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World Journal of Pediatrics 2024年第4期20卷 404-412页

作者： Xin‑Nan Zong Hui Li Ya‑Qin Zhang department of Growth and development Capital Institute of PediatricsBeijing 100020China

Background A more comprehensive assessment of growth and nutrition in children is required in China due to rapid socioeconomic *** aimed to investigate height and body mass index(BMI)trajectories from 1975 to 2015 and the prevalence of stunting and obesity in 2016 among children in Chinese *** A total of 904,263 children from birth to 6.9 years were collected from a series of nationally representative surveys in *** and BMI trajectories and prevalence of stunting,underweight,overweight and obesity were *** The average height level of Chinese urban children under 7 years presented a positive secular trend from 1975 to 2015;however,a slowing tendency occurred in 2005‒*** apparent increase was observed at the 5th,50th and 95th percentiles of BMI in urban children aged 3 years and older,with a more prominent increase at the 95th *** total prevalence of stunting and underweight under 7 years was 1.4%and 2.0%,*** total prevalence of overweight and obesity under 7 years was 12.6%and 4.3%,respectively,with 12.7%and 4.9%for boys,12.6%and 3.6%for girls,12.1%and 4.0%in urban areas and 13.1%and 4.5%in suburban rural *** The average height level of Chinese urban children has reached World Health Organization child growth standards since 2005 and presented a slowing tendency in secular trend in 2005‒*** attention and efforts and public health interventions should be urgently made to combat overweight and obesity among preschool children.

关键词： Body mass index Children Height Obesity Stunting

Dual PPAR delta/gamma agonist offer therapeutic potential for Alzheimer's disease

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Neural Regeneration Research 2024年第6期19卷 1175-1176页

作者： Ian Steinke Meenakshi Singh Rajesh Amin department of Drug Discovery and development Auburn UniversityAuburn AlabamaALUSA

The increasing incidence of Alzheimer's disease(AD)in the aging population,indicates the critical need for the development of novel targeted molecular therapies for ameliorating AD ***,clinical and preclinical evidence demonstrates that peroxisomal proliferator activating receptors(PPAR)agonists regulate energy and lipid homeostasis in models of diabetes,as well as improve spatial memory in animal models of AD(Khan et al.,2019).

关键词： Alzheimer clinical homeostasis

Growth and development of children in China:achievements,problems and prospects

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World Journal of Pediatrics 2024年第2期20卷 97-104页

作者： Xin-Nan Zong Hui Li department of Growth and development Capital Institute of PediatricsBeijing 100020China

Growth reflects the general condition of society,and is a measure of the nutritional and hygienic status of a population[1,2].Nutrition is one of the most important components of children’s well-being[3].The Chinese government attaches great importance to children’s health and development,with a clear statement and consistent practice for“Children are the future and hope of the motherland”.

关键词： mother statement children

Quantitative characterization of the brittleness of deep shales by integrating mineral content,elastic parameters,in situ stress conditions and logging analysis

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International Journal of Coal Science & Technology 2024年第1期11卷 167-179页

作者： Tongtong Luo Jianguo Wang Li Chen Chaoya Sun Qian Liu Fenggang Wang CCDC Geological Exploration&development Research Institute Chengdu610056SichuanChina China University of Petroleum(Beijing) ChangpingBeijing102249China Exploration and development department of Chongqing Shale Gas Exploration and development Co. Ltd.Chongqing834000China

Deep shale reservoirs(3500–4500 m)exhibit significantly different stress states than moderately deep shale reservoirs(2000–3500 m).As a result,the brittleness response mechanisms of deep shales are also *** is urgent to investigate methods to evaluate the brittleness of deep shales to meet the increasingly urgent needs of deep shale gas *** this paper,the quotient of Young’s modulus divided by Poisson’s ratio based on triaxial compression tests under in situ stress conditions is taken as SSBV(Static Standard Brittleness Value).A new and pragmatic technique is developed to determine the static brittleness index that considers elastic parameters,the mineral content,and the in situ stress conditions(BIEMS).The coefficient of determination between BIEMS and SSBV reaches 0.555 for experimental data and 0.805 for field *** coefficient is higher than that of other brittleness indices when compared to *** can offer detailed insights into shale brittleness under various conditions,including different mineral compositions,depths,and stress *** technique can provide a solid data-based foundation for the selection of‘sweet spots’for single-well engineering and the comparison of the brittleness of shale gas production layers in different areas.

