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Design and redesign journey of a drug for transthyretin amyloidosis

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Neural Regeneration Research 2025年第4期20卷 1096-1097页

作者： Francisca Pinheiro Salvador Ventura Institut de Biotecnologia i Biomedicina Departament de Bioquímica i Biologia MolecularUniversitat Autònoma de BarcelonaBellaterraSpain

The misfolding and subsequent aggregation of proteins into amyloid fibrils underlie the onset of a variety of human disorders collectively known as ***(TTR)is one of the>30 amyloidogenic proteins identified to date and is associated with a group of highly debilitating and life-threatening disorders called TTR amyloidosis(ATTR).ATTR comprises senile systemic amyloidosis,which is linked to wild-type(WT)TTR aggregation,and hereditary ATTR,a dominantly inherited disorder caused by the deposition of one of over 130 TTR genetic *** systemic amyloidosis is a prevalent age-related amyloidosis,affecting up to 25%of the population over 80 years of age,and is characterized by the build-up of TTR fibrils in the *** hereditary ATTR,the clinical presentation is highly heterogeneous,primarily affecting the peripheral nervous system(familial amyloid polyneuropathy-FAP)or the heart(familial amyloid cardiomyopathy).In rare cases,aggregation develops in the central nervous system,giving rise to a phenotype known as familial leptomeningeal amyloidosis(Carroll et al.,2022).

关键词： amyloid aggregation senile

Structure, Electronic Properties and Chemical Bonding in Bis(1H-imidazolium-κN^3)silver(Ⅰ) Nitrate from Periodic DFT Computations

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Chinese Journal of Structural Chemistry 2013年第8期32卷 1143-1152页

作者： Arvids Stashansa Soraya Jácome Grupo de fisicoquímica de Materiales Universidad Técnica Particular de Loja Escuela de Ingeniería Química Universidad Técnica Particular de Loja

Using the first-principles density functional theory calculations within the genera- lized gradient approximation we study the bis（1H-imidazolium-kN3）silver（I） nitrate molecular crystal. A number of different exchange-correlation functionals are considered for a possible treatment of the system. Perdew-Burke-Emzerhof （PBE） GGA exchange-correlation ftmctionals are found to be adequate for our system. The obtained results show that it is possible to reproduce very well the geometry of at least some molecular crystals if computational parameters are chosen adequately. In addition to the reproducing crystal structure of the bis（1H-imidazolium-kN3）silver（I） nitrate in close agreement with the available experimental data, the present work reports analysis on the chemical bonding in the material and gives total and partial density of states of this system.

关键词： crystal structure electronic properties chemicalbonding density functional theory

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria S.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdiSNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression

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World Journal of Gastroenterology 2017年第29期23卷 5266-5281页

作者： maría l bacigalupo pablo carabias maría f troncoso Facultad de Farmacia y Bioquímica Instituto de Química y Fisicoquímica Biológicas (IQUIFIB) Consejo Nacional de lnvestigaciones Científicas y Técnicas Universidad de Buenos Aires

Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial for treatment. Galectin-1(Gal-1) belongs to a family of glycan-binding proteins, or lectins, with the ability to cross-link specific glycoconjugates. A variety of biological activities have been attributed to Gal-1 at different steps of tumor progression. Herein, we summarize the current literature regarding the roles of Gal-1 in gastrointestinal malignancies. Accumulating evidence shows that Gal-1 is drastically up-regulated in human gastric cancer, hepatocellular carcinoma, colorectal cancer and pancreatic ductal adenocarcinoma tissues, both in tumor epithelial and tumor-associated stromal cells. Moreover, Gal-1 makes a crucial contribution to the pathogenesis of gastrointestinal malignancies, favoring tumor development, aggressiveness, metastasis, immunosuppression and angiogenesis. We also highlight that alterations in Gal-1-specific glycoepitopes may be relevant for gastrointestinal cancer progression. Despite the findings obtained so far, further functional studies are still required. Elucidating the precise molecular mechanisms modulated by Gal-1 underlying gastrointestinal tumor progression, might lead to the development of novel Gal-1-based diagnostic methods and/or therapies.

关键词： Galectin-1 Gastric cancer Hepatocellular carcinoma Colorectal carcinoma Pancreatic cancer β1 6-N-acetylglucosaminyltransferase V

Busting the myth: more good than harm in transgenic cells

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Neural Regeneration Research 2019年第6期14卷 967-968页

作者： Gonzalo Pi?ero Patricia Setton-Avruj Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicasy TécnicasInstituto de Químicay Fisicoquímica Biológicas (IQUIFIB)Facultad de Farmaciay Bioquímica

Peripheral neuropathy constitutes a highly incidental condition and a major public health concern worldwide(Hanewinckel et al.,2016).This pathology is triggered by peripheral nervous system damage as a consequence of systemic disease or ischemic-traumatic *** the latter case,nerve crush,partial or total transection and stretch injury interrupt nerve conduction and impair sensitivity and motility of the innervated area,which brings about partial or total functional loss in the affected limb and disabling neuropathic *** these reasons,digging into the molecular mechanisms underlying peripheral neuropathy becomes essential for the development of successful therapeutic strategies.

