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Mechanism of action of Balanophora involucrata polyphenolic compounds in the treatment of myocardial injury based on network pharmacology and molecular docking techniques

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Journal of Polyphenols 2024年第2期6卷 45-55页

作者： Shipeng Duan Ting Gao Feifei Li Xuehan Li Haojun Shen Fang Wang Xiaoshu Zhang faculty of functional food and wine Shenyang Pharmaceutical UniversityShenyang 110016China

The objective of this work was to investigate the mechanism of action of Balanophora involucrata polyphenolic compounds in the treatment of myocardial *** the present study,Balanophora involucrata was extracted by reﬂuxing 75%of *** obtained extract was extracted with petroleum ether,ethyl acetate and n-butanol *** the ethyl acetate layer was *** extract was prepared by silica gel column chromatography,sephadex LH-20 elution and thin layer *** that,the Swiss target prediction database was utilized to obtain the targets of Balanophora involucrata,and the Genecards,OMIM and TTD databases were used to predict and screen the targets of Balanophora involucrata for the treatment of myocardial *** active ingredient-target network was constructed using Cytoscape software,and the PPI network was mapped using String database and Cytoscape *** bioprocess enrichment analysis and KEGG pathway enrichment analysis were performed by Metascape software to predict the mechanism of *** docking was performed in Discovery Studio 2016 client software to verify the binding of Balanophora involucrata polyphenols to key *** this study,six polyphenolic compounds were isolated from Balanophora *** GO enrichment analysis,1614 biological processes(BP),127 cellular compositions(CC),and 215 molecular functions(MF)were obtained;a total of 155 cross-targets were involved in the KEGG enrichment *** PPI network showed that quercetin was the main active component of polyphenolic compounds against myocardial injury and that AKT1,EGFR,STAT3,SRC,ESR1,MMP9,HSP90AA1 and other related signals were associated with myocardial injury ***,the multi-component-multi-target-multi-pathway action of Balanophora involucrata was concluded,which provided new ideas and methods for further research on the mechanism of action of Balanophora involucrata in myocardial injury.

关键词： Balanophora involucrata myocardial injury phenolic compounds network pharmacology molecular docking

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Mechanism of Rosae Rugosae Flos flavonoids in the treatment of hyperlipidemia and optimization of extraction process based on network pharmacology

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Journal of Polyphenols 2024年第2期6卷 65-77页

作者： Yunxiao Xia Aijinxiu Ma Zihan Hou Xu Zhao faculty of functional food and wine Shenyang Pharmaceutical UniversityShenyang 110016China

This study aims to identify a natural plant chemical with hypolipidemic effects that can be used to treat high cholesterol without adverse *** network pharmacology screening,it was found that Rosae Rugosae Flos(RF)flavonoids had potential therapeutic effects on hyperlipidemia and its mechanism of action was *** and GeneCards databases were used to obtain active ingredients and disease *** diagrams were drawn to illustrate the *** interaction network diagram was created using Cytoscape 3.8.0 *** PPI protein network was constructed using *** and KEGG enrichment analysis was performed using *** results revealed 2 active flavonoid ingredients and 60 potential targets in *** key targets,including CCL2,PPARG,and PPARA,were found to play a role in multiple pathways such as the AGE-RAGE signaling pathway,lipid and atherosclerosis,and cancer pathway in diabetic *** solvent extraction method was optimized for efficient flavonoid extraction based on network pharmacology prediction *** was achieved through a single factor and orthogonal test,resulting in an optimum process with a reflux time of 1.5 h,a solid-liquid ratio of 1:13 g/mL,and an ethanol concentration of 50%.

关键词： Rosae Rugosae Flos flavonoids extraction process optimization network pharmacology hyperlipidemia

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Qualitative and quantitative analysis of characteristic free and bound phenolics in three colored quinoas

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Journal of Polyphenols 2024年第2期6卷 78-86页

作者： Jianxin Song Dezhi Gao Xiaodong Wang faculty of functional food and wine Shenyang Pharmaceutical UniversityShenyang 110016China School of Biological Science and food Engineering Chuzhou UniversityChuzhou 239000China

