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Third-Trimester Spontaneous Uterine Rupture After Ultrasound-Guided High-Intensity Focused Ultrasound Therapy

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Maternal-Fetal medicine 2024年第1期6卷 57-59页

作者： Juanjuan Yang Jiayi Zhang Yun Shi Jie Shui Hongying Qian department of Obstetrics Suzhou Ninth People's HospitalSuzhou 215000China

To editor:Uterine rupture,despite its low incidence,is a severe obstetric complication that is associated with adverse maternal and neonatal *** uterine scarring is a known risk factor for uterine *** scars can form from hysterotomy after abdominal/hysteroscopic myomectomy,cesarean delivery,or hysteroscopic *** the past few decades,ultrasound-guided high-intensity focused ultrasound(USgHIFU)has emerged as a non-invasive therapeutic tool and has found wide application for the safe and effective management strategy of uterine fibroids and adenomyosis.

关键词： Uterine rupture Pregnancy Cesarean delivery Ultrasound-guided high-intensify focused ultrasound(USgHIFU)

Clinical practice guideline on liver transplantation for hepatocellular carcinoma in China(2021 edition)

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Chinese Medical Journal 2022年第24期135卷 2911-2913页

作者： Jun Chen Tian Shen Jianhui Li Sunbin Ling Zhe Yang Guoying Wang Liying Sun Zhaoxu Yang Li Zhuang Jie Gao Wenyuan Guo Jie Li Shengjun Xu Qiang Wei Shusen Zheng Xiao Xu department of Hepatobiliary and Pancreatic Surgery The Affiliated Hangzhou First HospitalZhejiang University School of MedicineKey Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang ProvinceHangzhouZhejiang 310006China department of Liver Transplantation The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalHangzhouZhejiang 310004China department of Hepatobiliary Surgery The First Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdong 510120China Liver Transplantation Center Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China department of Hepatobiliary Surgery Xijing HospitalAir Force Medical UniversityXi’anShaanxi 710032China department of Hepatobiliary Surgery People’s HospitalPeking UniversityBeijing 100044China department of Liver Surgery and Organ Transplantation Changzheng HospitalNaval Medical UniversityShanghai 200003China

Hepatocellular carcinoma(HCC)is the main cause of cancer-related deaths in adult men under the age of 60 years in China.^([1])Liver transplantation(LT)is generally recognized as one of the most effective therapeutic approaches for end-stage liver *** guidelines for HCC were firstly launched in 2014 and were updated in ***,further updates are required to adapt to the new situation of LT in China and to continue advancing the recommendations.(Full version in Supplementary file,http://***/CM9/B362).

关键词： liver Liver Clinical

Gene expression profiles of human bone marrow derived mesenchymal stem cells and tendon cells

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Chinese Medical Journal 2003年第8期116卷 1270-1272页

作者：胡庆柳朴英杰邹飞 department of Thermal Environmental medicine First Military Medical University department of Anatomy First Military Medical University

Objective To study the gene expression profiles of human bone marrow derived mesenchymal stem cells and tendon *** Total RNA extracted from human bone marrow derived mesenchymal stem cells and tendon cells underwent reverse transcription,and the products were labeled with α- 32 P dCTP. The cDNA probes of total RNA were hybridized to cDNA microarray with 1176 genes,and then the signals were analyzed by AtlasImage analysis software Version *** Fifteen genes associated with cell proliferation and signal transduction were up-regulated,and one gene that takes part in cell-to-cell adhesion was down-regulated in tendon *** The 15 up-regulated and one down-regulated genes may be beneficial to the orientational differentiation of mesenchymal stem cells into tendon cells.

关键词： cDNA microarray·gene expression stem cells·tendon cells

Integrative Proteomic Analysis of Multiple Posttranslational Modifications in Inflammatory Response

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Genomics, Proteomics & Bioinformatics 2022年第1期20卷 163-176页

作者： Feiyang Ji Menghao Zhou Huihui Zhu Zhengyi Jiang Qirui Li Xiaoxi Ouyang Yiming Lv Sainan Zhang Tian Wu Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003China The first Affiliated Hospital College of MedicineZhejiang UniversityHangzhou 310003China department of Colorectal Surgery Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhou 310003China Quzhou Second People’s Hospital Quzhou 324000China

Posttranslational modifications(PTMs)of proteins,particularly acetylation,phosphorylation,and ubiquitination,play critical roles in the host innate immune ***’dynamic changes and the crosstalk among them are *** build a comprehensive dynamic network of inflammation-related proteins,we integrated data from the whole-cell proteome(WCP),acetylome,phosphoproteome,and ubiquitinome of human and mouse *** datasets of acetylation,phosphorylation,and ubiquitination sites helped identify PTM crosstalk within and across proteins involved in the inflammatory *** of macrophages by lipopolysaccharide(LPS)resulted in both degradative and non-degradative ***,this study contributes to the interpretation of the roles of known inflammatory molecules and the discovery of novel inflammatory proteins.

