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Pledget-assisted hemostasis to fix residual access-site bleedings after double pre-closure technique

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World Journal of Cardiology 2022年第5期14卷 297-306页

作者： Francesco Burzotta Cristina Aurigemma Mila Kovacevic Enrico Romagnoli stefano Cangemi Francecso Bianchini Marialisa Nesta Piergiorgio Bruno Carlo Trani Dipartimento di scienze Cardiovascolari Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Universitàcattolica del sacro cuore Rome 00168Italy faculty of medicine University of Novi SadNovi SadSerbia Institute of Cardiovascular Diseases of Vojvodina Cardiology ClinicSremska KamenicaSerbia

BACKGROUND The use of pre-closure suture-based devices represents a widely access-site hemostasis technique in percutaneous transfemoral transcatheter-aortic-valvereplacement(TF-TAVR);yet this technique is associated with the risk of a device failure that may result in clinically relevant residual ***,a bailout intervention is *** far,the best management of pre-closure device failure has not been *** To report the first clinical results obtained using a novel bailout hemostasis technique for patients with double suture-based vascular closure device failure in the setting of *** We developed a“pledget-assisted hemostasis”technique to manage residual access-site *** consists of the insertion of a surgical,non-absorbable,polytetrafluoroethylene pledget over the sutures of the two ProGlide(Abbott Vascular,CA,United states).The ProGlide’s knot-pushers are used to push down the pledget and the hand-made slipknot to seal the femoral artery *** technique was used as a bailout strategy in patients undergoing TF-TAVR with a systematic double pre-closure ***-procedural access-site angiography was systematically ***-hospital complications were systematically detected and classified according to Valve Academic Research Consortium-2 *** Out of 136 consecutive patients who underwent TF-TAVR,15 patients(mean age 80.0±7.2 years,66.7%female)with access-site bleeding after double pre-closure technique failure were treated by pledget-assisted *** the majority of patients,16F sheath was used(n=12;80%).In 2 cases(13%),a peripheral balloon was also inflated in the iliac artery to limit blood loss during pledget ***-confirmed hemostasis(primary efficacy endpoint)was achieved in all *** the procedure,1 patient required blood transfusion(2 units),and no other bleeding or major ischemic complication was *** The“pledget assisted hemostasis”might be con

关键词： Transcatheter aortic valve replacement Transcatheter aortic valve implantation Vascular complications Preclosure device Pledget Hemostasis Personalized medicine

Incidence of umbilical vein catheter-associated thrombosis of the portal system: A systematic review and meta-analysis

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World Journal of Hepatology 2021年第11期13卷 1802-1815页

作者： Iliana Bersani Fiammetta Piersigilli Giulia Iacona Immacolata savarese Francesca Campi Andrea Dotta Cinzia Auriti Enrico Di stasio Matteo Garcovich Medical and surgical Neonatology Bambino GesùChildren's HospitalRome 00165Italy Department of Neonatology Cliniques Universitaires Saint LucUniversitèCatholique de LouvainBruxelles 1200Belgium faculty of medicine Imperial College LondonLondon SW72AZUnited Kingdom Department of Biochemistry and Clinical Biochemistry Fondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRoma 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center UniversitàCattolica del Sacro CuoreRome 00168Italy

BACKGROUND The use of umbilical venous catheters(UVCs)in the perinatal period may be associated with severe complications,including the occurrence of portal vein thrombosis(PVT).AIM To assess the incidence of UVC-related PVT in infants with postnatal age up to three *** A systematic and comprehensive database searching(PubMed,Cochrane Library,scopus,Web of science)was performed for studies from 1980 to 2020(the search was last updated on November 28,2020).We included in the final analyses all peer-reviewed prospective cohort studies,retrospective cohort studies and casecontrol *** reference lists of included articles were hand-searched to identify additional studies of *** were considered eligible when they included infants with postnatal age up to three months with UVC-associated *** estimates were pooled by using random effects *** quality of included studies was assessed using the Newcastle-Ottawa *** systematic review was performed according to the Preferred Reporting Items for systematic reviews and Meta-Analysis(PRIsMA)*** Overall,16 studies were considered eligible and included in the final *** data confirmed the relevant risk of UVC-related *** mean pooled incidence of such condition was 12%,although it varied across studies(0%-49%).In 15/16 studies(94%),diagnosis of thrombosis was made accidentally during routine screening controls,whilst in 1/16 study(6%)targeted imaging assessments were carried out in neonates with clinical concerns for a *** position was investigated by abdominal ultrasound(Us)alone in 1/16(6%)studies,by a combination of radiography and abdominal Us in 14/16(88%)studies and by a combination of radiography,abdominal Us and echocardiography in 1/16(6%)*** To the best of our knowledge,this is the first systematic review specifically investigating the incidence of UVC-related *** use of UVCs requires a high index of su

