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Role of copper chelating agents: between old applications and new perspectives in neuroscience

Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese Department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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On approach for obtaining approximate solution to highly nonlinear oscillatory system with singularity

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Acta Mechanica Sinica 2020年第4期36卷 910-917页

作者： Zvonko Rakaric Boris Stojic Department of Mechanics Faculty of Technical SciencesUniversity of Novi Sad21000 Novi SadSerbia Department of Mechanization and Design Engineering Faculty of Technical SciencesUniversity of Novi Sad21000 Novi SadSerbia

This paper deals with further investigations of recently introduced so-called low-frequency pendulum mechanism,which represents an extended form of classical *** equation of motion,which is in Eksergian’s form,is a singular and highly nonlinear second order differential *** is transformed by suitable choice of a new “coordinates”into classical form of nonlinear conservative oscillator containing only inertial and restoring force ***,due to the singularity of coefficient of governing equation that shows hyperbolic growth,Laurent series expansion was *** these,we derived a nonsingular nonlinear differential equation,for which there exists an exact solution in the form of a Jacobi elliptic *** using this exact solution,and after returning to the original coordinate,both explicit expression for approximate natural period and solution of motion of mechanism were *** between approximate solution and solution is obtained by numerical integration of exact equation shows noticeable *** of impact of mechanism parameters on period is given.

关键词： Pendulum mechanism Low frequency Singularity Laurent series Jacobi elliptic function

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Effect of yttrium on photosynthesis and water relations in young maize plants

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Journal of Rare Earths 2014年第4期32卷 371-378页

作者： Ivana Maksimovi Rudolf Kastori Marina Putnik-Deli Milan Boriev faculty of Agriculture University of Novi Sad Department of Biology and Ecology Faculty of SciencesUniversity of Novi Sad

Despite an increase in spectrum of industrial applications of yttrium （Y） and the fact that it is widely present in the soils and plants, some of which are agronomically important crops, its effects on plant growth and metabolism are still obscure. Therefore, the aim of this work was to examine the effect of different concentrations of Y on its accumulation and distribution, photosynthetic responses, water relations, free proline concentration and growth of young maize plants. The experiment was done with maize （Zea mays L., hybrid NS-640）, in water cultures, under semi-controlled conditions of a greenhouse. Plants were supplied with half-strength complete Hoagland nutrient solution, to which was added either 0 （control）, 10-5, 10-4 or 10-3 mol/L Y, in the form of Y（NO）3·5H2O. Each variant was set in thirteen replications, with six plants in each replication. Plants were grown for 21 d and they were at the stage of 3 and 4 leaves when they were analyzed. The presence of Y reduced maize growth and photosynthetic performance. Dimensions of stomata significantly decreased while their density significantly increased on both adaxial and abaxial epidermis. Plant height, root length, total leaf area and dry mass also declined. Concentration of photosynthetic pigments （chl a and b and carotenoids） and free proline decreased. Photosynthesis and transpiration were impaired in the presence of Y-their intensities were also reduced, and the same stands for stomatal conductance of water vapor, photosynthetic water use efficiency （WUE） and water content. Although the highest concentration of Y was found in maize roots in each treatment, Y concentration in the second leaf and shoot also significantly increased with an increase in Y concentration in the nutrient solution. Albeit Y concentration was much higher in roots than in shoots, shoot metabolism and growth were much more disrupted. The results demonstrated that young maize plants accumulated significant amount of Y and that th

关键词： yttrium maize photosynthesis water use efficiency rare earths

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Improving energy efficiency of apple production by reduced application of pesticides

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International Journal of Agricultural and Biological Engineering 2020年第4期13卷 93-102页

作者： Aleksandar Sedlar Ondrej Ponjican Ferenc Kiss Rajko Bugarin Vladimir Visacki Milivoj Radojcin Krstan Keselj University of novi sad Faculty of AgricultureTrg Dositeja Obradovića 821000 Novi SadSerbia University of novi sad Faculty of TechnologyBlv.Cara Lazara 121000 Novi SadSerbia

