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Artemisia vulgaris Induces Tumor-Selective Ferroptosis and Necroptosis via Lysosomal Ca^(2+) Signaling

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Chinese Journal of Integrative Medicine 2024年第6期30卷 525-533页

作者： Lucas dos Santos Zamarioli Michele Rosana Maia Santos Adolfo Garcia Erustes Vanessa Marques Meccatti Thais Cristine Pereira Soraya S Smaili Maria Cristina Marcucci Carlos Rocha Oliveira Gustavo JS Pereira Claudia Bincoletto Department of Pharmacology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Group on Phytocomplexes and Cell Signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective To evaluate the chemical composition and effects of Artemisia vulgaris(AV)hydroalcoholic extract(HEAV)on breast cancer cells(MCF-7 and SKBR-3),chronic myeloid leukemia(K562)and NIH/3T3 *** Phytochemical analysis of HEAV was done by high-performance liquid chromatography-mass(HPLC)*** and cell death studies were performed using trypan blue and Annexin/FITC-7AAD,***-1(Fer-1)and necrostatin-1(Nec-1)were used to assess the mode of HEAV-induced cell death and acetoxymethylester(BAPTA-AM)was used to verify the involvement of cytosolic calcium in this *** calcium measurements were made using *** HEAV decreased the viability of MCF-7,SKBR-3 and K562 cells(P<0.05).The viability of HEAV-treated K562 cells was reduced compared to HEAV-exposed fibroblasts(P<0.05).Treatment of K562 cells with HEAV induced cell death primarily by late apoptosis and necrosis in assays using annexin V-FITC/7-AAD(P<0.05).The use of Nec-1 and Fer-1 increased the viability of K562 cells treated with HEAV relative to cells exposed to HEAV alone(P<0.01).HEAV-induced Ca^(2+)release mainly from lysosomes in K562 cells(P<0.01).Furthermore,BAPTA-AM,an intracellular Ca^(2+)chelator,decreased the number of non-viable cells treated with HEAV(P<0.05).Conclusions HEAV is cytotoxic and activates several modalities of cell death,which are partially dependent on lysosomal release of Ca^(2+).These effects may be related to artemisinin and caffeoylquinic acids,the main compounds identified in HEAV.

关键词： Artemisia vulgaris necroptosis ferroptosis late apoptosis Ca^(2+)signaling

Dynamical control of nanoscale light-matter interactions in low-dimensional quantum materials

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Light(Science & Applications) 2024年第2期13卷 236-253页

作者： Yeonjeong Koo Taeyoung Moon Mingu Kang Huitae Joo Changjoo Lee Hyeongwoo Lee Vasily Kravtsov Kyoung-Duck Park Department of Physics Pohang University of Science and Technology(POSTECH)Pohang37673Republic of Korea School of Physics and Engineering ITMO UniversitySaint Petersburg197101Russia

Tip-enhanced nano-spectroscopy and-imaging have significantly advanced our understanding of low-dimensional quantum materials and their interactions with light,providing a rich insight into the underlying physics at their natural length ***,various functionalities of the plasmonic tip expand the capabilities of the nanoscopy,enabling dynamic manipulation of light-matter interactions at the *** this review,we focus on a new paradigm of the nanoscopy,shifting from the conventional role of imaging and spectroscopy to the dynamical control approach of the tip-induced light-matter *** present three different approaches of tip-induced control of light-matter interactions,such as cavity-gap control,pressure control,and near-field polarization ***,we discuss the nanoscale modifications of radiative emissions for various emitters from weak to strong coupling regime,achieved by the precise engineering of the ***,we introduce recent works on light-matter interactions controlled by tip-pressure and near-field polarization,especially tunability of the bandgap,crystal structure,photoluminescence quantum yield,exciton density,and energy transfer in a wide range of quantum *** envision that this comprehensive review not only contributes to a deeper understanding of the physics of nanoscale light-matter interactions but also offers a valuable resource to nanophotonics,plasmonics,and materials science for future technological advancements.

