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Hydroxytyrosol and Parkinson's disease:protective actions against alpha-synuclein toxicity

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Neural Regeneration Research 2024年第7期19卷 1427-1428页

作者： Ruth Hornedo-Ortega Ana M.Espinosa-Oliva Departamento de Nutrición y Bromatología Toxicología y Medicina LegalFacultad de FarmaciaUniversidad de SevillaSevilleSpain Instituto de Biomedicina de Sevilla IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Departamento de Bioquímica y Biología Molecular Facultad de FarmaciaUniversidad de SevillaSevillaSpain

Parkinson’s disease:Parkinson’s disease(PD) is the second most prevalent neurodegenerative disease,after Alzheimer’s disease,affecting 1%of the general population over the age of *** to data from the World Health Organization(WHO),its prevalence has doubled in the past 25 *** 2019,global estimates indicated over 8.5 million individuals with PD and it is suggested that PD caused 329000 deaths,an increase of over 100% since 2000(WHO,2022).

关键词： protective Alzheimer prevalence

Determination of sildenafil by preconcentration on surfactant coated polymeric resin followed by spectrofluorimetry

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Journal of Pharmaceutical Analysis 2013年第3期3卷 173-179页

作者： Chien C.Wang Roxana A.Gómez Liliana P.Fernandez INQUISAL-CONICET Chacabuco y Pedernera5700-San LuisArgentina Departamento de farmacia Facultad de QuímicaBioquímica y FarmaciaUniversidad Nacional de San LuisArgentina rea de Química Analítica Facultad de QuímicaBioqímica y FarmaciaUniversidad Nacional de San LuisArgentina

The illicit addition of phosphodiesterase type-5 （PDE-5） inhibitors like sildenafil （Viagra） in product offered as herbal medicine or dietary supplement for male erectile dysfunction has concerned authorities in recent times. In this paper, we proposed a sensitive surfactant-coated Amberlite XADTM resin for sildenafil preconcentration method with spectrofluorimetric detection. Retention capacity of micellar coated XAD resin for sildenafil was studied and the obtained eluate was measured by spectrofluorometer at excitation and emission wavelengths of 350 and 430 nm, respectively. This method allowed the detection of sildenafil at 0.15 ng/mL with linear range of 0.0003-7.0 μg/mL. The method has been successfully applied to the analysis of some local commercially available herbal medicines and urine.

关键词： Sildenafil Herbal medicines Spectrofluorimetricanalysis Surfactant

Effects of absolute fasting on reproduction and survival of the invasive apple snail Pomacea canaliculata in its native range

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Current Zoology 2016年第4期62卷 369-375页

作者： Nicolas E. TAMBURI Pablo R. MARTIN INBIOSUR (UNS-CONICET) Universidad Nacional del Sur Departamento de Biologla Bioquimica y Farmacia San Juan 670 8000 Bahia Blanca Argentina

A South American freshwater gastropod, the apple snail Pomacea canaliculata, has become a driver of ecosystemic changes in wetlands and an important rice pest after its introduction to various parts of the world, mainly Asia. The objective of this study was to study the effect of an abrupt interruption in food availability in the short term （up to 4 weeks） and long term （up to 8 months） on survival and re- productive activity. The main results indicate that short-term fasting mainly affects the survival of males, but only when they are raised together with females, probably due to a greater mate-searching activity that increases mortality in the individuals with lower reserves. The number of copulating snails or egg-laying females shows an abrupt drop when fasting and a rapid recovery after the food supply is restored. The strategy of discontinuing reproductive activity prioritizes energy conservation for the survival of the females. Interpopulation variation in resistance to starvation was observed in adults, which can be explained to some extent by the food availability that they experienced in their natural environment. No interpopulational differences in survival were seen in hatchlings. The mean maximum values of survival under starvation were 52.6 days in hatchlings and the 3.3% of adults survive over than 200 days, which may be a relevant trait in dispersal and establishment in new habitats.

