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Cognitive impairment associated with individual and joint exposure to PM2.5 constituents in a Chinese national cohort

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FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING 2024年第9期18卷 109-0页

作者： Deng, Boning Li, Yachen Zhu, Lifeng Zhou, Yuwei Sun, Aonan Zhang, Jingjing Wang, Yixiang Tan, Yuxi Shen, Jiajun Zhang, Yalin Ding, Zan Zhang, Yunquan Wuhan Univ Sci & Technol Inst Social Dev & Hlth Management Sch Publ Hlth Hubei Prov Key Lab Occupat Hazard Identificat & Co Wuhan 430065 Peoples R China Baoan Cent hosp Shenzhen Shenzhen 518102 Peoples R China

Nationwide longitudinal evidence linking cognitive decline with exposure to fine particulate matter (PM2.5) constituents remains scarce in China. By constructing a dynamic cohort based on the China Health and Retirement Longitudinal Study, we aimed to assess individual and joint associations of PM2.5 constituents with cognitive function among middle-aged and older adults in China. Linear mixed-effects models incorporated with quantile-based g-computation were applied to investigate individual and joint associations of long-term exposures to PM2.5 constituents with cognitive function. Among 13,507 respondents, we evaluated 38,950 follow-up records of cognitive function tests. Declines in global cognitive score associated with an interquartile range (IQR) increase in exposure were -1.477 (95% CI: -1.722, -1.232) for nitrate, followed by -1.331 (-1.529, -1.133) for ammonium, -1.033 (-1.184, -0.883) for sulfate, -0.988 (-1.144, -0.832) for organic matter and -0.822 (-0.946, -0.699) for black carbon. An IQR-equivalent increase in joint exposure to these PM2.5 constituents was associated with a decline of -1.353 (-1.659, -1.048) in global cognitive score. Female, younger, and well-educated individuals were at greater vulnerability to cognitive impairment related to individual and joint exposure to PM2.5 constituents. This study suggested that later-life exposures to PM2.5 constituents were associated with cognitive decline in middle-aged and older adults in China.

关键词： Air pollution PM2.5 constituents Cognitive function Joint exposure Middle-aged and older adults AIR-POLLUTION HEALTH CARE POPULATION DEPRESSION PREVALENCE DEMENTIA DISEASE TERM

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Enhanced wear resistance, antibacterial performance, and biocompatibility using nanotubes containing nano-Ag and bioceramics in vitro

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BIO-DESIGN AND MANUFACTURING 2024年第5期7卷 670-686页

作者： Wang, Qingge Liu, Jia Wu, Hong Liu, Jingbo Ren, Yaojia Liang, Luxin Yan, Xinxin Baker, Ian Liu, Shifeng Uglov, V. V. Yang, Chengliang Wang, Liqiang Cent South Univ State Key Lab Powder Met Changsha 410083 Peoples R China Youjiang Med Univ Nationalities Guangxi Zhuang Autonomous Reg Engn Res Ctr Biomat Guangxi Key Lab Preclin & Translat Res Bone & Join Guangxi Key Lab Biomed Mat ResAffiliated Hosp Baise 533000 Peoples R China Cent South Univ Xiangya Hosp 2 Dept Orthoped Changsha 410011 Peoples R China Wuhan Univ Renmin Hosp Dept Orthoped Wuhan 430060 Peoples R China Dartmouth Coll Thayer Sch Engn Hanover NH 03755 USA Xian Univ Architecture & Technol Sch Met Engn Xian 710055 Peoples R China Belarusian State Univ Minsk 220030 BELARUS Shanghai Jiao Tong Univ Sch Mat Sci & Engn State Key Lab Met Matrix Composites Shanghai 200240 Peoples R China