关键词： quantum precise shifting

Observability of parameter space for charged Higgs boson in its bosonic decays in two Higgs doublet model Type-1

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Chinese Physics C 2024年第2期48卷 57-65页

作者： Ijaz Ahmed Waqas Ahmad M.S.Amjad Jamil Muhammad federal Urdu university of Arts Science and TechnologyIslamabad Pakistan Riphah International university Sector I-14Hajj ComplexIslamabad Pakistan National university of technology Islamabad Pakistan Sang-Ho College and Department of PhysicsKonkuk UniversitySeoul 05029South Korea

This study explores the possibility of discovering H±through its bosonic decays,i.e.,H±→W±φ(whereφ=h or A),within the Type-I two Higgs doublet model(2HDM).The main objective is to demonstrate the available parameter space after applying recent experimental and theoretical exclusion *** suggest that mH±=150 GeV is the most probable mass for the H±→W±φdecay channel in pp collisions at s1/2=8,13,and 14 *** also report on the application of a modern machine learning approach to a multivariate technique for heavy charged Higgs production in association with a single top quark through weak interaction to demonstrate its observability in comparison with the most relevant Standard Model backgrounds using the neural networks of boosted decision Tree(BDT),likelihood(LH),and multilayer perceptron(MLP).

关键词： charged Higgs MSSM LHC

Semi-analytical calculation model for friction of polymers on the example of POM|PE-UHMW and steel|PE-UHMW

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Friction 2024年第10期12卷 2355-2369页

作者： André BERGMANN Jens SUMPF Niels DALLINGER Martin MONEKE Markus GOLDER Professorship of Conveying Engineering and Materials Handling Chemnitz University of TechnologySachsen 09126Germany Institute of Plastics Engineering Darmstadt University of Applied SciencesDarmstadt 64295Germany

In this paper,a semi-analytical calculation model for the coefficient of friction(COF)of single spherical protrusions is *** allows the prediction of the deformative friction part(μ_(def))and adhesive friction part(μ_(def))of the friction pairings steel|polyethylene with ultra-high molecular weight(PE-UHMW)and polyoxymethylene(POM)|*** experimental studies included unlubricated friction tests,which served to determine the total COF(μ_(def)),as well as tests being lubricated with silicone oil,from whichμ_(def)is *** on the verification tests,it could be shown that both states of lubrication result in the same deformation and that the relationship between the rear angle(w)andμ_(def)postulated in the calculation model is ***,friction tests with segmented spheres were carried out,which allow a specific variation of *** can be concluded that for both pairings theμ_(def)is generally of minor significance(approx.1/3μ_(tot))and the influence of theμ_(adh)predominates(approx.2/3μ_(tot))the friction *** themtot decreases with increasing contact pressure especially in the low pressure range and depends on the form of motion(continuous and discontinuous).

关键词： tribology friction polymers model contact polyoxymethylene(POM) polyethylene with ultra-high molecular weight(PE-UHMW)

Footprints of axion-like particle in pulsar timing array data and James Webb Space Telescope observations

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 55-62页

作者： Shu-Yuan Guo Maxim Khlopov Xuewen Liu Lei Wu Yongcheng Wu Bin Zhu Department of Physics Yantai UniversityYantai 264005 China Institute of Physics Southern Federal UniversityRostov on Don 344090 Russia National Research Nuclear university MEPhI(Moscow Engineering Physics Institute) Moscow 115409 Russia Virtual Institute of Astroparticle Physics Paris 75018 France Department of Physics and Institute of Theoretical Physics Nanjing Normal UniversityNanjing 210023 China

Several pulsar timing array(PTA) collaborations have recently reported the evidence for a stochastic gravitational-wave background(SGWB), which can unveil the formation of primordial seeds of inhomogeneities in the early universe. With the SGWB parameters inferred from PTAs data, we can make a prediction of the seeds for early galaxy formation from the domain walls in the axion-like particles(ALPs) field distribution. This also naturally provides a solution to the observation of high redshifts by the James Webb Space Telescope. The predicted photon coupling of the ALP is within the reach of future experimental searches.

