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Predictors of premature delivery in patients with intrahepatic cholestasis of pregnancy

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World Journal of Gastroenterology 2007年第46期13卷 6226-6230页

作者： Jurate Kondrackiene Ulrich Beuers Rimantas Zalinkevicius Horst-Dietmar Tauschel Vladas Gintautas Limas Kupcinskas Department of Gastroenterology Kaunas University of MedicineKaunasLithuania Department of Gastroenterology and Hepatology Academic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands Institute of Endocrinology Kaunas University of MedicineKaunasLithuania Dr.falk Pharma gmbh FreiburgGermany Department of Obstetrics and Gynecology Kaunas University of MedicineKaunasLithuania

AIM： To evaluate the predictive value of clinical symptoms and biochemical parameters for prematurity in intrahepatic cholestasis of pregnancy （ICP）. METHODS： Sixty symptomatic patients with ICP were included in this retrospective analysis. Preterm delivery was defined as delivery before 37 wk gestation. Predictors of preterm delivery were disclosed by binary multivariate logistic regression analysis. RESULTS： Mean time of delivery was 38.1 ± 1.7 wk. No stillbirths occurred. Premature delivery was observed in eight （13.3%） patients. Total fasting serum bile acids were higher （47.8 ±15.2 vs 41.0 ± 10.0 μmol/L, P 〈 0.05）, and pruritus tended to start earlier （29.0 ± 3.9 vs 31.6 ± 3.3 wk, P = 0.057） in patients with premature delivery when compared to those with term delivery. Binary multivariate logistic regression analysis revealed that early onset of pruritus （OR 1.70, 95% CI 1.23-2.95, P = 0.038） and serum bile acid （OR 2.13, 95% CI 1.13-3.25, P = 0.013） were independent predictors of preterm delivery. CONCLUSION： Early onset of pruritus and high levels of serum bile acids predict preterm delivery in ICP, and define a subgroup of patients at risk for poor neonatal outcome.

关键词： Intrahepatic cholestasis Delivery Pregnancy

Wireless data transmission using visual codes

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Photonics Research 2014年第5期2卷 150-160页

作者： Thilo Fath falk Schubert Harald Haas Institute for Digital Communications University of EdinburghEH93JL EdinburghUK Innovation Works Germany EADS Deutschland GmbH81663 MunichGermany

In this paper,a new approach for wireless data transmission within an aircraft cabin is *** proposed application enables the transmission of data to a passenger’s user *** wireless in-flight applications are subject to strict frequency and electromagnetic compatibility(EMC)regulations,the data is transferred by optical wireless transmission,specifically by two-dimensional visual *** this end,black-and-white or colored visual code sequences are displayed on the in-flight entertainment *** visual codes are captured by the built-in camera of the passenger’s mobile device and are decoded to reconstruct the transmitted *** order to compensate for frame losses caused by effects like occlusion and motion blur,a temporal forward error correction coding scheme is *** experiments within an Airbus A330 cabin mock-up demonstrate the functionality of the implemented system under realistic conditions such as ambient illumination and geometric *** user devices are used for evaluation;specifically,a low-cost and a high-end smartphone are employed as *** evaluations show that the proposed transmission system achieves data rates of up to 120 kbit/s per individual passenger seat with these user *** the user device has no physical connection to the sensitive on-board system,the proposed transmission system provides an intrinsic safety feature.

