检索结果-南通市图书馆

Correlations of the expression of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

引用

World Journal of Gastrointestinal Oncology 2025年第1期17卷 207-213页

作者： Rong-Gang Luan Ming-Da Liu Zi-Feng Deng Cong-Lan Lu Mei-Ling Yu Ming-Yu Zhang Rong Liu Ran An You-Liang Yao Dong-Bei Guo Yong-Xing Zhang Lei Zhao Department of Gastrointestinal Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina state Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen 361102Fujian ProvinceChina Trauma Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina Department of Orthopaedics Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ***,reduced expression results in a loss of this capacity to facilitate cyclin E *** ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical *** To investigate the correlation between expression of Cx43,SKP1/Cullin1/F-box(SCF)FBXW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon *** Expression levels of Cx43,SCFFBXW7,p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their *** Positive rate of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%*** expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node ***43 and SCFFBXW7(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCFFBXW7 and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(P<0.05),and expressions of the above proteins were positively correlated in colon *** Cx43 may facilitate the phosphorylation of cyclin E1 at the Ser73 and Thr195 sites through its interaction with SCFFBXW7,thereby influencing the ubiquitination and degradation of cyclin E1.

关键词： Colon cancer Cx43 SCFFBXW7 Phosphorylation of cyclin E1 Sites of cyclin E1 Correlation analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Subgrade-reinforcement techniques for the dangerously deforming sections of railway lines in the north of the Russian far East

引用

Research in Cold and Arid Regions 2017年第3期9卷 197-204页

作者： Alexey Piotrovich Svetlana Zhdanova far eastern state transport university

This paper lists difficult railway construction conditions that are typical for the northern areas of the Russian far ***-bound issues of railway and highway construction and operation are *** of the authors'developme... 详细信息

关键词： permafrost subgrade reinforcement techniques

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

To the issue of stabilization of permafrost soil subgrade

引用

Research in Cold and Arid Regions 2015年第4期7卷 329-334页

作者： Aleksey A.Piotrovich vetlana M.Zhdanova far eastern state transport university

This paper summarizes an analysis of consequences of railway subgrade construction and maintenance solutions in northern areas of the Russian far East. An idea of the natural long-term stabilization of the subgrade-base geotechnical system is presented. Proposals to improve the decision-making of construction and engineering solutions are formulated.

关键词： permafrost soil subgrade stabilization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Investigation of Sintered Maraging Steels

引用

Journal of Materials Science & Technology 2001年第1期17卷 47-48页

作者： S. Chtchegolikhina far eastern state Technical university, Vladivostok, Russia far eastern state Tech Univ Vladivostok Russia

Processing of five grades of sintered maraging steels containing 13% Cr, 9% Ni, 1% Ti and different quantities of Mo, Co is described. Variations of ageing temperatures and ageing holding times had resulted in choosing optimum regime of ageing f T=550℃, T=2.5 h. It allowed to receive mechanical properties of these steels like to them for compact steels; UTS=1200 MPa, EL=5.3%, RA=7%, and Charpy impact =1445 kJ/m2. X-ray analysis had shown phases Fe7Mo6, Fe2Mo in steels containing Co and decreasing of the period 'of or-phase lattice in these steels after ageing.

关键词： Investigation of Sintered Maraging Steels

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biochemical Factors Affecting the Quality of Products and the Technology of Processing Deep-Sea Fish, the Giant Grenadier Albatrossia pectoralis

引用

Journal of Ocean university of China 2020年第3期19卷 681-690页

作者： PIVNENKO T.N. KARPENKO Yu.V. KRASHCHENKO V.V. POZDNYAKOVA Yu.M. ESIPENKO R.V. far eastern state Technical Fisheries university Vladivostok 690087Russia

The composition of muscle tissues of a deep-sea species, the giant grenadier(Albatrossia pectoralis), and a mesopelagic species, the Alaska pollock(Theragra chalcogramma), are compared. Grenadier is proved to have a higher moisture content(91.7%) and lower protein(7.4%) and lipid(0.3%) contents. The factors responsible for the softening and moisture separation during processing of grenadier are identified. Contents of some fractions of non-protein nitrogenous components, including trimethylamine oxide(TMAO) and free amino acids, are clarified. The proportion of the main myofibrillar proteins myosin and actin, which is considered as an indicator of efficiency of structure formation in fish muscle tissue during processing, is almost 20% lower in giant grenadier than in pollock. The effects of endogenous protease, Са^2+-ATPase and transglutaminase on the processes of autolysis, denaturation, and possibility of myofibrillar proteins cross-linking were also studied. The proposed technology of getting a nutritionally balanced, gel-like, ready-to-use foodstuff from grenadier fillet includes its enrichment with pollock muscle tissue and supplementing with a binary structure-forming agent containing collagen and chitosan. Nutritional value of the products is assessed by the method of biological assay and by determining the denaturation changes of myofibrillar proteins. The modes of fine mincing and thermal processing, as well as the shelf-life of the finished product are justified. The developed technology of producing a ready-to-eat food from giant grenadier will allow a more efficient use of this underutilized resource.

