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Easy One-Pot Synthesis of 1-Monosubstituted Aliphatic 1,2,3-Triazoles from Aliphatic Halides, Sodium Azide and Propiolic Acid by a Click Cycloaddition/Decarboxylation Process

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Chinese Journal of Chemistry 2013年第8期31卷 1011-1014页

作者： Zhongkui Zhang Chunxiang Kuang Department of Chemistry Tongji University Shanghai 200092 China Key Laboratory of Yangtze River Water Environment Ministry of Education Shanghai 200092 China Email: Chunxiang Kuang (kuangcx@***)[*]Department of Chemistry Tongji University Shanghai 200092 China Tel.: 0086-021-65983191 fax: 0086-021-65983191

1-Monosubstituted aliphatic 1,2,3-triazoles were synthesized by a one-pot reaction from aliphatic halides （C1 and Br）, sodium azide and propiolic acid. The yields ranged from moderate to good. The reaction was easil... 详细信息

关键词： click chemistry copper-catalyzed decarboxylation 1-monosubstitued aliphatic 1,2,3-triazole

A Photo-responsive Catalytic Vesicle with GPx Activity

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Chinese Journal of Chemistry 2014年第1期32卷 37-43页

作者： Ruiqing Xiao Lipeng Zhou Zeyuan Dong Yuzhou Gao Junqiu Liu[*] State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun Jilin 130012 China Email: Junqiu Liu (junqiuliu@***)[*]State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun Jilin 130012 China Tel.: 0086-0431-85168452 fax: 0086-0431-85168491

Glutathione peroxidase (GPx) is a vital antioxidant enzyme involved in the reduction of reactive oxygen species and protects cells from oxidative *** enormous efforts have been devoted to developing artificial catalysts with GPx *** the research on enhancing the catalytic activity of GPx mimics,the design and construction of smart GPx models has also inspired great ***,a novel photo-responsive seleniumcontaining vesicular GPx model was successfully constructed by supramolecular self-assembly of the cationic surfactant PyC10AZoC10Py with benzeneseleninic acid (PhSeO2H) through hydrophobic and electrostatic interactions in aqueous *** selenium-containing vesicular catalyst showed remarkable GPx-like activity,which is 692times more effective than PhSeO2H for the reduction of cumene hydroperoxide (CUOOH) by 4-nitrobenzenethiol (NBT).Interestingly,when an equimolar amount of α-CD was added,the GPx-like activity of the catalytic vesicle declines remarkably due to the vesicle disaggregation in the presence ofα-*** the biomimetic system was irradiated by UV light at 365 nm,the catalytic vesicle was formed again and the GPx-like activity recovered.

关键词： photo-responsive self-assembly vesicle GPx mimics

Incorporation of Lysine-Containing Copolymer with Polyurethane Affording Biomaterial with Specific Adsorption of Plasminogen

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Chinese Journal of Chemistry 2014年第1期32卷 44-50页

作者： Haichao Xu Yafei Luan Zhaoqiang Wu Xinming Li Yuling Yuan Xiaoli Liu Lin Yuan Dan Li[*] Hong Chen[*] Department of Polymer Science and Engineering College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou Jiangsu 215123 China Email: Dan Li (lidan@***) Hong Chen (chenh@***)[*]Department of Polymer Science and Engineering College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou Jiangsu 215123 China Tel.: 0086-0512-65880827 fax: 0086-0512-65880583

A novel biomaterial based on polyurethane (PU) was prepared through physical incorporation of lysine-containing copolymer to improve its hemocompatibility and surface recognition of *** lysine-containing copolymer was synthesized via the copolymerization of 2-ethylhexyl methacrylate (EHMA),oligo (ethylene glycol)methyl ether methacrylate (OEGMA) and 6-tert-butoxycarbonyl amino-2-(2-methyl-acryloylamino)-hexanoic acid tert-butyl ester (Lys(P)MA),followed by the deprotection of COOH and ε-NH2 groups on lysine residues in the *** composition of the copolymer can be adjusted by varying the monomer feed *** three components contribute to improving the compatibility with PU,resistance to nonspecific protein adsorption and specific binding of plasminogen,*** binding capacity towards plasminogen increased with the lysine content in the *** approach illustrates a simple way for the generation of novel biomaterials with improved hemocompatibility and surface recognition of specific biomolecules.

