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Endogenous norepinephrine desensitizes α_1D-Adrenoceptors in Cultured Rat Aorta

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Journal of Biosciences and Medicines 2023年第10期11卷 168-180页

作者： Itzell Alejandrina Gallardo-Ortíz Jesús David Gómez-Rodríguez Juan Javier López-Guerrero Santiago C. Sigrist-Flores Rafael Villalobos-Molina Unidad de Biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Carrera de Enfermería Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Ciencias de la Salud Unidad Xochimilco Universidad Autónoma Metropolitana Ciudad de México México Carrera de Médico Cirujano Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México

desensitization is a process characterized by the loss of cellular response to an agonist when this is present for a long time. α1D-adrenergic receptor (α1D-AR) desensitization is important since this receptor is involved in the contraction of large caliber arteries, such as the aorta. The aim of this research was to evaluate the desensitization of α1D-AR due to the endogenous release of norepinephrine in cultured rat aorta. Wistar rat aorta was incubated for 2 h or 24 h in DMEM at 37°C, and then subjected to isometric tension and the action of added norepinephrine, in concentration-response curve (CRC). In some experiments, BMY-7378 (α1D-AR antagonist) or 5-methylurapidil (α1A-AR antagonist) was used to identify the α1-AR involved in the response, or BMY-7378 to protect the α1D-AR from desensitization. Results showed that α1D-AR was desensitized when the aorta was incubated for 24 h, since the CRC to exogenous norepinephrine showed lower maximal contraction and the curve was displaced to the right, indicating that the receptor involved in contraction was not the α1D-AR, as compared to the aorta incubated 2 h. The receptor stimulated by norepinephrine at 24 h was neither the α1A-AR, as shown by the lack of displacement of the curve by 5-methylurapidil, but rather it seems that α1B-AR is inducing contraction. When the aorta was incubated with BMY-7378 for 24 h, the α1D-AR antagonist protected the receptor from desensitization. Endogenous norepinephrine desensitizes α1D-AR in the cultured aorta, and the α1D-AR is protected by BMY-7378.

关键词： desensitization norepinephrine α1D-Adrenergic Receptor BMY-7378 Rat Aorta

Problem-Based Learning <i>in Situ</i>Applied to Students in the Assessment of nursing Process

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Open Journal of nursing 2021年第5期11卷 378-389页

作者： Margarita Acevedo-Peñ a Rosa María Ostiguín-Meléndez José Luis Cadena-Anguiano Marcela Patricia Ibarra-Gonzalez Jesús Rigoberto Hernández-Hernández Rafael Villalobos-Molina Diana Cecilia Tapia-Pancardo facultad de estudios superiores Iztacala Universidad Nacional Autónoma de México Mexico City Mexico Escuela nacional de Enfermería y Obstetricia Universidad Nacional Autónoma de México Mexico City Mexico facultad de estudios superiores Iztacala Universidad Nacional Autónoma de México Mexico City Mexico Colegio de Posgrado de la Ciudad de México city Mexico Unidad de Biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Mexico City Mexico

Background: nursing is considered a science in the making that recognizes the nursing process (nP) as the scientific and methodological tool to provide care. The nP is composed of five stages of which the assessment i... 详细信息

ng>Background:ng> nursing is considered a science in the making that recognizes the nursing process (nP) as the scientific and methodological tool to provide care. The nP is composed of five stages of which the assessment is the first and fundamental to identify the health problems of the people. This research aimed to evaluate a pedagogical didactic strategy that is based on situated constructivism, the Based-Problem Learning (BPL), in order to improve significant learning. ng>Methods:ng> Quantitative research with an explanatory scope, was transversal, and it was applied to 30 students of the first year of the nursing career at the Faculty of Higher Studies Iztacala, national Autonomous University of Mexico. The sample was chosen considering the inclusion criteria. Data were collected using a Likert-type instrument validated in a previous investigation. ng>Results: ng>The average value obtained from the Likert scale to evaluate the intervention was 103.4, the highest score was 135 and the lowest was 83, which reflects that it was evaluated as good and particularly good. The grade given to the teacher as an agent of the ZPD, was between agree and totally agree, the highest percentages scored at 93%, since it provoked challenge in their thinking, and favored interaction among classmates. ng>Conclusions:ng> The application of the in situ teaching strategy, BPL favored significant learning of the assessment stage, the students were able to carry out the assessment in the hospital, the experience contributed to generate significant learning when students face real scenarios, which showed the effectiveness of the method.