关键词： visual illumination correction

Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease

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World Journal of Gastroenterology 2015年第44期21卷 12519-12543页

作者： Emilio G Quetglas Zlatan Mujagic Simone Wigge Daniel Keszthelyi Sebastian Wachten Ad Masclee Walter Reinisch Project Strategy and Science Grünenthal GmbH Internal Medicine University of Maastricht Medical Center Translational Science Grünenthal GmbH Molecular Pharmacology Grünenthal GmbH Internal Medicine. Mc Master University

The search for biomarkers that characterize specific aspects of inflammatory bowel disease(IBD), has received substantial interest in the past years and is moving forward rapidly with the help of modern technologies. Nevertheless, there is a direct demand to identify adequate biomarkers for predicting and evaluating therapeutic response to different therapies. In this subset, pharmacogenetics deserves more attention as part of the endeavor to provide personalized medicine. The ultimate goal in this area is the adjustment of medication for a patient's specific genetic background and thereby to improve drug efficacy and safety rates. The aim of the following review is to utilize the latest knowledge on immunopathogenesis of IBD and update the findings on the field of Immunology and Genetics, to evaluate the response to the different therapies. In the present article, more than 400 publications were reviewed but finally 287 included based on design, reproducibility(or expectancy to be reproducible and translationable into humans) or already measured in humans. A few testshave shown clinical applicability. Other, i.e., genetic associations for the different therapies in IBD have not yet shown consistent or robust results. In the close future it is anticipated that this, cellular and genetic material, as well as the determination of biomarkers will be implemented in an integrated molecular diagnostic and prognostic approach to manage IBD patients.

关键词： Mucosal immunology Biomarkers Pharmacology Mode of

Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

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Matter and Radiation at Extremes 2024年第1期9卷 71-84页

作者： Josef Krása Tomás Burian Vera Hájková Jaromír Chalupský Šimon Jelínek Katerina Frantálová Michal Krupka Zuzana Kuglerová Sushil Kumar Singh Vojtech Vozda Ludek Vysín MichalŠmíd Pablo Perez-Martin Marion Kühlman Juan Pintor Jakub Cikhardt Matthias Dreimann Dennis Eckermann Felix Rosenthal Sam M.Vinko Alessandro Forte Thomas Gawne Thomas Campbell Shenyuan Ren YuanFeng Shi Trevor Hutchinson Oliver Humphries Thomas Preston Mikako Makita Motoaki Nakatsutsumi Xiayun Pan Alexander Köhler Marion Harmand Sven Toleikis Katerina falk Libor Juha Department of Radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of Physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany DESY Photon Science Notkestraße 85D-22607 HamburgGermany Institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft Nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL gmbh Holzkoppel 4D-22869 SchenefeldGermany Technische Universität Dresden 01062 DresdenGermany

We report on an experiment performed at the FLASH2 free-electron laser(FEL)aimed at producing warm dense matter via soft x-ray isochoric *** the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups with varying *** find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi

Energy efficiencies and CO_(2)emissions associated with lowtemperature separation technologies for the processing of formation fluid from the Achimov deposits

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Petroleum Research 2023年第3期8卷 413-423页

作者： Alexandra Saitova Sergey Strokin falk Ahnert Aleksandr Chepurnov Peter the Great St Petersburg Polytechnic University Politechnicheskaya str.29Saint Petersburg195251Russian Federation Wintershall Dea AG Friedrich-Ebert-Straße 160Kassel34119Germany Wintershall Dea Russia gmbh Reshetnikova str.14ASaint Petersburg196105Russian Federation

Three different technologies for the low-temperature separation(LTS)of gas condensate from the Achimov deposits in the Russian Urengoyskoe gas and condensate field were assessed using exergy *** options examined included turbo-expansion and *** exergy values were calculated for material streams and exergy losses and efficiencies were estimated for dedicated equipment used in the *** lowest exergy loss of 4221.2 kW was obtained using turboexpansion and electricity *** carbon release associated with each scenario was calculated while considering different production rates,technological parameters and natural decreases in wellhead *** integral carbon footprint after 40 years of LTS operation was estimated for all cases.A classical ejector-based LTS scheme was shown to produce 1200 t of CO_(2)emissions over 40 years of *** same scheme combined with a turboexpander and electricity generator produced 59%less CO_(2)in the same *** expansion-cogeneration LTS scheme was found to be the most effective and ecologically friendly among the various options based on this analysis.

