检索结果-南通市图书馆

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and Notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria S.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdiSNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

Symplectic feedback using Hamiltonian Lie algebra and its applications to an inverted pendulum

在线全文

学校读者我要写书评

暂无评论

控制理论与应用（英文版） 2013年第2期11卷 275-281页

作者： J. Lorca ESPIRO C. Munoz POBLETE departamento de ciencias Fisicas Facultad de Ingenieria Ciencias y Administracion Universidad de La FronteraAvenida Francisco Salazar 01145 Casilla 54-D Temuco Chile departamento de ingenieria Electrica Facultad de Ingenieria Ciencias y Administracion Universidad de La FronteraAvenida Francisco Salazar 01145 Casilla 54-D Temuco Chile

From the symplectic representation of an autonomous nonlinear dynamical system with holonomic con- straints, i.e., those that can be represented through a symplectic form derived from a Hamiltonian, we present a new proof on the realization of the symplectic feedback action, which has several theoretical advantages in demonstrating the uniqueness and existence of this type of solution. Also, we propose a technique based on the interpretation, construction and character- ization of the pull-back differential on the symplectic manifold as a member of a one-parameter Lie group. This allows one to synthesize the control law that governs a certain system to achieve a desired behavior; and the method developed from this is applied to a classical system such as the inverted pendulum.

关键词： Hamiltonian systems Symplectic structures Lie algebra Nonlinear dynamical systems Geometric con-trol

Assessment of Technical and Economic Impacts of EV User Behavior on EV Aggregator Smart Charging

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2020年第2期8卷 356-366页

作者： Jean-Michel Clairand Javier Rodriguez-Garcia Carlosalvarez-Bel the facultad de ingenieria y ciencias Agropecuarias Universidad de las Americas-Ecuador170122 QuitoEcuador the Institute for Energy Engineering Universitat Politecnica de Valencia46022 ValenciaSpain

The increase in global electricity consumption has made energy efficiency a priority for ***,there has been a focus on the efficient integration of a massive penetration of electric vehicles(EVs)into energy *** study presents an assessment of various strategies for EV *** this analysis,the smart charging methodology proposed in a previous study is *** smart charging technique employs charging power rate modulation and considers user *** adopt several strategies,this study simulates the effect of these actions in a case study of a distribution system from the city of Quito,*** actions are simulated,and the EV aggregator costs and technical conditions are evaluated.

关键词： Electric vehicle(EV) smart grid aggregator smart charging charging power modulation charging strategies

Photolysis of a mixture of anthracene and benzo[a] pyrene at ultra-trace levels in natural water with disinfection purposes

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2020年第6期32卷 79-94页

作者： Ainhoa Rubio-Clemente Edwin Chica Gustavo A.Penuela facultad de ciencias de La Salud.Universidad Catolica de Murcia(UCAM) Murcia 30107Spain Grupo GDCON Facultad de IngenieriaSede de Investigaciones Universitarias(SIU)Universidad de Antioquia(UdeA)Medellín 050010Colombia facultad de ingenieria Tecnologico de Antioquia-Institucion Universitaria(TdeA)Medellín 050034Colombia departamento de ingenieria Mecanica Facultad de IngenieriaUniversidad de Antioquia(UdeA)Medellín 050010Colombia

The photodegradation of anthracene(AN)and benzo[a]pyrene(BaP),two priority polycyclic aromatic hydrocarbons(PAHs),was examined at ultra-trace levels in surface water to elucidate their behaviour under several irradiance values and types of *** emitting flux and the spectrum of the lamps were found to develop a crucial role in AN and BaP degradation since removal efficiencies of the target contaminants higher than 99%were found after 15 min of irradiation under an ultraviolet C(UVC)irradiance of 0.63 mW/cm^2,corresponding to a fluence of 560.25 mJ/cm^*** the other hand,although ultraviolet A(UVA)lamps exhibited a higher irradiance compared to that of UVC lamps,they were not efficient for degrading the target *** removal kinetic studies corroborated these findings,being the AN elimination rate in surface water higher than that in deionized water at optimal operating *** potential was also measured.A rapid microbial load inactivation,in terms of total coliforms naturally contained in the water matrix studied,was evidenced within 15 min of treatment for the fluence ***,after 24 hr in the dark,a regrowth was ***,photolysis products more toxic than the parent compounds were found,which were not removed even by extending the treatment *** this regard,it can be concluded that the individual action of UVC light for removing AN and BaP with disinfection purposes is not an efficient treatment;therefore,the use of radiation in combination with other kinds of treatments is required.