关键词： plasminogen protein adsorption hemocompatibility blending lysine

Supramolecular Micelles and Reverse Micelles Based on Cyclodextrin Polyrotaxanes

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Chinese Journal of Chemistry 2014年第1期32卷 73-77页

作者： Qiao Jin Gongyan Liu Jian Ji[*] MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 China Email: Jian Ji (jijian@***)[*]MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 China Tel.: 0086-0571-87953729 fax: 0086-0571-87953729

A new supramolecular self-assembly approach to construct micelles and reverse micelles was ***-hydrophilic block copolymers poly(ethylene oxide)-b-poly(N-isopropylacrylamide) (PEO-b-PNIPAAm) was synthesized via atom transfer radical polymerization (ATRP) using PEO *** of the lower critical solution temperature (LCST) phase behavior of PNIPAAm,PEO-b-PNIPAAm block copolymers self-assembled to form PNIPAAm-core micelles at 40 ℃.The PNIPAAm-core micelles were disassembled to unimers when the temperature was decreased to 25 ℃.But the addition of α-cyclodextrins (α-CDs) could induce the formation of PNIPAAm-shell micelles because of the 'channel-type' crystallities induced by PEO/α-CDs *** assembly and disassembly procedure of micelles and reverse micelles were investigated by dynamic light scattering (DLS),X-ray diffraction (XRD),1H NMR and transmission electron microscopy (TEM).

关键词： cyclodextrin polyrotaxane reverse micelle supramolecular

Selective Reduction of Nitroarenes with Molybdenum Disulfide

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Chinese Journal of Chemistry 2013年第8期31卷 987-991页

作者： Lei Huang Pingfei Luo Man Xiong Rizhi Chen Yong Wang Weihong Xing Jun Huang[*] State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemistry and Chemical Engineering Nanjing University of Technology Nanjing Jiangsu 210009 China Email: Jun Huang (junhuang@***)[*]State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemistry and Chemical Engineering Nanjing University of Technology Nanjing Jiangsu 210009 China Tel.: 0086-025-83172276 fax: 0086-025-83172261

Commercial MoS2 was found to be a highly selective catalyst for the reduction of nitrobenzenes to the corre- sponding anilines with hydrazine under mild conditions. MoS2 is not only much cheaper, but also more selective than noble metal catalysts for the reduction of functional nitrobenzenes to the corresponding anilines. Nitrobenzenes with halides （F, C1, Br and I） were reduced selectively, and the corresponding anilines were obtained in excellent yields, and no dehalogenation was detected. Functional groups such as NH2, OH, alkene groups were tolerated dur- ing the reduction of the nitro compounds. The reduction ofp-chloronitrobenzene was studied over MoS2 and Pd/C respectively with hydrazine. The yield ofp-chloroaniline was much higher with MoS2 than that with Pd/C at full conversion.

关键词： anilines reduction molybdenum disulfide nitrobenzenes

Syntheses, Structures and Properties of Four New Transitional Metal Complexes Based on Benzotriazole-5-carboxylic Acid

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Chinese Journal of Chemistry 2013年第8期31卷 1059-1064页

作者： Yang Li Changyan Sun[*] Wenjun Li Hualei Zhou Bin Dong Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials School of Chemistry and Biological Engineering University of Science and Technology Beijing Beijing 100083 China Email: Changyan Sun (cysun@***)[*]Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials School of Chemistry and Biological Engineering University of Science and Technology Beijing Beijing 100083 China Tel.: 0086-010-62333871 fax: 0086-010-62332126

Four new complexes, [Zn（btca）（2,2＇-bpy）] （1）, [Mn（btca）（2,2＇-bpy）] （2）, [Co（btca）（phen）] （3）, and [Cu（btca）- （phen）] （4）, （Hzbtca=benzotriazole-5-carboxylic acid, 2,2＇-bpy=2,2＇-bipyridine, phen= 1,10-phenanthroline）, were successfully synthesized and characterized by elemental analysis, single crystal X-ray diffraction, and IR spectros- copy. Complexes 1-4 crystallize in the orthorhombic system with space group of Pbca and show similar 2D layers, which are interlinked to supramolecular networks by π-π stacking interactions. Furthermore, TGA curves show that complexes 1-4 have good thermal stability. Solid-state fluorescent property of complex 1 was also investigated at room temperature.