A good Ti-based joint implant should prevent stress shielding and achieve good bioactivity and anti-infection performance. To meet these requirements, the low-elastic-modulus alloy-Ti-35Nb-2Ta-3Zr-was used as the substrate, and functional coatings that contained bioceramics and Ag ions were prepared for coating on TiO2 nanotubes (diameter: (80 +/- 20) nm and (150 +/- 40) nm) using anodization, deposition, and spin-coating methods. The effects of the bioceramics (nano-beta-tricalcium phosphate, microhydroxyapatite (micro-HA), and meso-CaSiO3) and Ag nanoparticles (size: (50 +/- 20) nm) on the antibacterial activity and the tribocorrosion, corrosion, and early in vitro osteogenic behaviors of the nanotubes were investigated. The tribocorrosion and corrosion results showed that the wear rate and corrosive rate were highly dependent on the features of the nanotube surface. Micro-HA showed great wear resistance with a wear rate of (1.26 +/- 0.06)x10-3 mm3/(N center dot m) due to adhesive and abrasive wear. Meso-CaSiO3 showed enhanced cell adhesion, proliferation, and alkaline phosphatase activity. The coatings that contained nano-Ag exhibited good antibacterial activity with an antibacterial rate of >= 89.5% against Escherichia coli. These findings indicate that hybrid coatings may have the potential to accelerate osteogenesis. [GRAPHICS] .

关键词： beta Ti alloy Surface modification Wear resistance Corrosion resistance Osteogenic behavior Antibacterial activity TITANIUM SURFACES DOPED HYDROXYAPATITE SILVER NANOPARTICLES TIO2 NANOTUBES BEHAVIOR ALLOY DIFFERENTIATION MICROSTRUCTURES POLARIZATION COATINGS

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Macrophage polarization disorder in the endometrial immune microenvironment may contribute to recurrent implantation failure

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REPRODUCTIVE AND DEVELOPMENTAL MEDICINE 2024年第3期8卷 162-168页

作者： Liu, Yun Tan, Xian-Ming He, Tian-Tian Sun Yat sen Univ Affiliated Hosp 7 Dept Obstet & Gynecol Shenzhen 518000 Peoples R China Sun Yat sen Univ Sch Med Shenzhen Campus Shenzhen 518000 Peoples R China Sun Yat sen Univ Affiliated Hosp 3 Dept Obstet Guangzhou 510000 Peoples R China

Objective:To investigate the role and mechanisms by which macrophages (M Phi) contribute to the immune environment of the endometrium in cases of recurrent implantation failure (RIF).Methods:Endometrial transcriptome data from women with and without RIF (control group) were collected. The CIBERSORT software was used to determine the abundance of immune cells within the endometrial tissue based on expression profiles. Weighted gene co-expression network analysis was used to identify crucial regulatory genes and ***:Application of CIBERSORT confirmed significant infiltration of macrophages in the RIF group. SOX6, TTC21A, KLHL31, NFIA, TNNT1, TPM1, CPVL, FUS, PEX5, and SLC43A3 were all closely correlated with M2 and M0 macrophages. Metascape and DisNor analyses revealed that these genes contribute to the regulation of macrophage polarization via the Wnt signaling ***:This study identified dysregulation of macrophage polarization within the immune microenvironment of the endometrium in patients with RIF. A comprehensive analysis was conducted to investigate the potential mechanisms underlying this disorder. Dysregulation of macrophage polarization in the endometrium of patients with RIF is strongly associated with the Wnt signaling pathway.

关键词： Macrophage Polarization disorder Immune microenvironment Recurrent implantation failure Assisted reproductive technology EXPRESSION ACTIVATION

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Single-cell transcriptomics reveals T-cell heterogeneity and immunomodulatory role of CD4+T native cells in Candida albicans infection

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BIOCELL 2024年第9期48卷 1355-1368页

