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Changes in acute and late toxicity and patient-reported health-related quality of life following radiotherapy in women with breast cancer:A 1-year longitudinal study

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Journal of Integrative nursing 2024年第1期6卷 15-21页

作者： Gonca Hanedan USLU Aydanur AYDIN Ayla GÜRSOY Department of Radiation Oncology Faculty of MedicineRecep Tayyip Erdogan UniversityRizeTurkey Department of nursing Antalya Bilim UniversityFaculty of Health SciencesGumushane UniversityGumushaneTurkey Department of nursing Faculty of Health SciencesAntalya Bilim UniversityAntalyaTurkey

Objective:The objective of this study was to investigate the frequency of acute and late toxicities,as well as changes in the quality of life(QOL)for breast cancer patients following radiotherapy(RT).Materials and Methods:A total of 108 breast cancer women were recruited for this prospective *** were collected at various intervals;prior to,and 1,3,6 months,and 1 year after radiation *** primary outcomes were toxicity radiation therapy oncology group/European Organization for Research and Treatment of Cancer(EORTC)*** secondary outcome was QOL,measured using EORTC QLQ-C30 and Edmonton Symptom Assessment *** employed Friedman’s two-way analysis to evaluate the changes in QOL over the course of 1 ***:The early toxicities that are most commonly experienced include pharyngeal,skin,and mucous membrane *** toxicities frequently involve skin and submucosal *** measure patient functionality,all functional subscale scores except for the patient’s emotional state increased over time compared to *** of the patients,which were included in the QOL symptom scale,decreased during the follow-up period,except for fatigue;however,changes in pain,insomnia,and loss of appetite did not significantly *** identified the analogous symptom profiles in *** patients’overall health scores declined in the 1st and 3rd months after radiotherapy(RT),they rebounded at 6 and 12 ***:For breast cancer patients,RT did not adversely affect functional capacity or exacerbate symptoms,but persistent fatigue did increase during the observation ***-care professionals ought to devise strategies to assist patients with skin toxicity and fatigue.

关键词： Breast cancer health‑related quality of life radiotherapy toxicity

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nursing student volunteers and their level of involvement during the COVID-19 pandemic:a systematic review

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Frontiers of nursing 2024年第1期11卷 23-37页

作者： Yayu Nidaul Fithriyyah Syahirul Alim Department of Medical Surgical-nursing Faculty of MedicinePublic Health and NursingUniversitas Gadjah MadaYogyakarta 55281Indonesia Department of Basic&Emergency nursing Faculty of MedicinePublic Health and NursingUniversitas Gadjah MadaYogyakarta 55281Indonesia

Objective:Many strategic efforts were made to address nurses'shortage in controlling Coronavirus disease 2019(COVID-19),including recruiting student health *** review aimed to explore the contribution and involvement of nursing student volunteers during ***:A systematic review was registered in PROSPERO International *** databases for ar ticle search included:SCOPUS,EBSCO MEDLINE,Pub Med,Pro Quest,Springer,Sage Pub,and hand *** critical appraisal study quality using The Joanna Briggs *** extraction and synthesis used Population,Intervention,Comparison,Outcome,and Design(PICO and D)framework with thematic ***:Twelve studies were enrolled from 2545 retrieved,with 4 synthesized themes:(1)determinant of the involvement of nursing student volunteers during COVID-19,which includes 3 subthemes:motivations,perception,and barriers,(2)expectations and actual condition of nursing students as volunteers,(3)the need for nursing student volunteers,and(4)the impact and level of student volunteers'*** student volunteers contribute to providing direct or indirect services to ***:This review provides an overview of nursing student volunteers'needs useful in developing competency frameworks and the role of culturally sensitive volunteers in education and *** the future,student volunteers could choose the appropriate volunteer program and location according to their competence.

关键词： COVID-19 nursing students systematic review volunteers

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Amyloid-beta and tau protein beyond Alzheimer's disease

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Neural Regeneration Research 2024年第6期19卷 1262-1276页

作者： Morteza Abyadeh Vivek Gupta Joao A.Paulo Arezoo Gohari Mahmoudabad Sina Shadfar Shahab Mirshahvaladi Veer Gupta Christine T.O.Nguyen David I.Finkelstein Yuyi You Paul A.Haynes Ghasem H.Salekdeh Stuart L.Graham Mehdi Mirzaei ProGene Technologies Pty Ltd. 2. Department of Clinical medicine Faculty of Medicine Health and Human Sciences Macquarie Medical School Macquarie University Department of Cell Biology Harvard Medical School School of medicine Deakin University Department of Optometry and Vision sciences School of Health Sciences Faculty of Medicine Dentistry and Health Sciences University of Melbourne The Florey Institute of Neuroscience and Mental health The University of Melbourne School of Natural sciences Macquarie University

The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer’s disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. Physiologically, these two proteins are produced and expressed within the normal human body. However, under pathological conditions, abnormal expression, posttranslational modifications, conformational changes, and truncation can make these proteins prone to aggregation, triggering specific disease-related cascades. Recent studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, as well as retinal neurodegenerative diseases like Glaucoma and age-related macular degeneration. Additionally, these proteins have been linked to cardiovascular disease, cancer, traumatic brain injury, and diabetes, which are all leading causes of morbidity and mortality. In this comprehensive review, we provide an overview of the connections between amyloid-beta and tau proteins and a spectrum of disorders.