Quinoa is a good source of phenolics,which both exist as free and bound *** order to mark clear the characteristic free and bound phenolics in different quinoa samples,in this study,characteristic free and bound phenolics in three colored quinoas including WQ(white quinoa),RQ(red quinoa)and BQ(black quinoa)were *** showed a total of 14 phenolics both acted as free and bound form were analyzed in three colored quinoas(WQ,RQ and BQ).Gallic acid,vanillic acid,epicatechin,p-coumaric acid and quercetin existed both as free and bound forms were common phenolics in *** highest total free phenolics(238.10 mg/kg)and bound phenolics(3377.75 mg/kg)were presented in WQ and RQ,*** indicated WQ and RQ were respectively good source of free and bound ***,characteristic free and bound phenolics in three colored quinoas could be well analyzed by principal component analysis(PCA),indicating it was an effective and reliable method in distinguishing three colored quinoas based on their characteristic free and bound phenolics,respectively.

关键词： quinoa free phenolics bound phenolics PCA

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Comparative metabolomics reveal histamine biodegradation mechanism by salt stressed Bacillus subtilis JZXJ-7

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food Science and Human Wellness 2024年

作者： Rundong Wang Yijia Deng Yuhao Zhang Xuepeng Li Ravi Gooneratne Jianrong Li College of food Science and Engineering Bohai University Chongqing Key Laboratory of Speciality food Co-Built by Sichuan and Chongqing Department of wine food and Molecular Biosciences faculty of Agriculture and Life Sciences Lincoln University Lincoln 7647 New Zealand College of food Science Southwest University College of food Science and Engineering Lingnan Normal University

Bacillus subtilis (B. subtilis) JZXJ-7 isolated from shrimp paste can significantly degrade histamine under salt stress but the mechanism is unclear. This study aims to evaluate the effect of 170 and 340 mmol/L NaCl on B. subtilis JZXJ-7 growth， histamine degradation， antioxidant enzymes [catalase (CAT)， superoxide dismutase (SOD) and glutathione S-transferase (GST)] activities and Na+， K+-ATPase activity. Furthermore， comparative metabolomics was used to investigate histamine biodegradation mechanism by *** JZXJ-7 subjected to salt stress. Both 170 and 340 mmol/L NaCl promoted B. subtilis JZXJ-7 growth in late stages of reproduction (32 - 48 h)， increased histamine degradation rate by 64.85% and 79.87% (P food fermentation industry.

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Nutritional and therapeutic benefits of coconut milk and its potential as a plant-based functional yogurt alternative: a review

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food Science and Human Wellness 2024年

作者： Gengghatarani Gengan Nurul Solehah Mohd Zaini Nazamid Saari Anis Shobirin Meor Hussin Ahmad Haniff Jaafar Hanan Hasan Elicia Jitming Lim Wan Abd Al Qadr Imad Wan-Mohtar Muhamad Hafiz Abd Rahim functional Omics and Bioprocess Development Laboratory Institute of Biological Sciences faculty of Science Universiti Malaya faculty of food Science and Technology Universiti Putra Malaysia School of Life and Environmental Sciences The University of Sydney

Plant-based milks are on the rise due to an increased awareness of their sustainability and health benefits. Currently， dairy milk is the most nutritionally complete beverage， but it suffers from the presence of indigestible lactose and allergenic proteins. Coconut milk has been around for a long time， but its application is limited due to a perceived lack of specific nutrients， high saturated fat levels， and low acceptability. Recent evidence indicates， however， that the saturated fat and other plant-based components found in coconut milk are good for metabolic outcomes and brain health. The conversion of coconut milk to yoghurt will further improve its functionality by boosting its existing nutritional qualities. In this article， the nutritional value of coconut milk， as well as its potential downsides， its application as yoghurt， and suggestions for enhancing its nutritional functionality will be examined.

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Analysis of plant resources and diversity in the southeast area of Taihang Mountains

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Asian Journal of Traditional Medicines 2024年第2期19卷 88-98页

作者： Junpeng Lin Jingming Jia Anhua Wang School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China School of functional food and wine Shenyang Pharmaceutical UniversityShenyang 110016China

