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Elasticity solution of laminated beams with temperature-dependent material properties under a combination of uniform thermo-load and mechanical loads

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Journal of Central South University 2018年第10期25卷 2537-2549页

作者： ZHANG Zhong ZHOU Wen-ling ZHOU Ding HUO Rui-li XU Xiu-li College of Civil Engineering Nanjing Tech UniversityNanjing 211816China flood control and drought relief rescue center of jiangsu province Nanjing 211500China

An exact solution for simply-supported laminated beams with material properties variable with temperature under a combination of uniform thermo-load and mechanical loads was investigated,based on the two-dimensional(2-D)thermo-elasticity ***,the beam was divided into a series of layers with uniform material properties along the interfaces of the *** uniform thermo-load acted on each layer was transformed into a combination of the normal surface forces acted at the two ends and the transverse ***,the state space method was employed to obtain the general solutions of displacements and stresses in an arbitrary ***,based on the interfacial continuity conditions between adjacent layers,the relations of displacement and stress components between the top and bottom layers of the beam were recursively derived by use of the transfer-matrix *** unknowns in the solutions can be solved by the mechanical loads acted on the top and bottom *** convergence of the present solutions was *** comparative study of the present solutions with the Timoshenko’s solutions and the finite element(FE)solutions was carried *** effects of material properties variable with temperature on the thermo-elastic behavior of laminated beams were discussed in detail.

关键词： laminated beam thermo-elasticity analytical solution transfer-matrix method temperature-dependent material

Evaluation of the Effectiveness and Efficiency of the Combination of Levamlodipine Besylate and Valsartan in the Treatment of Hypertension

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Proceedings of Anticancer Research 2024年第1期8卷 92-98页

作者： Dazhuan Li Lianyungang Xuwei New District People’s Hospital Lianyungang 222000Jiangsu ProvinceChina jiangsu Lianyungang Xuhui New District Medical Emergency rescue center Lianyungang 222006China

Objective:To investigate the effectiveness and efficiency of combining levamlodipine besylate and valsartan in the treatment of ***:This study selected 28 patients with hypertension as observation *** treatment duration ranged from January 2020 to June *** the random number table method,patients were divided into two *** control group received treatment with valsartan,while the observation group received a combination of valsartan and levamlodipine *** effects and safety were compared between the groups,and changes in the patient’s blood pressure and renal function index levels were ***:The total clinical effective rate of the observation group was significantly higher than that of the control group(Pcontrol group(P0.05).Conclusion:The combined treatment of levamlodipine besylate and valsartan in patients with hypertension showed significant clinical efficacy and holds broad application value.

关键词： Levamlodipine besylate Valsartan Hypertension Renal function Effective rate

Overexpression of vascular endothelial growth factor enhances the neuroprotective effects of bone marrow mesenchymal stem cell transplantation in ischemic stroke

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Neural Regeneration Research 2023年第6期18卷 1286-1292页

作者： Cui Liu Zhi-Xiang Yang Si-Qi Zhou Ding Ding Yu-Ting Hu Hong-Ning Yang Dong Han Shu-Qun Hu Xue-Mei Zong Institute of Emergency rescue Medicine Emergency Centerthe Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Emergency Department of Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People’s Hospital of Lianyungang LianyungangLianyungangJiangsu ProvinceChina Laboratory of Emergency Medicine Second Clinical Medical College of Xuzhou Medical UniversityXuzhou Medical UniversityXuzhouJiangsu ProvinceChina Key Laboratory of Brain Diseases Bioinformation Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina

Although bone marrow mesenchymal stem cells(BMSCs)might have therapeutic potency in ischemic stroke,the benefits are *** current study investigated the effects of BMSCs engineered to overexpress vascular endothelial growth factor(VEGF)on behavioral defects in a rat model of transient cerebral ischemia,which was induced by middle cerebral artery ***-BMSCs or control grafts were injected into the left striatum of the infarcted hemisphere 24 hours after *** found that compared with the stroke-only group and the vehicle-and BMSCs-control groups,the VEGF-BMSCs treated animals displayed the largest benefits,as evidenced by attenuated behavioral defects and smaller infarct volume 7 days after ***,VEGF-BMSCs greatly inhibited destruction of the blood-brain barrier,increased the regeneration of blood vessels in the region of ischemic penumbra,and reducedneuronal degeneration surrounding the infarct *** mechanistic studies showed that among all transplant groups,VEGF-BMSCs transplantation induced the highest level of brain-derived neurotrophic *** results suggest that BMSCs transplantation with vascular endothelial growth factor has the potential to treat ischemic stroke with better results than are currently available.

