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Crosstalk among canonical Wnt and Hippo pathway members in skeletal muscle and at the neuromuscular junction

Neural Regeneration Research 2025年第9期20卷 2464-2479页

作者： Said Hashemolhosseini Lea Gessler Institute of Biochemistry Medical FacultyFriedrich-Alexander-University of Erlangen-NürnbergErlangenGermany

Skeletal muscles are essential for locomotion,posture,and metabolic *** understand physiological processes,exercise adaptation,and muscle-related disorders,it is critical to understand the molecular pathways that underlie skeletal muscle *** process of muscle contra ction,orchestrated by a complex interplay of molecular events,is at the core of skeletal muscle *** contraction is initiated by an action potential and neuromuscular transmission requiring a neuromuscular *** muscle fibers,calcium ions play a critical role in mediating the interaction between actin and myosin filaments that generate *** of calcium release from the sarcoplasmic reticulum plays a key role in excitation-contraction *** development and growth of skeletal muscle are regulated by a network of molecular pathways collectively known as *** regulators coordinate the diffe rentiation of myoblasts into mature muscle *** pathways regulate muscle protein synthesis and hypertrophy in response to mechanical stimuli and nutrient *** ral muscle-related diseases,including congenital myasthenic disorders,sarcopenia,muscular dystrophies,and metabolic myopathies,are underpinned by dys regulated molecular pathways in skeletal *** interventions aimed at preserving muscle mass and function,enhancing regeneration,and improving metabolic health hold promise by targeting specific molecular *** molecular signaling pathways in skeletal muscle include the canonical Wnt signaling pathway,a critical regulator of myogenesis,muscle regeneration,and metabolic function,and the Hippo signaling *** recent years,more details have been uncovered about the role of these two pathways during myogenesis and in developing and adult skeletal muscle fibers,and at the neuromuscular *** fact,research in the last few years now suggests that these two signaling pathways are interconnected and

关键词： canonical Wnt"Wingless-related integration site"pathway beta-catenin(CTNNB1) Hippo pathway myogenesis myotube neuromuscular junction satellite cell skeletal muscle fiber transcriptional co-activator with PDZ-binding motif(TAZ) T-cell-specific transcription factor/lymphoid enhancer-binding factor(TCF/LEF) TEA domain family member(TEAD) transducin-like enhancer of split(TLE) yes-associated protein 1(YAP1)

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Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： Daniella Da Silva Madeleen Jansen van Rensburg Anine Crous Heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

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Performance Analysis of AODV Routing forWireless Sensor Network in FPGA Hardware

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Computer Systems Science & engineering 2022年第3期40卷 1073-1084页

作者： Namit Gupta Kunwar Singh Vaisla Arpit Jain Adesh Kumar Rajeev Kumar Department of Computer Science&engineering Uttarakhand Technical UniversityDehradun248007India Department of Computer Science B T Kumaon Institute of Technology DwarahatIndia faculty of engineering&cs Teerthanker Mahaveer UniversityMoradabadIndia Department of Electrical&Electronics engineering School of EngineeringUniversity of Petroleum and Energy StudiesDehradun248007India

Wireless sensor network(WSN)is a group of interconnected sensor nodes that work wirelessly to capture the information of *** routing of the network is a challenging *** routing of WSN is classified as proactive,reactive,and *** on-demand distance vector(AODV)routing is an example of reactive routing based on the demand route formations among different nodes in the *** research article emphasizes the design and simulation of the AODV routing hardware chip using very-high-speed integrated circuit hardware description language(VHDL)programming in Xilinx integrated synthesis environment(ISE)14.7 *** performance of the chip is studied based on the field-programmable gate array(FPGA)hardware parameters such as slices,lookup table(LUTs),input/output block(IOB),flipflops,and memory for the different configurations of the network(N=10,20….100).The delay and frequency are also estimated on the Virtex-5 *** performance of the WSN with AODV routing is also analyzed based on the packet delivery ratio,throughput,delay,and control *** simulation test cases verified the 8-bit,64-bit,and 128-bit data communication within the nodes.

