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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li Xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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Structure and floristic composition of old-growth wet evergreen forests of Nelliampathy Hills, Southern Western Ghats

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Journal of forestry research 2013年第1期24卷 37-46页

作者： V.S. Ramachandran K. Swarupanandan forest Ecology and Biodiversity Conservation Division Kerala Forest Research InstitutePeechiThrissur-680653KeralaIndia.

We analyze the structure and composition of old-growth wet evergreen forest of Nelliampathy hills, the chain of hills lying immediately south of Palghat Gap, in the southern Western Ghats of India. We sampled 30 plots of 0.1 ha each （50 m × 20 m） at six locations enumerating all plants ？ 10 cm girth at breast height. We pooled the data and computed various structural parameters. There were 152 species of 120 genera and 51 families of the study area. Of these, 118 （77%） were trees, 24 were climbers （16%） and 10 were shrubs （7%）. Species richness varied from 58–99 per 0.5 ha sample and Shannon indices of diversity ranged from 4.4 to 5.2. Fifty-nine per cent （89 species） of the species were Indian Sub-continent elements and 34% （51 species） are endemic to the Western Ghats. Fifteen species are listed in various threat categories. Aglaia and Litsea were the most species-rich genera. Numbers of families ranged from 27–43 per 0.5 ha sample. Euphorbiaceae and Lauraceae were the most species-rich families. Stand density varied from 1714 to 2244 stems·ha？1 and basal area from 53.6 to 102.1 m2·ha？1. The vegetation was dominated by 3–6 species and six dominance patterns characterized the species composition within the hill complex. The old-growth evergreen forests of Nelliampathy exist as small fragments rich in biodiversity and can be used as benchmarks for comparison with disturbed forests.

关键词： Old-growth evergreen forest Nelliampathy Western Ghats species richness tree density relative abundance stand structure.

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Stand development patterns of forest cover types in the natural forests of northern Baekdudaegan in South Korea

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Journal of forestry research 2015年第2期26卷 381-390页

作者： Ji Hong Kim Guangze Jin Sang Hoon Chung Department of forest Management College of Forest and Environmental SciencesKangwon National University School of forestry Northeast Forestry University forest Ecology Division Forest Conservation DepartmentKorea Forest Research Institute

The purpose of this study was to classify current forest cover types,and to investigate stand development patterns for natural forests in six areas in northern Baekdudaegan,South ***-eight independent forest communities were aggregated into eight forest cover types by species composition in the overstory of each forest *** forest cover types were of mixed mesophytic,‘‘others’ ’ deciduous,Quercus mongolica dominant,*** pure,Pinus densiflora–***,***,Betula ermanii,and ***–*** ecological information was organized by importance value and species diversity for each forest *** on the correlation between species diversity index and the abundance of *** plus *** for corresponding forest cover types,we compared the developmental process and approximate successional pathway between each cover *** *** forest cover type changes into the ***–*** cover type,followed by the *** dominant cover type through continuous invasion of the oak ***,the *** pure cover type would spread toward the *** dominant cover type with a mixture of various deciduous tree *** *** dominant cover type progresses through the other deciduous cover types to the mixed mesophytic cover type with diversified composition and *** the mid to lower slopes,with loamy soils and good moisture conditions,various deciduous forest types should progress,by ecological succession,toward the mixed mesophytic cover type without any further disturbance.

关键词： Baekdudaegan forest cover type Species composition Species diversity Stand development patterns

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Assessment of Pb uptake,translocation and immobilization in kenaf (Hibiscus cannabinus L.) for phytoremediation of sand tailings

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Journal of Environmental Sciences 2008年第11期20卷 1341-1347页

作者： HO Wai Mun ANG Lai Hoe LEE Don Koo forest research institute Malaysia 52109 KepongSelangorMalaysia Department of forest Sciences Seoul National UniversitySeoul 151-921Korea

The potential of kenaf (Hibiscus cannabinus L.) for phytoremediation of lead (Pb) on sand tailings was investigated.A pot experiment employing factorial design with two main effects of fertilizer and lead was conducted in a nursery using sand tailings from an ex-tin mine as the growing *** showed that Pb was found in the root,stem,and seed capsule of kenaf but not in the *** of organic fertilizer promoted greater biomass yield as well as higher accumulation capacity of *** Pb-spike...

