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Databases and Web Tools for Cancer Genomics Study

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Genomics, Proteomics & Bioinformatics 2015年第1期13卷 46-50页

作者： Yadong Yang Xunong Dong Bingbing Xie Nan Ding Juan Chen Yongjun Li Qian Zhang Hongzhu Qu Xiangdong Fang CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences University of Chinese Academy of Sciences Technical Service center of family planning and Reproductive Health National Research Institution for Health and Family Planning

Publicly-accessible resources have promoted the advance of scientific discovery. The era of genomics and big data has brought the need for collaboration and data sharing in order to make effective use of this new knowledge. Here, we describe the web resources for cancer genomics research and rate them on the basis of the diversity of cancer types, sample size, omics data comprehensiveness, and user experience. The resources reviewed include data repository and analysis tools; and we hope such introduction will promote the awareness and facilitate the usage of these resources in the cancer research community.

关键词： Cancer Genomics Data integration Resource Collaboration

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Report from 24 hours reproductive health hotline in Shanghai:a preliminary analysis on first 9 months hotline data

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生殖医学杂志 2002年第Z1期11卷 50-55页

作者： Hu Xiaoyu(胡晓宇) Tong Chuanliang(童传良) Chen Junling(陈军玲) Xiao Zhiqin(肖志琴) Cheng Linan(程利南) Shanghai Institute of family planning Technical Instruction 200030 Shanghai Shanghai Institute of Family Planning Technical Instruction 200030 Shanghai Shanghai Institute of Family Planning Technical Instruction 200030 Shanghai Shanghai Institute of Family Planning Technical Instruction 200030 Shanghai Shanghai Institute of Family Planning Technical Instruction 200030 Shanghai

Objectives: To study reproductive health needs of Shanghai people, and to develop appropriate measures to meet their ***: Statistical analysis of 24 hours reproductive health hotline data 4,000 random sampled sex questions, comparing answers from differen t gender and different questions (sex questions vs other non-sex questions).Results: During the first 9 months a total of 44,216 calls wer e received by medical staff. The callers included various age groups (aged 12-7 8), different marital status, from Shanghai and outside. In total, the numbers o f men and women on hotline calls were almost same. The contents of the hotline c ounseling covered all aspects of reproductive health care; among them, the issue concerning male and female sex problems and prenatal and infant health care con stituted 26.5% and 34% respectively. Men asked questions about sex more frequent ly than women, whereas women asked questions more about baby care. Questions a bout sex problems were asked more often in the late evening until next early mor ning. Conclusions: Shanghai people showed higher needs in sexual heal th care, prenatal care and baby care. When they came across some related problem s or confusions, they would like to receive the professional instant counseling. Relevant health care programmes should be established in order to meet the fer tile-aged public's reproductive health needs.

关键词： Reproductive health Hotline Counseling Needs Sex questions

Space reconstruction process and internal driving mechanisms of Taobao villages in metropolitan fringe areas:A case study of Lirendong village in Guangzhou,China

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Journal of Geographical Sciences 2022年第12期32卷 2599-2623页

作者： YANG Ren School of Geography and planning&Land Research center Sun Yat-Sen UniversityGuangzhou 510275China

This paper examines the process and internal mechanisms of rural ecommerce industry agglomeration and space reconstruction in metropolitan fringe areas,employing Lirendong village in Guangzhou,China,as a case *** surveys and in-depth interviews were utilized and interpreted through the perspective of the actor-network *** results show that,in Lirendong village,local government,processing enterprises,rural collectives,e-commerce entrepreneurial talent,and other key actors participate in the pursuit and realization of suburban land value according to their action *** jointly evolved and constructed the phased industrial processes and space value accumulation process of the e-commerce *** reconstruction process experienced three stages,including the government-led agricultural decentralization stage,the market-oriented industrialization stage,and the Internet+stage dominated by the social network of fellow *** development process has evolved from the dominance of exogenous forces to that of endogenous forces,and,as a result,the types and structures of rural land use are *** spatial texture and rural environment of the traditional country gradually disappeared,forming a diversified mixed form of urban-rural land and mixed-use landscape of industrial,commercial,and residential land in vertical *** the same time,the social network changed from a single and homogeneous social network of acquaintances to a multiple network of strangers.