作者： Jia, Keran Zhang, Yanhao Jiang, Mengyu Cui, Mengge Wang, Jia Zhang, Jiajia Zhao, Huihai Li, Mengyan Wang, Hua Zou, Quanming Zeng, Hao Army Med Univ Coll Pharm Natl Engn Res Ctr Immunol Prod Dept Microbiol & Biochem Pharm Chongqing 400038 Peoples R China Bethune Int Peace hosp 980th Hosp PLA Joint Logist Support Force Dept Clin Lab Shijiazhuang 050082 Peoples R China

Objective: Candida albicans is a common fungal pathogen that triggers complex host defense mechanisms, including coordinated innate and adaptive immune responses, to neutralize invading fungi effectively. Exploring the immune microenvironment has the potential to inform the development of therapeutic strategies for fungal infections. Methods: The study analyzed individual immune cell pro f iles in peripheral blood mononuclear cells from Candida albicans-infected mice and healthy control mice using single-cell transcriptomics, fl uorescence quantitative PCR, and Western blotting. We investigated intergroup differences in the dynamics of immune cell subpopulation in fi ltration, pathway enrichment, and differentiation during Candida albicans infection. Results: Our fi ndings indicate that in f iltration of CD4 + naive cells, regulatory T (Treg) cells, and Microtubules-associated (MT)-associated cells increased after infection, along with impaired T cell activity. Notably, CD4 ' T cells and plasma cells were enhanced after infection, suggesting that antibody production is dependent on T cells. In addition, we screened 6 hub genes, transcription factor forkhead box protein 3(Foxp3), cytotoxic T-lymphocyte associated protein 4 (CTLA4), Interleukin 2 Receptor Subunit Beta (Il2rb), Cd28, C-C Motif Chemokine Ligand 5 (Ccl5), and Cd27 for alterations associated with CD4 ' T cell differentiation. Conclusions: These results provide a comprehensive immunological landscape of the mechanisms of Candida albicans infection and greatly advance our understanding of adaptive immunity in fungal infections.

关键词： Candida albicans Single-cell transcriptomics Immune microenvironment Fungal infections Hub gene NEUTROPHILS IMMUNITY

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Clinical Practice Guideline on Acupuncture and Moxibustion: Adult Major Depressive Disorder (Mild-Moderate Degree) : Determination of clinical questions

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WORLD JOURNAL OF ACUPUNCTURE-MOXIBUSTION 2024年第3期34卷 246-251页

作者： Tang, Han Fan, Qi Guo, Li-hua Zhang, Yu-qing Feng, Yi-xuan Xu, Yu-qing Kuang, Hong-jun Yang, Yun-hong Gou, Yi Zhao, Hong Shanghai Univ Tradit Chinese Med Shenzhen Hosp Shenzhen 518004 Peoples R China Shanghai Univ Tradit Chinese Med Shanghai 201203 Peoples R China Qingdao Univ Taian City Cent Hosp Tai An 271000 Peoples R China McMaster Univ Hamilton ON L8S 4L8 Canada Beijing Coll Social Adm Beijing 102600 Peoples R China Guangzhou Univ Chinese Med Guangzhou 510006 Peoples R China

Determining clinical questions is fundamental to the development of clinical practice guidelines (CPGs), which bridges the initial phases and the final recommendations. It is essential for evidence retrieval and the formulation of recommendations. The scientific rigor and precision in determination of clinical questions directly influence the future implementation and applicability of guidelines. In 2020, the World Federation of Acupuncture-Moxibustion Societies initiated the project of clinical practice guideline on acupuncture and moxibustion for adult major depressive disorder (mild-moderate degree) to address clinical and medical decision-making issues in acupuncture treatment for adult mild to moderate major depressive disorder. This CPG provides systematic recommendations based on clinical evidence, patient values, and other factors, aiding decision-makers, clinicians, and patients in selecting appropriate interventions. This paper discusses and analyzes the determination process of clinical questions, and the related issues during the development of this guideline, aiming to provide a reference for determining clinical questions and developing CPGs in the field of acupuncture and exploring more scientific tools and methods for determining clinical questions in future CPGs. (c) 2024 World Journal of Acupuncture - Moxibustion House. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license ( http://***/licenses/by-nc-nd/4.0/ )