关键词： Learning Method nursing Process Assessment

Effect of Cyclooxygenase-2 Blockade on Renal Hypertrophy development during Early Diabetes Mellitus

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Pharmacology & Pharmacy 2013年第3期4卷 288-295页

作者： Beatriz Vázquez-Cruz Josseline Rangel-Veladiz David Segura-Cobos Pedro López-Sánchez Maximiliano Ibarra-Barajas Dante Amato Laboratorio de Farmacología Unidad de Investigación Interdisciplinaria en Ciencias de la Salud y la Educación Facultad de Estudios Superiores Iztacala (FESI) Universidad Nacional Autónoma de México (UNAM) Tlalnepantla México Sección de estudios de Posgrado e Investigación Escuela Superior de Medicina Instituto Politécnico Nacional México DF México Unidad de Biomedicina Facultad de Estudios Superiores Iztacala (FESI) Universidad Nacional Autónoma de México (UNAM) Tlalnepantla México

Diabetes mellitus is the leading cause of diabetic nephropathy;the early phase of diabetes is associated with kidney growth and hyperfiltration;several factors modulate these changes, among them, prostaglandins and angiotensin II. Previous studies have shown that cyclooxygenase-2 is implicated in experimental models of diabetes. The aim of this work was to study the effect of celecoxib treatment on renal hypertrophy development in early diabetes mellitus. In our rats with early streptozotocin-induced diabetes there was renal hypertrophy, and increased renal expression of cyclooxygenase-2, AT1 receptor, and transforming growth factor-β1. Treatment with the selective cyclooxygenase-2 inhibitor celecoxib reduced the urinary excretion of prostaglandins such as prostaglandin E2, 6-keto prostaglandin F1α, and thromboxane B2. Kidney hypertrophy was reversed by the treatment, and the renal expression of cyclooxygenase-2, AT1 receptor, and transforming growth factor-β1 decreased. The renoprotective effects of celecoxib were independent of the changes in plasma glucose levels. These results confirm that cyclooxygenase-2 inhibition in rats with streptozotocin-induced diabetes decrease renal hypertrophy;this effect in turn, may be mediated by reduction of the expression of AT1 receptors and transforming growth factor-b1 in the kidney.

关键词： COX-2 Prostaglandins TGF-β Diabetic nephropathy Renal Hypertrophy Angiotensin II

Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Damián Sánchez-Ramírez Mónica G Mendoza-Rodríguez Omar R Alemán Fernando A Candanedo-González Miriam Rodríguez-Sosa Juan JoséMontesinos-Montesinos Mauricio Salcedo Ismael Brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas Unidad de Investigacion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico department of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biomedicina y Oncologia Genomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC)remains one of the most commonly diagnosed and deadliest types of cancer *** displays a desmoplastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form a part of the tumor *** are directly involved in tumorigenesis through different ***,their role in immunosuppression in CRC is not well understood,and the precise role of signal transducers and activators of transcription(STATs)in mediating CAF activity in CRC remains *** the myriad chemical and biological factors that affect CAFs,different cytokines mediate their function by activating STAT signaling ***,the harmful effects of CAFs in favoring tumor growth and invasion may be modulated using STAT ***,we analyze the impact of different STATs on CAF activity and their immunoregulatory role.

关键词： Cancer-associated fibroblasts Signal transducer and activator of transcription signaling Colorectal cancer Immunity Immunosuppression

Clinicopathological alterations in wild mammals from the reservoir system of Trypanosoma cruzi:a scoping review

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Animal Diseases 2024年第1期4卷 48-58页

作者： Ricardo Sanchez Pérez JoséManuel Aranda-Coello JoséAntonio de Fuentes Vicente Oscar Rico Chavez facultad de estudios superiores Cuautitlan Universidad Nacional Autonoma deMexicoCuautitlan lzcalliEstadodeMexicoMexico El Colegio de la Frontera Sur-Unidad Campeche CampecheCampecheMexico Instituto de Ciencias Biologicas-Universidad de Ciencias y Artes de Chiapas Tuxtla GutierrezChiapasMexico facultad de Medicina Veterinaria y Zootecnia-Universidad nacional Autonoma deMexico Ciudad deMexicoMexico

