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Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

World Journal of Gastroenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li Brittney O Baumert Nikos Stratakis Jesse A Goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah P Eckel Douglas I Walker Damaskini Valvi Michele A La Merrill Justin R Ryder Thomas H Inge Todd Jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A Baccarelli Rob McConnell David V Conti Lida Chatzi Department of Population and Public Health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Barcelona Institute of Global Health Barcelona Institute of Global HealthBarcelona 08036Spain Department of environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa Department of environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Department of environmental Medicine and Public Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of environmental Toxicology University of CaliforniaDavisCA 95616United States Department of Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University Feinberg School of Medicine Northwestern UniversityChicagoIL 60611United States Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States Department of Pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Department of Gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and *** ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inflammation and/or fibrosis coexist with *** microRNA(miRNA)levels have been suggested to be altered in NAFLD,but the extent to which miRNA are related to NAFLD features remains *** analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in *** To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with *** This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of Bariatric Surgery ***-operative core liver biopsies were collected from participants and used to characterize histological features of *** samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTG EdgeSeq *** examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key *** Pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of *** We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NASH,fibrosis,ballooning degeneration,and lobular inflammation,***,16 miRNAs were associated with two or more histological features of *** those miRNAs,miR-411-5p was downregulated in NASH,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and posi

关键词： MicroRNA Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Lobular inflammation Ballooning degeneration

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Strengthening mechanisms analysis and tailoring of bimodal grain structures for enhanced strength in CoCrFeMnNi high-entropy alloys

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Rare Metals 2024年第8期43卷 3893-3903页

作者： Jaesoung Lee Seulgi Kim Taehyun Kwon Young II Kim Suyeon Kim Sung Ho Song Bin Lee Dongju Lee Department of Urban Energyand Environmental EngineeringChungbuk National UniversityCheongju 28644Republic of Korea Division of Advanced Materials Engineering Kongju National UniversityChungnam 330-717Republic of Korea Department of Advanced Materials Engineering for Information and Electronics Integrated-Education Institute for Frontier Science and Technology(BK21 Four)Kyung Hee UniversityYongin17104Republic of Korea

The CoCrFeMnNi high-entropy alloys(HEAs)with a(face-centered cubic) FCC structure has garnered considerable attention for its exceptional ductility and strain hardening ***,its yield strength is insufficient for structural *** this study,strengthening mechanisms in these HEAs were investigated to gain insight into the mechanical properties according to alloy powder ***,we present a novel approach to achieve both high strength and high ductility through the creation of a bimodal structure consisting of both coarse and fine grains via gas atomization and spark plasma sintering processes.A bimodally structured HEA prepared with a mass ratio of 2:8 between coarse particles(75-106 μm) and fine particles(≤25 μm)yielded optimal results,with a strength of 491.95 MPa and elongation of 19.64%.This strength value represents an~41% increase compared with the sample that displayed a fine single microstructure(347.08 MPa for yield strength).The strength enhancement was attributed to the prevention of plastic deformation initiation from the fine particles during *** innovative approach to the creation of HEAs with bimodal structures shows promise for various applications,such as structural components that require a combination of high strength and high ductility.

关键词： High-entropy alloys CrCoFeMoNi Bimodal Gas atomization Mechanical properties

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Thermo-Mechanical, Physico-Chemical, Morphological, and Fire Characteristics of Eco-Friendly Particleboard Manufactured with Phosphorylated Lignin Addition

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Journal of Renewable Materials 2024年第7期12卷 1311-1341页

