnologyBannuKhyber PakhtunkhwaPakistan Department of Crop Physiology University of Agricultural SciencesGKVKBengaluruKarnataka 560065India Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai Univers

Fungi are an understudied,biotechnologically valuable group of *** to the immense range of habitats that fungi inhabit,and the consequent need to compete against a diverse array of other fungi,bacteria,and animals,fungi have developed numerous survival *** unique attributes of fungi thus herald great promise for their application in biotechnology and ***,fungi can be grown with relative ease,making production at scale *** search for fungal biodiversity,and the construction of a living fungi collection,both have incredible economic potential in locating organisms with novel industrial uses that will lead to novel *** manuscript reviews fifty ways in which fungi can potentially be utilized as *** provide notes and examples for each potential exploitation and give examples from our own work and the work of other notable *** also provide a flow chart that can be used to convince funding bodies of the importance of fungi for biotechnological research and as potential *** have provided the world with penicillin,lovastatin,and other globally significant medicines,and they remain an untapped resource with enormous industrial potential.

关键词： Biocontrol Biodiversity biotechnology food Fungi Mushrooms

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Forecasting the number of species of asexually reproducing fungi(Ascomycota and Basidiomycota)

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Fungal Diversity 2022年第3期114卷 463-490页

作者： Nalin N.Wijayawardene Alan J.L.Phillips Diana Santos Pereira Dong-Qin Dai AndréAptroot Josiane S.Monteiro Irina S.Druzhinina Feng Cai Xinlei Fan Laura Selbmann Claudia Coleine Rafael F.Castañeda-Ruiz Martin Kukwa Adam Flakus Patricia Oliveira Fiuza Paul M.Kirk Kunhiraman C.Rajesh Kumar Ilesha S.leperuma Arachchi Nakarin Suwannarach Li-Zhou Tang Teun Boekhout Chen Shuhui Tan R.P.Prabath K.Jayasinghe Marco Thines Centre for Yunnan Plateau Biological Resources Protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujing 655011YunnanPeople’s Republic of China Section of Genetics Institute for Research and Development in Health and Social CareNo:393/3Lily AvenueOff Robert Gunawardane MawathaBattaramulla 10120Sri Lanka Faculdade de Ciências Biosystems and Integrative Sciences Institute(BioISI)Universidade de LisboaCampo Grande1749-016 LisbonPortugal Laboratório de Botânica/Liquenologia Instituto de BiociênciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva S/NBairro UniversitárioCampo GrandeMS CEP 79070-900Brazil Coordination of Botany Museu Paraense Emílio GoeldiBelémPA 66077830Brazil Fungal Genomics Laboratory(FungiG) College of Resources and Environmental SciencesNanjing Agricultural UniversityWeigang 1Nanjing 210095JiangsuPeople’s Republic of China The Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry UniversityBeijing 100083People’s Republic of China Department of Ecological and Biological Sciences University of TusciaViterboItaly Italian National Antarctic Museum(MNA) Mycological SectionGenoaItaly Alejandro de Humboldt’(INIFAT) Instituto de Investigaciones Fundamentales en AgriculturaTropicalSantiago de Las VegasHavanaCuba Department of Plant Taxonomy and Nature Conservation Faculty of BiologyUniversity of GdańskWita Stwosza 5980-308 GdańskPoland W.Szafer Institute of Botany Polish Academy of SciencesLubicz 4631-512 KrakowPoland Universidade Federal do Rio Grande do Norte(UFRN) Programa de Pós-Graduação em Sistemática e EvoluçãoCentro de BiociênciasCampus UniversitárioAv.Senador Salgado Filho3000Lagoa NovaNatalRN 59078-970Brazil Biodiversity Informatics and Spatial Analysis Jodrell LaboratoryRoyal Botanic GardensKewRichmond TW93DSSurreyUK National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology GroupMACS Agharkar Research InstituteG.G.