关键词： kenaf lead fertilizer bioaccumulation capacity phytoremediation

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A Comprehensive Survey on Federated Learning Applications in Computational Mental Healthcare

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 49-90页

作者： Vajratiya Vajrobol Geetika Jain Saxena Amit Pundir Sanjeev Singh Akshat Gaurav Savi Bansal Razaz Waheeb Attar Mosiur Rahman Brij B.Gupta institute of Informatics and Communication University of DelhiDelhi110021India Maharaja Agrasen College University of DelhiDelhi110096India Computer Engineering Ronin InstituteMontclairNJ 07043USA Department of research and Innovation Insights2TechinfoJaipur302001India University Centre for research and Development(UCRD) Chandigarh UniversityChandigarh140413India Management Department College of Business AdministrationPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia CCRI&Department of Computer Science and Information Engineering Asia UniversityTaichung413Taiwan Symbiosis Centre for Information Technology(SCIT) Symbiosis International UniversityPune411057India Center for Interdisciplinary research University of Petroleum and Energy Studies(UPES)Dehradun248007India

Mental health is a significant issue worldwide,and the utilization of technology to assist mental health has seen a growing *** aims to alleviate the workload on healthcare professionals and aid *** applications have been developed to support the challenges in intelligent healthcare ***,because mental health data is sensitive,privacy concerns have *** learning has gotten some *** research reviews the studies on federated learning and mental health related to solving the issue of intelligent healthcare *** explores various dimensions of federated learning in mental health,such as datasets(their types and sources),applications categorized based on mental health symptoms,federated mental health frameworks,federated machine learning,federated deep learning,and the benefits of federated learning in mental health *** research conducts surveys to evaluate the current state of mental health applications,mainly focusing on the role of Federated Learning(FL)and related privacy and data security *** survey provides valuable insights into how these applications are emerging and evolving,specifically emphasizing FL’s impact.

关键词： Depression emotional recognition intelligent healthcare systems mental health federated learning stress detection sleep behaviour

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Landscape gradient of autumn photosynthetic decline in Abies sachalinensis seedlings

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Journal of forestry research 2023年第1期34卷 187-195页

作者： Tetsuto Sugai Wataru Ishizuka Toshihiro Watanabe Hokkaido research Center Forestry and Forest Products Research InstituteHitsujigaoka 7Sapporo 062-8516Japan Plant Nutrition Laboratory Research Faculty of AgricultureHokkaido UniversitySapporo 060-8689Japan forest research institute Hokkaido Research OrganizationBibaiHokkaido 079-0198Japan

Understanding what environmental factors are genetically linked to a phenologic al event is critical for predicting responses to climate *** synthetic phenology often varies among a species of evergreen conifers due to local ***,few empirical studies have revealed relevant relationships between climatic factors in provenance environments and photosynthetic *** study evaluated the effects of environmental conditions of the growing site and seed source provenance on the seasonal changes in maximal photochemical quantum yield of photo systemⅡ(Fv/Fm)in a common garden experiment with 2-year-old seedlings of Sakhalin fir(Abies sachalinensis),a representative species with local adaptation,from four seed source provenances.A logistic model was constructed to explain the seasonal variation of Fv/Fmfrom July to October and the relationships between the estimated model parameters and representative factors featuring provenance environments were *** landscape gradient of the detected model parameters responsible for the provenance environments was visualized in a map of the distribution *** lowest temperature was the most plausible factor in the growing environment to explain the seasonal changes of Fv/*** the representative meteorological factors of provenance environments,the lowest temperatures in July showed significant relationships with two model parameters,explaining the lower limit of Fv/Fmand the higher sensitivity of autumn Fv/*** estimated spatial maps of model parameters consistently showed that the higher the lowest temperature in July in the provenance environment,the lower the Fv/Fmin October and the greater the decrease in the autumn Fv/***,the lowest summer temperature could be associated with the local adaptation of autumn photosynthetic phenology in ***.