关键词： stochastic gravitational-wave background pulsar timing array axion-like particle JWST

Porous Shish-Kebab Structure Prepared from Oriented UHMWPE Films by Processing in Supercritical CO_(2)

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Chinese Journal of Polymer Science 2024年第1期42卷 97-104,I0009页

作者： Sergey A.Lermontov Aleksey V.Maksimkin Nataliya A.Sipyagina Tarek Dayyoub Alena N.Malkova Evgeniy A.Kolesnikov Elena A.Straumal Inna O.Gozhikova Saidkhodzha G.Nematulloev Dmitry V.Telyshev Institute of Physiologically Active Compounds of the Russian Academy of Sciences Chernogolovka 142432Russia Institute for Bionic Technologies and Engineering I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 19991Russia National university of Science and technology"MISIS"Moscow 119049 Russia Institute of Biomedical Systems National Research University of Electronic TechnologyZelenogradMoscow 124498Russia

For the first time, a highly crystalline porous shish-kebab structure with a high degree of crystallinity was obtained by using a combination of two methods for the formation of porous polymeric materials. A treatment procedure using supercritical carbon dioxide(sc CO_(2))was carried out for oriented ultrahigh molecular weight polyethylene(UHMWPE) films, which provided special conditions for the crystallization of dissolved UHMWPE macromolecules on the surface of oriented UHMWPE crystals. The prepared porous materials were investigated by scanning electron microscopy(SEM) and differential scanning calorimetry(DSC). The particularity of the obtained porous shish-kebab is the absence of the amorphous phase between lamellar crystals(kebabs). The obtained pores had an oval shape, and they were oriented in the orientation direction of the UHMWPE macromolecules. The pore size ranged from 0.05 μm to 4 μm. Controlling the conditions for the crystallization of the UHMWPE macromolecules using supercritical CO_(2) gives the possibility to control the size of both lamellar disks and pores formed.

关键词： UHMWPE Supercritical CO_(2) Porous shish-kebab structure

Surface decoration of mesocarbon microbeads with multifunctional TiNbO_(4-x)@C coating layer as high rate and stable anode of Li-ion batteries

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Rare Metals 2024年第5期43卷 2053-2066页

作者： Jia-Mei Lai Zhi-Min Zou Yu Bai Yu-Tao Xing Chun-Hai Jiang Fujian Provincial Key Laboratory of Functional Materials and Applications Institute of Advanced Energy MaterialsSchool of Materials Science and EngineeringXiamen University of TechnologyXiamen 361024China Shanghai XFH Science and technology Development Co. Ltd.Shanghai 200949China Fujian XFH New Energy Materials Co. Ltd.Yong'an 366000China Shenzhen XFH Science and technology Co. Ltd.Shenzhen 518071China Laboratorio de Microscopia Eletronica de Alta Resolucao Centro de Caracterizagao Avangada Para a Industria de Petroleo(LaMAR/CAIPE)Universidade Federal FluminenseNiteroiRJ 24210-346Brazil

