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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria S.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdiSNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ordó?ez-Gutiérrez Francisco Wandosell Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM) Nicolas Cabrera 1 Universidad Autónoma de Madrid Fisiología Animal Departamento de Biología Facultad de Ciencias Universidad Autónoma de Madrid department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset Solna departamento de bioquímica y Biología Molecular Universidad Complutense de Madrid Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called "autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

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Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden departamento de bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

Microglia depletion as a therapeutic strategy:friend or foe in multiple sclerosis models?

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Neural Regeneration Research 2023年第2期18卷 267-272页

作者： Victoria Sofia Berenice Wies Mancini Anabella Ayelen Di Pietro Laura Andrea Pasquini Universidad de Buenos Aires Facultad de Farmacia y BioquímicaDepartamento de Química BiológicaCátedra de Química Biológica PatológicaBuenos AiresArgentina Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicas y TécnicasInstituto de Química y Fisicoquímica Biológicas Prof.Dr.Alejandro C.PaladiniFacultad de Farmacia y BioquímicaBuenos AiresArgentina

M ultiple sclerosis is a chro nic central nervous system demyelinating disease whose onset and progression are driven by a combination of immune dysregulation,genetic predisposition,and environmental fa *** activation of microglia and astrocytes is a key player in multiple sclerosis immunopathology,playing specific roles associated with anatomical location and phase of the disease and controlling demyelination and *** though reactive mic roglia can damage tissue and heighten deleterious effects and neurodegeneration,activated microglia also perform neuroprotective functions such as debris phagocytosis and growth fa ctor *** can be activated into pro-inflammato ry phenotype A1 through a mechanism mediated by activated neuroinflammatory microglia,which could also mediate *** A1 phenotype inhibits oligodendrocyte prolife ration and differe ntiation and is toxic to both oligodendrocytes and *** r,astroglial activation into phenotype A2 may also take place in response to neurodegeneration and as a protective mechanism.A variety of animal models mimicking specific multiple sclerosis features and the associated pathophysiological processes have helped establish the cascades of events that lead to the initiation,progression,and resolution of the *** colonystimulating facto r-1 receptor is expressed by myeloid lineage cells such as peripheral monocytes and macrophages and central nervous system ***,as microglia development and survival critically rely on colony-stimulating factor-1 receptor signaling,colony-stimulating factor-1 receptor inhibition can almost completely eliminate microglia from the *** this context,the present review discusses the impact of microglial depletion through colo ny-stimulating factor-1 receptor inhibition on demyelination,neurodegeneration,astroglial activation,and behavior in different multiple sclerosis models,highlighting the diversity of micr

关键词： astrocytes colony-stimulating factor-1 receptor inhibition cuprizone demyelnation microglia multiple sclerosis neurodegeneration

Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression

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World Journal of Gastroenterology 2017年第29期23卷 5266-5281页

作者： maría l bacigalupo pablo carabias maría f troncoso facultad de farmacia y bioquímica Instituto de Química y Fisicoquímica Biológicas (IQUIFIB) Consejo Nacional de lnvestigaciones Científicas y Técnicas Universidad de Buenos Aires

Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial for treatment. Galectin-1(Gal-1) belongs to a family of glycan-binding proteins, or lectins, with the ability to cross-link specific glycoconjugates. A variety of biological activities have been attributed to Gal-1 at different steps of tumor progression. Herein, we summarize the current literature regarding the roles of Gal-1 in gastrointestinal malignancies. Accumulating evidence shows that Gal-1 is drastically up-regulated in human gastric cancer, hepatocellular carcinoma, colorectal cancer and pancreatic ductal adenocarcinoma tissues, both in tumor epithelial and tumor-associated stromal cells. Moreover, Gal-1 makes a crucial contribution to the pathogenesis of gastrointestinal malignancies, favoring tumor development, aggressiveness, metastasis, immunosuppression and angiogenesis. We also highlight that alterations in Gal-1-specific glycoepitopes may be relevant for gastrointestinal cancer progression. despite the findings obtained so far, further functional studies are still required. Elucidating the precise molecular mechanisms modulated by Gal-1 underlying gastrointestinal tumor progression, might lead to the development of novel Gal-1-based diagnostic methods and/or therapies.

