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Safety Assessment of a Novel Topical Vehicle for Personalized Treatments in Acne

Journal of Cosmetics, Dermatological Sciences and Applications 2022年第4期12卷 187-200页

作者： Hudson Polonini Anton Ameneiro-Alvarez Clark Zander fagron bv Rotterdam The Netherlands fagron US Saint Paul USA

Acne vulgaris is a common inflammatory disease of the pilosebaceous unit, with a profound impact on the quality of life of patients. In this work, we aimed to study the safety characteristics of CleodermTM, a novel functional semisolid vehicle developed for the compounding of treatments for acne and oily skin. The primary and cumulative irritation and sensitization potential were evaluated in 54 healthy volunteers in a comparative single-blinded study, while the acnegenic and comedogenic potential of the product were assessed in 31 healthy volunteers with combination to oily skin through a non-comparative study. CleodermTM was applied (0.05 g/cm2) in filter paper discs in both studies. For the evaluation of the irritation and sensitization potential, the investigational product, or a control (0.9% NaCl) was applied to the right or left scapular area of the study subjects. No clinical reactions were observed during the induction or challenge phases, suggesting that CleodermTM presents no irritating or allergenic potential. Regarding acnegenicity and comedogenicity, no significant increase in the number of acne lesions linked to the application of the product in four areas of the face was reported, indicating that CleodermTM appears not to display acnegenic and comedogenic potential. Furthermore, over 60% of the study subjects exhibited a decrease in the number of acne lesions after product use. These results show that CleodermTM exhibited no irritating, sensitizing, acnegenic or comedogenic potential, and suggest that it can be considered safe under the study conditions and that the claims dermatologically tested, clinically tested, and non-comedogenic/acnegenic can be supported.

关键词： Acne Vulgaris Personalized Medicine Irritation Sensitization Comedogenicity

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Beauty from within: A Review of the Science behind Yuliv<sup>TM</sup>Collagen Drink: An Anti-Aging Nutraceutical

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Journal of Cosmetics, Dermatological Sciences and Applications 2021年第3期11卷 263-278页

作者： Hudson Polonini Eli Dijkers Anderson O. Ferreira fagron bv Fascinatio Boulevard 350 3065 WB Rotterdam The Netherlands

The use of nutraceuticals to improve skin properties and decelerate skin aging has been gaining attention among dermatologists, over the last years. In this article, we are presenting the theoretical scientific support for YulivTM Collagen Drink, a liquid supplement containing bovine type I collagen peptides, ascorbic acid and Camellia sinensis (green tea) extract and its benefits on the skin. The available literature shows that the ingredients contained in the supplement have the potential to improve of skin hydration, dermis collagen density, and decrease the fragmentation of the dermal collagen network—and therefore reduce wrinkles and sagging and improving elasticity. Additionally, other health benefits could also be observed, such as protection against oxidative stress, contribution to the normal function of the immune system and reducing tiredness and fatigue, and reduction of skin inflammation, improvement of elasticity and prevention of oxidation. For those benefits to be visible, it is likely that continuous use of at least 4 weeks is needed.

关键词： Collagen Peptides Vitamin C Green Tea Beauty Supplement Anti-Aging

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