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Mechanisms Underlying the Antifatigue Effects of the Mycelium Extract of <i>Cordyceps</i>(<i>Paecilomyces hepiali</i>, CBG-CS-2) in Mice in the Forced Swimming Test

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Food and Nutrition Sciences 2015年第2期6卷 287-298页

作者： Soo-Wan Chae Fusako Mitsunaga Su-Jin Jung Ki-Chan Ha Hong-Sig Sin Seung-Hwan Jang Shin Nakamura Department of Pharmacology Chonbuk National University Medical School Jeonju-si Republic of Korea Clinical Trial Center for Functional Foods (CTCF2) Chonbuk National University Hospital Jeonju-si Republic of Korea Intelligence and Technology lab.Inc. Kaizu Japan NPO Primate Agora Inuyama Japan Healthcare Claims & Management Inc. Jeonju-si Republic of Korea Chebigen Inc. Jeonju-si Republic of Korea

Cordyceps (CS) is used as an alternative medicine and functional food. We examined in vivo mechanisms underlying the antifatigue effects of the cultured mycelium extract of CS (CS extract) in forced swimming mice, a fatigue model that is induced by muscle exercise. Animals orally administered with CS extract significantly extended the loaded forced-swimming time, indicating its antifatigue effects. CS extract modulated the increased levels of blood IL-6 that was induced by forced swimming. CS extract protected the forced swimming-induced increase in NKp46 expression of splenic NK cells, suggesting regulation of fatigue-elicited hyper-reactivity by activated NK cells. By DNA microarray analysis of the quadriceps femoris muscle, it was uncovered that CS extract prevented the forced swimming-mediated upregulation of the expression of 5 genes associating with muscular inflammation (Ccl6, Ccl8, and Wfdc17) and muscle regeneration (Sfrp4 and Nfil3), whereas it regulated the downregulation in the expression of Svs5 participating in actin binding. CS extract exhibits the antifatigue effects through preventing IL-6 accumulation in blood, regulating NK cell activation in the spleen, and alleviating altered expression of genes related to inflammation, regeneration, and actin binding in the local muscle. Thus, CS extract is an effective functional food for preventing fatigue.

关键词： DNA Microarray IL-6 NK Cell Activation Muscle Inflammation

Posterior shoulder fracture-dislocation:A systematic review of the literature and current aspects of management

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Chinese Journal of Traumatology 2021年第1期24卷 18-24页

作者： Georgios Paparoidamis Efthymios Iliopoulos AAli Narvani Ofer Levy Eleftherios Tsiridis loannis Polyzois The Rowley Bristow Unit Ashford&St Peter's HospitalsNHS Foundation TrustChertseySurreyUnited Kingdom Academic Orthopaedic Department Papageorgiou General HospitalFaculty of Health SciencesMedical SchoolAristotle University of Thessalonikiand CORE LabCIRI-AUThThessalonikiGreece Shoulder and Elbow Centre-Reading Shoulder Unit United Kingdom International Center for Arthroplasty&Robotic Orthopaedic Surgery(ICAROS) European Interbalkan Medical CenterThessalonikiGreece Surrey Orthopaedic Clinic United Kingdom

Purpose Posterior fracture-dislocation of shoulder is an infrequent traumatic event;however,most orthopaedic surgeons may face the challenge of treating *** aim of this study is to review and summarise systematically the current principles of the management of this complex injury,and create a treatment *** Both PubMed and Scopus Databases were systematically searched for the terms“posterior shoulder fracture-dislocation”or“posterior glenohumeral fracture-dislocation”or“posterior glenoid fracture-dislocation”for articles written in English and published in the last *** A total of 900 articles were identified,of which 13 were retained for analysis.A total of 153 patients(161 shoulders)were *** patients were treated either with open reduction and internal fixation,modified McLaughlin procedure,allograft/autograft humeral head reconstruction or shoulder *** mean age was 40.15 *** mean postoperative Constant score in cases treated by open reduction and internal fixation was 86.45,whereas by bone graft was ***,the mean postoperative Constant score was between 79.6 and 67.1 in those that were managed by modified McLaughlin and arthroplasty procedure,*** The management of posterior shoulder fracture-dislocation may be challenging,and the best surgical option depends on many variables such as the chronicity of the injury,the presence of a fracture at the level of the surgical neck or tuberosities and the extend of the Hill-Sachs lesion if any.A treatment algorithm is proposed,based on the current literature in an effort to create a consensus for these *** the acute shoulder fracture-dislocations,an open reduction should be *** the chronic fracture/dislocations in the elderly low-demand patients,conservative treatment should be *** the rest of the patients,depending on the severity of the Hill-Sachs lesion different surgical options are availab.e such as the