关键词： giant grenadier Alaska pollock myosin actin proteases ATPase transglutaminase softening structure formation ready-to-eat foodstuffs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Propagation of vibrations in thawing deep seasonally frozen soils in railway subgrade

引用

Research in Cold and Arid Regions 2015年第5期7卷 534-540页

作者： Gennady M.Stoyanovich Viktor V.Pupatenko transport Construction Institute Department of Railway Track and Railway Engineering Far Eastern State Transport University

In this study, in-situ testing results are given, and the analytical relationship of the vibrations＇ amplitudes inside an em- bankment by the thawing of the subgrade surface of seasonably deep frozen soils is provided. The peculiarities of the vi- bration waves＇ propagation during the springtime thawing of soils compared to those during the summertime period and the correlation of the vibrations with the under-rail basement moduln~ nf ala^tieitv nro dofinod

关键词： railroad subgrade vibrational force deep seasonable frost

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthetic CaSiO3 sol-gel powder and SPS ceramic derivatives: “In vivo” toxicity assessment

引用

Progress in Natural Science:Materials International 2019年第5期29卷 569-575页

作者： Evgeniy Konstantinovich Papynov Oleg Olegovich Shichalin Vladimir Iosifovich Apanasevich Igor Sergeevich Afonin Ivan Olegovich Evdokimov Vitaliy Yurievich Mayorov Arseniy Sergeevich Portnyagin Irina Grigorievna Agafonova Yulia Evgenievna Skurikhina Mikhael Azarievich Medkov Institute of Chemistry Far Eastern Branch of Russian Academy of Sciences far eastern Federal university Pacific state Medical university G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch of Russian Academy of Sciences

The paper presents template strategy using siloxane-acrylate latex and its modified form to prepare nanostructured calcium silicate(wollastonite) containing nanosized gold and regular porosity. Optimal conditions for the annealing of silicate xerogel were outlined leading to nanoporous wollastonite with minimal porous defects(pore size corresponds to latex particles 150–200 nm). The fabrication of nanostructured wollastonite ceramics was suggested to use spark plasma sintering(SPS). The formation of porous ceramic framework(compressive strength ～120 MPa) via SPS consolidation of silicate xerogel(xonotlite) contained latex template(poreformer),a feature of the method for wollastonite template synthesis. The ceramic wollastonite samples have been implanted into ICR/CD1 mice to test the toxicity of the material "in vivo". The results are of great interest for the preparation of high-quality biomaterials for modern medicine using simple technological approaches and available raw materials.

关键词： Porous wollastonite Biomaterials Sol-gel synthesis SPS Toxicity

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Kinetics and Structure of Refractory Compounds and Alloys Obtained by Mechanical Alloying

引用

Journal of Materials Science & Technology 2001年第1期17卷 63-64页

作者： A.A.Popovich V.P.Reva T.A.Popovich O.V Arestov far eastern state Technical university 10 Pushkin Street 690600 VladivostokRussia

Refractory compounds are material with interesting properties for structural applications. However, the processing of Such material is a great challenge because of their high melting temperature and limited ductility. Mechanical alloying is a novel technique of producing refractory compounds with specific properties. Kinetical and structural peculiarities of refractory compounds and alloys obtained by mechanical alloying are discussed.

关键词： mechanical alloying specific properties melting temperature great challenge

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Detection of ground ice using ground penetrating radar method

引用

Research in Cold and Arid Regions 2015年第5期7卷 541-546页

作者： Gennady M.Stoyanovich Viktor V.Pupatenko Yury A.Sukhobok transport Construction Institute Department of Railway Track and Railway Engineering Far Eastern State Transport University

The paper presents the results of a ground penetrating radar （GPR） application for the detection of ground ice. We com- bined a reflection traveltime curves analysis with a frequency spectrogram analysis. We found special anomalies at specific traces in the traveltime curves and ground boundaries analysis, and obtained a ground model for subsurface structure which allows the ground ice layer to be identified and delineated.

关键词： ground penetrating radar ground ice common-offset reflection survey wide angle reflection and refractionmethod

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecules “buckle up” to drive layered hybrid perovskites into single-crystal nanowires in water

引用

Science China Chemistry 2025年第01期 3-4页

作者： Seokhyoung Kim Department of Chemistry Michigan State University

Layered 2D metal halide perovskites (MHPs) are one of the most exciting candidates for next-generation light sources owing to their outstanding optoelectronic properties. These properties are readily tunable by controlling the halide composition, number of inorganic layers, and the chemistry of organic cations. Another key element that can substantially impact the materials’ functionalities is crystal morphology [1].

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：