Taihang Mountains are situated between Shanxi Province and the North China Plain,spanning Beijing,Hebei,Shanxi,and Henan provinces and *** mountains extend from northeast to southwest for over 400 km,naturally deviding the second step from the third one in *** southeastern area of Taihang Mountains specifically refers to Changzhi City and Jincheng Administrative Region of Shanxi *** Shanxi Province’s robust development plans for the southeast area of Taihang Mountains,the medicinal plant resources in this area will be ***,it is imperative and urgent to conduct a comprehensive investigation and study on the medicinal plant resources in the southeast area of Taihang *** means of field investigation,literature review,and specimen identification,the plant resources and diversity of two counties in the southeast of Taihang Mountains were *** findings revealed 234 plants species across 172 genera in 70 families,primarily comprising *** families with more species included Compositae,Leguminosae,Rosaceae,Labiatae,*** the genera,those with more species were Cynanchum,Selaginella,Clematis,Thalictrum,and Rhamnus.A total of 114 medicinal plants were identified,constituting 48.72%of the *** medicinal parts,the concentration is in roots and rhizomes,followed by whole plants and *** the basis of investigation and study,some suggestions on the development,utilization,and protection of medicinal plant resources in southeast Taihang Mountains were *** suggestions provide valuable insights for the study on medicinal plant resources and vegetation in the southeast of Taihang Mountains,serving as a scientific basis for the protection and sustainable utilization of wild medicinal plant resources.

关键词： plant resources diversity medicinal use protection and utilization Taihang Mountains

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Preparation, characterization and evaluation of kaempferol phospholipid complex: Improvement of its solubility and biological effect

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Journal of Polyphenols 2024年第2期6卷 56-64页

作者： Dezhi Gao Honghui Zhao Fengmao Zou Ming Yang Jing Wang Lina Fang Xu Zhao faculty of functional food and wine Shenyang Pharmaceutical UniversityShenyang 110016China School of Traditional Chinese Material Medica Shenyang Pharmaceutical UniversityShenyang 110016China College of Pharmacy Shenyang Medical CollegeShenyang 110034China

Kaempferol(KA),as one of the flavonoids,has extensive pharmacological ***,the poor solubility of KA severely limits its clinical *** our study,the kaempferol phospholipid complex(KA-PC)has been prepared by solvent evaporation for the enhancement of the bioavailability of ***-PC was verified by scanning electron microscope characterization *** loading,solubility and long-term stability were *** characterization results showed that KA-PC was formed through the intermolecular interaction between KA and *** solubility of KA-PC in water was 189 times higher than that of KA,and the solubility in n-octanol was also significantly ***,pharmacodynamic studies showed that KA-PC can significantly reduce the level of serum uric acid in mice without causing renal *** study expanded the clinical application of KA by preparing KA-PC.

关键词： kaempferol phospholipid complex solubility uric acid-lowering effect

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A multi-omics technology to the study of lactic acid bacteria responses to environmental stress: the past， current and future trends

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food Science and Human Wellness 2024年

作者： Yaqi Liu Wen Ma Gang Jin wine Research Institute Ningxia University Engineering Research Center of Grape and wine Ministry of Education

Lactic acid bacteria and the fermentation environment interact to form an intertwined system. Lactic acid bacteria are constantly evolving to adapt to different fermentation environments， causing changes in their physiological processes. To achieve a targeted improvement of their adaptability to various environments， a detail analysis of their evolutionary physiological processes is required. While several studies have been carried out in the past by using single-omics techniques to investigate their response to environmental stress， most researchers are now using a multi-omics approach to explore more detail in the biological regulatory networks and molecular mechanisms of lactic acid bacteria in response to environmental stress， thereby overcoming the limitations of single- omics analysis. Scope and approach: In this review， we describe the various single-omics approaches that have been used to study environmental stress in lactic acid bacteria， present the advantages of various multi-omics combined analysis approaches， and discuss the potential and practicality of applying emerging single-cell transcriptomics and single-cell metabolomics techniques to the molecular mechanism study of microbes response to environmental stress. Key ?ndings and conclusions: Multi-omics approaches enable the accurate identification of complex microbial physiological processes in different environments， allow people to comprehensively reveal the molecular mechanisms of microbes response to stress from different perspectives. Single-cell omics techniques， analyze the targeted regulation of microbial functions in a multi-dimensional space， provides a new perspective on understanding microbes responses environment stress.