作者： Apri Heri Iswanto Harisyah Manurung Asma Sohail Lee Seng Hua Petar Antov Deded Sarip Nawawi Sarah Latifah Dewi Shafa Kayla Sukma Surya Kusumah Muhammad Adly Rahandi Lubis Linda MakovickáOsvaldová MohdHazwan Hussin Rangabhashiyam Selvasembian Lum Wei Chen Puji Rahmawati Nurcahyani Nam Hun Kim Widya Fatriasari Department of Forest Products Faculty of ForestryUniversitas Sumatera UtaraKampus USU Padang BulanMedanNorth Sumatra20155Indonesia Department of Chemistry Lahore College for Women UniversityLahore4444Pakistan Department of Wood Industry Faculty of Applied SciencesUniversiti Teknologi MARA(UiTM)Cawangan Pahang Kampus JengkaShah Alam26400Malaysia Faculty of Forest Industry University of ForestrySofia1797Bulgaria Department of Forest Product Faculty of Forestry and EnvironmentIPB UniversityBogor16680Indonesia Research Center for Biomass and Bioproducts National Research and Innovation Agency(BRIN)Cibinong16911Indonesia Department of Forest Engineering Faculty of Security EngineeringUniversity of ZilinaZilina01001Slovakia Materials Technology Research Group(MaTReC) School of Chemical SciencesUniversiti SainsMalaysiaMindenPenang11800Malaysia Department of environmental Science and Engineering School of Engineering and SciencesSRM University-APAmaravatiAndhra Pradesh522240India Department of Bio and Natural Resources Faculty of Bioengineering and TechnologyUniversitiMalaysia KelantanJeliKelantan17600Malaysia Department of Forest Biomaterials Engineering College of Forest and Environmental SciencesKangwon National UniversityChuncheon24341Republic of Korea

Lignin,lignosulfonate,and synthesized phosphorylated lignosulfonate were introduced as greenﬁllers in citric acid-sucrose adhesives for bonding particleboard fabricated from areca leaf sheath(ALS).The characteristics of particleboards were compared to that of ultralow emitting formaldehyde(ULEF-UF).Theﬁllers derived from Eucalyptus ***-lignin were added forﬂame retardancy enhancement.10%of each lignin and modiﬁed lig-nin was added into the ULEF-UF and citric acid-sucrose bonded *** applied to particle-boards included thermal characteristics,X-ray diffraction analysis(XRD),morphological properties,Fourier transform infrared spectroscopy(FTIR),as well as physical,mechanical,andﬁre resistance characteristics of the laboratory-fabricated *** and modiﬁed lignin resulted in improved thermal stability of the composites bonded with ULEF-UF while the improvement in the particleboard bonded with citric acid-sucrose was not signiﬁ*** introduction ofﬁller exerted a higher inﬂuence on the UF-bonded particleboards compared to composites fabricated with citric ***,the presence of lignin,lignosulfonate,and phosphorylated lignosulfonate enhanced the mechanical strength of the ULEF-bonded particleboards,although their dimensional stability has ***,the use of lignin and lignosulfonate enhanced theﬁre resis-tance of the particleboards produced with lower observed weight *** laboratory particleboards exhibited satisfactoryﬁre resistance,attaining a V-0 rating in according to the UL-94 standard.

关键词： Modiﬁed lignin eco-friendly particleboard ﬁre and thermal properties citric acid-sucrose ultralow-emitting urea-formaldehyde resin

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Objective frequency-specific hearing thresholds definition for medicolegal purposes in case of occupational NIHL: ASSR outperforms CERA

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Journal of Otology 2021年第4期16卷 210-219页

作者： P.H.DeJonckere B.Millet R.Van Gool A.Martens J.Lebacq federal agency for Occupational Risks BrusselsBelgium Institute of Neurosciences University of LouvainBrusselsBelgium

Audiological use of the 40 Hz-ASSR (auditory steady state responses) could be valuable for objectivelyestimating the frequency-specific threshold in adults undergoing an expertise examination for medicolegal and/or compensation purposes. The present prospective study was set up to clarify the relationship between the thresholds obtained by cortical evoked response audiometry (CERA) and by 40 HzASSR, in the same ears, within a large homogeneous sample of 164 subjects (328 ears) with NIHL andwell documented exposure to noise. All these subjects claimed financial compensation for occupationalNIHL, and there was a suspicion of exaggeration of the reported NIHLs. ASSR thresholds show a goodcorrelation with the CERA thresholds. However, a systematic shift is noticed, ASSR thresholds being onaverage (1e2 e 3 kHz) 4.38 dB lower (i.e. showing less hearing loss) than CERA thresholds. Moreover, thebinaural multiple ASSR technique allows a considerable time gain when compared to the CERA.