Surface modification of graphite anode with electroactive matters has been proven of a more practical strategy in enhancing the performance of Li-ion batteries than exploring alternative novel anode ***,rutile TiNbO_(4-x) nanoparticles with a tunnel structure are employed as multifunctional decoration substances in combination with a carbon coating layer to improve the rate and cycle properties of mesocarbon microbeads(MCMBs).As compared to pristine MCMB,the Li^(+)diffusion coefficients of the composite anodes are enhanced due to the synergistic effect of TiNbO_(4-x)@***,the overcharge and voltage polarization of the composite anodes at high rate are obviously minimized due to the current sharing effect of the high-potential TiNbO_(4-x).Moreover,the amorphous Li_(y)TiNbO_(4-x) converted from TiNbO_(4-x) in the initial lithiation process can deliver pseudocapacitive capacity to the composite anodes from the second *** of these functions of TiNbO_(4-x)@Ccoating layer have directly contributed to the improved rate and cycle performance of the MCMB/TiNbO_(4-x)@C composite *** one containing 12.0 wt%TiNbO_(4-x) exhibits a high reversible specific capacity of 118 m Ah·g^(-1)at 10C(1C=372 m A·g^(-1)),together with a high capacity retention of 90.9%after 300 cycles at 3C,which are all much superior to those of pristine MCMB.

关键词： Li-ion batteries MCMB TiNbO_(4-x)@C Surface decoration Rate capability

Anticancer therapeutic strategies for targeting mutant p53-Y220C

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Journal of Biomedical Research 2024年第3期38卷 222-232页

作者： Vitaly Chasov Damir Davletshin Elvina Gilyazova Regina Mirgayazova Anna Kudriaeva Raniya Khadiullina Youyong Yuan Emil Bulatov Institute of Fundamental Medicine and Biology Kazan Federal UniversityKazan 420008Russia Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of SciencesMoscow 117997Russia Institute of Life Sciences School of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China

The tumor suppressor p53 is a transcription factor with a powerful antitumor activity that is controlled by its negative regulator murine double minute 2(MDM2,also termed HDM2 in humans)through a feedback *** the same time,TP53 is the most frequently mutated gene in human *** p53 proteins lose wild-type p53 tumor suppression functions but acquire new oncogenic properties,among which are deregulating cell proliferation,increasing chemoresistance,disrupting tissue architecture,and promoting migration,invasion and metastasis as well as several other pro-oncogenic *** oncogenic p53 mutation Y220C creates an extended surface crevice in the DNA-binding domain destabilizing p53 and causing its denaturation and *** cavity accommodates stabilizing small molecules that have therapeutic *** development of suitable small-molecule stabilizers is one of the therapeutic strategies for reactivating the Y220C mutant *** this review,we summarize approaches that target p53-Y220C,including reactivating this mutation with small molecules that bind Y220C to the hydrophobic pocket and developing immunotherapies as the goal for the near future,which target tumor cells that express the p53-Y220C neoantigen.

关键词： p53 Y220C mutation small molecule DNA-binding domain immunotherapy T cell receptor mimic antibody

Digital Generative Multimedia Tool Theory (DGMTT): A Theoretical Postulation

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Journalism and Mass Communication 2024年第3期14卷 189-204页

作者： Timothy Ekeledirichukwu Onyejelem Eric Msughter Aondover federal university Otuoke Bayelsa State Caleb university ImotaLagos

The development of digital technology has brought about a substantial evolution in the multimedia *** use of generative technologies to produce digital multimedia material is one of the newer developments in this ***“Digital Generative Multimedia Tool Theory”(DGMTT)is therefore presented in this theoretical postulation by Timothy Ekeledirichukwu Onyejelem and Eric Msughter *** discusses and describes the principles behind the development and deployment of generative tools in multimedia *** DGMTT offers an all-encompassing structure for comprehending and evaluating the fundamentals and consequences of generative tools in the production of multimedia *** provides information about the creation and use of these instruments,thereby promoting developments in the digital media *** tools create dynamic and interactive multimedia content by utilizing machine learning,artificial intelligence,and *** theory emphasizes how crucial it is to comprehend the fundamental ideas and principles of generative tools in order to use them efficiently when creating digital media content.A wide range of industries,including journalism,advertising,entertainment,education,and the arts,can benefit from the practical use of *** gives artists the ability to use generative technologies to create unique and customized multimedia content for its viewers.

关键词： digital generative tools multimedia creation theory artificial intelligence machine learning techniques