关键词： Phenology Local adaptation Genetic cline Lowest temperature

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Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui Peng Peng Wu Zong-Lin Li Xue-Feng Zhu School of Physics and Innovation institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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Soil quality assessment across different stands in tropical moist deciduous forests of Nagaland,India

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Journal of forestry research 2019年第4期30卷 1479-1485页

作者： Gaurav Mishra Rossana Marzaioli Krishna Giri Shailesh Pandey Rain forest research institute JorhatAssamIndia Department of Environmental Biological and Pharmaceutical Sciences and TechnologiesSecond University of NaplesCasertaItaly forest research institute DehradunUttarakhandIndia

To analyze the relationship between the management of three forest stand plantations and soil quality in the Dimapur district of the Northeastern Himalayan region,India,three forest soil profiles,covered by different species stands,at three depths were tested for 13 physical and chemical *** four of these variables(electric conductivity,bulk density exchangeable Mg and available P)were included in a minimum data set,after using a varimax rotation algorithm in a principal component analysis,and subsequently used to calculate a soil quality index(SQI).Results showed higher SQIs in the surface layers(0–20 cm depth)than in the deeper *** weighed SQI varied significantly(Pforest sites,with the lowest value at site *** findings reveal that the approach used here is suitable for preliminary screening of the impact of a forestry species on soil,to aid in species selection and improve soil health for afforestation and reforestation projects.

关键词： forest stand Nagaland Soil quality indicators Soil quality index

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Biochemical investigations during in vitro adventitious shoot regeneration in leaflet explants from nodal segments of a mature Albizia procera tree

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Journal of forestry research 2016年第3期27卷 699-705页

作者： Ekta Rai Sulochna Bouddha Shamim Akhtar Ansari Genetics and Plant Propagation Division Tropical Forest Research Institute Jabalpur 482021 India institute of forest Productivity Lalgutwa Ranchi 835303India

The in vitro adventitious shoot differentiation in leaflet explants of an adult tree differed from that of leaflet explants of seedlings of Albizia procera（Roxb.）Benth. reported previously elsewhere. The leaflet explants from an adult tree passed through an initial callus phase for30 days on MS medium supplemented with 3 % sucrose,2.5 l M 2,4-D followed by a subsequent adventitious shoot differentiation phase for another 30 days on half MS medium supplemented with 0.25 l M each of BA and *** regeneration rate of in vitro adventitious shoots in explants from the adult tree, i.e.1.66 shoots/callus, was lower than that from seedlings, i.e. [10 shoots/callus,which was reported elsewhere. Correspondingly, the activities of nitrate reductase and peroxidase, and endogenous phenol content remained very low during in vitro adventitious shoot differentiation in leaflet explants of an adult tree possibly due to lower availability of competent stem（juvenile） cells for the process.

关键词： Adventitious shoot differentiation Nitratereductase activity Peroxidase activity Phenol Solublesugar

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Effects of Nitrogen Source and Bacterial Elicitor on Isoflavone Accumulation in Root Cultures of Albizzia kalkora （Roxb.） Prain

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Journal of Integrative Plant Biology 2006年第9期48卷 1108-1114页

作者： So-Young Park Wi-Young Lee Youngki Park Jin-Kwon Ahn Biotechnology Division Korea Forest Research Institute Suwon 441-350 Korea

Changes in cellular isoflavone （daidzein and genistein） contents were monitored in root cultures of Albizzia kalkora （Roxb.） Prain after feeding different ratios of NH4^＋/NO3^- and treatment with a biotic elicitor （three strains of Rhizobium sp.）. The NH4^＋/NO3^- ratio appears to be positively correlated with daidzein content in the roots and shows a negative correlation with genistein. Among the three different strains of Rhizobium used, the strain ATCC 15834 caused a 35% increase in daidzein production by infection. In the case of genistein, maximum production （94%） was obtained when cultures were treated on Day 6 by the strains ATCC 15834 and KCTC 1541. The biosynthetic pathway of the two isoflavones apparently reacts differently to the same culture conditions and the same strains of Rhizobium. Therefore, the present data suggest that the production of daidzein and genistein could be modulated by changing the NH4^＋/NO3^- ratio and the application of Rhizobium.

关键词： Albizzia kalkora infection isoflavone nitrogen root culture

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