关键词： rural revitalization spatial reconstruction actor-network Internet+ Taobao village China

Three Novel Real-Time RT-PCR Assays for Detection of COVID-19 Virus

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China CDC weekly 2020年第25期2卷 453-457页

作者： Peihua Niu Roujian Lu Li Zhao Huijuan Wang Baoying Huang Fei Ye Wenling Wang Wenjie Tan Key Laboratory of Biosafety National Health and Family Planning CommissionNational Institute for Viral Disease Control and PreventionChina CDCBeijingChina

What is already known on this topic?A novel human coronavirus,known as SARS-CoV-2 or 2019-nCoV,is the causative agent of the coronavirus disease 2019(COVID-19).We have released the primers and probes of real-time reverse transcription polymerase chain reaction(rRT-PCR)assays for the laboratory detection of COVID-19 *** is added by this report?Here we provide detailed technical data and evaluate the performance of three novel rRT-PCR assays targeting the ORF1ab,N,and E genes for detection of COVID-19 *** application of rRT-PCR assays among four types of specimens(alveolar lavage,sputum,throat swabs,and stool)from patients with COVID-19 indicated that the mean viral loads detected in sputum were higher than other *** are the implications for public health practice?These rRT-PCR assays reported here could be used for laboratory diagnosis of COVID-19 infection with high sensitivity,specificity,and *** rather than throat swabs and stool should be a priority for specimen collection for laboratory detection of COVID-19.

关键词： diagnosis specificity stool

Couple＇s infertility in relation to male smoking in a Chinese rural area

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Asian Journal of Andrology 2017年第3期19卷 311-315页

作者： Fen Yang Lin Li Jian-Ping Chen Xiao-Qin Liu Chun-Li Zhong Yuan Yang Yan-Feng Ren Wei Yuan Hong Liang Mao-Hua Miao Department of Reproductive Epidemiology and Social Science National Population and Family Planning Key Laboratory of Contraceptive Drugs and Devices Shanghai Institute of Planned Parenthood Research Shanghai China Shanghai Medical College Fudan University Shanghai China Guizhou family planning Research Institute Guiyang China Department of Health Statistics School of Public Health and Management Weifang Medical College Weifang China

Smoking is a well-known risk factor of reproductive health. However, the effect of paternal smoking on fertility has been less extensively examined. We conducted a cross-sectional study in a mountainous area of South-West China to assess the effect of male smoking on couples＇ fertility. A total of 8200 couples aged 18-49 years in the study area were invited to participate in the study. An in-person interview was performed to collect demographic characteristics of the couples, and husbands＇ life style factors including smoking and drinking habits. Information on time to pregnancy （TTP） was collected retrospectively. Infertility was defined as failure to achieve clinical pregnancy after regular unprotected intercourse for 〉12 months. Logistic regression model was used to estimate the association between male smoking and infertility. A total of 7025 couples were included in the final analysis. After adjusting for potential confounders, the couples were more likely to suffer from infertility if the husbands smoked （adjusted odds ratio [aOR] =1.28, 95% CI： 1.08-1.52） before the first pregnancy. After the analyses were performed according to husbands＇ smoking duration, an increased risk started at a relatively longer smoking duration of 5-10 years （aOR = 1.58, 95% CI. 1.26-1.99） and a stronger association （aOR = 3.34, 95% CI. 2.45-4.56） was observed in the group of 〉10 years. Similar patterns were found for the number of cigarettes smoked per day and the total amount of cigarettes smoked. From our findings, we conclude that male smoking may have an adverse impact on couples＇ infertility.

关键词： cross-sectional study infertility male smoking

Isolation and Characterization of Monkeypox Virus from the First Case of Monkeypox—Chongqing Municipality,China,2022

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China CDC weekly 2022年第46期4卷 1019-1024页

作者： Baoying Huang Hua Zhao Jingdong Song Li Zhao Yao Deng Wen Wang Roujian Lu Wenling Wang Jiao Ren Fei Ye Houwen Tian Guizhen Wu Hua Ling Wenjie Tan Key Laboratory of Biosafety National Health and Family Planning CommissionNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing MunicipalityChina Chongqing center for Disease Control and Prevention Chongqing Municipal Key Laboratory for High Pathogenic MicrobesChongqing MunicipalityChina

Introduction:The first imported case of monkeypox(MPX)from the mainland of China was reported in September ***,the study reports the isolation and characterization of MPX virus(MPXV)in this ***:Clinical specimens including skin blister fluid,oropharyngeal and nasopharyngeal swabs,and blood were collected and inoculated onto Vero *** isolated virus was identified as MPXV using quantitative polymerase chain reaction(qPCR),cytopathic effects(CPEs),immunofluorescence assay(IFA)and transmission electron microscopy(TEM).Plaque assays were employed to quantify infectious plaque-forming units(PFUs).The plaque reduction neutralization test(PRNT)was developed to determine the neutralizing antibody(nAb)against ***:MPXV replication was confirmed with *** CPEs were observed 48 h *** isolated virus was named *** showed that MPXV reacted with serum of MPX *** morphology was observed using *** virus titer increased to>106 PFU/mL after three *** serum PRNT 50%neutralization titer(NT50)was 35 for the MPX patient 6 days after symptom ***:The study successfully isolated the first MPXV strain in the mainland of China,*** titration and PRNT methods have been *** study provides key resources and technical platforms for further research as well as anti-viral drug and vaccine development against MPX.

