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Colorectal cancer:Metastases to a single organ

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World Journal of Gastroenterology 2015年第41期21卷 11767-11776页

作者： Sina Vatandoust Timothy J Price Christos S Karapetis Department of Medical Oncology Flinders Medical Centre flinders centre for innovation in cancer Flinders University Department of Medical Oncology The Queen Elizabeth Hospital The University of Adelaide

Colorectal cancer(CRC) is a common malignancy worldwide. In CRC patients, metastases are the main cause of cancer-related mortality. In a group of metastatic CRC patients, the metastases are limited to a single site(solitary organ); the liver and lungs are the most commonly involved sites. When metastatic disease is limited to the liver and/or lungs, the resectability of the metastatic lesions will dictate the management approach and the outcome. Less commonly, the site of solitary organ CRC metastasis is the peritoneum. In these patients, cytoreduction followed by hyperthermic intraperitoneal chemotherapy may improve the outcome. Rarely, CRC involves other organs, such as the brain, bone, adrenals and spleen, as the only site of metastatic disease. There are limited data to guide clinical practice in these cases. Here, we have reviewed the disease characteristics, management approaches and prognosis based on the metastatic disease site in patients with CRC with metastases to a single organ.

关键词： Colorectal cancer Metastasis Prognosis Disease man

Prognostic model of survival outcomes in non-small cell lung cancer patients initiated on afatinib: pooled analysis of clinical trial data

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cancer Biology & Medicine 2019年第2期16卷 341-349页

作者： Ashley M. Hopkins Adel Shahnam Sasha Zhang Chris S. Karapetis Andrew Rowland Michael J. Sorich flinders centre for innovation in cancer Department of Clinical Pharmacology College of Medicine and Public Health Flinders University Adelaide 5042 Australia The Canberra Hospital Garran 2605 Australia

Objective: Several predictors of survival have been identified in EGFR-positive non-small cell lung cancer(NSCLC) patients treated with first generation EGFR inhibitors. Prognostic models of survival outcomes with afatinib have not been ***: A prognostic tool for overall survival(OS)/progression free survival(PFS) based on pre-treatment clinicopathological factors was developed for EGFR-positive advanced NSCLC patients treated with first-line afatinib using penalised regression of individual-participant data from LUX-Lung 3 and 6(n = 468). Favourable, intermediate and poor risk groups were identified and externally validated using LUX-Lung 1(n = 390) and LUX-Lung 2(n = 129) trials that initiated afatinib following previous chemotherapy or EGFR inhibitor ***: Discriminative performance was good in the development and validation cohorts. For patients treated with first-line afatinib, the median OS for the favourable, intermediate and poor risk groups were > 47.7, 29.3 and 16.4 months, respectively, and the median PFS were 17.3, 13.2 and 8.3 months, respectively. The improvement in median OS with afatinib use compared to chemotherapy was > 12.4 months for the favourable risk group, whereas no OS benefit was apparent for the poor risk group. The improvement in median PFS with afatinib use compared to chemotherapy was 10.2 months for the favourable risk group and 3.2 months for the poor risk ***: A prognostic tool was developed and validated to identify favourable, intermediate and poor risk groups for OS/PFS in EGFR-positive advanced NSCLC patients treated with afatinib. The prognostic groups can inform the likely absolute OS/PFS benefit expected from afatinib compared to chemotherapy in first-line treatment.

关键词： Afatinib non-small cell lung cancer prognostic model

Multiplexed imaging detection of live cell intracellular changes in early apoptosis with aggregation-induced emission fluorogens

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Science China Chemistry 2018年第8期61卷 892-897页

作者： Yabin Zhou Haixiang Liu Na Zhao Zhiming Wang Michael Z.Michael Ni Xie Ben Zhong Tang Youhong Tang Faculty of Biological Engineering Sichuan University of Science and Engineering Department of Chemistry the Hong Kong University of Science and Technology centre for Nano Scale Science and Technology College of Science and Engineering Flinders University Department of Gastroenterology and Hepatology Flinders Centre for Innovation in Cancer Flinders University AIEgen Biotech Co. Limited

Apoptosis is an important process for maintaining tissue homeostasis and eliminating abnormal cells in multicellular *** in apoptosis often leads to severe diseases such as cancers. Better understanding of its mechanisms and processes is therefore important. Accompanying molecular biology events of apoptosis is a series of cellular morphology changes: nucleus condensation, cell shrinkage and rounding, cell surface blebbing, dynamic blebbing, apoptotic membrane protrusions and nucleus fragmentations and finally, the formation and release of apoptotic bodies. It is difficult to detect cellular changes in the early phase of apoptosis due to the subtle changes at this phase. In the current study, we induced apoptosis in He La cells with H2 O2 and used nuclear dye Hoechst 33258, mitochondria, lysosome and cytoplasmic protein specific aggregation-induced emission fluorogens(AIEgens), TPE-Ph-In, 2 M-DABS and BSPOTPE to successfully perform live cell multiplexed imaging to investigate early apoptosis cellular events. We showed the gradual dissipation of mitochondria membrane potential until it is nondetectable by TPE-Ph-In. Increased mitophagy detected by TPE-Ph-In and 2 M-DABS, condensed nucleus detected by Hoechst33258, increased permeability and/or reduced integrity of nuclear membrane, and increased intracellular vesicles detected by2 M-DABS are some of the early events of apoptosis.

