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Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells

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Science China Life sciences 2025年

作者： Shi Chen Yuanyuan He Lejun Lv Bei Liu Cheng Li Hongkui Deng Jun Xu Department of Cell Biology School of Basic Medical Sciences Peking University Stem Cell Research Center Peking University Health Science Center Peking University Academy of Advanced Interdisciplinary Studies Peking University BeiCell Therapeutics School of Life sciences Center for Bioinformatics Center for Statistical Science Peking University MOE Engineering Research Center of Regenerative Medicine School of Basic Medical Sciences State Key Laboratory of Natural and Biomimetic Drugs Peking University Health Science Center and the MOE Key Laboratory of Cell Proliferation and Differentiation College of Life Sciences Peking-Tsinghua Center for Life Sciences Peking University

Human primed pluripotent stem cells are capable of generating all the embryonic ***,their extraembryonic trophectoderm potentials are *** remains unclear how to expand their developmental potential to trophectoderm *** we show that transient treatment with a cocktail of small molecule epigenetic modulators imparts trophectoderm lineage potentials to human primed pluripotent stem cells while preserving their embryonic *** chemically treated cells can generate trophectoderm-like cells and downstream trophoblast stem cells,diverging into syncytiotrophoblast and extravillous trophoblast *** and CUT&Tag analyses reveal that these induced cells share transcriptional profiles with in vivo trophectoderm and cytotrophoblast,and exhibit reduced H3K27me3 modification at gene loci specific to trophoblast lineages compared with primed pluripotent *** exploration highlighted the critical roles of epigenetic modulators HDAC2,EZH1/2,and KDM5s in the activation of trophoblast lineage *** findings demonstrate that transient epigenetic resetting activates unrestricted lineage potential in human primed pluripotent stem cells,and offer new mechanistic insights into human trophoblast lineage specification and in vitro models for studying placental development and related disorders.

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Stabilization of 4-manifolds

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Science China Mathematics 2014年第9期57卷 1835-1840页

作者： CHO YongSeung Division of mathematical and Physical sciences College of Natural SciencesEwha Womans University

The complex surface X obtained by 8 points blown up on CP2 and Barlow’s surface Y are homeomorphic,but not *** the Gromov-Witten invariant Ruan showed that the stabilized manifolds X×S2and Y×S2are not deformation *** this note,we show that the stabilized manifolds X×S1and Y×S1are diffeomorphic and non-deformation equivalent in cosymplectic sense.

关键词： cosymplectic manifold symplectic manifold Gromov-Witten invariant h-cobordism Whitehead group deformation

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Insights from an academic endeavor into central nervous system drug discovery

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Neural Regeneration Research 2025年第6期20卷 1717-1718页

作者： Lieve van Veggel An M.Voets Tim Vanmierlo Rudy Schreiber BIOMED Biomedical Research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium Department of Psychiatry and Neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharmacology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands University MS Center(UMSC) Hasselt-PeltBelgium

Historically,"big pharma"did most central nervous system drug discovery R&D ***,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(Mazzucato,2013).

关键词： academic approval consequences

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Dynamic Multi-Graph Spatio-Temporal Graph Traffic Flow Prediction in Bangkok:An Application of a Continuous Convolutional Neural Network

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Computer Modeling in Engineering & sciences 2025年第1期142卷 579-607页

作者： Pongsakon Promsawat Weerapan Sae-dan Marisa Kaewsuwan Weerawat Sudsutad Aphirak Aphithana Department of Civil Engineering Faculty of EngineeringRamkhamkaeng UniversityBangkok10240Thailand Department of Computer Engineering Faculty of EngineeringRamkhamkaeng UniversityBangkok10240Thailand Department of Statistics Faculty of ScienceRamkhamkaeng UniversityBangkok10240Thailand

The ability to accurately predict urban traffic flows is crucial for optimising city ***,various methods for forecasting urban traffic have been developed,focusing on analysing historical data to understand complex mobility *** learning techniques,such as graph neural networks(GNNs),are popular for their ability to capture spatio-temporal ***,these models often become overly complex due to the large number of hyper-parameters *** this study,we introduce Dynamic Multi-Graph Spatial-Temporal Graph Neural Ordinary Differential Equation Networks(DMST-GNODE),a framework based on ordinary differential equations(ODEs)that autonomously discovers effective spatial-temporal graph neural network(STGNN)architectures for traffic prediction *** comparative analysis of DMST-GNODE and baseline models indicates that DMST-GNODE model demonstrates superior performance across multiple datasets,consistently achieving the lowest Root Mean Square Error(RMSE)and Mean Absolute Error(MAE)values,alongside the highest *** the BKK(Bangkok)dataset,it outperformed other models with an RMSE of 3.3165 and an accuracy of 0.9367 for a 20-min interval,maintaining this trend across 40 and 60 ***,on the PeMS08 dataset,DMST-GNODE achieved the best performance with an RMSE of 19.4863 and an accuracy of 0.9377 at 20 min,demonstrating its effectiveness over longer *** Los_Loop dataset results further emphasise this model’s advantage,with an RMSE of 3.3422 and an accuracy of 0.7643 at 20 min,consistently maintaining superiority across all time *** numerical highlights indicate that DMST-GNODE not only outperforms baseline models but also achieves higher accuracy and lower errors across different time intervals and datasets.