A large number of apple orchards are treated over 20 times during the vegetation period with high application rates(over 1000 L/hm^(2))or medium application rates(500-1000 L/hm^(2))of pesticides which require significant energy *** research was carried out in the Serbian region of Vojvodina with the aim to show the possibilities to reduce energy usage in apple production by reducing pesticide application rates(200-500 L/hm^(2))and smaller controlled number of treatments with pesticides while maintaining the biological efficiency of apple chemical *** results showed that the cumulative life cycle energy demand of apple production in Vojvodina,assuming a typical 22 annual treatments and relatively high pesticide application rate(1150 L/hm^(2)),was 48 GJ/hm^(2)and energy output was 94 GJ/hm^(2).Reduced number of treatments and lower pesticide application rates have a favorable impact on energy inputs associated with diesel fuel,machinery,chemicals,water and electricity consumption and usage,whereas other energy inputs remain *** energy input for 12 treatments with pesticide application rates of 381 L/hm^(2)was 36 GJ/hm^(2),which is a 25%reduction in comparison to 22 treatments with a pesticide application rate of 1150 L/hm^(2).Reduced number of treatments and pesticide application rate increased the energy use efficiency from 1.96 to 2.61,energy productivity from 0.82 kg/MJ to 1.09 kg/MJ,and net energy from 46 GJ/hm^(2)to 58 GJ/hm^(2).Results also suggest that applying the correct IPM approach can easily lead to a strong reduction in the number of treatments and a major energy saving.

关键词： apple production energy flow pesticide application rates total energy input energy balancing

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An Application of the Shark Skin Denticle Geometry for Windbreak Fence Design and Fabrication

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Journal of Bionic Engineering 2017年第3期14卷 579-587页

作者： Ivana Bajsanski Vesna Stojakovic Bojan Tepavcevic Marko Jovanovic Dejan Mitov Department of Architecture Faculty of Technical Sciences University of Novi Sad Trg Dositeja Obradoviea 6 21000 Novi Sad Serbia

Windbreak fences in open and urban areas can be used to effectively reduce the wind velocity. In this paper we examine how the geometrical shape of the windbreak fence can optimally mitigate wind velocity. We propose an approach for windbreak fence design based on a bionic parametric model of the shark skin denticle geometry, which improves the reduction of the wind velocity around and behind the windbreak fences. The generative model was used to estimate improvements by variations in the parameters of the fence panel＇s geometrical shape, inspired by shark skin denticles. The results of the Computational Fluid Dynamics （CFD） analysis indicates that the fence surface inspired by shark skin performs much better than both flat and cor- rugated surfaces. Taking into account the complex geometry of the surface inspired by shark skin denticles, we propose a fab- rication process using an expanded polystyrene foam （EPS） material, created using an industrial robot arm with a hot-wire tool. Creating EPS moulds for the shark skin denticle panels allows for a richer variety material to be used in the final design, leading both to higher efficiency and a more attractive design.

关键词： bioinspiration shark skin denticle windbreak fence design generative models CFD

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Abstract Volterra equations in locally convex spaces

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Science China Mathematics 2012年第9期55卷 1797-1825页

作者： KOSTIC Marko faculty of Technical Sciences University of Novi SadNovi Sad 21125Serbia

A general class of(a,k)-regularized C-resolvent families is one of efficient research tools for dealing with non-degenerate abstract Volterra equations of scalar *** main purpose of this expository paper is to provide... 详细信息

关键词： abstract Volterra equation locally convex space (a k)-regularized C-resolvent family well-posedness

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Exciton dynamics in different aromatic hydrocarbon systems

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Chinese Physics B 2020年第10期29卷 438-443页

作者： Milica Rutonjski Petar Mali Slobodan Radosevic Sonja Gombar Milan Pantic Milica Pavkov-Hrvojevic Department of Physics Faculty of SciencesUniversity of Novi SadTrg Dositeja Obradovicu 421000 Novi SadSerbia

The exciton dispersion is examined in the case of four selected prototypical molecular solids: pentacene, tetracene, picene, and chrysene. The model parameters are determined by fitting to experimental data obtained by inelastic electron scattering. Within the picture that relies on Frenkel-type excitons we obtain that theoretical dispersion curves along different directions in the Brillouin zone are in good agreement with the experimental data, suggesting that the influence of charge-transfer excitons on exciton dispersion of the analyzed organic solids is not as large as proposed. In reciprocal space directions where Davydov splitting is observed we employ the upgraded version of Hamiltonian used in Materials 11, 2219 (2018).