Asexually reproducing fungi play a significant role in essential processes in managed and wild ecosystems such as nutrients cycling and multitrophic interactions.A large number of such taxa are among the most notorious plant and animal *** addition,they have a key role in food production,biotechnology and *** without or rare sexual reproduction are distinguished based on their sporulating structures and conidiomata in traditional morphology-based *** number,variation and diversity of asexually reproducing taxa are insufficiently known,even though fungi capable of asexual reproduction may provide an untapped,rich biological resource for future ***,ca.30,000 asexual species belonging to ca.3800 genera have been reported(including 1388 coelomycetous and 2265 hyphomycetous genera).Recent reports(2017–2020)reiterate that the number of asexually producing fungi is higher than the number of frequently sexually-reproducing *** the advent of molecular tools and the abandonment of the dual nomenclature system for pleomorphic fungi,priority criteria were established and revisited in the latest outline of fungi and fungus-like ***,species numbers and taxonomic boundaries of pleomorphic taxa and their synanamorphs or synasexual morphs have yet to be *** number of species of speciose genera(***,Aspergillus,Cercospora,Fusarium,Phoma and Pseudocercospora),cryptic species,species of pleomorphic genera,less studied life modes(such as lichenicolous taxa,taxa from extreme environments)and species from biodiversity-rich areas still need evaluation to achieve more reliable estimates of their *** paper discusses the current knowledge on the matter,with diversity estimates,and potential obstacles in several chapters on(1)speciose genera;(2)pleomorphic genera;(3)cryptic species;(4)well-studied but insufficiently resolved taxa,*** inhabiting species,marine fungi,(5)less studied life modes,e.g.

关键词： Cryptic species DNA sequences Morphology Pleomorphism Speciose genera Species identificat

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Diterpenoids from Scutellaria barbata induce tumour-selective cytotoxicity by taking the brakes off apoptosis

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Medicinal Plant Biology 2022年第1期1卷 8-23页

作者： Matthew L.Tomlinson Man Zhao Elaine J.Barclay Jie Li Haixiu Li Juri Felix Lionel Hill Gerhard Saalbach Martin Rejzek Dongfeng Yang Qing Zhao Paul Kroon Wei Wang Yongping Bao Melanie-Jayne R.Howes Evangelos C.Tatsis Cathie Martin The John Innes Centre NorwichNR47UHUnited Kingdom College of Bioengineering and biotechnology Zhejiang University of TechnologyHangzhou 310058China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China Royal Botanic Gardens Kew RichmondSurreyLondon TW93ABUnited Kingdom College of Life Sciences Zhejiang Sci-Tech UniversityXiasha Higher Education ZoneHangzhou 310018China Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai Chenshan Plant Science Research CenterChinese Academy of SciencesShanghai 201602China Quadram Institute Bioscience Norwich Research ParkNorwichNR47UAUnited Kingdom Norwich Medical School University of East AngliaNorwichNorfolkNR47TJUnited Kingdom CEPAMS:CAS-JIC Centre of Excellence in Plant and Microbial Sciences

Medicinal plants are an excellent source of structurally diverse,bio-active compounds with potential in the fight against *** of the most promising is Scutellaria barbata,prescribed traditionally for the treatment of *** A is the major diterpenoid,produced in specialized large,peltate trichomes on leaves of *** induces dose-dependent apoptosis,specifically in cancer *** major class of proteins down-regulated are pro-survival proteins,the Inhibitors of Apoptosis(IAPs),and IAP regulating *** propose that scutebarbatine A works by releasing the molecular brakes(the IAPs)on apoptosis in cell death-evading cancer *** between the cytotoxicity of methanolic extracts of *** leaves and decoctions(Ban Zhi Lian)prepared traditionally,showed substantially different chemical compositions and differential induction of *** suggest polyvalency between the constituents in both extracts,and ways to produce enhanced chemopreventive preparations for the treatment of cancer.

关键词： prescribed methanol structurally

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Pilot Study on the Intercalibration of a Categorisation System for FAlRer Digital Objects Related to Sensitive Data in the Life Sciences

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Data Intelligence 2022年第2期4卷 196-211页