关键词： Busting the myth transgenic cells highly incidental

One step synthesis of high efficiency nickel/mesoporous TiO_2 hybrid catalyst for hydrogen evolution reaction

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Journal of Energy Chemistry 2019年第2期28卷 79-87页

作者： Esteban A.Franceschini Melisa J.Gomez Gabriela I.Lacconi INFIQC-CONICET Dto.de Fisicoquímica – Facultad de Ciencias QuímicasUniversidad Nacional de CórdobaCiudad Universitaria Departamento de Física de la Materia Condensada Centro Atómico ConstituyentesComisión Nacional de Energía Atómica

Nickel-Ti O_2 hybrid catalysts are synthesized by electrodeposition and their catalytic activity with respect to the hydrogen evolution reaction is *** types of titanium oxide particles,which are commercial particles of dense Ti O_2 and mesoporous TiO_2 particles synthesized by an aerosol method,are incorporated into the matrix of the nickel *** nickel catalysts containing Ti O_2 particles presented higher catalytic activity than the conventional nickel Watts *** TiO_2-modified nickel catalyst showed the highest catalytic activity towards HER in alkaline *** addition,this type of nickel catalyst increases its catalytic activity after ageing treatment,which is an indication of an increase in the electro-active area of the electrode.

关键词： Co-deposition Impedance spectroscopy Titanium oxide Ageing process Raman spectroscopy

Oxidative effects of glyphosate on the lipophobic intracellular environment in the microalgae Chlorella vulgaris

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BIOCELL 2022年第3期46卷 795-802页

作者： JUAN MANUEL OSTERA SUSANA PUNTARULO GABRIELA MALANGA fisicoquímica Facultad de Farmacia y BioquímicaUniversidad de Buenos AiresBuenos AiresCP 1113Argentina Instituto de Bioquímica y Medicina Molecular(IBIMOL) CONICET-Universidad de Buenos AiresBuenos AiresCP 1113Argentina

The studied hypothesis is that the herbicide glyphosate(GLY)can affect the oxidative balance in the hydrophobic intracellular medium in non-target Chlorella vulgaris *** GLY and RoundUp(RUP)supplementation,affected the growth profile.A significant 42%decrease in the cellular biomass in stationary(St)phase was observed in cultures supplemented with either 5μM of GLY or RUP,as compared to control *** treatment with 0.3μM of GLY generated non-significant effects on the oxidation rate of 2’,7’dichlorofluorescein diacetate(DCFH-DA),neither in exponential(Exp)nor in St phase of development,as compared to control ***,the treatment with either 5μM GLY or 0.3 and 5μM RUP lead to a significant decrease in the DCFH-DA oxidation rate,as compared to control *** lipid radical(LR●)generation rate,detected by Paramagnetic Resonance Spectroscopy(EPR),was significantly increased in the presence of RUP,in Lag and Exp phase of *** non-enzymatic antioxidants,α-Tocopherol(α-T)andβ-Carotene(β-C),are aimed to protect membranes against the damage produced by the radical *** content ofβ-C was not significantly affected,as compared to control cultures,by any of the treatments,in both growth phases of cellular *** content ofα-T was significantly decreased by the supplementation with either 0.3 or 5μM of RUP or 5μM *** LR●/α-T ratio,used as indicator of the oxidative balance in the hydrophobic cellular media,was significantly different between samples obtained from control and RUP-exposed microalgae in both,Exp and St phase of development,with either 0.3 or 5μM *** data presented here showed evidence that suggested that oxidative balance in the hydrophobic environment was affected by either GLY or RUP.

关键词： 2’,7’dichlorofluorescein diacetate oxidation rate Lipid soluble antioxidants Round up Redox balance

Oxidative stress in the hydrophilic medium of algae and invertebrates

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BIOCELL 2016年第1期40卷 35-38页

作者： GABRIELA MALANGA PAULA MARIELA GONZALEZ JUAN MANUEL OSTERA SUSANA PUNTARULO Instituto de Bioquímica y Medicina Molecular(IBIMOL)-Universidad de Buenos Aires(UBA) CONICETFisicoquímicaFacultad de Farmacia y BioquímicaJunín 956(C1113AAD)Buenos Aires.Argentina.

The harmful effects of the reactive species may be due to the increase in their steady state concentration either by the enhancement of their production rates and/or the decrease of their consumption rate by antioxidant *** ascorbyl radical(A^(·))can be considered as a final product of radical oxidative transformations of ascorbate(AH^(-)).The ratio A^(·)content/AH^(-)content(A^(·)/AH^(-))has been widely used as an interesting tool to estimate mild to moderate oxidative transformations,providing a quick and simple method of diagnosis of stress in the hydrophilic cellular *** aim of this work was to summarize studies on the cellular oxidative condition in algae and invertebrates by assessing the A^(·)/AH^(-)ratio under environmentally changing *** use of indices of oxidative stress increasingly sensitive and,somewhat more specific,can bring a new light to the still unknown world of oxidative responses in marine organisms.

关键词： algae ascorbyl/ascorbate ratio invertebrates oxidative stress

Dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo Aguilar-Hernández Fernado García-Dolores Humberto Nicolini Andrea Judith Vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress