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The protective effect of Limosilactobacillus reuteri against gestational diabetes mellitus through restoring intestinal microbiota homeostasis and attenuating inflammation in mice

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Food Science and Human Wellness 2024年

作者： Ce Qi Haowen Zhang Zhenli Liu Xiaolin Liu Lintao Zhang Liangliang You Jin Sun institute of Nutrition and Health， Qingdao University QingDao Newhope QinPai Dairy Co.Ltd. Tai'an Maternal and Child Health Hospital Jiaozhou Maternity and Child Health and family planning Service Center

Limosilactobacillus reuteri QS01 is potential probiotic isolated from the intestinal microbiota of healthy women in early pregnancy. In the current study， we examined whether QS01 can prevent gestational diabetes mellitus (GDM) in an enhanced mouse model of the condition. Female C57BL/6J mouse offspring (F1 generation) born to dams fed a control (CON) or low-protein diet (GDM group) during gestation and lactation were used. Pregnant F1 mice fed a standard diet were randomly assigned to 5 groups: CON， GDM， and GDM mice treated with metformin， QS01 or Lacticaseibacillus rhamnosus HN001. An oral glucose tolerance test was performed before sacrifice at gestational day 17. Glucose tolerance was significantly ameliorated by all three treatments. QS01 supplementation fortified the intestinal mucosal barrier and inhibited the escalation of plasma inflammatory cytokines. QS01 treatment altered the cecal microbiota composition and function. Plasma and cecal metabolite profiles were modulated by QS01， prominently demonstrating significant upregulation of indole lactate and L-tryptophan in plasma and 5-hydroxy-tryptophan in the cecum， positively correlated with gut Lactobacillus abundance. In summary， QS01 plays a role in preventing GDM by remodeling the intestinal microbiota， reinforcing the intestinal mucosal barrier and alleviating chronic inflammation.

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Identification of two compound heterozygous GNRHR mutations in two siblings with congenital hypogonadotropic hypogonadism

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Asian Journal of Andrology 2024年第1期26卷 120-122页

作者： Xiao-Bin Wang Ping Chen Xue-Er Yu Zu-Liang Yao Ting-Chao Guo Bo-Chen Pan Center for Reproductive Medicine Department of Obstetrics and GynecologyShengjing Hospital of China Medical UniversityShenyang 110004China NuProbe Shanghai 200433China Urology Surgery of The Affiliated Reproductive Hospital of China Medical University and Liaoning Key Laboratory of Reproductive Health Liaoning Research Institute of Family Planning(The Affiliated Reproductive Hospital of China Medical University)Shenyang 110031China NHC Key Laboratory of Reproductive Health and Medical Genetics China Medical UniversityShenyang 110122China

DearEditor,Congenital hypogonadotropic hypogonadism(CHH)is a rare genetic disease characterized by gonadotropin-releasing hormone(GnRH)deficiency or insufficiency and normal hypothalamic-pituitary structures,resulting in defective sexual maturation or/and infertility.!CHH presents as a variety of nonreproductive phenotypes,such as renal hypoplasia,dental hypoplasia,or oculomotor abnormalities.

关键词： pogon compound ism

Improvements in energy saving and thermal comfort for electric vehicles in summer through coupled electrochromic and radiative cooling smart windows

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Building Simulation 2024年第8期17卷 1231-1251页

作者： Zhoujie Duan Shuangdui Wu Hongli Sun Borong Lin Pei Ding Tao Cui Jeremy To Xi Zhang College of Architectureand Environment Sichuan UniversityChengdu610065China Department of Building Science Tsinghua UniversityBejing 100084China KeyLaboratoryofEco planning&Green Building MinistryofEducationTsinghua UniversityBeijing100084China State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu 610065China School of EmergencyManagement Xihua UniversityChengdu 610039China Department of PSVD Mercedes-benz Group China Ltd.Beijing 100102China

In hot climates,the large amount of cooling load in electric vehicle(EV)results in a lot of battery energy consumption,leading the decrease of driving *** the widespread application of windows in EV,the electrochromic glass(EC)shows great prospect in lowering the cooling ***,researches on the application of EC in EV lack the consideration of both passive cooling measures and passenger comfort,which limits the further application of *** this paper,we proposed an idea combining the novel techniques of both electrochromism and radiative *** fluid dynamics(CFD)is modeled to simulate the application of electrochromic and radiative cooling coupled smart windows in hot parking conditions,exploring the improvement effect of the window on the thermal environment,comfort and energy saving of the *** results indicate that,under the intense sunlight with an outdoor temperature of 33℃,activating the air conditioning to maintain an average interior temperature of 26℃,the coupled windows reduced the cooling capacity of the air conditioning by 762 W compared to regular windows,which can further increase the range of ***,compared to simple electrochromic fully colored glass,the integration of radiative cooling technology can lower the window surface temperature by up to 10.7℃.Moreover,compared to regular windows,the coupled windows lowered the standard effective temperature(SET*)for passengers by approximately 7℃,significantly improving *** research findings are expected to provide guidance for optimizing window design and enhancing the performance of EV.

关键词： electrochromism radiative cooling smart windowel ectric vehicle cabin thermal comfort energy saving

A New Species of the Genus Scincella Mittleman,1950(Squamata:Scincidae)from sichuan Province,Southwest China

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Asian Herpetological research 2024年第2期15卷 115-129页

作者： Ruwan JIA Zongyuan GAO Dihao WU Jinlong REN Dechun JIANG Wei WU CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&Ecological Restoration and Biodiversity Conservation Key Laboratory of sichuan Province Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610213SichuanChina University of Chinese Academy of Sciences Beijing 100049China

The genus Scincella Mittleman,1950,within the family Scincidae,is a diverse group comprising 39 described *** taxonomy of the genus is complex due to morphological similarities among species,which often obscures the true extent of biodiversity,resulting in several undescribed species requiring further *** China,particularly within the unique ecosystems of the Hengduan Mountains,the diversity of Scincella is notably underestimated,with only 12 species currently *** the present study,we describe a new species of the genus Scincella,Scincella liangshanensis ***.,from sichuan Province,Southwest *** characteristics and phylogenetic analyses revealed that the putative new species is distinct from all other known *** discovery not only expands the known diversity of Scincella but also emphasizes the inadequacies in our current understanding of herpetological diversity in *** addition of this species to the scientific record highlights the necessity for ongoing biodiversity assessments to uncover hidden species and enhance our understanding of the intricate web of life in one of the world’s biodiversity hotspots.

关键词： morphology phylogeny Scincella liangshanensis sp.nov. taxonomy the Hengduan Mountains

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Pseudomonas aeruginosa regulator PvrA binds simultaneously to multiple pseudo-palindromic sites for efficient transcription activation

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Science China(Life Sciences) 2024年第5期67卷 900-912页

作者： Yibo Zhu Bingnan Luo Xingyu Mou Yingjie Song Yonghong Zhou Yongbo Luo Bo Sun Youfu Luo Hong Tang Zhaoming Su Rui Bao Center of Infectious Diseases Division of Infectious Diseases in State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Department of Geriatrics and National Clinical research Center for Geriatrics West China HospitalSichuan UniversityChengdu 610041China Key Laboratory of Biodiversity and Environment on the Qinghai-Tibetan Plateau Ministry of EducationSchool of Ecology and EnvironmentTibet UniversityLhasa 850000China Shanghai Advanced research institute Chinese Academy of SciencesShanghai 201210China College of Life Science Sichuan Normal UniversityChengdu 610101China Accurate Biotechnology(Hunan)Co. LtdChangsha 410006China

Tetracycline repressor(TetR)family regulators(TFRs)are the largest group of DNA-binding transcription factors and are widely distributed in bacteria and *** play vital roles in controlling the expression of various genes and regulating diverse physiological ***,a TFR protein Pseudomonas virulence regulator A(PvrA),was identified from Pseudomonas aeruginosa as the transcriptional activator of genes involved in fatty acid utilization and bacterial ***,we show that PvrA can simultaneously bind to multiple pseudo-palindromic sites and upregulate the expression levels of target ***-electron microscopy(cryo-EM)analysis indicates the simultaneous DNA recognition mechanism of PvrA and suggests that the bound DNA fragments consist of a distorted B-DNA double *** crystal structure and functional analysis of PvrA reveal a hinge region that secures the correct domain motion for recognition of the promiscuous ***,our results showed that mutations disrupting the regulatory hinge region have differential effects on biofilm formation and pyocyanin biosynthesis,resulting in attenuated bacterial ***,these findings will improve the understanding of the relationship between the structure and function of the TetR family and provide new insights into the mechanism of regulation of *** virulence.

关键词： Pseudomonas aeruginosa transcription regulator TetR protein-structure virulence

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Association of psychological stress with wives’hypertension across over 10 million Chinese married female population aged 20-49 years

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Chinese Medical Journal 2024年第13期137卷 1583-1591页

作者： Zhenyan Zhao Jiajing Jia Xinyi Lyu Lihua Zhang Yuanyuan Wang Yuan He Zuoqi Peng Ya Zhang Hongguang Zhang Qiaomei Wang Haiping Shen Yiping Zhang Donghai Yan Xu Ma Ying Yang State Key Laboratory of Cardiovascular Disease Department of CardiologyFuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100037China National research institute for family planning Beijing 100081China National Human Genetic Resources Center Beijing 102206China Graduate School of Peking Union Medical College Beijing 100730China Department of Maternal and Child Health National Health and Family Planning Commission of the PRCBeijing 100044China

Background:Psychological stress has been reported to be a potential risk factor for hypertension among females,but it remains unclear whether spousal chronic stress levels alter the risk of hypertension among *** examined the associations between stress within the family and hypertension among married ***:Reproductive-aged women who were planning for pregnancy and their husbands were recruited from the National Free Pre-pregnancy Checkup Projects(NFPCP)across 31 provinces in China in 2016 and *** stress of wives or husbands was measured with a 5-point Likert-type scale,and assessed from three domains:work/life-related stress,economic stress,and overall ***-adjusted logistic regression models were used to assess the associations between stress status and the prevalence of ***:Of 10,027,644 couples,261,098(2.60%)women had *** results showed that higher stress levels among themselves or their husbands were associated with a higher prevalence of hypertension in women(P_(for trend)<0.001).Compared with non-stressed participants,female participants with the highest stress themselves were at a greater risk of hypertension,with adjusted odds ratio(OR)of 1.31(95%confidence interval[CI]:1.25-1.37);and compared with participants whose husbands had no stress,those whose husbands had the highest stress level were at a higher risk of hypertension with adjusted OR of 1.24(95%CI:1.20-1.29).Moreover,compared with non-stressed status for both couples,only-wife-stressed,only-husband-stressed,and both-stressed couples were found to be significantly associated with increased risks of wives’hypertension,with adjusted ORs of 1.28(95%CI:1.25-1.31),1.19(95%CI:1.17-1.21),and 1.28(95%CI:1.26-1.31),***:Moderate to severe stress in both spouses might be associated with female hypertension prevalence,which highlights the importance of paying attention to the psychological stresses of couples within the f

关键词： Psychological stress Hypertension Occupational stress Life stress Financial stress

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Abnormal function of EPHA2/p.R957P mutant in congenital cataract

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1007-1017页

作者： Jing-Jin Zhang Zong-Fu Cao Bi-Ting Zhou Ju-Hua Yang Zhong Li Shuang Lin Xiao-Le Chen Nan-Wen Zhang Qin Ye Xu Ma Yi-Hua Zhu Department of Ophthalmology the First Affiliated Hospital of Fujian Medical UniversityFujian Institute of OphthalmologyFujian Provincial Clinical Medical Research Center of Eye Diseases and OptometryFuzhou 350005Fujian ProvinceChina Department of Ophthalmology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Chinese Academy of Medical Sciences&Peking Union Medical College Beijing 100000China National Human Genetic Resources Center National Research Institute for Family PlanningBeijing 100081China Department of Bioengineering and Biopharmaceutics School of PharmacyFujian Medical UniversityFuzhou 350004Fujian ProvinceChina

AIM:To identify genetic defects in a Chinese family with congenital posterior polar cataracts and assess the ***:A four-generation Chinese family affected with autosomal dominant congenital cataract was *** individuals took part in this study including 5 affected and 14 unaffected *** sequencing targeted hot-spot regions of 27 congenital cataract-causing genes for variant *** pathogenicity of the variant was evaluated by the guidelines of American College of Medical Genetics and InterVar *** microscopy was applied to detect the subcellular localization of fluorescence-labeled ephrin type-A receptor 2(EPHA2).Co-immunoprecipitation assay was implemented to estimate the interaction between EphA2 and other lens membrane *** mRNA and protein expression were analyzed by reverse transcription-polymerase chain reaction(qRT-PCR)and Western blotting assay,*** cell migration was analyzed by wound healing *** model was generated by ectopic expression of human EPHA2/p.R957P mutant to demonstrate whether the mutant could cause lens opacity in ***:A novel missense and pathogenic variant c.2870G>C was identified in the sterile alpha motif(SAM)domain of *** studies demonstrated the variant’s impact:reduced EPHA2 protein expression,altered subcellular localization,and disrupted interactions with other lens membrane *** mutant notably enhanced human lens epithelial cell migration,and induced a central cloudy region and roughness in zebrafish lenses with ectopic expression of human EPHA2/p.R957P mutant under differential interference contrast(DIC)***:Novel pathogenic c.2870G>C variant of EPHA2 in a Chinese congenital cataract family contributes to disease pathogenesis.