关键词： Proteome Crosstalk Inflammation Lipopolysaccharide Macrophage

Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration

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Bioactive Materials 2023年第2期20卷 221-242页

作者： Zhicheng Cao Hongmei Wang Jialin Chen Yanan Zhang Qingyun Mo Po Zhang Mingyue Wang Haoyang Liu Xueyang Bao Yuzhi Sun Wei Zhang Qingqiang Yao department of Orthopaedic Surgery Institute of Digital MedicineNanjing First HospitalNanjing Medical University210006NanjingChina School of medicine Southeast University210009NanjingChina department of Pharmaceutical Sciences Binzhou Medical University264003YantaiShandongChina Jiangsu Key Laboratory for Biomaterials and Devices Southeast University210096NanjingChina China Orthopedic Regenerative medicine Group(CORMed) China

Osteochondral defects(OCD)cannot be efficiently repaired due to the unique physical architecture and the pathological microenvironment including enhanced oxidative stress and *** strategies,such as the control of implant microstructure or the introduction of growth factors,have limited functions failing to manage these complex *** we developed a multifunctional silk-based hydrogel incorporated with metal-organic framework nanozymes(CuTA@SF)to provide a suitable microenvironment for enhanced OCD *** incorporation of CuTA nanozymes endowed the SF hydrogel with a uniform microstructure and elevated *** vitro cultivation of mesenchymal stem cells(MSCs)and chondrocytes showed that CuTA@SF hydrogel accelerated cell proliferation and enhanced cell viability,as well as had antioxidant and antibacterial *** the inflammatory environment with the stimulation of IL-1β,CuTA@SF hydrogel still possessed the potential to promote MSC osteogenesis and deposition of cartilage-specific extracellular matrix(ECM).The proteomics analysis further confirmed that CuTA@SF hydrogel promoted cell proliferation and ECM *** the full-thickness OCD model of rabbit,CuTA@SF hydrogel displayed successfully in situ OCD regeneration,as evidenced by micro-CT,histology(HE,S/O,and toluidine blue staining)and immunohistochemistry(Col I and aggrecan immunostaining).Therefore,CuTA@SF hydrogel is a promising biomaterial targeted at the regeneration of OCD.

关键词： Osteochondral regeneration Metal-organic framework Nanozyme Inflammation ROS Silk

Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance

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Genes & Diseases 2024年第1期11卷 189-204页

作者： Ebrahim H.Maleki Ahmad Reza Bahrami Maryam M.Matin department of Biology Faculty of ScienceFerdowsi University of Mashhad*** MashhadIran Jagiellonian Centre for Experimental Therapeutics(JCET) Jagiellonian University31-007 KrakowPoland Doctoral School of Exact and Natural Sciences Jagiellonian University30-348 KrakowPoland Industrial Biotechnology Research Group Institute of BiotechnologyFerdowsi University of Mashhad*** MashhadIran Novel Diagnostics and Therapeutics Research Group Institute of BiotechnologyFerdowsi University of Mashhad***MashhadIran Stem Cell and Regenerative medicine Research Group Iranian Academic Center for EducationCulture and Research(ACECR)Khorasan Razavi Branch917751376 MashhadIran

Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology,as it represents a major obstacle to effective cancer *** tumor cells are highly diverse at genetic,epigenetic,and phenotypic levels,intra-tumor heterogeneity can be assumed as an important contributing factor to the nullification of chemotherapeutic effects,and recurrence of the *** on the role of heterogeneous subpopulations of cancer cells with varying cell-cycle dynamics and behavior during cancer progression and treatment;herein,we aim to establish a comprehensive definition for adaptation of neoplastic cells against *** discuss two parallel and yet distinct subpopulations of tumor cells that play pivotal roles in reducing the effects of chemotherapy:"resistant"and"tolerant"***,this review also highlights the impact of the quiescent phase of the cell cycle as a survival mechanism for cancer *** understanding the mechanisms under-lying the quiescence,it provides an insightful perspective on cancer stem cells(CsCs)and their dual and intertwined functions based on their cell cycle state in response to ***-over,CSCs,epithelial-mesenchymal transformed cells,circulating tumor cells(CTCs),and disseminated tumor cells(DTCs),which are mostly in a quiescent state of the cell cycle are proved to have multiple biological links and can be implicated in our viewpoint of cell cycle heterogeneity in ***,increasing our knowledge of cell cycle heterogeneity is a key to identifying new therapeutic solutions,and this emerging concept may provide us with new opportunities to prevent the dreadful cancer recurrence.