作者： Christian Ohmann Romain David Monica Cano Abadia Florence Bietrix Jan-Willem Boiten Steve Canham Maria Luisa Chiusano Walter Dastru Arnaud Laroquette Dario Longo Michaela Theresia Mayrhofer Maria Panagiotopoulou Audrey Richard Pablo Emilio Verde European Clinical Research Infrastructure Network(ECRIN) Paris 75013France European Research Infrastructure on Highly Pathogenic Agents(ERINHA AISBL) Brussels 10ooBelgium Biobanking and Biomolecular Resources Research Infrastructure(BBMRI) Graz 8010Austria European Infrastructure for Translational Medicine(EATRIS) Amsterdam 1081 HZThe Netherlands European Advanced Translational Research Infrastructure(EATRIS)/Lygature Utrecht 3521 ALThe Netherlands European Marine Biological Resource Centre(EMBRC)Department of Agricultural Sciences University Federico Il of Naples via UniversitaNaples 80138Italy Department of Molecular biotechnology and Health Sciences Molecular Imaging CenterUniversity of TorinoTorino I-10125Italy European Marine Biological Resource Centre(EMBRC) Paris 75252France European Research Infrastructure for Biological and Biomedical Imaging(Euro-Biolmaging) Torino 10126Italy European Research Infrastructure on Highly Pathogenic Agents(ERINHA AISBL) Brussels 1000Belgium Coordination Centre for Clinical Trials Heinrich Heine University Dusseldorf Ringgold standard institutionNordrhein-Westfalen 40225Germany

Sharing sensitive data is a specific challenge for research infrastructures in the field of life *** that reason a toolbox has been developed,providing resources for researchers who wish to share and use sensitive data,to support the workflows for handling these kinds of digital *** and community approved annotations are required to be compliant with FAIR principles(Findability,Accessibility,Interoperability,Reusability).The toolbox makes use of a tagging(categorisation)system,allowing consistent labelling and categorisation of digital objects,in terms relevant to data sharing tasks and activities.A pilot study was performed within the Horizon 2020 project EOSC-Life,in which 2 experts from 6 life sciences research infrastructures were recruited to independently assign tags to the same set of 10 to 25 resources related to sensitive data management and data sharing(in total 110).Summary statistics of agreement and observer variation per research infrastructure are *** pilot study has shown that experts were able to attribute tags but in most cases with a considerable observer variation between *** the context of CWFR(Canonical Workflow Frameworks for Research),this indicates the necessity for careful definition,evaluation and validation of parameters and processes related to workflow *** results from this pilot study were used to tackle this issue by revising the categorisation system and providing an updated version.

关键词： Sensitive data CWFR EOSC-Life Life sciences Toolbox Categorisation system Tagging FAIR

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Words apart:Standardizing forestry terms and definitions across European biodiversity studies

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森林生态系统:英文版 2023年第4期10卷 459-471页

作者： Giovanni Trentanovi Thomas Campagnaro Tommaso Sitzia Francesco Chianucci Giorgio Vacchiano Christian Ammer MichałCiach Thomas ANagel Miren del Río Yoan Paillet Silvana Munzi Kris Vandekerkhove Andrés Bravo-Oviedo Andrea Cutini Ettore D'Andrea Pallieter De Smedt Inken Doerfler Dimitris Fotakis Jacob Heilmann-Clausen Jeňýk Hofmeister Jan Hošek Philippe Janssen Sebastian Kepfer-Rojas Nathalie Korboulewsky Bence Kovács Daniel Kozák Thibault Lachat Anders Mårell Radim Matula Martin Mikoláš Björn Nordén PéterÓdor x Marko Perović Elisabeth Pötzelsberger Peter Schall Miroslav Svoboda Flóra Tinya Mariana Ujházyová Sabina Burrascano Research Institute on Terrestrial Ecosystems-National Research Council(IRET-CNR) Via Madonna Del Piano 1950019Sesto FiorentinoFIItaly Department of Land EnvironmentAgriculture and ForestryUniversitàdegli Studi di PadovaViale Dell’Università1635020LegnaroPDItaly National Biodiversity Future Center Piazza Marina 6190133PalermoItaly CREA Research Centre for Forestry and Wood Viale S.Margherita 8052100ArezzoItaly Department of Agricultural and Environmental Sciences(DISAA) University of MilanVia Celoria 220133MilanItaly Silviculture and Forest Ecology of the Temperate Zones University of GöttingenGermany Department of Forest Biodiversity Faculty of ForestryUniversity of Agricultureal.29 Listopada 4631-425KrakówPoland Department of Forestry and Renewable Forest Resources Biotechnical FacultyUniversity of LjubljanaVecna pot 831000LjubljanaSlovenia Instituto de Ciencias Forestales(ICIFOR-INIA) CSICCtra.de la Coruña Km 7.528040MadridSpain University Grenoble Alpes LessemINRAE2 Rue de la Papeterie38402 Saint-Martin-d'HèresFrance Centro Interuniversitário de História Das Ciências e da Tecnologia Faculdade de CiênciasUniversidade de LisboaPortugal Centre for Ecology Evolution and Environmental ChangesFaculdade de Ciências&CHANGE-Global Change and Sustainability InstituteUniversidade de LisboaPortugal Research Institute for Nature and Forest(INBO) Havenlaan 88 Bus 731000BrusselBelgium Department of Biogeography and Global Change National Museum of Natural Sciences-CSICC/Serrano 115bis28006MadridSpain Research Institute on Terrestrial Ecosystems-National Research Council(IRET-CNR) Via G.Marconi N.205010PoranoTRItaly Forest&Nature Lab Department of EnvironmentGhent UniversityGeraardsbergsesteenweg 2679090GontrodeBelgium Institute of Biology and Environmental Science Vegetation Science&Nature ConservationUniversity of OldenburgAmmerländer Heerstraße 114-11826129OldenburgGermany Forest Research Institute Hellenic Agricultural Organization DimitraVassilikaThessal