关键词： Portal vein thrombosis Umbilical venous catheter Portal system thrombosis Hepatic thrombosis Neonate Incidence

Epidemiology and risk factors for mortality in critically ill patients with pancreatic infection

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Journal of Intensive medicine 2024年第1期4卷 81-93页

作者： Marie Dejonckheere Massimo Antonelli Kostoula Arvaniti Koen Blot Ben CreaghBrown Dylan Wde Lange Jan De Waele Mieke Deschepper Yalim Dikmen George Dimopoulos Christian Eckmann Guy Francois Massimo Girardis Despoina Koulenti sonia Labeau Jeffrey Lipman Fernando Lipovestky Emilio Maseda Philippe Montravers Adam Mikstacki JoseArtur Paiva Cecilia Pereyra Jordi Rello JeanFrancois Timsit Dirk Vogelaers stijn Blot the Abdominal sepsis study(Abses)group on behalf of the Trials Group of the European society of Intensive Care medicine Department of Internal medicine and Pediatrics Faculty of Medicine and Health SciencesGhent UniversityGhentBelgium Department of Anesthesiology Intensive Care and Emergency MedicineFondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly Universitàcattolica del sacro cuore RomeItaly Intensive Care Unit Papageorgiou University Affiliated HospitalThessaloníkiGreece Department of Epidemiology and Public Health SciensanoIxellesBelgium surrey Perioperative Anaesthetic Critical Care Collaborative Research Group(sPACeR) Royal Surrey County HospitalGuildfordUK Department of Clinical and Experimental medicine University of SurreyGuildfordUK Department of Intensive Care medicine University Medical Center UtrechtUniversity UtrechtUtrechtthe Netherlands Department of Intensive Care medicine Ghent University HospitalGhentBelgium Data science Institute Ghent University HospitalGhentBelgium Department of Anesthesiology and Reanimation Cerrahpasa School of MedicineIstanbul University-CerrahpasaIstanbulTurkey rd Department of Critical Care “EVGENIDIO”HospitalNational and Kapodistrian University of AthensAthensGreece Department of General Visceral and Thoracic SurgeryKlinikum Hannoversch-MuendenGoettingen UniversityGöttingenGermany Division of scientific Affairs-Research European Society of Intensive Care MedicineBrusselsBelgium Anesthesia and Intensive Care Department University Hospital of ModenaModenaItaly UQ Centre for Clinical Research Faculty of MedicineThe University of QueenslandBrisbaneQLDAustralia nd Critical Care Department Attikon University HospitalAthensGreece Department of Nursing Faculty of EducationHealth and Social WorkUniversity College GhentGhentBelgium Jamieson Trauma Institute The University of QueenslandBrisbaneQLDAustralia Nimes University Hospital University of MontpellierNimesFrance Critical Care Department Hospital of the Interamerican Open University(UAI)Buenos AiresArgentina surgical Critical Care Department of AnesthesiaHospital Universitario