关键词： Objective audiometry CERA ASSR NIHL Medicolegal

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Levels and statistical analysis of aerosol phase PAHs over Qingdao alongshore

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第7期8卷 1164-1169页

作者： ZHANG Yan-qing WANG Yan TAN Pei-gong Department of environmental Science and Engineering Ocean University of China Qingdao 266033 China Institute of Environment and Municipal Engineering Qingdao Technological University Qingdao 266033 China Qingdao environmental Protection agency Qingdao 266033 China

Atmospheric concentrations of polycyclic aromatic hydrocarbons (PAHs) were measured during various seasons at six different cities/locations in Qingdao alongshore. The annual average PAHs concentration ranged from 16 ng/m3 (at a clean com- pared site) to 308 ng/m3 (in an industry site). The average total particulate PAHs concentration was 74.5 ng/m3 with a higher concentration of particulate PAHs in winter. Based on a year-round dataset, the sources of PAHs in the air of Qingdao were drawn by principal factor analysis and correlation analysis. The results indicated that vehicle emissions and oil burning were the main source of PAHs in Qingdao alongshore.

关键词： Polycyclic aromatic hydrocarbons (PAHs) Atmosphere aerosol Factor analysis Correlation analysis

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Technical challenges in tackling regulatory concerns for urban atmospheric nanoparticles

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Particuology 2011年第6期9卷 566-571页

作者： Prashant Kumar Alan Robins Sotiris Vardoulakis Paul Quincey Division of Civil Chemical and Environmental EngineeringFaculty of Engineering and Physical Sciences(FEPS)University of Surrey environmental Flow(EnFlo)Research Centre FEPSUniversity of Surrey Centre for Radiation Chemical and Environmental HazardsHealth Protection Agency Analytical Science Division National Physical Laboratory

Recent Euro 5 and Euro 6 vehicle emission standards are the first ever initiative to control particles on a number basis at the source. Related standards are also desirable for ambient nanoparticles （taken in this article to be those below 300 rim） to protect against possible adverse effects on public health and the environment. However, there are a number of technical challenges that need to be tackled before developing a regulatory framework for atmospheric nanoparticles. Some of the challenges derive from a lack of standardisation of the key measurement parameters, including sampling, necessary for robust evaluation of particle number concentrations, especially in the context of insufficient knowledge of the physicochemical characteristics of emerging sources （i.e. bio-fuel derived and manufactured nanoparti- cles）. Ideally, ambient concentrations of primary particles could be linked to primary particle emissions by use of nanoparticle dispersion models, and secondary nanoparticles using photochemical modeling tools. The limitations in these areas are discussed. Although there is inadequate information on the exact biological mechanism through which these particles cause harm, it is argued that this should not in itself delay the introduction of regulation. This article reviews the missing links between the existing knowledge of nanoparticle number concentrations and the advances required to tackle the technical challenges implied in developing regulations.

关键词： Airborne and manufactured nanoparticles Particle number concentrations Size distributions Street canyons Ultrafine particles Vehicle emissions

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Distribution of trace metals and Pb isotopes in bottom sediments of the Murucupi River,North Brazil

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International Journal of Sediment Research 2016年第3期31卷 226-236页

作者： Diomar Cavalcante Oliveira Jean Michel Lafon Marcelo de Oliveira Lima Institute of Geosciences Federal University of Pára environmental Section Evandro Chagas Institute

The Murucupi River belongs to the hydrographic network of the Para River estuary,at the southern portion of the Amazon River mouth,which consists of a fluvial-marine transitional zone under strong impact of both tidal and fluvial *** geochemical results obtained for bottom sediments from the Murucupi River,the Arrozal Channel,and the Para River indicate a natural variation of Pb,Cr,Cu,Zn,and Ni content among these water ways with no significant anthropogenic *** to the threshold effects level(TEL),the contents of trace metals do not offer risk to the local *** contrast,the differences in the Pb isotopic composition of sediments in the Murucupi River,the Arrozal Channel,and the Para River are *** isotopic signatures indicate an anthropogenic contribution of Pb in the Murucupi River originating from the domestic effluents of urban centers;industrial waste represented by red mud is not *** results demonstrate that the Pb isotopic signature is a prospective indicator for future contamination of bottom sediments by trace metals and is useful for identifying contaminants among the possible anthropogenic sources.