Trypanosoma cruzi is the etiologic agent of Chagas *** flagellated protozoan is transmitted to humans as well as different species of domestic and wild animals via vectors from the Reduviidae family(known as"kissing bugs").despite the fact that hundreds of species of wild mammals are part of the reservoir system,the morphologi-cal changes and clinical manifestations resulting from the pathogenesis of the infection have been largely *** aim of this review is to systematically compile the available information regarding clinicopathological altera-tions in wild mammals due to natural infection by *** was obtained from six online bibliographic data search platforms,resulting in the identification of 29 publications that met the inclusion *** was the most common clinical manifestation,cardiac damage was the main finding at necropsy,and lymphoplas-macytic inflammation was the most frequent microscopic ***,regardless of its role as a reservoir,*** has the potential to affect the health status of wild mammals,a situation that highlights the need for further research to analyze,measure,and compare its effects at both the individual and population levels.

关键词： Trypanosoma cruzi Chagas disease American trypanosomiasis Clinicopathological alterations natural infection Wild mammals

Impact of payment source, referral site, and place of residence on outcomes after allogeneic transplantation in Mexico

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World Journal of Transplantation 2024年第2期14卷 76-87页

作者： Andrés Gómez-de León Yesica A López-Mora Valeria García-Zárate Ana Varela-Constantino Sergio U Villegas-de Leon Xitlaly J González-Leal Raúl del Toro-Mijares Anna C Rodríguez-Zúñiga Juan F Barrios-Ruiz Victor Mingura-Ledezma Perla R Colunga-Pedraza Olga G Cantú-Rodríguez César H Gutiérrez-Aguirre Luz Tarín-Arzaga Elías E González-López David Gómez-Almaguer Hematology Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico Hemato-logy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico Hematology Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BACKGROUnD The impact of social determinants of health in allogeneic transplant recipients in low-and middle-income countries is poorly *** observational study analyzes the impact of place of residence,referring institution,and transplant cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after allogeneic hematopoietic stem cell transplantation(alloHSCT)in two of Mexico's largest public and private *** To evaluate the impact of social determinants of health and their relationship with outcomes among allogeneic transplant recipients in *** In this retrospective cohort study,we included adolescents and adults≥16 years who received a matched sibling or haploidentical transplant from *** were selected without regard to their diagnosis and were sourced from both a private clinic and a public University Hospital in *** payment groups were compared:Out-of-pocket(OOP),private insurance,and a federal Universal healthcare program“Seguro Popular”.Outcomes were compared between referred and institution-diagnosed patients,and between residents of nuevo Leon and *** outcomes included overall survival(OS),categorized by residence,referral,and payment *** outcomes encompassed early mortality,event-free-survival,graft-versus-host-relapse-free survival,and non-relapse-mortality(nRM).Statistical analyses employed appropriate tests,Kaplan-Meier method,and Cox proportional hazard regression *** software included SPSS and R with tidycmprsk *** Our primary outcome was overall *** included 287 patients,n=164 who lived out of state(57.1%),and n=129 referred from another institution(44.9%).The most frequent payment source was OOP(n=139,48.4%),followed by private insurance(n=75,26.1%)and universal coverage(n=73,25.4%).no differences in OS,event-free-survival,nRM,or graft-versus-host-relapse-free survival were observed for patients dia

关键词： Hematopoietic cell transplant Social determinants of health Geography Haploidentical Out-of-pocket Financial toxicity Survival Health services and outcomes Hematopoietic malignancy Aplastic anemia

Reproductive performance of the Mesa silverside(Chirostoma jordani Woolman,1894)under natural and controlled photoperiods

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BIOCELL 2012年第3期36卷 105-111页

作者： JOSÉLUIS ARREDOnDO-FIGUEROA LAURA GEORGInA nÚÑEZ-GARCÍA PALOMA ADRIAnA HEREDIA-GUZMÁn JESÚS T.POnCE-PALAFOX Posta Zootécnica Departamento de ZootecniaCentro de Ciencias AgropecuariasUniversidad Autónoma de AguascalientesJesús MaríaAguascalientesMéxico Planta Experimental de Producción Acuícola Departamento de HidrobiologíaCBSUniversidad Autónoma Metropolitana IztapalapaMéxicoD.F facultad de estudios superiores Iztacala Universidad Nacional Autónoma de MéxicoEstado de MéxicoMéxico Centro de Innovación y Transferencia Tecnológica CEnITT Posgrado CBAPEscuela Nacional de Ingeniería PesqueraUniversidad Autónoma de NayaritTepicNayaritMéxico

Chirostoma jordani is a native annual species inhabiting lacustrine waters of the Central Mexico *** is widely distributed and is currently facing high environmental *** experi-ments were performed to study the reproductive performance of this *** of the experiments were conducted in 270-L indoor recirculation *** males and one female at the first stage of reproduction were included in each test.A photoperiod of 14 light hours and 10 dark hours was *** a fifth experiment,10 females and 15 males were kept in an outdoor 3,000-L recirculation tank under natural *** number of spawns,fertilised eggs and 30-day-old juveniles were counted and the survival rate was *** results indicated significant differences(Pn *** spawn numbers and greater egg production were observed under controlled photoperiod,and higher numbers of juveniles and a higher survival rate were observed under natural *** trials exhibited different patterns of egg produc-tion during the *** egg production in the natural-photoperiod trials followed a polynomial curve *** contrast,the trials under the controlled photoperiod showed an irregular pattern of increases and decreases in egg production.

关键词： breeding Atherinopsidae eggs juveniles survival rate

Evaluation Preliminary of a Dry Emulsion System as a <i>Pasteurella multocida</i>Oral Carrier for Pigs

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Journal of Biosciences and Medicines 2020年第9期8卷 114-124页

作者： David Quintanar-Guerrero Edgar Aguilera Cerón María Elena Trujillo Ortega Sofia González Gallardo Alejandro Vargas Sánchez Abel Ciprián Carrasco Susana Mendoza Elvira facultad de estudios superiores Cuautitlán Universidad Nacional Autónoma de México Mexico City México facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de México Mexico City México

Background: This work evaluated the capacity of a dry emulsion as a carrier of viable microorganisms with potential use as prophylaxis of infectious diseases. Methods: The aqueous phase containing P. multocida not via... 详细信息

ng>Background:ng> This work evaluated the capacity of a dry emulsion as a carrier of viable microorganisms with potential use as prophylaxis of infectious diseases. ng>Methods:ng> The aqueous phase containing P. multocida not viable in PBS was emulsified in mineral oil to obtain a w/o emulsion. The microorganisms remained stable and only in two cases (n = 6) did the bacterial concentration decrease. Scanning Electron Microscopy (SEM) revealed a structure of a system with the organized association of particles with cubic symmetry. Using two ex vivo bioadhesion systems, it was demonstrated that the disperse-adsorbed system is capable of adhering to the intestinal mucosa and remains adhered for long periods of time. ng>Results: ng>The no viability of the bacteria in the dry emulsion and the possibility of controlled release were confirmed. In vivo trial was conducted in pigs. It was possible to locate the emulsion and the bacteria attached to the gut of the living animal. An ELISA kit was used to monitor the mean antibody titer of treated pigs over a 2-week period, and a classic primary response curve occurred when the titer was plotted against time. ng>Conclusion: ng>We propose the disperse-adsorbed system as an alternative to commonly used vehicles for immunogens in the oral vaccines.

关键词： Dry Emulsion Oral Carrier Pasteurella multocida Pigs Bioadhesion

Propolis in Dogs: Clinical Experiences and Perspectives (A Brief Review)

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Open Journal of Veterinary Medicine 2015年第1期5卷 11-17页

作者： nelly Tovar Betancourt Lucila García-Contreras Tonatiuh Alejandro Cruz Sánchez facultad de estudios superiores Cuautitlán Universidad Nacional Autónoma de México Cuautitlán Izcalli México department of Pharmaceutical Sciences The University of Oklahoma Health Sciences Center Oklahoma City USA

In light of the scarcity of novel therapeutic agents that are effective, the pharmaceutical industry has found a newer source of therapeutic compounds in natural products and herbal medicine to address the current health problems in humans and animals. What is particularly promising about these agents is that they produce fewer side effects and are more cost effective than synthetic compounds. This means greater availability of these treatments particularly for less developed countries who can’t afford expensive treatments. The reduced side effects also mean greater patient tolerance and increased compliance thereby yielding maximal therapeutic effect without negatively impacting on quality of life. Among the natural products more frequently employed nowadays is propolis, a resin that is routinely collected by bees (Apis mellifera). Propolis contains flavonoids, caffeic acid esters and diterpenic acids, which provide the bactericidal, antiviral and antifungal properties to this product. The use of propolis to address a variety of conditions in small animal species is beginning to play an important role in the currently available treatments. Its use appears to be an effective treatment with no side effects at low cost. This paper reviews the different applications of this compound to treat diseases in dogs.

关键词： Dog Propolis Uses Treatments Perspectives