关键词： Major depressive disorder Acupuncture and moxibustion Guideline Clinical questions PICO COLLEGE MOOD

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Discovery and evaluation of a novel 18F-labeled vasopressin 1a receptor PET ligand with peripheral binding specificity

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ACTA PHARMACEUTICA SINICA B 2024年第9期14卷 4014-4027页

作者： Hu, Junqi Li, Yinlong Dong, Chenchen Wei, Huiyi Liao, Kai Wei, Junjie Zhao, Chunyu Chaudhary, Ahmad Chen, Jiahui Xu, Hao Zhong, Ke Liang, Steven H. Wang, Lu Ye, Weijian Jinan Univ Affiliated Hosp 1 Ctr Cyclotron & PET Radiopharmaceut Dept Nucl Med Guangzhou 510630 Peoples R China Jinan Univ Affiliated Hosp 1 Key Lab Basic & Translat Res Radiopharmaceut Guangzhou 510630 Peoples R China Emory Univ Dept Radiol & Imaging Sci Atlanta GA 30322 USA Sun Yat Sen Univ Sun Yat Sen Mem Hosp Dept Pharm Guangzhou 510120 Peoples R China

The arginine-vasopressin (AVP) hormone plays a pivotal role in regulating various physiological processes, such as hormone secretion, cardiovascular modulation, and social behavior. Recent studies have highlighted the V1a receptor as a promising therapeutic target. In-depth insights into V1a receptor-related pathologies, attained through in vivo imaging and quantification in both peripheral organs and the central nervous system (CNS), could significantly advance the development of effective V1a inhibitors. To address this need, we develop a novel V1a-targeted positron emission tomography (PET) ligand, [F-18]V1A-2303 ([F-18]8), which demonstrates favorable in vitro binding affinity and selectivity for the V1a receptor. Specific tracer binding in peripheral tissues was also confirmed through rigorous cell uptake studies, autoradiography, biodistribution assessments. Furthermore, [F-18]8 was employed in PET imaging and arterial blood sampling studies in healthy rhesus monkeys to assess its brain permeability and specificity, whole-body distribution, and kinetic properties. Our research indicated [F-18]8 as a valuable tool for noninvasively studying V1a receptors in peripheral organs, and as a foundational element for the development of next-generation, brain-penetrant ligands specifically designed for the CNS.

关键词： Vasopressin Autism V1a receptor Positron emission tomography PET imaging Radiolabeling Fluorine 18 Kinetic modeling ARGININE-VASOPRESSIN SOCIAL RECOGNITION SEX-DIFFERENCES AVPR1A GENE AUTISM V1A ASSOCIATION ANTAGONIST OXYTOCIN POTENT

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Current status and trends in small nucleic acid drug development: Leading the future

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ACTA PHARMACEUTICA SINICA B 2024年第9期14卷 3802-3817页

作者： Miao, Yuxi Fu, Chen Yu, Zhaojin Yu, Lifeng Tang, Yu Wei, Minjie China Med Univ Sch Pharm Dept Pharmacol Shenyang 110122 Peoples R China China Med Univ Liaoning Key Lab Mol Targeted Antitumor Drug Dev & Shenyang 110122 Peoples R China Liaoning Med Diag & Treatment Ctr Shenyang 110000 Peoples R China China Med Univ Liaoning Canc Hosp & Inst Dept Oncol Canc Hosp Shenyang 110042 Peoples R China