关键词： Oil and gas field Gas condensate Carbon emission Carbon footprint Complex gas treatment unit

AMS 6915压力传感器在睡眠健康中的应用

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传感器世界 2022年第2期28卷 30-33页

作者： Stefan falk 施林生(译) (译) analog microelectronics gmbh公司德国美因茨55124 上海芸圣微电子有限公司上海201108

睡眠呼吸暂停是一种影响人类睡眠健康的常见疾病,然而许多患者通常并不知道他们患有此类疾病。如今,随着现代医疗技术的不断进步,此类疾病的诊断和治疗可以非常简单地在家中进行。高精度和小型化的压力测量技术可以在后台独立地进行工作... 详细信息

睡眠呼吸暂停是一种影响人类睡眠健康的常见疾病,然而许多患者通常并不知道他们患有此类疾病。如今,随着现代医疗技术的不断进步,此类疾病的诊断和治疗可以非常简单地在家中进行。高精度和小型化的压力测量技术可以在后台独立地进行工作,不仅可以帮助和改善受此影响的病人的生活,同时在降低医疗保健系统的成本方面有着很大的作用。文章叙述了有关睡眠呼吸暂停的疾病起因和监控办法,介绍了一种称为CPAP的呼吸机,通过智能化的压力和流量的测量和控制,可以用来诊断睡眠呼吸暂停疾病,同时也可以辅助病人呼吸。文章重点介绍了用于医用设备的小型OEM压力传感器——AMS 6915。

关键词：压力传感器呼吸监测睡眠健康 CPAP呼吸机

Phase imaging of irradiated foils at the OMEGA EP facility using phase-stepping X-ray Talbot–Lau deflectometry

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High Power Laser Science and Engineering 2023年第4期11卷 45-54页

作者： G.Pérez-Callejo V.Bouffetier L.Ceurvorst T.Goudal S.R.Klein D.Svyatskiy M.Holec P.Perez-Martin K.falk A.Casner T.E.Weber G.Kagan M.P.Valdivia Departamento de Física Teórica Atómica yÓptica Universidad de ValladolidValladolidSpain Universitéde Bordeaux-CNRS-CEA Centre Lasers Intenses et Applications(CELIA)UMR 5107TalenceFrance European XFEL gmbh SchenefeldGermany Laboratory for Laser Energetics RochesterNew YorkUSA CEA-DAM DIFArpajonFrance University of Michigan Ann ArborMichiganUSA Los Alamos National Laboratory Los AlamosNew MexicoUSA Lawrence Livermore National Laboratory LivermoreCaliforniaUSA Helmholtz-Zentrum Dresden-Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany Institute of Physics of the ASCR PragueCzech Republic CEA-CESTA CS 60001Le Barp CedexFrance Blackett Laboratory Imperial College LondonLondonUK Department of Astrophysics and Astronomy The Johns Hopkins UniversityBaltimoreMarylandUSA Center for Energy Research University of California San DiegoSan DiegoCaliforniaUSA

Diagnosing the evolution of laser-generated high energy density(HED)systems is fundamental to develop a correct understanding of the behavior of matter under extreme ***–Lau interferometry constitutes a promising tool,since it permits simultaneous single-shot X-ray radiography and phase-contrast imaging of dense *** present the results of an experiment at OMEGA EP that aims to probe the ablation front of a laser-irradiated foil using a Talbot–Lau X-ray interferometer.A polystyrene(CH)foil was irradiated by a laser of 133 J,1 ns and probed with 8 keV laser-produced backlighter radiation from Cu foils driven by a short-pulse laser(153 J,11 ps).The ablation front interferograms were processed in combination with a set of reference images obtained ex situ using *** managed to obtain attenuation and phase-shift images of a laser-irradiated foil for electron densities above 1022 cm−*** results showcase the capabilities of Talbot–Lau X-ray diagnostic methods to diagnose HED laser-generated plasmas through high-resolution imaging.

关键词： deflectometry OMEGA EP phase-contrast imaging Talbot-Lau X-ray interferometry