关键词： bone marrow mesenchymal stem cell brain-derived neurotrophic factor CD31 microtubule associated protein 2 middle cerebral artery occlusion stroke transplantation vascular endothelial growth factor

Endoscopy-assisted cerebral falx incision via unilateral approach for treatment of dissymmetric bilateral frontal contusion

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Chinese Journal of Traumatology 2012年第2期15卷 92-95页

作者： DONG Ji-rong XU Qin-yi CAI Xue-jian WANG Biao WANG Yu-hai SHI Zhong-hua LIU Bing CAI Sang HE Jian-qing HU Xu Neurosurgical Department the 101st Hospital of PLARescue Center of Craniocerebral Injuries of PLAWuxi 214044Jiangsu ProvinceChina

Objective： To investigate the clinical features and treatment strategy of dissymmetric bilateral frontal contusion, and to summarize our experience in treating these patients by minimally invasive surgery. Methods： Over the past 3 years, we have treated a total of 31 patients with dissymmetric bilateral frontal contusion using endoscopy-assisted unilateral cerebral falx incision. ~ ~ther 30 patients treated by routine bilateral approaches within the same period were taken as control. Results： Seventeen cases （54.8%） in the unilateral operation group survived and were in good condition, 8 （25.8%） had moderate disability, 4 （12.9%） had severe disability, 1 （3.2%） was in vegetative state, and 1 （3.2%） died. Compared with the control group, the Glasgow Out- come Scale score was not significantly different in the uni-lateral operation group, but the operation time, blood trans- fusion volume, the length of hospital stay, the incidences of mental disorder and olfactory nerve injury were greatly reduced in the unilateral operation group. Conclusions： Endoscopy-assisted unilateral cerebral falx incision can shorten the operation time, reduce surgical trauma and complications in treatment of patients with dissymmetric bilateral frontal contusion. It can obviously diminish the chance of delayed intracerebral hematoma and subsequently minimize the incidences of subfalcial and centrencephalic herniation.

关键词： Brain injuries Intracranial hemorrage,traumatic Endoscopy Surgically procedures, minimallyinvasive

Effect of intraoperative cell rescue on bleeding related indexes after cesarean section

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World Journal of Clinical Cases 2022年第8期10卷 2439-2446页

作者： Yu-Fang Yu Yong-Dong Cao Department of Blood Transfusion Hai’an People’s Hospital Affiliated to Nantong UniversityHai’an 226600Jiangsu ProvinceChina Department of Clinical Laboratory Hai’an Qutang Central Health CenterHai’an 226600Jiangsu ProvinceChina

BACKGROUND Obstetric hemorrhage is the leading cause of maternal mortality globally,especially in *** key to a successful rescue is immediate and rapid blood *** has become an integral part of clinical blood transfusion,with intraoperative cell salvage(IOCS)being the most widely *** To investigate the application of IOCS in cesarean *** A total of 87 patients who underwent cesarean section and blood transfusion in our hospital from March 2015 to June 2020 were included in this prospective controlled *** were divided into the observation(43 cases)and control(44 cases)groups using the random number table *** patients in both groups underwent lower-segment cesarean *** patients in the control group were treated with traditional allogeneic blood transfusion,whereas those in the observation group were treated with ***[Red blood cell count,platelet volume,and fibrinogen(FIB)]and coagulation function(partial prothrombin time,prothrombin time(PT),platelet count,and activated coagulation time)were measured before and 24 h after *** the two groups,adverse reactions,such as choking and dyspnea,within 2 h after cesarean section were *** Before and after transfusion,no significant differences in hemorheology and coagulation function indices between the two groups were observed(P>0.05).About 24 h after transfusion,the erythrocyte count,platelet ratio,and FIB value significantly decreased in the two groups(P0.05).Furthermore,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).CONCLUSION In patients undergoing cesarean sectio

关键词： Intraoperative cell salvage Cesarean section Amniotic fluid embolism Hemorheology Coagulation function

Modeling Residual Circulation and Stratification in Oujiang River Estuary

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China Ocean Engineering 2012年第2期26卷 351-362页

作者：林伟波王义刚阮晓红徐群 Key Laboratory of Coastal Disaster and Defense Ministry of EducationHohai University Tidal Flat Research center of jiangsu province Department of Hydrosciences Nanjing University Nanjing Hydraulic Research Institute

A 3D, time-dependent, baroclinic, hydrodynamic and salinity model was implemented and applied to the Oujiang River estuarine system in the East China Sea. The model was driven by the forcing of tidal elevations along the open boundaries and freshwater inflows from the Oujiang River. The bottom friction coefficient and vertical eddy viscosity were adjusted to complete model calibration and verification in simulations. It is demonstrated that the model is capable of reproducing observed temporal variability in the water surface elevation and longitudinal velocity, presenting skill coefficient higher than 0,82. This model was then used to investigate the influence of freshwater discharge on residual current and salinity intrusion under different freshwater inflow conditions in the Oujiang River estuary. The model results reveal that the river channel presents a two-layer structure with flood currents near the bottom and ebb currents at the top layer in the region of seawater influenced on north shore under high river flow condition. The river discharge is a major factor affecting the salinity stratification in the estuarine system, The water exchange is mainly driven by the tidal forcing at the estuary mouth, except under high river flow conditions when the freshwater extends its influence from the river＇s head to its mouth.

关键词： hydrodynamics circulation saline intrusion salinity stratification Oujiang River estuary

Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons

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Neural Regeneration Research 2020年第12期15卷 2335-2343页

作者： Shu-Ting Chen Wan-Jing Lai Wei-Jia Zhang Qing-Pei Chen Li-Bing Zhou Kwok-Fai So Ling-Ling Shi Guangdong-Hong Kong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Clinical Medicine Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Psychiatry the First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Co-innovation center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

SHANK2 is a scaffold protein that serves as a protein anchor at the postsynaptic density in *** variants of SHANK2 are strongly associated with synaptic dysfunction and the pathophysiology of autism spectrum *** studies indicate that early neuronal developmental defects play a role in the pathogenesis of autism spectrum disorder,and that insulin-like growth factor 1 has a positive effect on neurite *** investigate the effects of SHANK2 knockdown on early neuronal development,we generated a sparse culture system using human induced pluripotent stem cells,which then differentiated into neural progenitor cells after 3–14 days in culture,and which were dissociated into single *** in the experimental group were infected with shSHANK2 lentivirus carrying a red fluorescent protein reporter(shSHANK2 group).control neurons were infected with scrambled sh control lentivirus carrying a red fluorescent protein reporter(sh control group).Neuronal somata and neurites were reconstructed based on the lentiviral red fluorescent protein *** dendritic and motility changes in VGLUT1^+glutamatergic neurons and TH+dopaminergic neurons were then evaluated in both *** with sh control VGLUT1^+neurons,the dendritic length and arborizations of shSHANK2 VGLUT1^+neurons were shorter and fewer,while cell soma speed was ***,dendritic length and arborization were significantly increased after insulin-like growth factor 1 treatment of shSHANK2 neurons,while cell soma speed remained *** results suggest that insulin-like growth factor 1 can rescue morphological defects,but not the change in neuronal ***,our findings demonstrate that SHANK2 deficiency perturbs early neuronal development,and that IGF1 can partially rescue the neuronal defects caused by SHANK2 *** experimental procedures and protocols were approved by the Laboratory Animal Ethics Committee of Jinan Universi

关键词： cells factor growth in vitro model neural differentiation neurogenesis plasticity

Using multi-satellite microwave remote sensing observations for retrieval of daily surface soil moisture across China

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Water Science and Engineering 2019年第2期12卷 85-97页

作者： Ke Zhang Li-jun Chao Qing-qing Wang Ying-chun Huang Rong-hua Liu Yang Hong Yong Tu Wei Qu Jin-yin Ye State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China College of Hydrology and Water Resources Hohai UniversityNanjing 210098China China Institute of Water Resources and Hydropower Research Beijing 100038China Research center on flood&drought Disaster Reduction of the Ministry of Water Resources Beijing 100038China School of Civil Engineering Tsinghua UniversityBeijing 100084China Anhui Branch of China Meteorological Administration Training Centre Hefei 230031China

The objective of this study was to retrieve daily composite soil moisture by jointly using brightness temperature observations from multiple operating satellites for near real-time application with better coverage and higher *** approach was to first apply the single-channel brightness radiometric algorithm to estimate soil moisture from the respective brightness temperature observations of the SMAP,SMOS,AMSR2,FY3B,and FY3C satellites on the same day and then produce a daily composite dataset by averaging the individual satellite-retrieved soil *** further evaluated our product,the official soil moisture products of the five satellites,and the ensemble mean (i.e.,arithmetic mean) of the five official satellite soil moisture products against ground observations from two networks in Central Tibet and Anhui province,*** results show that our product outperforms the individual released products of the five satellites and their ensemble means in the two validation *** root mean square error (RMSE ) values of our product were 0.06 and 0.09 m3/m3 in Central Tibet and Anhui province,*** to the ensemble mean of the five satellite products,our product improves the accuracy by 9.1% and 57.7% in Central Tibet and Anhui province,*** demonstrates that jointly using brightness temperature observations from multiple satellites to retrieve soil moisture not only improves the spatial coverage of daily observations but also produces better daily composite products.

关键词： Soil moisture retrieval Passive microwave remote sensing Multiple satellites Surface hydrology SMAP SMOS AMSR2 FY3B FY3C

Transcriptome Analysis of Schwann Cells at Various Stages of Myelination Implicates Chromatin Regulator Sin3A in control of Myelination Identity

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Neuroscience Bulletin 2022年第7期38卷 720-740页

作者： Bin Zhang Wenfeng Su Junxia Hu Jinghui Xu Parizat Askar Shuangxi Bao Songlin Zhou Gang Chen Yun Gu jiangsu Key Laboratory of Neuroregeneration Co-innovation Center of NeuroregenerationJiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairNMPAKey Laboratory for ResearchEvaluation of Tissue Engineering Technology ProductsNantong UniversityNantong 226001China

Enhancing remyelination after injury is of utmost importance for optimizing the recovery of nerve *** the formation of myelin by Schwann cells(SCs)is critical for the function of the peripheral nervous system,the temporal dynamics and regulatory mechanisms that control the progress of the s lineage through myelination require further ***,using in vitro co-culture models,gene expression profiling of laser capture-microdissected SCs at various stages of myelination,and multilevel bioinformatic analysis,we demonstrated that SCs exhibit three distinct transcriptional characteristics duringmyelination:the immature,promyelinating,and myelinating *** showed that suppressor interacting 3a(Sin3A)and 16 other transcription factors and chromatin regulators play important roles in the progress of ***3A knockdown in the sciatic nerve or specifically in SCs reduced or delayed the myelination of regenerating axons in a rat crushed sciatic nerve model,while overexpression of Sin3A greatly promoted the remyelination of ***,in vitro experiments revealed that Sin3A silencing inhibited SC migration and differentiation at the promyelination stage and promoted SC proliferation at the immature *** addition,SC differentiation and maturation may be regulated by the Sin3A/histone deacetylase2(HDAC2)complex functionally cooperating with Sox10,as demonstrated by rescue ***,these results complement the recent genome and proteome analyses of SCs during peripheral nerve myelin *** results also reveal a key role of Sin3A-dependent chromatin organization in promoting myelinogenic programs and SC differentiation to control peripheral myelination and *** findings may inform new treatments for enhancing remyelination and nerveregeneration.

关键词： (Re)myelination Schwann cells Sin3A Transcriptome Peripheral nerve injury