关键词： GASTROPODA POMACEA canaliculata WETLANDS STARVATION ENERGy conservation

Microglia depletion as a therapeutic strategy:friend or foe in multiple sclerosis models?

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Neural Regeneration Research 2023年第2期18卷 267-272页

作者： Victoria Sofia Berenice Wies Mancini Anabella Ayelen Di Pietro Laura Andrea Pasquini Universidad de Buenos Aires Facultad de Farmacia y BioquímicaDepartamento de Química BiológicaCátedra de Química Biológica PatológicaBuenos AiresArgentina Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicas y TécnicasInstituto de Química y Fisicoquímica Biológicas Prof.Dr.Alejandro C.PaladiniFacultad de Farmacia y BioquímicaBuenos AiresArgentina

M ultiple sclerosis is a chro nic central nervous system demyelinating disease whose onset and progression are driven by a combination of immune dysregulation,genetic predisposition,and environmental fa *** activation of microglia and astrocytes is a key player in multiple sclerosis immunopathology,playing specific roles associated with anatomical location and phase of the disease and controlling demyelination and *** though reactive mic roglia can damage tissue and heighten deleterious effects and neurodegeneration,activated microglia also perform neuroprotective functions such as debris phagocytosis and growth fa ctor *** can be activated into pro-inflammato ry phenotype A1 through a mechanism mediated by activated neuroinflammatory microglia,which could also mediate *** A1 phenotype inhibits oligodendrocyte prolife ration and differe ntiation and is toxic to both oligodendrocytes and *** r,astroglial activation into phenotype A2 may also take place in response to neurodegeneration and as a protective mechanism.A variety of animal models mimicking specific multiple sclerosis features and the associated pathophysiological processes have helped establish the cascades of events that lead to the initiation,progression,and resolution of the *** colonystimulating facto r-1 receptor is expressed by myeloid lineage cells such as peripheral monocytes and macrophages and central nervous system ***,as microglia development and survival critically rely on colony-stimulating factor-1 receptor signaling,colony-stimulating factor-1 receptor inhibition can almost completely eliminate microglia from the *** this context,the present review discusses the impact of microglial depletion through colo ny-stimulating factor-1 receptor inhibition on demyelination,neurodegeneration,astroglial activation,and behavior in different multiple sclerosis models,highlighting the diversity of micr

关键词： astrocytes colony-stimulating factor-1 receptor inhibition cuprizone demyelnation microglia multiple sclerosis neurodegeneration

High passage numbers induce resistance to apoptosis in C2C12muscle cells

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BIOCELL 2013年第1期37卷 1-9页

作者： LUCIA PRONSATO ANABELA LA COLLA ANA CAROLINA RONDA LORENA MILANESI RICARDOBOLAND ANDREA VASCONSUELO Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur.San Juan 6708000 Bahía BlancaArgentina

Cell lines with high passage numbers exhibit alterations in cell morphology and *** thepresent work,C2C12 skeletal muscle cells with either low(60)passage numbers(identified as l-C2C12 or h-C2C12,respectively)were used to investigate the apoptotic response to H2O2 as a function ofculture age *** found that older cultures(h-C2C12 group)were depleted of mitochondrial DNA(mtDNA).When we analyzed the behavior of Bad,Bax,caspase-3 and mitochondrial transmembrane potential,we observed that cells in the h-C2C12 group were resistant to H2O2 induction of *** propose seriallycultured C2C12 cells as a refractory model to H2O2-induced *** addition,the data obtained in thiswork suggest that mtDNA is required for apoptotic cell death in skeletal muscle C2C12 cells.