关键词： Treatment algorithm Shoulder injury Posterior dislocation fracture-dislocation Shoulder dislocation

Using Microscopy to Help with the Understanding of Degradation Mechanisms Observed in Materials of Pressurized Water Reactors

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材料科学与工程（中英文B版） 2017年第5期7卷 187-220页

作者： Laurent Legras Alexandre Volgin Bertrand Radiguet Philippe Pareige Cedric Pokor Brigitte Decamps Thierry Couvant Nicolas Huin Romain Soulas EDF R&D-EDF lab.Les Renardieres Moret sur Loing cedex 77818 France GPM Rouen Avenue de l'Universite Saint-F.tienne-du-Rouvray 76800 France CSNSM IN2P3 Universite de Paris Sud Orsay 91400 France Institut PPrime Universite de Poitiers ISAE-ENSMA UPR 3346 BP 30179 F86962 Futuroscope Chasseneuil France INP Grenoble SIMAP Saint-Martin-d'Heres 38402 France

What is going on in magnesium alloys？

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Journal of Materials Science & Technology 2018年第2期34卷 245-247页

作者： X.J. Wang D.K. Xu R.Z. Wu X.B. Chen Q.M. Peng L. Jin Y.C. Xin Z.Q. Zhang Y. Liu X.H. Chen G. Chen K.K. Deng H.Y. Wang School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China Key lab.ratory of Nuclear Materials and Safety Assessment Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Key lab.ratory of Superlight Materials & Surface Technology (Ministry of Education) Harbin Engineering University Harbin 150001 China School of Engineering RMIT University City Campus Carlton VIC 3053 Australia State Key lab.ratory of Metastable Materials Science and Technology Yanshan University Qinhuangdao 066004 China National Engineering Research Center of Light Alloy Net Forming Shanghai Jiao Tong University Shanghai 200240 China College of Materials Science and Engineering Chongqing University Chongqing 400030 China Key lab.of Electromagnetic Processing of Materials Ministry of Education Northeastern UniversityShnenyang 110819China Key lab.ratory of Lightweight and High Strength Structural Materials of Jiangxi Province Nanchang University Nanchang 330031 China School of Chemical Engineering and Technology Tianjin University Tianjin 300350 China Shanxi Key lab.ratory of Advanced Magnesium-Based Materials Taiyuan University of Technology Taiyuan 030024 China Key lab.ratory of Automobile Materials of Ministry of Education & School of Materials Science and Engineering Jilin University Changchun 130025 China

China has been developed into one of the most active regions in terms of both fundamental and applied research on magnesium （Mg） and its alloys in the world from a solid base laid by its prominent metallurgist and materials scientists over the past decades. Nowadays, a large number of young-generation researchers have been inspired by their predecessors and become the key participants in the fields of Mg alloys, which consequently led to the establishment of China Youth Scholar Society for Magnesium Alloys Research in 2015. Since then, the first two China Youth Scholars Symposiums on Mg Alloys Research had been held at Harbin （2015） and Chongqing （2016） China, respectively. A number of crucial research inter- ests related to fundamental and applied Mg research were discussed at the conferences and summarized in this short perspective, aiming to boost far-reaching initiatives for development of new Mg-based materials to satisfy the requirements for a broad range of industrial employments. Herein, four main aspects are included as follows： i） Plastic deformation mechanism and strengthening strategy, ii） Design and development of new Mg-based materials, iii） Key service properties, and iv） New processing technologies.

关键词： Mg alloys Plastic deformation Strengthening Alloying design High performance Corrosion fatigue behavior Creep Processing technologies Purification

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骨质疏松症影像学检查的进展

中国骨质疏松杂志 2010年第12期16卷 985-993页

作者：戴哲浩戴如春萧毅吕国华蒋业斌中南大学湘雅二医院脊柱外科长沙410011 中南大学湘雅二医院代谢内分泌研究所 Osteoporosis and Arthritis lab University of Michigan1500 E Medical Center Dr.TC-2910Ann ArborMI 48109-5326USA

骨质疏松症是以骨量减少、骨组织微细结构被破坏、骨强度下降、骨脆性增加、极易发生骨折为特征的全身性骨骼疾病。随着老龄人口的增加,骨质疏松成为了一个严峻的公共健康问题。二维双能X线骨密度仪(DXA)是目前临床上检查骨质疏松症的... 详细信息