关键词： Bottom sediments Pb isotopes Trace metals Murucupi River Barcarena

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Aspects of forest restoration and hydrology:the hydrological function of litter

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Journal of Forestry Research 2022年第2期33卷 543-552页

作者： Luara Castilho Pereira Leonardo Balbinot Marcelle Teodoro Lima Julieta Bramorski Kelly Cristina Tonello Hydrology in Forest Ecosystems Lab.(Hidrolef) Department of Environmental SciencesFederal University of São Carlos(UFSCar)SorocabaSão PauloBrazil Hydrology in Forest Ecosystems Lab.(Hidrolef) Department of Environmental SciencesFederal University of Amapá(UNIFAP)MacapáAmapáBrazil

Although forests play important roles in the hydrological cycle,there is little information that relates the water retention capacity of litter in areas under passive restoration,especially in Cerrado *** study relates litter levels to water holding capacity and effective water retention among forest fragments under different passive restoration stages:46,11,and 8 years to better understand litter hydrological functions in the *** retention capacity and effective water retention capacity of litters(unstructured materials,branches and leaves)in the field were monitored on a monthly *** litter accumulation at 46 years was significantly higher than that of the other succession *** litter mass was significantly higher than that of leaves and *** 46-year stage had the highest water holding capacity in the leaf fraction,followed by unstructured material and *** the water holding capacity was lower in the oldest resto-ration,this site showed the highest efficiency under field *** process was quickly reestablished,as the 11-year restoration showed results closer to that for the 46-year stage in comparison to the area at 8 ***,passive restoration plays a key role in soil water mainte-nance due to the influence of litter in Cerrado *** and the imminent need of restoring degraded sites,highlight the need for further studies focused on bet-ter understanding of the process of forest restoration and its temporal effect on soil water recovery dynamics.

关键词： Forest hydrology Litter interception Stemflow Cerrado Águas Perenes Forest Water holding capacity

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Recovery of valuable metals from waste cables by employing mechanical processing followed by spouted bed elutriation

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Particuology 2019年第4期17卷 74-80页

作者： Eduardo H. Tanabe Roger M. Silva Daliomar L. Oliveira Junior Daniel A. Bertuol environmental Processes Laboratory (LAPAM) Chemical Engineering Department Federal University of Santa Maria - UFSM Santa Maria RS Brazil

Cables and wires, which are essential parts of equipment for the transmission of both information and electricity, contain valuable materials including copper (Cu) and aluminum (Al). This experimental work evaluates the use of mechanical processing (grinding and sieving), followed by spouted bed elutriation, for separation of the valuable materials (steel-coated copper, copper, and aluminum) present in waste coaxial and internet cables. A recovery efficiency of approximately 90% was achieved for the steel-coated copper in coaxial cables. For in ternet cables, the copper recovery efficiency was approximately 87%. These findings dem on strate that it is possible to separate, recover, and recycle the valuable materials (metals) present in waste cables using simple, low-cost, and efficient mechanical processing followed by spouted bed elutriation.

关键词： Waste cable Elutriation Copper Recycling Mechanical process

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Estimating the effects of meteorology on PM_(2.5) reduction during the 2008 Summer Olympic Games in Beijing, China

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Frontiers of environmental Science & Engineering 2011年第3期5卷 331-341页

作者： Liu YANG Ye WU Jerry M.DAVIS Jiming HAO School of Environment Tsinghua UniversityBeijing 100084China Office of Air Quality Planning and Standards Health and Environmental Impacts DivisionUS Environmental Protection AgencyRaleighNC 27513USA

Particulate pollution was a critical challenge to the promise of good air quality during the 2008 Beijing Olympic Games,which took place from August 8th to *** ensure good air quality for the Games,several temporary emission control measures were implemented in Beijing and surrounding *** particulate matter concentration decreased significantly during the Olympic period;however,it is difficult to distinguish the effectiveness of those control measures since meteorology also affects ambient PM_(2.5) *** this work,a multiple linear regression model based on continuous field monitoring at a roadside site was conducted to evaluate the effects of meteorology and emission control measures on the reduction of PM_(2.5) during the 2008 Olympic *** hourly data set was divided into two time periods,the no control period,June 22nd to July 4th,and the control period,July 28th to August *** response variable was PM_(2.5) and the meteorology covariates used in the model were hourly temperature,dew point temperature,wind speed and *** direction was not a significant predictor of PM_(2.5) levels in either the control or the no control *** the meteorologically-based regression coefficients from the two time periods,meteorology was found to contribute to at least a 16%reduction in PM_(2.5) levels in the roadside microenvironment;while the pollution control measures contributed to at least a 43%reduction in PM_(2.5) levels.

关键词： meteorology emission control measures Beijing Olympic Games PM_(2.5) linear statistical models

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