关键词： apoptosis multiplexed imaging He La aggregation-induced emission fluorogens(AIEgens)

Taxonomic and metabolic shifts in the Coorong bacterial metagenome driven by salinity and external inputs

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Journal of Oceanology and Limnology 2018年第6期36卷 2033-2049页

作者： Kelly NEWTON Thomas C.JEFFRIES Renee J.SMITH Justin R.SEYMOUR Laurent SEURONT James G.MITCHELL School of Biological Sciences Flinders University School of Science and Health Western Sydney University flinders centre for innovation in cancer Flinders University Climate Change Cluster University of Technology Sydney centre National de la Recherche Scientifi que Laboratoire d'Océanologie et de Géosciences

The Coorong estuary lies at the terminus of Australia's largest river system, the Murray-Darling; both are strongly influenced by human activities; including farming and extensive flow modification. Metagenomic approaches were used to determine the planktonic bacterial community composition and potential metabolic function at two extremes in the Coorong, the river mouth which exhibits marine-like salinity, and the hypersaline upper-reaches of the estuary. Significant shifts in taxa and metabolic function were seen between the two sites. The river mouth exhibited an increase in abundance of R hodobacteriaceae and Alteromonadaceae; families readily able to adapt to change in nutrient conditions; and the potentially pathogenic families B rucellaceae, Enterobacteriaceae and Vibrionaceae. Metabolisms over-represented include motility and chemotaxis, RNA metabolism and membrane transport, all of which are involved in actively searching for and obtaining nutrients. Also over-represented were metabolisms involved in population succession and stress response. An over-representation of taxa and metabolisms indicative of environmental change is reflective of anthropogenically af fected riverine input. In the hypersaline upper reaches of the estuary, the halophilic family Ectothiorhodospiraceae was over-represented, as were the families Flavobacteriaceae, Cytophagaceae and Nocardioidaceae, members of which are able to survive over a wide salinity range. Metabolisms over-represented here were reflective of increased bacterial growth, characteristic of hypersaline environments, and included DNA metabolism, nucleotide and nucleoside synthesis and cell cycle. Coorong metagenomes clustered taxonomically and metabolically with other planktonic metagenomes, but remained an outlier of this group with only 71% and 84% similarity, respectively. This indicates that the Coorong exhibits a unique planktonic bacterial community that is influenced by riverine input at the river mouth and sali

关键词： hypersaline estuary bacteria taxonomy metabolic potential

Global transplantation:Lessons from organ transplantation organizations worldwide

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World Journal of Transplantation 2025年第1期15卷 44-56页

作者： Solonas Symeou Eleni Avramidou Vassilios Papalois Georgios Tsoulfas Medical School University of IoanninaIoannina 45110Greece Department of Transplantation Surgery Center for Research and Innovation in Solid Organ TransplantationSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece Imperial College Renal and Transplant centre Imperial College Healthcare NHS TrustHammersmith HospitalLondon W120HSUnited Kingdom Department of Surgery and cancer Imperial College LondonLondon SW72AZUnited Kingdom

Although national transplant organizations share common visions and goals,the creation of a unified global organization remains *** in ethnicity,culture,religion,and education shape local practices and infrastructure,making the establishment of a single global entity *** with these social disparities aside,logistical factors such as time and distance between organ procurement and transplantation sites pose significant *** technological advancements have extended organ preservation times,they have yet to support the demands of transcontinental transplantations *** review presents a comparative analysis of the structures,operational frameworks,policies,and legislation governing various transplant organizations around the *** differences pertain to the administration of these organizations,trends in organ donation,and organ allocation policies,which reflect the financial,cultural,and religious diversity across different *** a global transplant organization may be out of reach,agreeing on best practices for the benefit of patients is essential.

关键词： Organ transplantation National transplant organizations Organ donation Global transplantation Transplant systems

Increasing Employees’ Fruit Consumption through Access and Peer Support at Work

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Food and Nutrition Sciences 2013年第10期4卷 88-95页

作者： Amanda D. Hutchinson Georgina Howlett Carlene Wilson flinders centre for innovation in cancer Flinders University Adelaide Australia cancer Council South Australia Adelaide Aus- tralia School of Psychology Flinders University Adelaide Australia.