关键词： amyloid-beta cancer cardiovascular diseases diabetes neurodegeneration Tau traumatic brain injury

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Efficacy of intraovarian autologous platelet-rich plasma administration in women with low ovarian reserve: A systematic review and meta-analysis

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Asian pacific Journal of Reproduction 2024年第2期13卷 60-67页

作者： Yasmin Sabina Sa’diah Agung Dewanto Lukman A Chandra Department of Obstetrics and Gynecology Faculty of MedicinePublic Health and NursingUniversitas Gadjah MadaYogyakartaIndonesia Department of Pharmacology and Therapy Faculty of MedicinePublic Health and NursingUniversitas Gadjah MadaYogyakartaIndonesia

Objective:To conduct a systematic examination and meta-analysis of the most reliable data from experimental studies evaluating the efficacy of autologous platelet-rich plasma(PRP)on low ovarian ***:A comprehensive search was performed utilizing pertinent search terms across electronic databases,including PubMed,Cochrane,and Google *** included studies that assigned infertile women with low ovarian reserve in experimental *** reserve parameters were measured before and after PRP injection into *** data of each study was retrieved and subsequently ***:Of 301 articles collected and reviewed,six studies were finally included in the *** PRP injection,infertile women showed a non-significant increase in anti-Mullerian hormone(AMH)level(MD=0.10;95%CI-0.04,0.23),a significant increase in antral follicular count(AFC)(MD=1.88;95%CI 0.47,3.29),and a non-significant reduction in follicle-stimulating hormone(FSH)level(MD=-0.22;95%CI-8.32,7.87).Conclusions:Autologous PRP may increase AFC,but not *** it is found beneficial in enhancing ovarian reserve(AFC),further research with strong evidence is still required.

关键词： Platelet-rich plasma Low ovarian reserve Ovarian rejuvenation

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Peer pressure and academic stress among junior high school students:a cross-sectional study

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Frontiers of nursing 2024年第2期11卷 191-199页

作者： Rika Sarfika I Made MohYanuar Saifudin Hema Malini Nursyirwan Effendi Bunga Permata Wenny Mental health and Community Department Faculty of NursingUniversitas AndalasPadangWest Sumatra 25163Indonesia Department of medicine and health Faculty of MedicinePublic Healthand NursingUniversitas Gadjah MadaYogyakarta 55281Indonesia Department of Medical Surgical Faculty of NursingUniversitas AndalasPadangWest Sumatra 25163Indonesia Anthropology Department Faculty of Social and Political SciencesUniversitas AndalasPadangWest Sumatra 25163Indonesia

Objective:The objective of the study was to explore the connection between peer pressure and academic stress among junior high school ***:This descriptive correlational study was conducted to investigate the link between perceived peer pressure and academic *** study involved a total of 525 adolescents,aged 14-19 years,drawn from 6 public junior high schools(PJHS)in Padang,Indonesia,using purposive *** stress and perceived peer pressure were assessed using the Educational Stress Scale for Adolescents(ESSA)and the Perceived Peer Pressure Scale(PPPS).Results:The findings indicated significant variations in stress levels among students in different grade levels(7th,8th,and 9th grades)(P0.05).Additionally,there was a positive correlation observed between perceived peer pressure and academic stress(r=0.14,P<0.05).Furthermore,multiple regression analyses,incorporating demographic variables and perceived peer pressure as independent factors,yielded statistically significant results(adjusted R^(2)=0.082,F=4.33,P<0.001).Notably,peer pressure had a direct impact on academic stress among adolescents,with class level and parents’educational background mediating the relationship between academic stress and adolescent behavioral ***:These findings underscore the importance of addressing both external and internal factors at the individual,family,school,and societal levels to enhance adolescents’psychological resilience and mitigate problem behaviors.