关键词： mainland Chongqing fir

Strengthening Organizational Support Is Essential for the High-Quality Development of Disease Prevention and Control Initiatives

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China CDC weekly 2024年第38期6卷 982-985页

作者： Ying Cui Qingfeng Chen Hao Chen Kaixuan Liu Yuan Wang Chengyu Lai Zhi Zeng Jun Yan Office of Policy and planning Research Chinese Center for Disease Control and PreventionBeijingChina Chinese center for Disease Control and Prevention BeijingChina

Organizational security in public health encompasses structural and supportive measures designed to ensure public health security and effectively prevent and control disease *** measures include organizational leadership,investment mechanisms,information technology support,scientific research,and international exchange and *** prevention and control is often described as an“invisible war”,emphasizing the need for preparedness and proactive measures(1).As the adage states,“Before soldiers and horses move,food and grass go first,”highlighting the critical role of a robust organizational security foundation for successful disease prevention and control *** foundation is essential for promoting high-quality development within the *** its 14th Five-Year Plan period,the Chinese government has implemented policies to bolster organizational *** this commitment,on December 25,2023,the State Council issued the“Guiding Opinions on Promoting the High-Quality Development of Disease Prevention and Control.”

关键词： prevention measures foundation

Strengthening the Construction of the Talent Team and Promoting the High-Quality Development of Disease Prevention and Control

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China CDC weekly 2024年第38期6卷 986-988页

作者： Qingfeng Chen Ying Cui Hao Chen Chengyu Lai Yuan Wang Kaixuan Liu Yuhui Zhou Office of Policy and planning Research Chinese Center for Disease Control and PreventionBeijingChina Chinese center for Disease Control and Prevention BeijingChina

Talent is essential for development,and career development strategies should prioritize talent cultivation(1–2).China’s CDC workforce comprises a diverse,multidisciplinary team of disease prevention and control *** workforce includes personnel from various CDC agencies,public medical institutions,township health centers,and community health service *** the development of this pool of talent is crucial for enhancing the quality of disease prevention and control systems and forms the foundation of a robust public health infrastructure(3).On December 25,2023,the State Council released the Guideline on Promoting the High-Quality Development of Disease Prevention and Control,outlining a comprehensive strategy for strengthening the CDC’s talent *** paper analyzes this policy to clarify the historical context,principal actions,and future trajectory of workforce development within China’s CDC.

关键词： prevention policy strengthening

Comparison of T-2 Toxin and HT-2 Toxin Distributed in the Skeletal System with That in Other Tissues of Rats by Acute Toxicity Test

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Biomedical and Environmental Sciences 2017年第11期30卷 851-854页

作者： YU Fang Fang LIN Xia Lu YANG Lei LIU Huan WANG Xi FANG Hua Mikko J.LAMMI GUO Xiong Institute of Endemic Diseases School of Public Health of Health Science Center Xi'an Jiaotong University Key Laboratory of Trace Elements and Endemic Diseases National Health and Family Planning Commission Department of Integrative Medical Biology University of Ume?

Twelve healthy rats were divided into the T-2 toxin group receiving gavage of 1 mg/kg T-2 toxin and the control group receiving gavage of normal saline. Total relative concentrations of T-2 toxin and HT-2 toxin in the skeletal system（thighbone, knee joints, and costal cartilage） were significantly higher than those in the heart, liver, and kidneys（P 〈 0.05）. The relative concentrations of T-2 toxin and HT-2 toxin in the skeletal system（thighbone and costal cartilage） were also significantly higher than those in the heart, liver, and kidneys. The rats administered T-2 toxin showed rapid metabolism compared with that in rats administered HT-2 toxin, and the metabolic conversion rates in the different tissues were 68.20%-90.70%.

关键词： Comparison of T-2 Toxin HT-2 Toxin Distributed in the Skeletal System That in Other Tissues of Rats by Acute Toxicity Test