关键词： over-subculturing changes aged muscle cultures mitochondrial DNA

Nanoencapsulation of antioxidant peptides from Lupinus mutabilis in chitosan nanoparticles obtained by ionic gelling and spray freeze drying intended for colonic delivery

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Food Bioscience 2022年第6期50卷 603-613页

作者： Arturo Intiquilla Karim Jiménez-Aliaga Amparo Iris Zavaleta Alexander Gamboa Nelson Caro Mario Diaz Martin Gotteland Lilian Abugoch Cristian Tapia Laboratorio de Biología Molecular Facultad de Farmacia y BioquímicaUniversidad Nacional Mayor de San MarcosJirón Puno1002Lima 1Peru Departamento de Ciencia de los Alimentos y tecnología Química Facultad de Ciencias Químicas y FarmacéuticasUniversidad de ChileSantos Dumont 964SantiagoChile Centro de investigación Austral Biotech Universidad de Santo TomasSantiago de ChileChile Facultad de Odontología Universidad de ChileSantiagoChile Departamento de Nutrición Facultad de MedicinaUniversidad de ChileChile.y Laboratorio de Microbiología y ProbióticosInstituto de Nutrición y Tecnología de Alimentos (INTA)Universidad de ChileChile y Núcleo Milenio en la Biología de la Microbiota IntestinalSantiagoChile

Oxidative stress has long been associated with the pathogenesis of inflammatory bowel disease(IBD),and it has been suggested that the combined administration of antioxidants and anti-inflammatory agents may be helpful for its *** from plant proteins,such as soybean glycinin tripeptide VPy,effectively inhibit pro-inflammatory mediators in intestinal epithelial and immune cells,which are both involved in the pathogenesis of *** study aimed to produce antioxidant biopeptides from proteins of Lupinus mutabilis seeds and then encapsulate them in chitosan nanoparticles(NPs)for colonic *** antioxidant peptide fraction of less than three kDa(UF3)was obtained and added at different concentrations(0.1–0.4 mg/ml)in chitosan *** NPs were prepared by gelation with tripolyphosphate(CTPP-UF3)or spray freeze-drying of the chitosan solution(SFDC-UF3).Sizes of 332±13 and 465±58 nm and maximum encapsulation efficiencies of 63.80 and 71.75%,respectively,were ***3 maintained its antioxidant capacity(>80%)and showed different release profiles in 1X PBS buffer at pH 7.4,depending on the encapsulation ***-IR showed hydrogen bonding and electrostatic interactions between the peptide and *** nanosystems maintained cell viability greater than 70%in colonic cell lines *** results show that both methods are appropriate for the nanoencapsulation of UF3 and can be used to design nanoparticles for colonic delivery.

关键词： Antioxidant Peptidic fraction Lupinus mutabilis,chitosan nanoparticles

Ultrastructure of multicellular dwarf males with external gametangium in Oedogonium macrandrium(Oedogoniales,Chlorophyta)

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BIOCELL 2013年第3期37卷 85-90页

作者： Silvana L.D’AMICO Patricia I.LEONARDI Eduardo J.CÁCERES Laboratorio de Ficología y Micología Departamento de BiologíaBioquímica y FarmaciaUniversidad Nacional del SurBahía BlancaArgentina CERZOS-CONICET Camino La Carrindanga Km 7Bahía BlancaArgentina

This is the first comprehensive ultrastructural study on dwarf males with external gametangia in the ge in the genus Oedogonium,from androspore germination to the liberation of mature male *** ultrastructure of the process in *** Wittrok is similar to that of Bulbochaete hiloensis(Nordstedt)Tiffany,butwith two remarkable *** ***:(1)instead of a true transverse wall,only condensed mucilage appears between the gametes of each antheridial cell,and (2)the cell wall between the basal cell and the basal most antheridial cell has simple plasmodesmata similar to those present in the transverse walls of vegetative cells,which are absent in ***.