关键词： academic stress adolescents behavioral problem Indonesia peer pressure students

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Irregular dietary habits as a predictor of stunting occurrence among children under 5 years of age:a literature review

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Frontiers of nursing 2024年第1期11卷 17-22页

作者： Risnah Huriati Eka Hadrayani Arbianingsih Muthahharah Nurhidayah Sally Purwanti nursing Department Faculty of Health and MedicineUniversitas Islam Negeri AlauddinSouth Sulawesi 92118Indonesia

Objective:To identify the illustration of feeding patterns of stunting children using literature review ***:This study was a descriptive narrative research using literature review approach to explore dietary habits of children with stunting *** the literature review processes employed Guideline Review measurement of Joanna Briggs *** ar ticles in literature were obtained from journal databases,such as Pub Med,Science Direct,Google Scholar,and Dimensions through structured research question with Patient,Exposure an interest,Outcome or response(PEO)***:This study found 2246 published ar ticles from 2018 to 2021 about children with *** process was conducted fur ther to eliminate ar ticles with irrelevant titles and abstracts,and also the unsuitable ar ticles with the research question;hence,about 9 ar ticles were eligible to be reviewed *** these ar ticles mentioned that children with irregular dietary habits would likely experience *** low intake of nutritional food became the major predictor of ***:Inappropriate feeding patterns and the variety of food were being the factors of stunting emergence among children<5 years of *** consumption of carbohydrates,less animal-based protein,and misunderstanding about intake of sweetenedcondensed milk predisposed children to suffer stunting.

关键词： children dietary habit feeding pattern stunting literature review

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Association of spiritual well-being with quality of life among undergraduate nursing students

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Journal of Integrative nursing 2024年第1期6卷 49-54页

作者： Ahmad SHAHID Hina HUSSAIN Nazia SHUAIB Ahmad RASOOL Fatima YOUNIS Zoya NASAB Department of nursing Professional College of Nursing and Health SciencesIslamabadPakistan Department of nursing Rawal Institute of Health SciencesIslamabadPakistan Department of nursing Rawal College of NursingIslamabadPakistan School of nursing and health Zhengzhou UniversityZhengzhouChina

Objective:The study was conducted with the aim of determining the spiritual well-being(SWB)of nursing students and its association with quality of life(QOL).Materials and Methods:A cross-sectional analytical study was conducted with a sample size of 504 nursing students collected from January 2023 to March 2023 in the nursing institutes of Khyber Pakhtunkhwa,Pakistan,using convenient sampling techniques.A Spiritual health and Life-Orientation Measure(SHALOM)questionnaire for SWB and K-27 QOL(K-27 QOL)instrument were used for data collection that contains three ***:The number of female participants was in the majority(50.4%)compared to male nurses(49.6%).The overall mean score of SWB of the students was 3.79±0.48,while the mean K-27 QOL score was 3.73±*** were significant differences between the groups of gender(P=0.001),while no significant difference within the groups of semester(P=0.061)and college status(0.285).In QOL,there were significant differences within the groups of semester(P=0.000)and college status(P=0.036)while no significant difference in gender category(P=0.480).SHALOM score is positively and moderately correlated with QOL score(r=0.597,P<0.05).Conclusion:Spiritual practices are one of the important factors that are associated positively with QOL,therefore to enhance the QOL,it will require spiritual practices.

关键词： nursing education nursing student quality of life spiritual nursing care spirituality well‑being

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Physical activity volume,frequency,and intensity:Associations with hypertension and obesity over 21 years in Australian women

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Journal of Sport and health Science 2024年第5期13卷 631-641页

作者： Gregore I.Mielke Ding Ding Shelley E.Keating Bruno P.Nunes Ruth Brady Wendy J.Brown School of Public health The University of QueenslandBrisbaneQLD 4006Australia Sydney School of Public health Faculty of Medicine and HealthThe University of SydneySydneyNSW 2006Australia The Charles Perkins Centre The University of SydneySydneyNSW 2006Australia School of Human Movement and Nutrition sciences The University of QueenslandBrisbaneQLD 4072Australia School of nursing Federal University of PelotasPelotasRio Grande do Sul 96010-610Brazil faculty of health sciences and medicine Bond UniversityGold CoastQLD 4226Australia