Forest biodiversity studies conducted across Europe use a multitude of forestry terms,often *** hinders the comparability across studies and makes the assessment of the impacts of forest management on biodiversity highly *** attempts to standardize forestry and stand description terminology mostly used a top-down approach that did not account for the perspectives and approaches of forest biodiversity *** work aims to establish common standards for silvicultural and vegetation definitions,creating a shared conceptual framework for a consistent study on the effects of forest management on *** have identified both strengths and weaknesses of the silvicultural and vegetation information provided in forest biodiversity *** quantitative data on forest biomass and dominant tree species are frequently included,information on silvicultural activities and vegetation composition is often lacking,shallow,or based on broad and heterogeneous *** discuss the existing classifications and their use in European forest biodiversity studies through a novel bottom-up and top-driven review process,and ultimately propose a common *** will enhance the comparability of forest biodiversity studies in Europe,and puts the basis for effective implementation and monitoring of sustainable forest management *** standards here proposed are potentially adaptable and applicable to other geographical areas and could be extended to other forest interventions.

关键词： Forest management Multi-taxon Terminology Silviculture Data harmonization

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Notes,outline and divergence times of Basidiomycota

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Fungal Diversity 2019年第6期99卷 105-367页

作者： Mao-Qiang He Rui-Lin Zhao Kevin D.Hyde Dominik Begerow Martin Kemler Andrey Yurkov Eric H.C.McKenzie Olivier Raspe Makoto Kakishima Santiago Sanchez-Ramırez Else C.Vellinga Roy Halling Viktor Papp Ivan V.Zmitrovich Bart Buyck Damien Ertz Nalin N.Wijayawardene Bao-Kai Cui Nathan Schoutteten Xin-Zhan Liu Tai-Hui Li Yi-Jian Yao Xin-Yu Zhu An-Qi Liu Guo-Jie Li Ming-Zhe Zhang Zhi-Lin Ling Bin Cao Vladimir Antonin Teun Boekhout Bianca Denise Barbosa da Silva Eske De Crop Cony Decock Balint Dima Arun Kumar Dutta Jack W.Fell Jozsef Geml Masoomeh Ghobad-Nejhad Admir J.Giachini Tatiana B.Gibertoni Sergio P.Gorjon Danny Haelewaters Shuang-Hui He Brendan P.Hodkinson Egon Horak Tamotsu Hoshino Alfredo Justo Young Woon Lim Nelson Menolli Jr Armin Mesic Jean-Marc Moncalvo Gregory M.Mueller La szlo G.Nagy RHenrik Nilsson Machiel Noordeloos Jorinde Nuytinck Takamichi Orihara Cheewangkoon Ratchadawan Mario Rajchenberg Alexandre G.S.Silva-Filho Marcelo Aloisio Sulzbacher Zdenko Tkalcec Ricardo Valenzuela Annemieke Verbeken Alfredo Vizzini Felipe Wartchow Tie-Zheng Wei Michael WeiB Chang-Lin Zhao Paul M.Kirk State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101People’s Republic of China Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand College of Life Sciences University of Chinese Academy of SciencesHuairou DistrictBeijing 100408People’s Republic of China Ruhr-Universitat Bochum AG GeobotanikND03UniversitatsstraBe 15044801 BochumGermany Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures InhoffenstraBe 7B38124 BrunswickGermany Manaaki Whenua-Landcare Research Private Bag 92170AucklandNew Zealand Research Department Meise Botanic GardenNieuwelaan 381860 MeiseBelgium Service General de l'Enseignement superieur et de la Recherche scientifique Federation Wallonie-BruxellesLavallee 11080 BrusselsBelgium University of Tsukuba TsukubaIbaraki 305-8572Japan Department of Ecology and Evolutionary Biology University of Toronto25 Willcocks St.TorontoON M5S 3B2Canada Berkeley USA Institute of Systematic Botany The New York Botanical GardenBronxNY 10458-5126USA Department of Botany Szent Istvan University1518 BudapestHungary Komarov Botanical Institute Russian Academy of SciencesProfessor Popov st.2Saint PetersburgRussia 197376 Institut pour Systematique Ecologie Biodiversite(ISYEB UMR 7205) Sorbonne universiteMuseum National d’Histoire Naturelle CP 39CNRSDepartement Origines et Evolution12 Rue Buffon75005 ParisFrance Institute of Microbiology Beijing Forestry UniversityBeijing 100083People’s Republic of China Department of Biology Research Group MycologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Institute of MicrobiologyGuangzhou 510070People’s Republic of China Department of Botany Moravian Mu