关键词： androspores Chlorophyta dwarf males Oedogoniales Oedogonium macrandrium ultrastructure

Comparative Analysis of the Antioxidant and Free-Radical Scavenging Activities of Different Water-Soluble Extracts of Green, Black and Oolong Tea Samples

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Food and Nutrition Sciences 2014年第22期5卷 2157-2166页

作者： Jesús Tejero Sara Gayoso Irma Caro Damián Cordoba-Diaz Javier Mateo José E. Basterrechea Tomás Girbés Pilar Jiménez Nutrició n y Bromatologí a Facultad de Medicina and CINAD (Centro de Investigaci&oacute n en Nutrició n Alimentaci&oacute n y Dietética Edificio Lucia-Parque Cientí fico) Universidad de Valladolid Valladolid Spain farmacia y tecnologí a Farmacéutica Facultad de Farmacia and IUFI (Instituto Universitario de Farmacia Industrial) Universidad Complutense de Madrid Madrid Spain Higiene de los Alimentos y tecnologí a Facultad de Veterinaria Universidad de Le&oacute n Le&oacute n Spain

Extracts of 40 green, black or oolong high quality tea samples from China, Japan or India among others, have been prepared according to the manufacturer instructions and assayed for total polyphenols content using the Folin-Ciocalteu phenol reagent. In addition, the antioxidant activity was assessed by the CUPRAC method and the free-radical scavenging activity was determined using the antioxidant-promoting decay of the stable free-radical DPPH. Caffeine and the most important catechins were identified using RP-HPLC previously validated method. Results from this study suggest that teas, even though they content similar amounts of caffeine, differ considerably in polyphenolic content and therefore in antioxidant and free-radical scavenging activities, depending on the part of the plant used and the process applied to the material for the preparation of the final tea presentation. Correlations among Folin-Ciocalteau’s reactivity of tea samples, the neocuproine reactivity, the DPPH decolourization and the HPLC analysis suggest that the antioxidant activity is due essentially to polyphenolic compounds present in teas, mainly EGCG. The best extraction method of tea powder was the one indicated by dealers. In general, the richest samples belong to green teas and the poorest samples belong to the black teas.

关键词： Tea Polyphenols Antioxidants Free-Radical Scavenging

Impact of the non-indigenous shrub species Spartium junceum (Fabaceae) on native vegetation in central Spain

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Journal of Plant Ecology 2016年第2期9卷 132-143页

作者： Rosario G.Gavilán Daniel Sánchez-Mata Mylena Gaudencio Alba Gutiérrez-Girón Beatriz Vilches Departamento de Biología Vegetal II Facultad de FarmaciaUniversidad ComplutensePlaza de Ramón y Cajal s/nE-28040 MadridSpain

Aims The introduction of potentially invasive species through ornamental cultivation or for rehabilitation purposes is a serious environmental *** cause damage to biodiversity through loss,increased mortality or‘in situ’selection phenomena in natural *** junceum is a Mediterranean shrub that is not native in most areas of the Iberian Peninsula,although it is extensively grown for the rehabilitation of *** have investigated the effect on the native vegetation of an old ***(Fabaceae)plantation in a conservation area in the centre of the Iberian Peninsula:the Cuenca Alta del Manzanares nature reserve in *** We compared *** stands with the native nanophanerophytic Cistus ladanifer community at different ecosystem properties:soil properties,temporal soil seed bank contents,standing vegetation and net primary production of annual grasslands growing in these *** Findings The results highlighted ***’s ability to become established in the new environment(marginal areas of the nature reserve)and ensure its successful *** is more apparent in northern and eastern exposures where this formation contacts with the core of the best conserved native vegetation in the nature *** under Spartium showed a higher nitrogen content,indicating its capacity-in common with other legumes-to fix N,and conferring an advantage over Cistus,which is *** soil nutrients such as phosphorus,magnesium and calcium and water availability are also higher in Spartium soils than in *** is usually a constraint for N-fixers,but in our study,it is the most significant soil variable in both shrub formations and is important to the success of *** availability is a key factor for Mediterranean vegetation,and particularly in autumn when soils are *** Spartium formation is able to retain water as its growth produces a closer canopy than Cistus,thereby preventing water evaporatio

关键词： Cistus ladanifer community structure old fields invasive species Mediterranean plant communities non-native species soil seed bank shrublands rehabilitation practices