Background:The Abses-classification defines specific phenotypes of patients with intra-abdominal infection based on the(1)setting of infection onset(community-acquired,early onset,or late-onset hospital-acquired),(2)presence or absence of either localized or diffuse peritonitis,and(3)severity of disease expression(infection,sepsis,or septic shock).This classification system demonstrated reliable risk stratification in intensive care unit(ICU)patients with intra-abdominal *** study aimed to describe the epidemiology of ICU patients with pancreatic infection and assess the relationship between the components of the Abses-classification and ***:This was a secondary analysis of an international observational study(“Abses”)investigating ICU patients with intra-abdominal *** patients with pancreatic infection were included in this analysis(n=165).Mortality was defined as ICU mortality within 28 days of observation for patients discharged earlier from the *** with mortality were assessed using logistic regression analysis and reported as odds ratio(OR)and 95%confidence interval(CI).Results:The overall mortality was 35.2%(n=58).The independent risk factors for mortality included older age(OR=1.03,95%CI:1.0 to 1.1 P=0.023),localized peritonitis(OR=4.4,95%CI:1.4 to 13.9 P=0.011),and persistent signs of inflammation at day 7(OR=9.5,95%CI:3.8 to 23.9,Psource control interventions within the first week(OR=4.0,95%CI:1.3 to 12.2,P=0.013).Gramnegative bacteria were most frequently isolated(n=58,49.2%)without clinically relevant differences in microbial etiology between survivors and ***:In pancreatic infection,a challenging source/damage control and ongoing pancreatic inflammation appear to be the strongest contributors to an unfavorable short-term *** this limited series,essentials of the Abses-classification,such as the setting of infection onset,diffuse

关键词： Pancreatic infection Intensive care unit Mortality Intra-abdominal infection sepsis

The COVID-19 pandemic and physical activity

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sports medicine and Health science 2020年第2期2卷 55-64页

作者： Jeffrey A.Woods Noah T.Hutchinson scott K.Powers William O.Roberts Mari Carmen Gomez-Cabrera Zsolt Radak Istvan Berkes Anita Boros Istvan Boldogh Christiaan Leeuwenburgh Helio Jose Coelho-Júnior Emanuele Marzetti Ying Cheng Jiankang Liu J.Larry Durstine Junzhi sun Li Li Ji Department of Kinesiology and Community Health University of Illinois at Urbana-ChampaignUSA Division of Nutritional sciences University of Illinois at Urbana-ChampaignUSA Department of Applied Physiology and Kinesiology University of FloridaGainesvilleUSA Department of Family medicine and Community Health University of Minnesota Medical SchoolMinneapolisUSA Freshage Research Group Department of Physiology Faculty of MedicineUniversity of Valencia and CIBERFES.Fundacion Investigacion Hospital Clínico Universitario/INCLIVAValenciaSpain Research Institute of sport science University of Physical EducationBudapestHungary National University of Public service BudapestHungary Department of Microbiology and Immunology University of Texas Medical Branch at GalvestonUSA Institute on Aging College of MedicineUniversity of FloridaGainesvilleUSA universita cattolica del sacro cuore RomeItaly Fondazione Policlinico universitario“Agostino Gemelli”IRCCs Universita Cattolica Del Sacro CuoreRomeItaly Center for Mitochondrial Biology and medicine The Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and TechnologyXi'an Jiaotong UniversityXi'anChina Department of Exercise science Norman J.Arnold School of Public HealthUniversity of South CarolinaColumbiaUSA Institute of sports medicine and Health Chengdu Sport UniversityChengduChina The Laboratory of Physiological Hygiene and Exercise science School of KinesiologyUniversity of Minnesota Twin CitiesMinneapolisUSA

The sARs-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat to human society in terms of health,economy,and *** the virus usually first invades and infects the lung and respiratory track tissue,in extreme cases,almost all major organs in the body are now known to be negatively impacted often leading to severe systemic failure in some ***,there is currently no effective treatment for this ***-existing pathological conditions or comorbidities such as age are a major reason for premature death and increased morbidity and *** immobilization due to hospitalization and bed rest and the physical inactivity due to sustained quarantine and social distancing can downregulate the ability of organs systems to resist to viral infection and increase the risk of damage to the immune,respiratory,cardiovascular,musculoskeletal systems and the *** cellular mechanisms and danger of this“second wave”effect of COVID-19 to the human body,along with the effects of aging,proper nutrition,and regular physical activity,are reviewed in this article.