The Basidiomycota constitutes a major phylum of the kingdom Fungi and is second in species numbers to the *** present work provides an overview of all validly published,currently used basidiomycete genera to date in a single *** outline of all genera of Basidiomycota is provided,which includes 1928 currently used genera names,with 1263 synonyms,which are distributed in 241 families,68 orders,18 classes and four *** provide brief notes for each accepted genus including information on classification,number of accepted species,type species,life mode,habitat,distribution,and sequence ***,three phylogenetic analyses with combined LSU,SSU,5.8s,rpb1,rpb2,and ef1 datasets for the subphyla Agaricomycotina,Pucciniomycotina and Ustilaginomycotina are conducted,*** time estimates are provided to the family level with 632 species from 62 orders,168 families and 605 *** study indicates that the divergence times of the subphyla in Basidiomycota are 406-430 Mya,classes are 211-383 Mya,and orders are 99-323 Mya,which are largely consistent with previous *** this study,all phylogenetically supported families were dated,with the families of Agaricomycotina diverging from 27-178 Mya,Pucciniomycotina from 85-222 Mya,and Ustilaginomycotina from 79-177 *** times as additional criterion in ranking provide additional evidence to resolve taxonomic problems in the Basidiomycota taxonomic system,and also provide a better understanding of their phylogeny and evolution.

关键词： Classification Molecular clock Fungi Systematics Taxonomy

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Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults:Big Data from Seven Randomized Controlled Trials Worldwide

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Health Data Science 2021年第1期2021卷 174-183页

作者： Tao Huang Zhenhuang Zhuang Yoriko Heianza Dianjianyi Sun Wenjie Ma Wenxiu Wang Meng Gao Zhe Fang Emilio Ros Liana C.Del Gobbo Jordi Salas-Salvadó Miguel A.Martínez-González Jan Polak Markku Laakso Arne Astrup Dominique Langin Jorg Hager Gabby Hul Torben Hansen Oluf Pedersen Jean-Michel Oppert Wim H.M.Saris Peter Arner Montserrat Cofán Sujatha Rajaram Jaakko Tuomilehto Jaana Lindström Vanessa D.de Mello Alena Stancacova Matti Uusitupa Mathilde Svendstrup Thorkild I.A.Sørensen Christopher D.Gardner Joan Sabaté Dolores Corella J.Alfredo Martinez Lu Qi Department of Epidemiology&Biostatistics School of Public HealthPeking UniversityChina Department of Global Health School of Public HealthPeking UniversityChina Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education China Global Health Institute Peking University China Department of Epidemiology School of Public Health and Tropical MedicineTulane UniversityNew OrleansLAUSA Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMAUSA Department of Endocrinology&Nutrition Institut d’Investigacions Biomèdiques August Pi SunyerHospital ClínicBarcelonaSpain CIBER Fisiopatologia de la Obesidad y Nutrición(CIBERobn) Instituto de Salud Carlos III(ISCIII)MadridSpain Stanford Prevention Research Center Stanford UniversityStanford CAUSA Human Nutrition Unit Faculty of Medicine and Health SciencesPere Virgili Health Research InstituteRovira i Virgili UniversityReusSpain University of Navarra Department of Preventive Medicine and Public HealthMedical School&IDISNAPamplonaSpain Department for the Study of Obesity and Diabetes Third Faculty of MedicineCharles UniversityPragueCzech Republic Department of Medicine University of Eastern FinlandKuopioFinland University of Copenhagen Department of NutritionExercise and SportsFaculty of ScienceCopenhagenDenmark Institut National de la Santéet de la Recherche Médicale(Inserm) UMR1048Institute of Metabolic and Cardiovascular DiseasesUniversity of Toulouse and Paul Sabatier UniversityToulouseFrance NestléInstitute of Health Sciences LausanneSwitzerland Department of Human Biology NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Medical Centre+MaastrichtNetherlands Section of Metabolic Genetics Novo Nordisk Foundation Center for Basic Metabolic ResearchFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark Sorbonne Université Institute of Cardiometabolism and Nutrition(ICAN)Department of NutritionPitié-Salpêtrière HospitalAssistance Publique-