Small nucleic acid drugs, composed of nucleotides, represent a novel class of pharmaceuticals that differ significantly from conventional small molecule and antibody-based therapeutics. These agents function by selectively targeting specific genes or their corresponding messenger RNAs (mRNAs), further modulating gene expression and regulating translation-related processes. Prominent examples within this category include antisense oligonucleotides (ASO), small interfering RNAs (siRNAs), microRNAs (miRNAs), and aptamers. The emergence of small nucleic acid drugs as a focal point in contemporary biopharmaceutical research is attributed to their remarkable specificity, facile design, abbreviated development cycles, expansive target spectrum, and prolonged activity. Overcoming challenges such as poor stability, immunogenicity, and permeability issues have been addressed through the integration of chemical modifications and the development of drug delivery systems. This review provides an overview of the current status and prospective trends in small nucleic acid drug development. Commencing with a historical context, we introduce the primary classifications and mechanisms of small nucleic acid drugs. Subsequently, we delve into the advantages of the U.S. Food and Drug Administration (FDA) approved drugs and mainly discuss the challenges encountered during their development. Apart from researching chemical modification and delivery system that efficiently deliver and enrich small nucleic acid drugs to target tissues, promoting endosomal escape is a critical scientific question and important research direction in siRNA drug development. Future directions in this field will prioritize addressing these challenges to facilitate the clinical transformation of small nucleic acid drugs.

关键词： Small nucleic acid drugs Oligonucleotide drugs siRNA ASO miRNA Aptamer RNAi Drug development RNA-DERIVED FRAGMENTS ANTISENSE OLIGONUCLEOTIDES DELIVERY-SYSTEMS GENE-EXPRESSION C-ELEGANS THERAPEUTICS INTERFERENCE COMPLEX TARGETS COMPLEMENTARITY

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Beyond ribosomal function: RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing

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ACTA PHARMACEUTICA SINICA B 2024年第9期14卷 3931-3948页

作者： Fu, Wenkang Lin, Yanyan Bai, Mingzhen Yao, Jia Huang, Chongfei Gao, Long Mi, Ningning Ma, Haidong Tian, Liang Yue, Ping Zhang, Yong Zhang, Jinduo Ren, Yanxian Ding, Liyun Dai, Lunzhi Leung, Joseph W. Yuan, Jinqiu Zhang, Wenhua Meng, Wenbo Lanzhou Univ Sch Clin Med 1 Lanzhou 730030 Peoples R China Lanzhou Univ Hosp 1 Key Lab Biotherapy & Regenerat Med Gansu Prov Lanzhou 730000 Gansu Peoples R China Lanzhou Univ Hosp 1 Dept Gen Surg Lanzhou 730030 Peoples R China Lanzhou Univ Sch Phys Sci & Technol Lanzhou 730000 Peoples R China Sichuan Univ West China Hosp Natl Clin Res Ctr Geriatr Chengdu 610041 Peoples R China Sichuan Univ West China Hosp Dept Gen Practice State Key Lab Biotherapy Chengdu 610041 Peoples R China UC Davis Med Ctr Div Gastroenterol Sacramento CA 95817 USA Sacramento VA Med Ctr Sacramento CA 95817 USA Sun Yat Sen Univ Affiliated Hosp 7 Clin Res Ctr Big Data Ctr Shenzhen 518107 Guangdong Peoples R China Lanzhou Univ Sch Life Sci Lanzhou 730000 Peoples R China

Cholangiocarcinoma (CCA) is a bile duct malignancy with a dismal prognosis. This study systematically investigated the role of the ribosomal protein S6 ( RPS6 ) gene, which is dependent in CCA. We found that RPS6 upregulation in CCA tissues was correlated with a poor prognosis. Functional investigations have shown that alterations in RPS6 expression, both gain- and loss-of function could affect the proliferation of CCA cells. In xenograft tumor models, RPS6 overexpression enhances tumorigenicity, whereas RPS6 silencing reduces it. Integration analysis using RNA-seq and proteomics elucidated downstream signaling pathways of RPS6 depletion by affecting the cell cycle, especially DNA replication. Immunoprecipitation followed by mass spectrometry has identified numerous spliceosome complex proteins associated with RPS6. Transcriptomic profiling revealed that RPS6 affects numerous alternative splicing (AS) events, and combined with RNA immunoprecipitation sequencing, revealed that minichromosome maintenance complex component 7 ( MCM7 ) binds to RPS6, which regulates its AS and increases oncogenic activity in CCA. Targeting RPS6 with vivo phosphorodiamidate morpholino oligomer (V-PMO) significantly inhibited the growth of CCA cells, patient-derived organoids, and subcutaneous xenograft tumor. Taken together, the data demonstrate that RPS6 is an oncogenic regulator in CCA and that RPS6-V-PMO could be repositioned as a promising strategy for treating CCA.