关键词： Wireless sensor network FPGA synthesis AODVrouting simulation and synthesis VHDL simulation

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Synthetic control of chiral pore surfaces in covalent organic frameworks for enantioselective separation of chiral drugs

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Science China Chemistry 2025年

作者： Shiguo Fu Xiaofeng Zhang Kaixuan Wang Linfeng Chen Fan Xia Yong Cui Yan Liu School of Chemistry and Chemical engineering Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University faculty of Materials Science and Chemistry China University of Geosciences

Enantioselective separations of racemates using porous materials are highly attractive and significant in both fundamental research and technological applications. However, achieving controlled chiral pore surfaces to create the necessary driving force for enantiomer discrimination poses a fundamental challenge. Herein, we demonstrate that chiral covalent organic frameworks(COFs) possess the essential characteristics for effective enantioseparations through synthetic control over pore surfaces. We synthesized three 3D chiral COFs (CCOFs) featuring abundant chiral recognition sites on the pore walls via the condensation of enantiopure dialdehyde of 2,2′-dihydroxy-1,1′-binaphthyl and tetraamine. All CCOFs with high stability exhibit an 11-fold interpenetrated framework with tubular open channels, decorated with dihydroxyl or diethoxyl groups. The CCOFs with dihydroxyl groups serve as solid adsorbents for the adsorptive separation and solid-phase extraction of various chiral 1-phenylethanol-derived enantiomers, particularly racemic drugs, achieving up to 98%enantiomeric excess. In contrast, the CCOF with diethoxy groups is unable to resolve the racemates. These CCOF materials can be recycled and reused without any apparent loss of performance. Density functional theory (DFT) calculations reveal that the enantiospecific recognition arises from the well-organized chiral inner sphere and multiple chiral host-guest interactions.

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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al Kabbani Christoph Köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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Fatigue Strength Analysis of Dissimilar Aluminum Alloy TIG Welds

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期 265-274页

作者：廖祥雲王瑞杰 LIU Guoshou ZHAO Pinglin faculty of Mechanical and Electrical engineering Kunming University of Science and Technology faculty of Civil engineering and Mechanics Kunming University of Science and Technology

The constant amplitude loading fatigue tests were carried out on the 6061/7075 aluminum alloy TIG fillet welded lap specimens in this study,and the weld seam cross-section hardness was *** experimental results show that most specimens mainly failed at the 7075 side weld toes even though the base material tensile strength of 7075 is higher than that of *** maximum stress-strain concentration in the two finite element models is located at the 7075 side weld toe,which is basically consistent with the actual fracture *** weld zone on the 7075 side experiences severe material softening,with a large ***,the Vickers hardness value on the 6061 side negligibly changes and fluctuates around 70 *** obvious defects are found on the fatigue fracture,but a large number of secondary cracks *** germinate from the weld toe and propagate in the direction of the plate *** reinforcement has a serious impact on fatigue *** life will decrease exponentially as the weld reinforcement increases under low *** is found that the notch stress method can give a better fatigue life prediction for TIG weldments,and the errors of the predicted results are within the range of two factors,while the prediction accuracy decreases under low *** equivalent structural stress method can also be used for fatigue life prediction of TIG weldments,but the errors of prediction results are within the range of three factors,and the accuracy decreases under high stress.

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Coarse to Fine: The Role of Severe Plastic Deformation in Advancing Titanium-Based Medical Implants - A Comprehensive Review

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 295-306页

作者： Dragana R Mihajlović Bojan I Međo Ivana Lj Cvijović-Alagić Veljko R Djokić faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear Sci-ences-National Institute of the Republic of Serbia University of Belgrade11001BeogradSerbia Innovation Centre of the faculty of Technology and Metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic *** the SPD process,a solid material sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure torsion(HPT)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more *** that grain size control is accepted as a method to obtain materials with desired characteristics,an overview of the properties of ultrafine-grained titanium-based biomaterials to be used in medicine is ***,particular attention is dedicated to the influences of HPT process parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.

关键词： high-pressure torsion process ultrafine-grained titanium-based materials electrochemical anodization physical properties mechanical properties

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Energy Efficiency of a Solar Green Building Using Bio-Sourced Materials for Indoor Temperature and Humidity Optimization

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Energy engineering 2025年第1期122卷 41-62页

作者： SoumiaMounir Youssef Maaloufa Abdelhamid Khabbazi ElinaMohd Husini Nurul SyalaAbdul Latip YakubuAminuDodo Rime ELHarrouni MinaAmazal Asma Souidi Malika Atigui Ahmed Aharoune National School of Architecture Agadir New Complex Ibn ZohrAgadirBP 20732Morocco EMDD CERNE2DUniversity of Mohammed V in RabatEst SaleSaleBP 227Morocco Thermodynamics and Energetics Laboratory Faculty of ScienceIbn Zohr UniversityAgadirBP 8106Morocco faculty of Built Environment University Sains Islam MalaysiaNilaiBP 71800Malaysia Architectural engineering Department Najran UniversityNajranBP 1988Saudi Arabia The Centre of Scientific and engineering Research Najran UniversityNajranBP 1988Saudi Arabia Euro-Mediterranean School of Architecture Design and UrbanismEuro-Mediterranean University of FezFezBP 51Morocco

A clean environment with low carbon emissions is the goal of research on the development of green and sustainable buildings that use bio-sourced materials in conjunction with solar energy to create more sustainable *** is particularly true in Africa,where there aren’t many studies on the *** current study suggests a 90 m^(2) model of a sustainable building in a dry climate that is movable to address the issue of housing in remote areas,ensures comfort in harsh weather conditions,uses solar renewable resources—which are plentiful in Africa—uses biosourced materials,and examines how these materials relate to temperature and humidity control while emitting minimal carbon *** order to solve the topic under consideration,the work is split into two sections:numerical and experimental *** TRNSYS and Revit,the suggested prototype building is examined numerically to examine the impact of orientation,envelope composition made of bio-sourced materials,and carbon *** a hygrothermal investigation,experiments are conducted to evaluate this prototype’s ***,an examination of the photovoltaic system’s production,consumption,and several scenarios used tomaximize battery life is included in the *** the biosourcedmaterial achieves a thermal transmittance of 0.15(W.m^(-2).K^(-1)),the results demonstrate an intriguing finding in terms of *** value satisfies the requirements of passive building,energy autonomy of the dwelling,and injection in-network with an annual value of 15,757 ***,compared to the literature,the heating needs ratio is 6.38(kWh/m^(2).an)and the cooling needs ratio is 49(kWh/m^(2).an),both of which are good *** to international norms,the inside temperature doesn’t go above 26℃,and the humidity level is within a comfortable range.

关键词： Bio-sourced materials energy sustainability green architecture built environment

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Dynamic Interaction Analysis of Coupled Axial-Torsional-Lateral Mechanical Vibrations in Rotary Drilling Systems

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Structural Durability & Health Monitoring 2025年第1期19卷 77-103页

作者： Sabrina Meddah Sid Ahmed Tadjer Abdelhakim Idir Kong Fah Tee Mohamed Zinelabidine Doghmane Madjid Kidouche Applied Automation Laboratory Faculty of Hydrocarbons and ChemistryUniversity of BoumerdesBoumerdes35000Algeria Institute of Electrical and Electronic engineering(IGEE) University of BoumerdesBoumerdes35000Algeria Laboratory of the Electrification of Industrial Enterprises University of BoumerdesBoumerdes35000Algeria Electrical engineering Department Mohamed Boudiaf University of M’silaM’sila28000Algeria Department of Civil and Environmental engineering King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Interdisciplinary Research Center for Construction and Building Materials King Fahd University of Petroleum&Minerals(KFUPM)Dhahran31261Saudi Arabia