关键词： Galectin-1 Gastric cancer Hepatocellular carcinoma Colorectal carcinoma Pancreatic cancer β1 6-N-acetylglucosaminyltransferase V

Oxidative effects of glyphosate on the lipophobic intracellular environment in the microalgae Chlorella vulgaris

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BIOCELL 2022年第3期46卷 795-802页

作者： JUAN MANUEL OSTERA SUSANA PUNTARULO GABRIELA MALANGA Fisicoquímica Facultad de Farmacia y BioquímicaUniversidad de Buenos AiresBuenos AiresCP 1113Argentina Instituto de bioquímica y Medicina Molecular(IBIMOL) CONICET-Universidad de Buenos AiresBuenos AiresCP 1113Argentina

The studied hypothesis is that the herbicide glyphosate(GLy)can affect the oxidative balance in the hydrophobic intracellular medium in non-target Chlorella vulgaris *** GLy and RoundUp(RUP)supplementation,affected the growth profile.A significant 42%decrease in the cellular biomass in stationary(St)phase was observed in cultures supplemented with either 5μM of GLy or RUP,as compared to control *** treatment with 0.3μM of GLy generated non-significant effects on the oxidation rate of 2’,7’dichlorofluorescein diacetate(DCFH-DA),neither in exponential(Exp)nor in St phase of development,as compared to control ***,the treatment with either 5μM GLy or 0.3 and 5μM RUP lead to a significant decrease in the DCFH-DA oxidation rate,as compared to control *** lipid radical(LR●)generation rate,detected by Paramagnetic Resonance Spectroscopy(EPR),was significantly increased in the presence of RUP,in Lag and Exp phase of *** non-enzymatic antioxidants,α-Tocopherol(α-T)andβ-Carotene(β-C),are aimed to protect membranes against the damage produced by the radical *** content ofβ-C was not significantly affected,as compared to control cultures,by any of the treatments,in both growth phases of cellular *** content ofα-T was significantly decreased by the supplementation with either 0.3 or 5μM of RUP or 5μM *** LR●/α-T ratio,used as indicator of the oxidative balance in the hydrophobic cellular media,was significantly different between samples obtained from control and RUP-exposed microalgae in both,Exp and St phase of development,with either 0.3 or 5μM *** data presented here showed evidence that suggested that oxidative balance in the hydrophobic environment was affected by either GLy or RUP.

关键词： 2’,7’dichlorofluorescein diacetate oxidation rate Lipid soluble antioxidants Round up Redox balance

Ketamine effect on intracellular and mitochondrial calcium mobilization

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BIOCELL 2016年第1期40卷 11-14页

作者： JUANITA BUSTAMANTE ANALIA CZERNICZyNIEC SILVIA LORES-ARNAIZ Centro de Altos Estudios en Ciencias Humanas y de la Salud(CAECIHS) Facultad de MedicinaUniversidad Abierta InteramericanaBuenos AiresArgentina Instituto de bioquímica y Medicina Molecular Facultad de Farmacia y BioquímicaUniversidad de Buenos AiresArgentina

The suppressive effects of ketamine on intracellular calcium has been reported in a variety of cells although the mechanisms involved are not well *** aim of this work was to evaluate the ketamine effect on the mitochondrial Ca^(2+)accumulation and the cellular Ca^(2+)mobilization using FLUO4-AM and flow *** results showed that mitochondria from ketamine injected animals presented a lower ability to retain calcium at concentrations higher than 20μM,as compared with controls(saline injected animals).In ad-dition,ketamine showed a significant decreased KCl-induced intracellular calcium *** increased calcium influx through cellular *** to the data presented herein,ketamine presents a clear inhibitory effect on cytosolic Ca2+transport mechanisms,independently from their action on the calcium channel associated NMDA receptor.