关键词： congenital cataract EPHA2 missense variant function analysis

A new production component method for natural gas development planning

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Energy Geoscience 2024年第1期5卷 283-292页

作者： Fanliao Wang Jiangchen Han Shucheng Liu Yanqing Liu Kun Su Jing Du Liru Wang Petroleum Exploration and Production research institute SINOPECBeijing102206China research institute of Petroleum Exploration&Development PetroChinaBeijing100083China

Based on an analysis of the limitations of conventional production component methods for natural gas development planning,this study proposes a new one that uses life cycle models for the trend fitting and prediction of *** this new method,the annual production of old and new wells is predicted by year first and then is summed up to yield the production for the planning *** shows that the changes in the production of old wells in old blocks can be fitted and predicted using the vapor pressure model(VPM),with precision of 80%e95%,which is 6.6%e13.2%higher than that of other life cycle ***,a new production prediction process and method for new wells have been established based on this life cycle model to predict the production of medium-to-shallow gas reservoirs in western sichuan Basin,with predication error of production rate in 2021 and 2022 being 6%and 3%*** new method can be used to guide the medium-and long-term planning or annual scheme preparation for gas *** is also applicable to planning for large single gas blocks that require continuous infill drilling and adjustment to improve gas recovery.

关键词： Production component method Production prediction Life cycle model Gas development planning Western sichuan Basin

Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ

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Frontiers of Medicine 2024年第3期18卷 465-483页

作者： Fei Xu Han Chen Changyi Zhou Tongtong Zang Rui Wang Shutong Shen Chaofu Li Yue Yu Zhiqiang Pei Li Shen Juying Qian Junbo Ge Department of Cardiology and Laboratory of Heart Valve Disease West China HospitalSichuan UniversityChengdu610041China Department of Cardiology Zhongshan HospitalFudan UniversityResearch Unit of Cardiovascular Techniques and DevicesChinese Academy of Medical SciencesShanghai200032China Shanghai institute of Cardiovascular Diseases Shanghai200032China National Clinical research Center for Interventional Medicine&Shanghai Clinical research Center for Interventional Medicine(19MC1910300) Shanghai200032China

Atherosclerosis is a chronic artery disease that causes various types of cardiovascular *** smooth muscle cells(VSMCs),the main components of atherosclerotic plaque,switch from contractile to synthetic phenotypes during *** is crucial in regulating VSMC phenotypes in atherosclerosis,and it can be reversely regulated by ***,the specific effects of deubiquitinases on atherosclerosis have not been thoroughly *** this study,RNAi screening in human aortic smooth muscle cells was performed to explore the effects of OTU family deubiquitinases,which revealed that silencing OTUB1 inhibited PDGF-BB-stimulated VSMC phenotype *** in vivo studies using Apoe−/−mice revealed that knockdown of OTUB1 in VSMCs alleviated atherosclerosis plaque burden in the advanced stage and led to a stable plaque ***,VSMC proliferation and migration upon PDGF-BB stimulation could be inhibited by silencing OTUB1 in *** RNA-sequencing data indicated that knocking down OTUB1 influenced VSMC differentiation,adhesion,and *** spectrometry of ubiquitinated protein confirmed that proteins related to cell growth and migration were differentially ***,we found that OTUB1 recognized the K707 residue ubiquitylation of PDGFRβwith its catalytic triad,thereby reducing the K48-linked ubiquitylation of PDGFRβ.Inhibiting OTUB1 in VSMCs could promote PDGFRβdegradation via the ubiquitin–proteasome pathway,so it was beneficial in preventing VSMCs’phenotype *** findings revealed that knocking down OTUB1 ameliorated VSMCs’phenotype switch and atherosclerosis progression,indicating that OTUB1 could be a valuable translational therapeutic target in the future.

关键词： atherosclerosis vascular smooth muscle cell ubiquitylation deubiquitinase OTUB1 PDGFRβ