Background:Optimal patterns of accrual of recommended levels of physical activity(PA)for prevention of hypertension and obesity are not *** overall aim of this study was to investigate whether different patterns of accumulation of PA are differentially associated with hypertension and obesity in Australian women over 21 ***,we investigated whether,for the same weekly volume of PA,the number of sessions(frequency)and vigorousness of PA(intensity)were associated with a reduction in the occurrence of hypertension and obesity in ***:Data from the 1973-1978 and 1946-1951 cohorts of the Australian Longitudinal Study on Women's health were analyzed(n=20,588;12%-16%with a Bachelor's or higher degree).Self-reported PA,hypertension,height,and weight were collected using mail surveys every 3 years from 1998/2000 to 2019/*** Estimating Equation models with a 3-year lag model were used to investigate the association of PA volume(metabolic equivalent min/week)(none;33-499;500-999;≥1000,weekly frequency(none;1-2 times;3-4times;5-7 times;≥8 times),and the proportion of vigorous PA to total volume of PA(none;0%;1%-33%;34%-66%;67%-100%)with odds of hypertension and obesity from 2000 to ***:The cumulative incidence of hypertension was 6%in the 1973-1978 and 23%in the 1946-1951 cohort;27%of women in the 1973-1978;and 15%in the 1946-1951 cohort developed obesity over the ***,a higher volume of PA was associated with reduced odds of hypertension and *** the volume of PA was considered,the odds of hypertension did not vary according to the frequency or intensity of ***,increased proportion of vigorous PA to the total volume of PA was associated with a small additional reduction in the risk of obe ***:PA volume appears to be more important than the pattern of accumulation for the prevention of hypertension and *** more sessions,particularly of vigorous-intensity PA,may provide extr

关键词： Physical activity Frequency Intensity Incidences Epidemiology Women

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Bilateral adrenal histoplasmosis in a Malaysian tertiary hospital:Report of four cases

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Asian Pacific Journal of Tropical medicine 2024年第2期17卷 91-94页

作者： Kang WH Norasyikin Abdul Wahab Department of medicine Faculty of Medicine and Health SciencesUniversity Tunku Abdul RahmanMalaysia Department of medicine Pusat Perubatan Universiti KebangsaanMalaysia

Rationale:Adrenal histoplasmosis can present as bilateral adrenal enlargement with constitutional symptoms and/or adrenal *** these patients are initially investigated as secondary adrenal metastases before eventually their diagnosis established by histopathological examination of the adrenal *** concerns:We report 4 cases of patients aged 55-78 who presented with hypocortisolism and bilateral adrenal ***:Bilateral adrenal ***:Three patients received antifungal treatment for at least one year while 1 patient passed away before the initiation of antifungal ***:Two patients’adrenal function recovered not requiring any steroid replacement,while 1 patient still requires long-term steroid ***:Adrenal histoplasmosis should be excluded in patients from endemic areas presenting with bilateral adrenal masses and adrenal *** patients have an exposure to bird droppings,bat guano or soil contaminated with histoplasmosis *** examination of biopsied adrenal tissues is still the gold standard investigation as serology and molecular diagnostic methods are still not widely available in most centers in Malaysia.

关键词： Adrenal histoplasmosis Histoplasmosis Bilateral adrenal masses

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Cardiovascular health awareness,risk perception,behavioural intention and INTERHEART risk stratification among middle-aged adults in Malaysia

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Asian Pacific Journal of Tropical medicine 2024年第2期17卷 61-70页

作者： Siew-Keah Lee Ang-Lim Chua Clement Heng Yew Fong Ban Hao Brian Cong Wen Ling Ng Jing Feng Kong Yik-Ling Chew Kai Bin Liew Yang Shao M.Kandiah faculty of medicine and health sciences Universiti Tunku Abdul RahmanMalaysia faculty of medicine Universiti Teknologi MARAMalaysia faculty of Pharmaceutical sciences UCSI UniversityMalaysia faculty of Pharmacy University of CyberjayaMalaysia The First Affiliated Hospital of Hainan Medical University China

Objective:To investigate the interrelationship between cardiovascular health awareness,risk perception,behavioural intention,and INTERHEART risk stratification in a middle-aged adult population in ***:A cross-sectional survey with convenience sampling was conducted during November 2022 and January *** completed validated questionnaires assessing cardiovascular health awareness,risk perception of cardiovascular diseases,behavioural intention towards adopting healthy habits,and INTERHEART risk stratification score(IHRS)based on established risk factors.A total of 602 respondents were included in the final *** were analysed with independent t-test/one-way ANOVA or Mann-Whitney/Kruskal-Wallis to test the differences,Pearson correlation or linear regression test to analyze the association of independent and dependent ***:There was a significant positive correlation between medical knowledge related to cardiovascular disease(CVD)and knowledge related to CVD risk prevention,risk perception,behavioural intention and IHRS(Phealthcare sector,and those who did not receive the CVD health brochure or are unaware of health self-assessment tools are likely to have lower levels of knowledge,risk perception,and poorer behavioural intention regarding cardiovascular health(P<0.05,one-way ANOVA).While educational level,smoking status,awareness about CVD poster,self-assessment tools were repeatedly significantly associated with knowledge related to CVD and CVD risk prevention,risk perception,behavioral intention and/or IHRS(P<0.05,linear regression).Conclusions:These findings underscore the importance of promoting car

关键词： Cardiovascular risk Knowledge Risk perception Behavioural intention INTERHEART Middle-aged Lifestyle Physical activity Psychosocial stress

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