关键词： Graph neural networks convolutional neural network deep learning dynamic multi-graph spatio-temporal

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Assessment of soil erodibility and aggregate stability for different parts of a forest road

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Journal of Forestry Research 2014年第1期25卷 193-200页

作者： Aidin Parsakhoo Majid Lotfalian Ataollah Kavian Seyed Ataollah Hosseini Department of Forestry Faculty of Forest SciencesGorgan Agricultural Sciences and Natural Resources University Associate Professors Department of ForestryFaculty of Natural ResourcesSari Agricultural Sciences and Natural Resources University Assistant Professor Department of Watershed ManagementFaculty of Natural ResourcesSari Agricultural Sciences and Natural Resources University

We measured erodibility and mean weight diameter （MWD） of soil aggregates in different parts of a forest road. Samples of topsoil were collected from cutslope, fillslope, road surface and forest ground to assess the texture, bulk density, moisture, CaCO3 and organic matter. Soil aggregate stability was determined by wet sieving. Soil erodibility on the road surface was 2.3 and 1.3 times higher than on the fillslope and cutslope, respectively. The forest soil had the lowest erodibility. Aggregate stability of cutslope and road surface were low and very low, respectively. There was a significant negative relationship between cutslope erodibility with CaCO3 and sand content. Cutslope erodibility increased with increasing silt, clay and moisture content. On fillslopes, MWD increased with in-creasing rock fragment cover, plant cover, litter cover, organic matter and sand. There was a strong negative correlation between fillslope erodibility and organic matter, sand and MWD. There was no significant difference between erodibility of bare soil and soils beneathRubus hyrcanusL. and Philonotis marchica （Hedw.） Brid.

关键词： road prism soil erodibility aggregate stability wet sieving Lat Talar forest

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Application of G′/G-expansion Method to Kuramoto-Sivashinsky Equation

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Acta Mathematicae Applicatae Sinica 2016年第3期32卷 623-630页

作者： Ghodrat Ebadi Anjan Biswas faculty of mathematical sciences University of Tabriz Department of mathematical sciences Delaware State University faculty of Science Department of MathematicsKing Abdulaziz University

This paper obtains the solutions of the Kuramoto-Sivashinsky equation. The G′/G method is used to carry out the integration of this equation. Subsequently, its special case, will be integrated and topological 1- soliton solution will be obtained by the soliton ansatz method. The restrictions on the parameters and exponents are also identified.

关键词： evolution equations solitons integrability

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An evaluation of harvesting costs in present and planned operations: case study—Waston District of Mazandaran Wood and Paper Industries

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Journal of Forestry Research 2018年第1期29卷 215-220页

作者： Majid Lotfalian Mohammad Ali Akbari Gorji Seyed Ataollah Hoseini Maryam Kazemi Department of Forestry Faculty of Natural Resources Sari University of Agricultural Sciences and Natural Resources Forestry Master of Science Graduates Faculty of Natural Resources Sari University of Agricultural Sciences and Natural Resources Department of Forestry Faculty of Natural ResourcesTehran University

Amongst all forest utilization phases, harvesting plays a key role as the beginning phase of the utilization cycle and has a significant effect on the following *** this research, in order to examine the reduction of costs with respect to present and planned operations, the starting time of the harvesting or cutting phase and work flow were recorded. The starting time of each phase of the entire operation was recorded as well. Before harvesting the marked tree, the appropriate felling direction was determined and the azimuth of the correct direction was *** results indicate that there was not a meaningful relationship between the differences in direction of a leaning tree compared with the felling direction. However, there was a significant relationship between the difference of the defined and felling direction and the difference in tree leaning and defined direction. The same trend was observed between tree leaning and felling directions and tree leaning and defined directions. On the other hand,there was no significant relationship between tree leaning and felling directions and the defined and tree felling directions. In addition, this research shows that with an increase in tree volume, the time for tree cutting ***, when the difference of tree leaning and felling direction decreased, the time to cut the tree *** regression equation is Y = 168.9–0.14（the difference between tree leaning and felling direction）＋ 0.7（volume）.

关键词： Chainsaw Felling direction Cutting time Tree leaning direction

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MARIE:One-Stage Object Detection Mechanism for Real-Time Identifying of Firearms

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Computer Modeling in Engineering & sciences 2025年第1期142卷 279-298页

作者： Diana Abi-Nader Hassan Harb Ali Jaber Ali Mansour Christophe Osswald Nour Mostafa Chamseddine Zaki Computer Science Department Faculty of SciencesLebanese UniversityBeirut146404Lebanon College of Engineering and Technology American University of the Middle EastEgaila54200Kuwait Lab-STICC CNRS UMR 6285ENSTA-BretagneBrest29200France

Security and safety remain paramount concerns for both governments and individuals *** today’s context,the frequency of crimes and terrorist attacks is alarmingly increasing,becoming increasingly intolerable to ***,there is a pressing need for swift identification of potential threats to preemptively alert law enforcement and security forces,thereby preventing potential attacks or violent *** advancements in big data analytics and deep learning have significantly enhanced the capabilities of computer vision in object detection,particularly in identifying *** paper introduces a novel automatic firearm detection surveillance system,utilizing a one-stage detection approach named MARIE(Mechanism for Realtime Identification of Firearms).MARIE incorporates the Single Shot Multibox Detector(SSD)model,which has been specifically optimized to balance the speed-accuracy trade-off critical in firearm detection *** SSD model was further refined by integrating MobileNetV2 and InceptionV2 architectures for superior feature extraction *** experimental results demonstrate that this modified SSD configuration provides highly satisfactory performance,surpassing existing methods trained on the same dataset in terms of the critical speedaccuracy *** these innovations,MARIE sets a new standard in surveillance technology,offering a robust solution to enhance public safety effectively.

关键词： Firearm and gun detection single shot multi-box detector deep learning one-stage detector MobileNet inception convolutional neural network

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Evaluation of heavy metal contamination hazards in nuisance dust particles, in Kurdistan Province, western Iran

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Journal of Environmental sciences 2013年第7期25卷 1346-1354页

作者： Reza Bashiri Khuzestani Bubak Souri Department of Environmental sciences Faculty of Natural Resources University of Kurdistan

The effects of natural andgeochemical factors depending on heavy metal contamination in nuisance dust particles were evaluated. The nuisance dust particles were sampled using passive deposit gauge method for one year from April2010 to March2011 and the obtained samples were measured for the total contents and the contamination levels of Fe, Mn, Cu and As usinggeo-accumulation index （Igeo ）, enrichment factor （EF） and the integrated pollution index （IPI）. The results showed that, the contamination levels of Fe and Mn based on Igeo values, were uncontaminated （Igeo 〈 0）（variations of the Igeo index was from -3.11 to -1.751 for Fe, from -0.630 to -1.925 for Mn）, while the values of Cu and As were demonstrated to have moderate contamination based on Igeo values （variations of Igeo index was from -1.125 to 0.848 for Cu, and from -2.002 to 1.249 for As）. The analysis of EF also revealed minor to moderate enrichment for Mn （1.215-4.214）, minor to moderately severe enrichment for Cu （2.791-6.484）, and As （1.370-8.462）, respectively. The variation of the IPI index also showed low to moderate level of heavy metal pollution in nuisance dust particulates （0.511-1.829）. The analysis of the results also approved that the natural processes andgeochemical variables （the changing meteorological parameters） can significantly affect the availability of heavy metals in nuisance dust particles in Western Iran.

关键词： heavy metal contamination nuisance dust deposit gauge method geo-accumulation index enrichment factor integrated pollution index

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Exhaustive Classification of the Invariant Solutions for a Specific Nonlinear Model Describing Near Planar and Marginally Long-Wave Unstable Interfaces for Phase Transition

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Communications in Theoretical Physics 2018年第5期69卷 477-505页

作者： Fatemeh Ahangari Department of Mathematics Faculty of Mathematical SciencesAlzahra University

Problems of thermodynamic phase transition originate inherently in solidification, combustion and various other significant fields. If the transition region among two locally stable phases is adequately narrow, the dynamics can be modeled by an interface motion. This paper is devoted to exhaustive analysis of the invariant solutions for a modified Kuramoto-Sivashinsky equation in two spatial and one temporal dimensions is presented. This nonlinear partial differential equation asymptotically characterizes near planar interfaces, which are marginally long-wave unstable. For this purpose, by applying the classical symmetry method for this model the classical symmetry operators are ***, the structure of the Lie algebra of symmetries is discussed and the optimal system of subalgebras, which yields the preliminary classification of group invariant solutions is constructed. Mainly, the Lie invariants corresponding to the infinitesimal symmetry generators as well as associated similarity reduced equations are also pointed out. Furthermore,the nonclassical symmetries of this nonlinear PDE are also comprehensively investigated.

关键词： phase transition modified Kuramoto-Sivashinsky ((2D) MKS) equation symmetries optimal system invariant solutions

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