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Methionine sources and genotype affect embryonic intestinal development, antioxidants, tight junctions, and growth-related gene expression in chickens

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Animal Nutrition 2024年第1期16卷 218-230页

作者： James K.Lugata Sawadi F.Ndunguru Gebrehaweria K.Reda Xénia E.Ozsváth Eszter Angyal Levente Czeglédi Gabriella Gulyás Renáta Knop János Oláh Zoltán Mészár Rita Varga Brigitta Csernus Csaba Szabó Department of Animal Nutrition and Physiology Faculty of Agriculture and Food Sciences and Environmental Management University of Debrecen faculty of Agriculture and food Sciences and Environmental Management Doctoral School of Animal Science University of Debrecen Department of Animal Husbandry Faculty of Agriculture and Food Sciences and Environmental Management University of Debrecen Department of Evolutionary Zoology and Human Biology Faculty of Science and Technology University of Debrecen Institutes for Agricultural Research and Educational Farm University of Debrecen Department of Anatomy Histology and Embryology Faculty of Medicine University of Debrecen

Methionine(Met) is an essential and first limiting amino acid in the poultry diet that plays a significant role in chicken embryonic development and growth. The present study examined the effect of in ovo injection of DL-Met and L-Met sources and genotypes on chicken embryonic-intestinal development and health. Fertilized eggs of the two genotypes, TETRA-SL layer hybrid(TSL)—commercial layer hybrid and Hungarian Partridge colored hen breed(HPC)—a native genotype, were randomly distributed into four treatments for each genotype. The treatment groups include the following: 1) control non-injected eggs(NoIn); 2) saline-injected(SaIn); 3) DL-Met injected(DLM); and 4) L-Met injected(LM). The in ovo injection was carried out on 17.5 d of embryonic development; after hatching, eight chicks per group were sacrificed, and the jejunum was extracted for analysis. The results showed that both DLM and LM groups had enhanced intestinal development as evidenced by increased villus width, villus height, and villus area(P < 0.05) compared to the control. The DLM group had significantly reduced crypt depth, glutathione(GSH) content, glutathione S-transferase 3 alpha(GST3), occludin(OCLN) gene expression and increased villus height to crypt depth ratio in the TSL genotype than the LM group(P < 0.05). The HPC genotype has overexpressed insulin-like growth factor 1(IGF1) gene, tricellulin(MD2), occludin(OCLN),superoxide dismutase 1(SOD1), and GST3 genes than the TSL genotype(P < 0.05). In conclusion, these findings showed that in ovo injection of Met enhanced intestinal development, and function, with genotypes responding differently under normal conditions. Genotypes also influenced the expression of intestinal antioxidants, tight junction, and growth-related genes.

关键词： DL-Methionine L-Methionine In ovo injection Intestinal development Poultry

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Metabolomics for quality assessment of poultry meat and eggs

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food Quality and Safety 2024年第1期8卷 27-40页

作者： M.S.Yogeswari Jinap Selamat Nuzul Noorahya Jambari Alf Khatib Mohd Hishammfariz Mohd Amin Suganya Murugesu Laboratory of food Safety and food Integrity Institute of Tropical Agriculture and Food SecurityUniversiti Putra MalaysiaSerdangSelangor Darul EhsanMalaysia Department of food Science Faculty of Food Science and TechnologyUniversiti Putra MalaysiaSerdangSelangor Darul EhsanMalaysia Department of Pharmaceutical Chemistry Kulliyyah of PharmacyInternational Islamic University MalaysiaKuantanPahang Darul MakmurMalaysia faculty of Pharmacy Airlangga UniversitySurabayaIndonesia Department of Veterinary Service Malaysia Federal Government Administration CentrePutrajayaMalaysia

The poultry industry is experiencing rapid growth *** accelerated growth has led to multiple food fraud incidents across the food supply chain,which consequently created a demand for precise determination of quality poultry *** increase in demand for precise poultry production quality has necessitated advanced *** has emerged as a viable solution by offering detailed differentiation of biochemical indicators throughout the poultry supply ***,this study provides a means to address risk factors affecting the poultry industry without compromising animal welfare,which is a critical *** review focuses on important issues related to poultry product quality *** adulteration has escalated in recent years as it is driven by the increasing focus on consuming high-quality and nutritious ***,there is no specifc guideline for such determinations,especially when appearance,texture,and taste can be manipulated by substituting for food *** can pave the way for a deeper understanding of existing and novel biochemical indicators responsible for determining the quality of poultry meat and *** approach holds the potential to enhance the overall quality of poultry meat and egg products while also preventing food fraud.

关键词： Poultry metabolomics welfare application authentication.

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