关键词： Cancer stem cells(CSCs) Carcinoma Cell cycle heterogeneity Quiescence Therapy resistance Therapy tolerance Tumor dormancy

Collision carcinoma of squamous cell carcinoma and small cell neuroendocrine carcinoma of the larynx: A case report and review of the literature

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World Journal of Clinical Cases 2019年第2期7卷 242-251页

作者： Qi Yu Ya-Lian Chen Shui-Hong Zhou Zhe Chen Yang-Yang Bao Han-Jin Yang Hong-Tian Yao Ling-Xiang Ruan department of Otolaryngology The First Affiliated Hospital College of Medicine Zhejiang University department of Pathology The First Affiliated Hospital College of Medicine Zhejiang University department of Radiology The First Affiliated Hospital College of MedicineZhejiang University

BACKGROUND Collision carcinoma is rare in clinical practice, especially in the head and neck region. In this paper, we report a case of squamous cell carcinoma(SCC) and neuroendocrine carcinoma(NEC) colliding in the larynx and review 12 cases of collision carcinoma in the head and neck to further understand collision carcinoma, including its definition, diagnosis, and *** SUMMARY A 61-year-old man presented with a 1-year history of hoarseness. Contrastenhanced magnetic resonance imaging of the larynx revealed that the right vocal cord had a nodule-like thickening with obvious enhancement. Laryngoscopy revealed a neoplasm on the right vocal cord, and a malignant tumor was initially considered. A frozen section of right vocal cord was performed under general anesthesia. The pathological result showed a malignant tumor in the right vocal cord. The tumor was excised with a CO_2 laser(Vc type). Routine postoperative pathology showed moderately differentiated SCC with small cell NEC in the right vocal cord. No metastatic lymph nodes or distant metastases were found on postoperative positron emission tomography/computed tomography. Because of the coexistence of SCC and NEC, the patient received adjuvant chemotherapy and radiotherapy. The patient was followed for 8 mo, and no recurrence or distant metastasis was *** The treatment of collision carcinoma in the head and neck region is uncertain due to the small number of cases.

关键词： Collision carcinoma Neuroendocrine carcinoma Squamous cell carcinoma Head and neck Larynx Case report

Potential pharmacological mechanisms of digallate in the treatment of enteritis based on network pharmacology and molecular docking

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Integrative medicine Discovery 2024年第7期8卷 1-10页

作者： Ning Tang Lian-Dong Zhao Yang Zhao Yu-Meng Han Yue Cao Yan Wang department of Integrative medicine Liaoning University of Traditional Chinese Medicine Xinglin CollegeShenyang 110167China department of Traditional Chinese medicine Liaoning University of Traditional Chinese Medicine Xinglin CollegeShenyang 110167China department of Integrative medicine Dalian Medical UniversityDalian 116044China

Background:In order to investigate the possible pharmacological mechanism of digallate in Galla Chinensis for treating enteritis,providing reference for the search and exploration of effective drugs for treating ***:Traditional Chinese medicines Systems Pharmacology Database and Analysis Platform,PharmMapper,DisGeNET,DrugBank,and GeneCards databases were used to obtain drug and disease-related target *** ontology functional annotation and Kyoto Encyclopedia of Genes and Genomes pathway enrichment were performed,and the main therapeutic pathways and targets were identified by combining protein-protein interaction networks and cytoHubba *** docking was used to validate the ***:297 drug related targets,2436 disease related targets,and 66 target points related to digallate were predicted to be associated with enteritis.10 related signal pathways and 10 key genes were ***:Digallate may be utilized to treat enteritis by acting on similar pathways,such those related to pathways in cancer,lipid and atherosclerosis,proteoglycans in cancer,Rap1 signaling pathway,PI3K-Akt signaling pathway and other targets such as IGF1,EGFR,SRC,IGF1R,PPARG.

关键词： digallate enteritis network pharmacology molecular docking

Mitigating the impact of mechanisms causing neuronal degeneration

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Neuroprotection 2024年第1期2卷 1-3页

作者： Xunming Ji Piotr Walczak Johannes Boltze Beijing Institute of Brain Disorders Capital Medical UniversityBejingChina Center for Advanced Imaging Research Department of Diagnostic Radiology and Nuclear MedicineUniversity of MarylandBaltimoreMarylandUSA School of Life Sciences University of WarwickCoventryUK

Primary and secondary neurodegeneration is a pathological hallmark of numerous central nervous system(CNS)*** many mechanisms leading to neurodegeneration are well understood,previous approaches aiming at providing protection from neurodegeneration were often futile.A potential explanation may be that recent research discovered additional pathomechanisms leading to ***,simply targeting single neurodegenerative mechanisms may only have minor therapeutic *** multiple neurodegenerative mechanisms may be a more viable ***,the restoration of lost brain tissue turned out to be a very complex endeavor.1 Despite making some initial progress with the use of biocompatible scaffolds and hydrogels.

关键词： Alzheimer's disease extracellular vesicles intracranial pressure microglia neurodegeneration stem cells stress stroke vascular dementia