骨质疏松症是以骨量减少、骨组织微细结构被破坏、骨强度下降、骨脆性增加、极易发生骨折为特征的全身性骨骼疾病。随着老龄人口的增加,骨质疏松成为了一个严峻的公共健康问题。二维双能X线骨密度仪(DXA)是目前临床上检查骨质疏松症的主要手段。近年来,影像学技术进展迅速,特别是三维定量计算机断层扫描(QCT)为进一步检测松质骨及皮质骨骨密度、骨微结构、骨几何特性与其他生物力学参数,探索骨质疏松症的病理生理过程,敏感地进行临床诊断、监控病程变化与疗效提供了技术支持。放射影像学技术与生物力学有限元模型相结合,有利于评价骨强度和骨的力学性能。

关键词：骨质疏松症骨密度骨微结构有限元分析双能X线吸收法定量计算机断层扫描

Unusual cause of acute renal failure from acute pyelonephritis due to Klebsiella pneumoniae in a young woman

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Chinese Medical Journal 2013年第8期126卷 1597-1597页

作者： Zheng Xun-hua Liang Meng-jun Chen Wen-fang Chen Wei-ying Huang Feng-xian Jiang Tang Chen Wei Yu Xue-qing Sun Yat Sen Univ Affiliated Hosp 1 Dept Nephrol Guangzhou 510080 Guangdong Peoples R China Sun Yat Sen Univ Affiliated Hosp 1 Dept Pathol Guangzhou 510080 Guangdong Peoples R China Sun Yat Sen Univ Affiliated Hosp 1 Dept Lab Med Guangzhou 510080 Guangdong Peoples R China

To the editor： Acute pyelonephritis is a common kidney disease in female adult, but an unusual cause of acute renal failure（ARF）. We reported one woman suffered from acute pyelonephritis due to Klehsiella pneumoniae infection presented with ARF and unremarkable abdominal signs, however with a favorable prognosis after appropriate antibiotic treatment.A 23-year-old woman was admitted to the First Affiliated Hospital of Sun Yat-sen University with a 10-day history of abdominal bloating, lower flank pain; 3-day history of fatigue, without fever, urinary urgency, frequency, dysuria or oliguria. She had a history of taking the herbs medicine lbr removing urinary calculi （Wu Lin Hua Shi Dan and other unknown herbs） by herself for one week.

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Iatrogenic opioid dependence is endemic and legal: Genetic addiction risk score (GARS) with electrotherapy a paradigm shift in pain treatment programs

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Health 2013年第11期5卷 16-34页

作者： Kenneth Blum David Han Marlene Oscar-Berman Gary Reinl Nicholas DiNubile Margaret A. Madigan Anish Bajaj Bernard William Downs John Giordano Wayne Westcott Leonard Smith Eric R. Braverman Kristina Dushaj Mary Hauser Thomas Simpatico Thomas McLaughlin Joan Borsten Debmayla Barh Center for Psychiatric Medicine North Andover USA Centre for Genomics and Applied Gene Technology Institute of Integrative Omics and Applied Biotechnology (IIOAB) Nonakuri Purba Medinipur India Department of Addiction Research & Therapy Malibu Beach Recovery Center Malibu Beach USA Department of Executive Health Path Research Foundation NY New York USA Department of Exercise Science Quincy College Quincy USA Department of Holistic Medicine and Pain Track National Institute for Holistic Addiction Studies North Miami Beach USA Department of Management Science and Statistics The University of Texas at San Antonio San Antonio USA Department of Molecular Nutrition Impact Genomics Inc. Austin USA Igene LLC Austin USA Department of Psychiatry Anatomy & Neurobiology Boston VA and Boston University School of Medicine Boston USA Department of Psychiatry College of Medicine & McKnight Brain Institute University of Florida Gainesville USA Department of Executive Health Path Research Foundation NY New York USA Department of Psychiatry College of Medicine & McKnight Brain Institute University of Florida Gainesville USA Electronic Waveform lab Department of Pain Research Huntington Beach USA Department of Orthopedic Surgery Hospital of the University of Pennsylvania Philadelphia USA Department of Molecular Nutrition Impact Genomics Inc. Austin USA Department of Executive Health Path Research Foundation NY New York USA Department of Holistic Medicine and Pain Track National Institute for Holistic Addiction Studies North Miami Beach USA Dominion Diagnostics LLC North Kingstown USA Department of Psychiatry Human Integrated Services Unit of Vermont Center for Clinical & Translational Science University of Vermont College of Medicine Burlington USA Department of Addiction Research & Therapy Malibu Beach Recovery Center Malibu Beach USA Centre for Genomics and Applied Gene Technology Institute of Integrative Omics and Applied Biotechnology (IIOAB) Nonakuri Purba Me