关键词： Cholangiocarcinoma Ribosomal protein S6 Alternative splicing p53 Minichromosome maintenance complex component 7 Vivo morpholino Patient-derived organoids PROTEIN S6 PhospHORYLATION PRE-MESSENGER-RNA EXPRESSION CANCER BINDING BIOGENESIS ACTIVATION GENERATION IMPAIRMENT THERAPIES

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Transparency and reporting characteristics of randomized controlled trials with Chinese herbal medicine formulas interventions

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FRONTIERS OF MEDICINE 2024年第4期18卷 757-761页

作者： Wang, Juan Shi, Dongni Wang, Yaochen Zhang, Xuanqi Li, Han Wang, Xihong Luo, Shufeng Hu, Lihan Deng, Jiashuai Zhang, Lin Lau, Chung Tai Cheng, Chung Wah Han, Fei Li, Ji Wang, Ping Lyu, Aiping Bian, Zhaoxiang Zhang, Xuan Hong Kong Baptist Univ Inst Res & Continuing Educ Shenzhen 518057 Peoples R China Hong Kong Baptist Univ Chinese EQUATOR Ctr Hksar 999077 Peoples R China Hong Kong Baptist Univ Sch Chinese Med Hksar 999077 Peoples R China Hong Kong Baptist Univ Ctr Chinese Herbal Med Drug Dev Hksar 999077 Peoples R China Tianjin Univ Tradit Chinese Med Sch Tradit Chinese Med Tianjin 301617 Peoples R China Beijing Univ Chinese Med Sch Chinese Med Beijing 100105 Peoples R China China Acad Chinese Med Sci Guanganmen Hosp Dept Pediat Beijing 100053 Peoples R China China Acad Chinese Med Sci Xiyuan Hosp Beijing 100091 Peoples R China

Transparency and reporting characteristics of randomized controlled trials with Chinese herbal medicine formulas interventions

关键词： Transparency reporting characteristics trials herbal medicine

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World Federation of Acupuncture-Moxibustion Societies (WFAS) Technical Benchmark of Acupuncture and Moxibustion: Moxibustion

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WORLD JOURNAL OF ACUPUNCTURE-MOXIBUSTION 2024年第3期34卷 237-241页

作者： Chu, Hao-ran Liu, Wei-hong Yang, Jun Wu, Xiao-dong Wang, Xiao-ming Wang, Jing-ji Liu, Yun Hu, Jin Anhui Univ Chinese Med Affiliated Hosp 2 Hefei 230001 Peoples R China China Acad Chinese Med Sci Inst Acupuncture & Moxibust Beijing 100091 Peoples R China Anhui Univ Chinese Med Affiliated Hosp 1 Hefei 230601 Peoples R China Japan TCM&Mi Assoc Tokyo 1350061 Japan

Technical Benchmark of Acupuncture and Moxibustion: Moxibustion was organized by the World Federation of Acupuncture-Moxibustion Societies and the revision was led by Anhui University of Chinese Medicine. This document was first issued in 2013, known as Moxibustion Manipulation. The technical benchmark of moxibustion include scope, normative reference, terms and definitions, operation and requirement and safety. This article introduces the above contents, explains the difficulties in the revision and give the suggestions for the application and popularization of this standard. (c) 2024 World Journal of Acupuncture - Moxibustion House. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/)

关键词： Technical benchmark Moxibustion WFAS Standard Guideline

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