Objective: To assess the effect of providing free fruit and peer support in the workplace, on employees’ consumption of fruits and high fat snacks at work and home. Methods: Three worksites, including 75 employees, were randomly assigned to a free fruit condition (Group A), a free fruit and peer education and modelling condition (Group B), and a control group (Group C). Groups A and B had free fruit delivered to their workplace each morning for four weeks. Consumption of fruit and high fat snacks was measured pre- and post-intervention, and after a two week maintenance period. Results: Despite a small sample, the intervention increased employees’ fruit intake at work, decreased high fat snacks and was more successful in those who were not currently meeting the recommendations of two pieces of fruit per day. Peer support led to increased fruit consumption at work and sustained decreases in unhealthy snacks post-intervention. Conclusions: The provision of fruit in the workplace with peer support is a simple and effective method for improving fruit consumption at work in the short-term, particularly in those not meeting current recommendations. In addition, those participating in the intervention reduced their consumption of high fat snacks. Further research is necessary to determine whether a longer larger scale intervention can sustain dietary changes and thereby reduce risk for chronic disease in the Australian population.

关键词： Workplace Peer Education Health Promotion Fruit

Speckle-type POZ protein mutations interrupt tumor suppressor function of speckle-type POZ protein in prostate cancer by affecting androgen receptor degradation

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Asian Journal of Andrology 2014年第5期16卷 659-660页

作者： John Lai cancer Program Institute of Health and Biomedical Innovation Queensland University of Technology Brisbane Queensland Australia Australian Prostate cancer Research centre-Queensland Translational Research Institute Queensland University of Technology Brisbane Queensland Australia

Large scale exome sequencing studies have ＇revealed regions of the genome, which contribute to the castrate resistant prostate cancer （CRPC） phenotype.1-3 Such studies have identified mutations in genes, which may have diagnostic/prognostic potential, or which may be targeted therapeutically. Two of these genes include the androgen receptor （AR） and speckle-type POZ protein （SPOP） genes. However, the findings from these exome sequencing studies can only be translated therapeutically once the functional consequences of these mutations have been determined. Here, we highlight the recent study by An et al.4 which investigated the functional effects of mutations in the SPOP gene that were identified in the aforementioned exome sequencing studies, particnlarly in the context of SPOP-mediated degradation of the AR.

关键词： Speckle-type POZ protein

Estrogen,male dominance and esophageal adenocarcinoma:Is there a link?

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World Journal of Gastroenterology 2012年第5期18卷 393-400页

作者： Huiqi Yang Olga A Sukocheva Damian J Hussey David I Watson Huiqi Yang Olga A Sukocheva Damian Hussey DavidI Watson Department of Surgery Flinders Medical CentreFlinders University Bedford Park South Australia 5042 Australia flinders centre for cancer Prevention and Control FlindersMedical Centre Bedford Park South Australia 5042

Esophageal adenocarcinoma is a cancer with poor prognosis, and its incidence has risen sharply over recent decades. Obesity is a major risk factor for developing this cancer and there is a clear male gender bias in the incidence that cannot be fully explained by known risk factors. It is possible that a difference in the expression of estrogen, or its signaling axes, may contribute to this gender bias. We undertook a com- prehensive literature search and analyzed the available data regarding estrogen and estrogen receptor expres- sion, and the possible sex-specific links with esopha- geal adenocarcinoma development. Potentially relevant associations between visceral vs subcutaneous fat deposition and estrogen expression, and the effect of crosstalk between estrogen and leptin signaling were identified. We also found limited studies suggesting a role for estrogen receptor 13 expression in esophageal adenocarcinoma development. The current literature supports speculation on an etiological role for estrogen in the male gender bias in esophageal adenocarcino- ma, but further studies are required.

关键词： Estrogen Estrogen receptors Male domi-nance Esophageal adenocarcinoma

MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines

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World Journal of Gastroenterology 2014年第40期20卷 14904-14912页

作者： Richard Hummel Corina Sie David I Watson Tingting Wang Alfiya Ansar Michael Z Michael Mark Van der Hoek Joerg Haier Damian J Hussey Department of Surgery Flinders University Bedford Park South Australia 5042 Australia Department of General and Visceral Surgery University of Muenster 48149 Muenster Germany Department of Gastroenterology and Hepatology Flinders University 5042 Bedford Park South Australia Australia Adelaide Microarray centre SA Pathology 5000 Adelaide South Australia Australia Comprehensive cancer centre University of Muenster 48149 Muenster Germany

AIM: To investigate expression of microRNA (miRNA) and potential targets in chemotherapy resistant esophageal cancer cell lines.

关键词： Esophageal cancer MicroRNA Chemotherapy Resistance Target