关键词： Deep shale reservoirs Brittleness Pressure effect Evaluation method Longmaxi formation Sichuan Basin

New frontiers in ectopic pancreatic tissue management

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1215-1217页

作者： Serghei Covantsev department of Clinical Research and development Botkin HospitalMoscow 125284Russia

The pancreatic development variations are relatively frequent but are often overlooked in clinical *** is due to the fact that they do not present with a distinct clinical picture and are usually *** also refers to the ectopic pancreatic tissue in the *** anomaly can be diagnosed in any part of the digestive system,but it is mostly seen in the upper gastrointestinal tract,especially in the stomach,duodenum and *** management of this condition has evolved due to the development of minimally invasive procedures.

关键词： Ectopic pancreatic tissue Stomach Endoscopy Laparoscopy Pancreas Anomalies

Design of an automated robotic microinjection system for batch injection of zebrafish embryos and larvae

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Microsystems & Nanoengineering 2024年第1期10卷 89-103页

作者： Zhongyi Guo Nana Ai Wei Ge Qingsong Xu department of Electromechanical Engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina department of Biomedical Sciences and Centre of Reproduction Development and Aging(CRDA)Faculty of Health SciencesUniversity of MacaoMacaoChina

This paper presents the design of a vision-based automated robotic microinjection system for batch injection of both zebrafish embryos and larvae.A novel visual recognition algorithm based on an automatic threshold and excessive dilatation is introduced to accurately identify the center of zebrafish embryos and larval yolks.A corresponding software system is developed using the producer-consumer model as the framework structure,and a friendly user interface is designed to allow operators to choose from a range of desired functions according to their different *** addition,a novel microstructural agarose device is designed and fabricated to simultaneously immobilize mixed batches of embryos and ***,a prototype microinjection system is fabricated by integrating hardware devices with visual *** experimental study is conducted to verify the performance of the robotic microinjection *** results show that the reported system can accurately identify zebrafish embryos and larvae and efficiently complete batch microinjection tasks of the mixtures with an injection success rate of 92.05%in 13.88 s per *** with manual and existing microinjection systems,the proposed system demonstrates the merits of versatility,excellent efficiency,high success rate,high survival rate,and sufficient stability.

关键词： zebra automated hardware

A quasi-zero stiffness energy harvesting isolator with triple negative stiffness

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Acta Mechanica Sinica 2024年第8期40卷 219-238页

作者： Xiangyu Cai Tao Yang Weiyang Qin Zhongliang Xie Research&development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen518057China department of Engineering Mechanics Northwestern Polytechnical UniversityXi’an710072China

Vibration isolation for low frequency excitation and the power supply for low power monitoring sensors are important issues in bridge *** main problem is how to effectively combine the vibration isolator with the energy harvester to form a multi-functional *** this paper,a system called quasi-zero stiffness energy harvesting isolator(QZS-EHI)with triple negative stiffness(TNS)is *** TNS structure consists of linear springs,rigid links,sliders,and ring permanent ***’s second law and Kirchhoff’s law construct dynamic equations of the QZS-EHI,and a comparison is made to contrast it with other QZS and linear *** comparison field includes the QZS range,amplitude-frequency relationship,force transmissibility,and energy harvested *** isolator can be applied to many engineering fields such as bridges,automobiles,and railway *** paper selects bridge engineering as the main field for the dynamic analysis of this *** the multi-span beam bridge,this paper compares different situations including the bridge with QZS-EHI support,with linear stiffness isolator support,and with single beam *** results show that the QZS-EHI is not only better than the traditional isolator with linear stiffness under both harmonic and stochastic excitation,but also better than some QZS isolators with double or single negative stiffness in bridge vibration isolation and energy *** analysis is verified to correspond to the simulation analysis,which means the proposed QZS-EHI has practical application value.

关键词： Quasi-zero stiffness Triple negative stiffness Vibration isolation Energy harvesting

Environmental Impact Assessment of Onshore Wind Farms in the Region of Central Greece Using a Modified RIAM Method

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Journal of Environmental & Earth Sciences 2024年第1期6卷 71-82页

作者： Olga Korozi Dimitra G.Vagiona department of Spatial Planning and development Aristotle University of ThessalonikiThessaloniki 54124Greece

Wind energy is one of the most basic forms of renewable energy,which shows an increasing rate of development worldwide and also at the European ***,this rapid deployment of wind farms makes the need for an impact assessment of this type of projects on the natural and man-made environment *** present paper aims to identify and assess the environmental impacts of wind farm projects in the Region of Central Greece.A modified Rapid Impact Assessment Matrix(RIAM)method is used for this *** methodology includes the identification of the existing onshore wind farm projects in the study area,the appropriate modifications of the RIAM method to respond to the characteristics of the projects and the study area,the qualitative assessment of their potential impacts during construction and operational phases and the computation of the Environmental Performance Grade(EPG)of projects based on the pro-posed modified RIAM *** results reveal that although there are some slight negative impacts on the natural environment of the study area,the examined wind farms contribute positively both to the atmosphere and to the socio-economic environment of the *** study extends the potential for using RIAM as a tool in environmental impact assessment studies of renewable energy projects.