*** strongest locus which associated with type 2 diabetes(T2D)by the common variant rs7903146 is the transcription factor 7-like 2 gene(TCF7L2).We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TCF7L2 rs7903146 on glycemic traits,body weight,or waist circumference in overweight or obese adults in several randomized controlled trials(RCTs).*** October 2016 to May 2018,a large collaborative analysis was performed by pooling individualparticipant data from 7 *** RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese *** treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all *** the joint analysis,a total of 7 eligible RCTs were included(n=4,114).Importantly,we observed a significant effect modification of diet/lifestyle-related interventions on the TCF7L2 variant rs7903146 and changes in fasting *** with the control group,diet/lifestyle interventions were related to lower fasting glucose by-3.06(95%CI,-5.77 to-0.36)mg/dL(test for heterogeneity and overall effect:I^(2)=45:1%,p<0:05;z=2:20,p=0:028)per one copy of the TCF7L2 T risk ***,regardless of genetic risk,diet/lifestyle interventions were associated with lower waist ***,there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of TCF7L2 risk *** findings suggest that carrying the TCF7L2 T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults.

关键词： TCF7L2 weight finding

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Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

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四川生理科学杂志 2022年第12期44卷 2223-2223页

作者： Danyel Lee St. Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA. Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Paris France. Paris City University Imagine Institute Paris France. Laboratory of Virology and Infectious Disease The Rockefeller University New York NY USA. Department of Cancer Biology Lerner Research Institute Cleveland Clinic Cleveland OH USA. Human Evolutionary Genetics Unit Institut Pasteur Paris City University CNRS UMR 2000 Paris France. Doctoral College Sorbonne University Paris France. Laboratory of Immunology Lyon Sud Hospital Lyon France. Pediatric Intensive Care Department Hospital Sant Joan de Déu Barcelona Spain. Kids Corona Platform Barcelona Spain. Center for Biomedical Network Research on Epidemiology and Public Health (CIBERESP) Instituto de Salud Carlos III Madrid Spain. Department of Surgery and Surgical Specializations Faculty of Medicine and Health Sciences University of Barcelona Barcelona Spain. Respiratory and Immunological Dysfunction in Pediatric Critically Ill Patients Institute of Recerca Sant Joan de Déu Barcelona Spain. Bursa City Hospital Bursa Turkey. Ankara City Hospital Yildirim Beyazit University Ankara Turkey. Immunology and Rheumatology Division Department of Pediatrics University of Montreal CHU Sainte-Justine Montreal QC Canada. Center for Translational Research Institut Pasteur Paris City University Paris France. Department of Biochemistry and Center for RNA Science and Therapeutics Case Western Reserve University Cleveland OH USA. Department of Surgery Weill Cornell Medical College New York NY USA. Department of Pediatrics School of Medicine Emory University Atlanta GA USA. International Center of Infectiology Research (CIRI) University of Lyon INSERM U1111 Claude Bernard University Lyon 1 CNRS UMR5308 ENS of Lyon Lyon France. Departments of Neurosurgery and Genetics and Yale Center for G

Multisystem inflammatory syndrome in children(MIS-C)is a rare and severe condition that follows benign *** report autosomal recessive deficiencies of OAS1,OAS2,or RNASEL in five unrelated children with *** cytosolic d... 详细信息

关键词： inflammatory children multisystem

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