The mounting endemic of prescription iatrogenic opioid dependence in pain patients provoked this treatise about an alternative method that can be used to treat pain, improve function and reduce the risk of opioid dependence. It is well known that as well as the side effects reported for chronic opioid therapy, genetically predisposed individuals are at risk for opioid dependence. We propose the use of the Genetic Addiction Risk Score (GARS) assessment to identify patients early in treatment who should avoid narcotic pain medications. Primarily, this review will be an exploration of the mechanisms of action of an electrotherapeutic alternative to narcotic treatment that can be used to augment tissue healing and reduce the pain associated with human injuries and neuropathies. This particular electrotherapeutic device was developed at the Electronic Waveform lab.ratory in Huntington Beach, California and is called the H-Wave? device. The primary effect of the H-Wave?device is stimulation (HWDS) of small diameter fibers of “red-slow-twitch” skeletal muscle. Mechanisms of action of HWDS have been investigated in both animal and human studies. They include edema reduction, induction of nitric oxide dependent augmented microcirculation and angiogenesis, small muscle contraction that eliminates transcapillary fluid shifts, reducing the painful effects of tetanizing fatigue and gradual loading of healing injured muscle tissue that helps repair and remodeling. A recent metaanalysis found a moderate-to-strong-positive effect of the HWDS in providing pain relief, reducing the requirement for pain medication, with the most robust effect being increased functionality. We are proposing that GARS can be used to identify those at risk of developing opioid dependence and that the need for opioid analgesia can be reduced by use of this electro therapeutic alternative to opioid analgesia in the treatment of pain and injuries.

关键词： Microcirculation Angiogenesis Analgesic Therapy Electrical Device Stimulation Tissue Loading Remodeling Genetic Addiction Risk Score (GARS) Reward Deficiency Syndrome (RDS)

Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress

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Natural Products and Bioprospecting 2023年第1期13卷 159-170页

作者： Lingli Ding Zhao Gao Siluo Wu Chen Chen Yamei Liu Min Wang Yage Zhang Ling Li Hong Zou Guoping Zhao Shengnan Qin Liangliang Xu Key lab.ratory of Orthopaedics and Traumatology Lingnan Medical Research CenterThe First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou University of Chinese MedicineGuangzhouChina Er Sha Sports Training Center of Guangdong Province GuangzhouChina School of Basic Medical Science Guangzhou University of Chinese MedicineGuangzhouChina Engineering lab.ratory for Nutrition Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghaiChina Master lab.for Innovative Application of Nature Products National Center of Technology Innovation for Synthetic BiologyTianjin Institute of Industrial BiotechnologyChinese Academy of SciencesTianjinChina CAS Key lab.ratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina CAS-Key lab.ratory of Synthetic Biology CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghaiChina Bio-Med Big Data Center Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghaiChina State Key lab.ratory of Genetic Engineering Department of Microbiology and ImmunologySchool of Life SciencesFudan UniversityShanghaiChina Department of Microbiology The Chinese University of Hong KongHong KongChina Department of Orthopaedics Guangzhou Institute of Traumatic SurgeryGuangzhou Red Cross HospitalMedical CollegeJinan UniversityGuangzhouChina

Osteoporosis(OP),a systemic and chronic bone disease,is distinguished by low bone mass and destruction of bone *** Compound-K(CK),one of the metabolites of ginsenoside Rb1,has anti-aging,anti-inflammatory,anti-cancer,and hypolipidemic *** have demonstrated CK could promote osteogenesis and fracture healing in our previous ***,the contribution of CK to osteoporosis has not been *** the present study,we investigated the effect of CK on osteoclastogenesis and ovariectomy(OVX)-induced *** results showed that CK inhibited receptor activator for nuclear factor-κB ligand(RANKL)-mediated osteoclast differentiation and reactive oxygen species(ROS)activity by inhibiting the phosphorylation of NF-κB p65 and oxidative stress in RAW264.7 *** addition,we also demonstrated that CK could inhibit bone resorption using bone marrow-derived ***,we demonstrated that CK attenuated bone loss by suppressing the activity of osteoclast and alleviating oxidative stress in *** together,these results showed CK could inhibit osteoclastogenesis and prevent OVX-induced bone loss by inhibiting NF-κB signaling pathway.

关键词： Ginsenoside CK NF-κB signaling pathway Osteoporosis Oxidative stress