关键词： Environmental impact assessment Environmental components Region of central Greece Rapid impact assessment matrix(RIAM) Environmental performance grade(EPG)

Multi‑omics integration identifies regulatory factors underlying bovine subclinical mastitis

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Journal of Animal Science and Biotechnology 2024年第3期15卷 987-1007页

作者： Mengqi Wang Naisu Yang Mario Laterriere David Gagne Faith Omonijo Eveline M.Ibeagha‑Awemu Agriculture and Agri‑Food Canada Sherbrooke Research and Development CentreSherbrookeQCCanada department of Animal Science Universite LavalQuebec CityQCCanada Quebec Research and development Centre Agriculture and Agri-Food CanadaQuebec CityQCCanada

Background Mastitis caused by multiple factors remains one of the most common and costly disease of the dairy ***-omics approaches enable the comprehensive investigation of the complex interactions between mul-tiple layers of information to provide a more holistic view of disease ***,this study investigated the genomic and epigenomic signatures and the possible regulatory mechanisms underlying subclinical mastitis by integrating RNA sequencing data(mRNA and lncRNA),small RNA sequencing data(miRNA)and DNA methylation sequencing data of milk somatic cells from 10 healthy cows and 20 cows with naturally occurring subclinical mastitis caused by Staphylococcus aureus or Staphylococcus *** Functional investigation of the data sets through gene set analysis uncovered 3458 biological process GO terms and 170 KEGG pathways with altered activities during subclinical mastitis,provided further insights into subclin-ical mastitis and revealed the involvement of multi-omics signatures in the altered immune responses and impaired mammary gland productivity during subclinical *** abundant genomic and epigenomic signatures with sig-nificant alterations related to subclinical mastitis were observed,including 30,846,2552,1276 and 57 differential methylation haplotype blocks(dMHBs),differentially expressed genes(DEGs),lncRNAs(DELs)and miRNAs(DEMs),***,5 factors presenting the principal variation of differential multi-omics signatures were *** important roles of Factor 1(DEG,DEM and DEL)and Factor 2(dMHB and DEM),in the regulation of immune defense and impaired mammary gland functions during subclinical mastitis were *** of the omics within Factors 1 and 2 explained about 20%of the source of variation in subclinical ***,networks of impor-tant functional gene sets with the involvement of multi-omics signatures were demonstrated,which contributed to a comprehensive view of the possible regu

关键词： Candidate discriminant multi-omics signature Gene Long non-coding RNA Methylation haplotype block MicroRNA Multi-omics integration Natural killer cell mediated cytotoxicity pathway Staphylococcus aureus infection pathway

Efficient Route Planning for Real-Time Demand-Responsive Transit

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Computers, Materials & Continua 2024年第4期79卷 473-492页

作者： Hongle Li SeongKi Kim development department Changseol Build SystemDaegu42601South Korea Division of Software Convergence Sangmyung UniversitySeoul03016South Korea

Demand Responsive Transit (DRT) responds to the dynamic users’ requests without any fixed routes and timetablesand determines the stop and the start according to the demands. This study explores the optimization of dynamicvehicle scheduling and real-time route planning in urban public transportation systems, with a focus on busservices. It addresses the limitations of current shared mobility routing algorithms, which are primarily designedfor simpler, single origin/destination scenarios, and do not meet the complex demands of bus transit systems. Theresearch introduces an route planning algorithm designed to dynamically accommodate passenger travel needsand enable real-time route modifications. Unlike traditional methods, this algorithm leverages a queue-based,multi-objective heuristic A∗ approach, offering a solution to the inflexibility and limited coverage of suburbanbus routes. Also, this study conducts a comparative analysis of the proposed algorithm with solutions based onGenetic Algorithm (GA) and Ant Colony Optimization Algorithm (ACO), focusing on calculation time, routelength, passenger waiting time, boarding time, and detour rate. The findings demonstrate that the proposedalgorithmsignificantly enhances route planning speed, achieving an 80–100-fold increase in efficiency over existingmodels, thereby supporting the real-time demands of Demand-Responsive Transportation (DRT) systems. Thestudy concludes that this algorithm not only optimizes route planning in bus transit but also presents a scalablesolution for improving urban mobility.

关键词： Autonomous bus route planning real-time dynamic route planning path finding DRT bus route optimization sustainable public transport