关键词： Aging Brain Cardiovascular COVID-19 Immune Muscle Nutrition Physical inactivity Respiratory

Maternal supply of methionine during late-pregnancy enhances rate of Holstein calf development in utero and postnatal growth to a greater extent than colostrum source

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Journal of Animal science and Biotechnology 2019年第1期10卷 103-114页

作者： Abdulrahman s.Alharthi Fernanda Batistel Mohamed K.Abdelmegeid Gustavo Lascano Claudia Parys Ariane Helmbrecht Erminio Trevisi Juan J.Loor Mammalian NutriPhysioGenomics Department of Animal Sciences and Division of Nutritional SciencesUniversity of Illinois Department of Animal Dairy and Veterinary SciencesUtah State University Department of Animal medicine Faculty of Veterinary MedicineKafrelsheikh University Department of Animal and Veterinary science Clemson University Evonik Nutrition & Care GmbH Department of Animal sciences Food and Nutrition Faculty of AgricultureFood and Environmental ScienceUniversità Cattolica del Sacro Cuore

Background: Pregnancy and early life are critical periods of plasticity during which the fetus and neonate may be influenced by environmental factors such as *** methionine(Met) supply in non-ruminants during pregnancy can affect offspring development and ***,the objective of this study was to investigate if increasing Met supply during late-pregnancy affects developmental parameters of the calf at birth and if either maternal Met or colostrum from Met-fed cows alters calf *** born to Holstein cows individually-fed a basal control [CON; 1.47 Mcal/kg dry matter(DM) and 15.3% crude protein] diet with no added Met or CON plus ethylcellulose rumen-protected Met(MET; Mepron? at 0.09% of diet DM; Evonik Nutrition & Care GmbH,Germany)during the last 28 ± 2 d of pregnancy were used.A total of 39 calves were in CON(n = 22 bulls,17 heifers) and 42 in MET(n = 20 bulls,22 heifers).At birth,calves were randomly allocated considering dam treatment and colostrum as fol ows: 1) calves from CON cows and colostrum from CON cows(n = 21); 2) calves from CON cows and colostrum from MET cows(n = 18); 3) calves from MET cows and colostrum from MET cows(n = 22); and 4) calves from MET cows and colostrum from CON cows(n = 20).Al calves were housed,managed,and fed individual y during the first 9 wk of ***: Despite greater daily DM intake pre-partum in cows fed MET(15.7 vs.14.4 ± 0.12 kg/d,P strum quality and quantity were not affected by maternal *** birth,MET calves had greater(P ≤ 0.05) body weight(BW,44.1 vs.42.1 ± 0.70 kg),hip height(HH,81.3 vs.79.6 ± 0.53 cm) and wither height(WH,77.8 vs.75.9 ± 0.47 cm).In contrast,concentrations of His,Lys,and Asn in plasma were lower(P ≤ 0.05) in MET *** of colostrum source,the greater BW,HH,and WH in MET calves at birth persisted through 9 wk of age resulting in average responses of + 3.1 kg BW,+ 1.9 cm HH,and + 1.8 cm WH compared with *** daily gain during the 9 wk was(P

关键词： Epigenetics Metabolism Methyl donors Nutritional programming

A novel ABHD5 mutation in two Chanarin Dorfman siblings with severe and heterogeneous clinical phenotype

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Genes & Diseases 2023年第3期10卷 690-693页

作者： solaf Mohamed Elsayed Enza Torre Daniela Tavian Laura Moro Corrado Angelini Tawhida Y.Abdel Ghaffar Khalid Zalata Enas Ezzeldein Fahmy sara Missaglia Medical Genetics Department Faculty of MedicineAin Shams UniversityCairoEgypt Yassin Abdel Ghaffar Center for Liver Disease and Research CairoEgypt Laboratory of Cellular Biochemistry and Molecular Biology CRIBENSCatholic University of the Sacred HeartMilan 20145Italy Department of Psychology Catholic University of the Sacred HeartMilan 20123Italy Department of Pharmaceutical sciences University of Piemonte OrientaleNovara 28100Italy Neuromuscular Lab Department of NeurosciencesUniversity of PadovaCampus Biomedico Pietro D'AbanoPadova 35131Italy

Chanarin Dorfman syndrome(CDs;MIM:275630)is a rare autosomal recessive disorder,characterized by triacylglycerol(TG)accumulation in lipid droplets(LDs)within different tissues including skin,liver,skeletal muscle,bone marrow,eyes,ears,and central nervous system.1 In CDs,the prevalent and always observed clinical feature is a non-bullous congenital ichthyosiform erythroderma(NCIE).

关键词： clinical congenital skeletal