关键词： calcium transport hippocampal mitochondria Vero cell culture

Oxidative metabolism of photosynthetic species and the exposure to some freshwater and marine biotoxins

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BIOCELL 2021年第4期45卷 813-821页

作者： SUSANA PUNTARULO PAULA MARIELA GONZÁLEZ Universidad de Buenos Aires Facultad de Farmacia y BioquímicaFisicoquímicaBuenos AiresCP 1113Argentina CONICET-Universidad de Buenos Aires.Instituto de bioquímica y Medicina Molecular(IBIMOL) Buenos AiresCP 1113Argentina

Environmental climate conditions could lead to an increasing global occurrence of microorganism blooms that synthesize toxins in the aquatic *** blooms could result in significantly toxic *** of photosynthetic organisms to adverse environmental conditions implicate reactive oxygen species generation;but,due to the presence of a varied cellular antioxidant defense system and complex signaling networks,this oxidative stress could act as an important factor in the environmental adaptive *** objective of this review was to assess how some biotoxins are implicated in the generation of oxidative and nitrosative metabolic changes,not only in biotoxin-producing organisms but also in non-producing ***,toxins may modify the oxidative cellular balance of several other ***,the effect of toxins on the oxidative and nitrosative conditions will be evaluated in freshwater and marine algae and vascular *** changing climate conditions could act as agents capable of modifying the community composition leading to alterations in the global health of the habitat,risking the survival of many species with ecological relevance.

关键词： Blooms Climate change Metabolic stress Photosynthetic organisms Toxins

Update on Fe-dependent oxidative metabolism in vivo:An integrative view

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BIOCELL 2016年第1期40卷 39-42页

作者： NATACHA E PILONI ELIZABETH ROBELLO JULIAN G BONETTO SUSANA PUNTARULO Instituto de bioquímica y Medicina Molecular(IBIMOL)-Universidad de Buenos Aires(UBA) CONICETFisicoquímicaFacultad de Farmacia y BioquímicaJunín 956(C1113AAD)Buenos Aires.Argentina.

Fe is essential for human life because it constitutes the required cofactor for proteins of diverse biological ***,the development of oxidative stress by exposure to excessive Fe,share signaling pathways with other treatments including activation of redox-sensitive *** study was focused on the comparison on the effects of Fe in the brain and other organs in *** oxidative effects triggered by Fe overload strongly depend not only on the administration protocol,but also on the Fe-compound used,and the studied *** both the liver and the brain,Fe content drastically increased after Fe-dextran ***,the comparatively low lipid peroxidation in the brain as compared to the liver,suggested that Fe-dependent oxidative stress might involve mechanisms of different *** the brain,acute and subchronic administration of Fe-dextran triggered signaling processes that lead to the prevention of injury by the participation of catalase activity as an antioxidant *** brief summary opens a huge range of possible points of risk,as well as opportunities,to encounter situations in which the appropriate election of the Fe management protocol could be able of allow oxidative stress to exert beneficial effects.

关键词： experimental models Fe-overload oxidative stress

Oxidative stress in the hydrophilic medium of algae and invertebrates

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BIOCELL 2016年第1期40卷 35-38页

作者： GABRIELA MALANGA PAULA MARIELA GONZALEZ JUAN MANUEL OSTERA SUSANA PUNTARULO Instituto de bioquímica y Medicina Molecular(IBIMOL)-Universidad de Buenos Aires(UBA) CONICETFisicoquímicaFacultad de Farmacia y BioquímicaJunín 956(C1113AAD)Buenos Aires.Argentina.

The harmful effects of the reactive species may be due to the increase in their steady state concentration either by the enhancement of their production rates and/or the decrease of their consumption rate by antioxidant *** ascorbyl radical(A^(·))can be considered as a final product of radical oxidative transformations of ascorbate(AH^(-)).The ratio A^(·)content/AH^(-)content(A^(·)/AH^(-))has been widely used as an interesting tool to estimate mild to moderate oxidative transformations,providing a quick and simple method of diagnosis of stress in the hydrophilic cellular *** aim of this work was to summarize studies on the cellular oxidative condition in algae and invertebrates by assessing the A^(·)/AH^(-)ratio under environmentally changing *** use of indices of oxidative stress increasingly sensitive and,somewhat more specific,can bring a new light to the still unknown world of oxidative responses in marine organisms.

关键词： algae ascorbyl/ascorbate ratio invertebrates oxidative stress