Maintaining the integrity and longevity of structures is essential in many industries,such as aerospace,nuclear,and *** achieve the cost-effectiveness of large-scale systems in petroleum drilling,a strong emphasis on structural durability and monitoring is *** study focuses on the mechanical vibrations that occur in rotary drilling systems,which have a substantial impact on the structural integrity of drilling *** study speciﬁcally investigates axial,torsional,and lateral vibrations,which might lead to negative consequences such as bit-bounce,chaotic whirling,and high-frequency *** events not only hinder the efﬁciency of drilling but also lead to exhaustion and harm to the system’s components since they are difﬁcult to be detected and controlled in real *** study investigates the dynamic interactions of these vibrations,speciﬁcally in their high-frequency modes,usingﬁeld data obtained from measurement while ***ﬁndings have demonstrated the effect of strong coupling between the high-frequency modes of these vibrations on drilling sys-tem *** obtained results highlight the importance of considering the interconnected impacts of these vibrations when designing and implementing robust control ***,integrating these compo-nents can increase the durability of drill bits and drill strings,as well as improve the ability to monitor and detect ***,by exploiting theseﬁndings,the assessment of structural resilience in rotary drilling systems can be ***,the study demonstrates the capacity of structural health monitoring to improve the quality,dependability,and efﬁciency of rotary drilling systems in the petroleum industry.

关键词： Rotary drilling systems mechanical vibrations structural durability dynamic interaction analysis ﬁeld data analysis

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A Fully‑Printed Wearable Bandage‑Based Electrochemical Sensor with pH Correction for Wound Infection Monitoring

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Nano-Micro Letters 2025年第3期17卷 355-375页

作者： Kanyawee Kaewpradub Kornautchaya Veenuttranon Husanai Jantapaso Pimonsri Mittraparp‑arthorn Itthipon Jeerapan Center of Excellence for Trace Analysis and Biosensor Prince of Songkla UniversityHat Yai 90110SongkhlaThailand Division of Physical Science Faculty of SciencePrince of Songkla UniversityHat Yai 90110SongkhlaThailand Center of Excellence for Innovation in Chemistry Faculty of SciencePrince of Songkla UniversityHat Yai 90110SongkhlaThailand The ijE Electrochemistry for All Laboratory Prince of Songkla UniversityHat Yai 90110SongkhlaThailand Division of Biological Science Faculty of SciencePrince of Songkla UniversityHat Yai 90110SongkhlaThailand

Wearable sensing systems have been designed to monitor health conditions in real-time by detecting analytes in human *** diagnosis remains challenging,necessitating suitable materials for high-performance wearable sensors to offer prompt *** devices have limitations in measuring pH and the concentration of pH-dependent electroactive species simultaneously,which is crucial for obtaining a comprehensive understanding of wound status and optimizing ***,improving materials and analysis system accuracy is *** article introduces the first example of a flexible array capable of detecting pyocyanin,a bacterial virulence factor,while correcting dynamic pH *** demonstrate that this combined sensor enhances accuracy by mitigating the impact of pH variability on pyocyanin sensor *** screen-printable inks were developed to enhance analytical *** analytical performances of two sensitive sensor systems(i.e.,fully-printed porous graphene/multiwalled carbon nanotube(CNT)and polyaniline/CNT composites for pyocyanin and pH sensors)are *** least square regression is employed to analyze nonzero-order data arrays from square wave voltammetric and potentiometric measurements of pyocyanin and pH sensors to establish a predictive model for pyocyanin concentration in complex *** sensitive and effective strategy shows potential for personalized applications due to its affordability,ease of use,and ability to adjust for dynamic pH changes.

关键词： Pyocyanin Bandages Wound monitoring Biosensor Wearable device

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