关键词： benzotriazole-5-carboxylic acid crystal structure luminescent property thermogravimetric analyses

Polyelectrolyte Multilayer Patterns Created by Capillary Force and Their Impact on Cell Migration

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Chinese Journal of Chemistry 2014年第1期32卷 66-72页

作者： Lulu Han Jindan Wu Tanchen Ren Zhengwei Mao[*] Yang Guo Changyou Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhengjiang 310027 China Email: Zhengwei Mao (zwmao@***)[*]MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhengjiang 310027 China Fax: 0086-571-87951108

Cell migration plays a crucial role in a variety of physiological and pathological *** this study a method of capillary force lithography was used to treat poly(sodium 4-styrenesulfonate) (PSS)/poly(diallyldimethylammonium) chloride (PDADMAC) multilayers with a PDMS stamp before or after etching by NaC1 solution,yielding physical patterns with various features such as double thin lines,double strips,meniscus-shaped ridges,and high *** ridge height is controllable in the range of 25 and 1100 *** of smooth muscle cells (SMCs) was restrained by the double-line patterns in a ridge height-dependent *** contrast,the mobility of SMCs was controlled by both the hydration ratio of the multilayers and the pattern features.

关键词： capillary force lithography polyelectrolyte multilayer cell migration ridge height salt etching

A Long-Wavelength Fluorescent Probe for Saccharides Based on Boronic-Acid Receptor

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Chinese Journal of Chemistry 2013年第8期31卷 1095-1101页

作者： Hongyan Bai Qian Sun Haiyu Tian Junhong Qian Lingyi Zhang Weibing Zhang Shanghai Key Laboratory of Scene Evidence Center of Material Evidence Identification Shanghai Public Security Bureau Shanghai 200083 China Shanghai Key Laboratory of Functional Materials Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai 200237 China Email: Junhong Qian (junhongqian@***) Weibing Zhang (weibingzhang@***)[*]Shanghai Key Laboratory of Scene Evidence Center of Material Evidence Identification Shanghai Public Security Bureau Shanghai 200083 China Tel.: 0086-021-64253068 fax: 0086-021-64233068

A single boronic acid-based fluorescent probe （compound CSP） for saccharides was designed and synthesized. The probe, with an a,fl-unsaturated ketone conjugated into the coumarin fluorophore, was synthesized by 4 steps from the commercial material 4-diethylamino salicylaldehyde. The electron push-pull effect is enhanced with the N,N-diethyl amino as the electron donor and the carbonyl as the electron acceptor. Both the absorption （463 nm） and emission （616 nm） maxima of CSP are in the visible wavelength region with a Stokes shift of about 150 nm, which ensures CSP a potential probe for biological application. Under near physiological conditions, significant fluores- cence enhancement of CSP was observed upon the addition of some saccharides, namely, D-sorbitol, D-fructose, D-glucose, D-mannose and D-galactose. The probe showed relatively high sensitivity towards D-fructose and D-sorbitol, and their detection limits were 0.05 mmol/L and 0.1 mmol/L, respectively.

关键词： saccharides coumarin boronic acid fluorescent probe

Label-free Fluorescent Sensor for Probing Heparin-Protein Interaction Based on Supramolecular Assemblies

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Chinese Journal of Chemistry 2014年第1期32卷 85-90页

作者： Lan Jia Lingyun Xu Zhaohui Wang Jianping Xu Jian Ji[*] MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 China Email: Jian Ji (jijian@***)[*]MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 China Tel./Fax: 0086-0571-87953729

In this paper a label-free fluorescent sensor for probing the interaction between heparin and protein was ***,the bioactive polyanions,formed supramolecular assemblies with cationic surfactant cetyltrimethyl ammonium bromide (CTAB).The environment-dependent dye pyrene,encapsulated in hydrophobic interiors of the supramolecular assemblies worked as the fluorescence *** the heparin-binding protein was added,competing interactions of protein with heparin would weaken the interaction between CTAB and *** a result,the noncovalently sequestered pyrene would be released upon disassembly and the fluorescence of the released pyrene was subsequently *** binding events were exemplified by protamine and Tat peptide,these processes were also verified by DLS and *** a strategy is appealing as organic synthesis was traded off against supramolecular *** label-free fluorescent system is simple,selective,convenient,and can serve as a good complement to other existing methods,also this method has the potential for preprimary drug screening.

关键词： supramolecular assemblies fluorescent sensor heparin protein interaction