关键词： aromatic hydrocarbons exciton dispersion Heisenberg model Davydov splitting

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In silico modelling of cancer nanomedicine, across scales and transport barriers

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npj Computational Materials 2020年第1期6卷 899-908页

作者： Namid R.Stillman Marina Kovacevic Igor Balaz Sabine Hauert Department of Engineering Mathematics University of BristolBristolUK Department of Chemistry Biochemistryand Environmental ProtectionFaculty Of SciencesUniversity of Novi SadNovi SadSerbia Laboratory for Meteorology Physicsand BiophysicsFaculty of AgricultureUniversity of Novi SadNovi SadSerbia

Nanoparticles promise to improve the treatment of cancer through their increasingly sophisticated functionalisations and ability to accumulate in certain *** recent work has shown that many nanomedicines fail during clinical *** issue is the lack of understanding of how nanoparticle designs impact their ability to overcome transport barriers in the body,including their circulation in the blood stream,extravasation into tumours,transport through tumour tissue,internalisation in the targeted cells,and release of their active *** computational power,as well as improved multi-scale simulations of tumours,nanoparticles,and the biological transport barriers that affect them,now allow us to investigate the influence of a range of designs in biologically relevant scenarios.

关键词： cancer transport overcome

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Numerical algorithm for rigid body position estimation using the quaternion approach

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Acta Mechanica Sinica 2018年第2期34卷 400-408页

作者： Miodrag Zigic Nenad Grahovac Department of Mechanics Faculty of Technical SciencesUniversity of Novi Sad

This paper deals with rigid body attitude estimation on the basis of the data obtained from an inertial measurement unit mounted on the body. The aim of this work is to present the numerical algorithm, which can be easily applied to the wide class of problems concerning rigid body positioning, arising in aerospace and marine engineering, or in increasingly popular robotic systems and unmanned aerial vehicles. Following the considerations of kinematics of rigid bodies, the relations between accelerations of different points of the body are given. A rotation matrix is formed using the quaternion approach to avoid singularities. We present numerical procedures for determination of the absolute accelerations of the center of mass and of an arbitrary point of the body expressed in the inertial reference frame, as well as its attitude. An application of the algorithm to the example of a heavy symmetrical gyroscope is presented, where input data for the numerical procedure are obtained from the solution of differential equations of motion, instead of using sensor measurements.

关键词： Rigid body Kinematics Inertial measurement unit Euler parameters Quaternion

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Investigation of chlorinated phenols sorption mechanisms on different layers of the Danube alluvial sediment

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Journal of Environmental Sciences 2020年第12期32卷 134-142页

作者： Tamara Apostolovic Jelena Trickovic Marijana Kragulj Isakovski Branislav Jovic Snežana Maletic Aleksandra Tubic Jasmina Agbaba University of novi sad Faculty of SciencesDepartment of ChemistryBiochemistry and Environmental ProtectionTrg Dositeja Obradovica 3Novi SadSerbia

The characteristics of the Danube river alluvial sediment are of great importance in assessing the risk for transport of pollutants to drinking water sources. Characterization of the sediment column layers has shown that the alluvial sediment, sampled near the city of novi sad, is a mesoporous sandy material with certain differences in the properties of individual layers. In order to investigate the sorption mechanisms of four chlorinated phenols(CPs) on the alluvial deposit, static sorption experiments were performed at pH 4, 7 and 10. The results of sorption experiments, confirmed by principal components analysis sugest different mechanisms govern the sorption process at different p H conditions. This can be attributed to the molecular characteristics of CPs, geosorbent properties and to variations in the surface charge of the sorbent at different p H conditions.

关键词： Sorption mechanisms Chlorinated phenols Alluvial sediment Principal component analysis

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