关键词： Polycyclic aromatic hydrocarbon Photolysis Matrix constituent Intermediate product Disinfection Regrowth

Alternative approaches for estimating missing climate data:application to monthly precipitation records in South- Central Chile

在线全文

学校读者我要写书评

暂无评论

Forest Ecosystems 2018年第4期5卷 390-399页

作者： Alonso Barrios Guillermo Trincado Rene Garreaud Escuela de Graduados Facultad de Ctencias Forestales y Recursos Naturales Universidad Austral de ChileBox 567ValdiviaChile departamento de ciencias Forestales Facuitad de Ingenieria ForestalUnlversidad del Tolima Box 6299 Ibague Colombia Instituto de Bosques y Sociedad Facultad de Ciencias Forestales y Recursos NaturalesUniversidad Austraide ChileBox 567 ValdiviaChile departamento de Geofistca Facultad de Ciencias Fisicas y MatematicasUniversidad de ChileSantiagoChile

Background: Over the last decades interest has grown on how climate change impacts forest resources. However,one of the main constraints is that meteorological stations are riddled with missing climatic data. This study compared five approaches for estimating monthly precipitation records: inverse distance weighting(IDW), a modification of IDW that includes elevation differences between target and neighboring stations(IDW_m), correlation coefficient weighting(CCW), multiple linear regression(MLR) and artificial neural networks(ANN).Methods: A complete series of monthly precipitation records(1995-2012) from twenty meteorological stations located in central Chile were used. Two target stations were selected and their neighboring stations, located within a radius of25 km(3 stations) and 50 km(9 stations), were identified. Cross-validation was used for evaluating the accuracy of the estimation approaches. The performance and predictive capability of the approaches were evaluated using the ratio of the root mean square error to the standard deviation of measured data(RSR), the percent bias(PBIAS), and the NashSutcliffe efficiency(NSE). For testing the main and interactive effects of the radius of influence and estimation approaches,a two-level factorial design considering the target station as the blocking factor was ***: ANN and MLR showed the best statistics for all the stations and radius of influence. However, these approaches were not significantly different with IDW_m. Inclusion of elevation differences into IDW significantly improved IDW_m estimates. In terms of precision, similar estimates were obtained when applying ANN, MLR or IDW_m, and the radius of influence had a significant influence on their estimates, we conclude that estimates based on nine neighboring stations located within a radius of 50 km are needed for completing missing monthly precipitation data in regions with complex ***: It is concluded that approaches based on ANN

关键词： Climatological data Cross-validation Artificial neural networks Multiple linear regression

Contrasting levels of genotype by environment interaction for life history and morphological traits in invasive populations of Zaprionus indianus(Diptera:Drosophilidae)

在线全文

学校读者我要写书评

暂无评论

Insect Science 2020年第5期27卷 1090-1100页

作者： Nicolas J.Lavagnino Marcos Imberti Victoria E.Ortizj Nicolas Flaibani Juan Jose Fanara Laboratorio de Evolucion Departamento de EcologiaGenetica y EvolucidnFacultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresArgentina IEGEBA-CONICET Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresArgentina

It has been demonstrated that phenotypic plasticity and genotype by envi-ronment interaction are important for coping with new and heterogeneous environments during *** indianus Gupta(Diptera:Drosophilidae)is an Afrotropical invasive fly species introduced to the South American continent in *** species is generalist and polyphagous,since it develops and feeds in several different fruit *** characteristics of *** suggest that phenotypic plasticity and genotype by environment interaction may be important in this species invasion *** this sense,our aim was to investigate the role of genetic variation for phenotypic plasticity(geno-type by environment interaction)in *** invasion of the South American ***,we quantified quantitative genetic variation and genotype by environment in-teractions of morphological and life history traits in different developmental environments,that is,host *** was done in different populations in the invasive range of ***-anus in *** showed that *** populations have considerable amounts of quantitative genetic ***,genotype by environment interactions was detected for the different traits analyzed in response to the different developmental ***,the amounts and patterns of these parameters differed between *** interpreled these results as the existence of diferences in evolutionary potential be-tween populations that have an important role in the short-and long-term success of the *** invasion process.

关键词： biological invasion genotype by env ironment interaction invaded range life history traits morphological traits Zaprionus indianus