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Amphibian richness along modified riparian areas of central Mexico:conservation priorities

Ecological Processes 2022年第1期11卷 902-915页

作者： Marco Tulio Oropeza‑Sánchez Ireri Suazo‑Ortuño Julieta Benítez‑Malvido Erandi Monroy‑Hernández Roberto Munguía‑Steyer Instituto de Investigaciones en Ecosistemas y Sustentabilidad(IIES) Universidad Nacional Autónoma de MéxicoAntigua Carretera a Pátzcuaro 8701CP 58190 MoreliaMichoacánMexico Instituto de Investigaciones Sobre los Recursos naturales(InIREnA) Universidad Michoacana de San Nicolás de HidalgoAv.San Juanito Itzícuaro S/NCP 58330 MoreliaMichoacánMexico facultad de estudios superiores Iztacala(FES‑Iztacala) Universidad Nacional Autónoma de MéxicoAv.de los Barrios No.1CP 54090 Tlalnepantla de BazEstado de MéxicoMexico.

Background:Land‑use change frequently affects faunistic populations and *** achieve successful conservation strategies,we need suitable information about species distribution and the causes of extinction *** amphibian species depend on riparian vegetation to complete their life *** 41%of amphibian species are globally threatened,and accurate estimations of population size,species richness and the identification of critical habitats are urgently needed *** evaluate the magnitude of changes in species richness and demography,estimations that include detection probability are *** this study,we employed multi‑species occupancy models to estimate detection probability and the effect of land cover type(i.e.,cropland,artificial pasture,secondary and mature forest)in a 500‑m radius on the occupancy probability and richness of diurnal amphibians in 60 riparian zones in the state of Michoacán in central ***,we evaluated the potential of the endemic salamander Ambystoma ordinarium as a flagship species for the conservation of other native amphibian ***:We registered a total of 20 amphibian species in the diurnal assemblage,of which 10 species are considered at risk of *** found that cropland was the most important land‑use type for explaining amphibian distribu‑tion in riparian zones,with negative effects on most amphibian *** found no differences in species richness between zones with and without *** riparian zones occupied by ***,however,we found a higher number of species at risk of ***:Our findings showed negative effects of croplands on the distribution of most amphibian *** riparian zones are important for the maintenance of native diurnal amphibian communities and *** can act as a flagship species for the conservation of threatened amphibian species.

关键词： Flagship species Habitat quality Occupancy models Salamanders Threatened species

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new Reports of Spiders in Three Mexican Ant-Acacias

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Open Journal of Ecology 2021年第1期11卷 32-40页

作者： Sandra Luz Gómez-Acevedo Unidad de Morfología y Función Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México México City México

The richness of spider species on the foliage of Mexican ant-acacias in Los Tuxtlas (Veracruz), and Santiago Pinotepa nacional (Oaxaca) was documented. A total of 11 species, grouped into five families were found;in Los Tuxtlas five species representing two families were identified, whereas in Santiago Pinotepa nacional, the number of taxa was eight, belonging to five families. The richness of spiders in Santiago Pinotepa nacional was higher than that found in Los Tuxtlas. In both locations nephila clavipes Linnaeus and Eustala illicita O. Pickard-Cambridge, both from Araneidae, were found;these species had been previously reported as common inhabitants of Central American ant-acacias. The presence of E. illicita in Mexican myrmecophytic acacias was confirmed. A total of 10 species grouped into five families are reported for the first time inhabiting Mexican ant-acacias, increasing the richness of spider interactions documented in Mexico. This study showed that the occurrence of spiders in the Vachellia-Pseudomyrmex mutualism system has been overlooked and is likely more common than what has been reported until now. This opens an opportunity for the study of the evolution of spider-ant-plant interactions.

关键词： Myrmecophily Mutualism Plant-Animal Interaction

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Molecular Docking of 4-Tert-buthyl-bis-(2,6-thiomorpholin-4-ylmethyl)-1-phenol (LQM319) on Fas Receptor (CD95)

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Journal of Cancer Therapy 2013年第1期4卷 176-181页

作者： Oscar Zuniga Victor HVazquez Ana Maria Velazquez Victor HAbrego Sandra Diaz-Barriga Arceo Patricia Ramirez Roberto Diaz Enrique Angeles Laboratorio de Toxicologia y Genetica Departamento de C.BiologicasFacultad de Estudios Superiores CuautitlanUniversidad Nacional Autonoma de MexicoCuautitlan IzcalliMexico Laboratorio de Quimica Medicinal departamento de Ciencias Quimicas facultad de estudios superiores Cuautitlan Universidad Nacional Autonoma de MexicoCuautitlan IzcalliMrxico.

The balance between cell proliferation and cell growth characterizes tissue homeostasis on one side and cell death on the other side. Fas receptor-mediated apoptosis is a control mechanism for tissue homeostasis, and avoiding this death pathway predisposes to many human diseases, including cancer. Current therapies for this disease are invasive and do not have the desired effect in the control of the disease. In this context, the search for new drugs that contribute to a better treatment is gaining more relevance. 4-tert-butyl-bis-(2,6-thiomorpholin-4-ylmethyl)-1-phenol (LQM319) [1,2] is a drug currently in preclinical stage, and we have shown that it has a hypertensive effect, similar to captopril, in a hypertensive rat model. Different studies have shown that some chemicals that are used as antihypertensive agents have an antineoplastic effect against certain types of cancer, as is the case of hydralazine [3], and captopril [4], among others [5]. On the other hand, it has been reported that morpholine derivatives may activate Fas (CD95)-mediated apoptosis. The aim of the present study was to show the interaction between CD95 (receptor) and thiomorpholine derivatives (ligand) using molecular modeling and docking studies, and to elucidate the possible action mechanism of 4-tert-butyl-bis-(2,6-thiomorpholin-4-ylmethyl)-1-phenol.

关键词： Fas Receptor (CD95) Fas Ligand (FasL) Docking

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Hepatitis C virus molecular evolution:Transmission,disease progression and antiviral therapy

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World Journal of Gastroenterology 2014年第43期20卷 15992-16013页

作者： Maria Victoria Preciado Pamela Valva Alejandro Escobar-Gutierrez Paula Rahal Karina Ruiz-Tovar Lilian Yamasaki Carlos Vazquez-Chacon Armando Martinez-Guarneros Juan Carlos Carpio-Pedroza Salvador Fonseca-Coronado Mayra Cruz-Rivera Laboratorio de Biología Molecular División PatologíaHospital de Ni?os "Ricardo Gutiérrez"Buenos Aires C1425EFDArgentina Instituto de Diagnóstico y Referencia Epidemiológicos Mexico 01480Mexico department of Biology Institute of BioscienceLanguage and Exact ScienceS?o Paulo State UniversityS?o José do Rio PretoSP 13560-970Brazil Laboratorio de Inmunobiología de Enfermedades Infecciosas Unidad de Investigación MultidisciplinariaFacultad de Estudios Superiores CuautitlánUniversidad Nacional Autónoma de MéxicoCuautitlán IzcalliEstado de México 54714Mexico departmento de Microbiología y Parasitología Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoMexico City 04510Mexico

Hepatitis C virus(HCV)infection represents an important public health problem *** of HCV morbidity and mortality is a current challenge owned to several viral and host *** molecular evolution plays an important role in HCV transmission,disease progression and therapy *** high degree of genetic heterogeneity characteristic of HCV is a key element for the rapid adaptation of the intrahost viral population to different selection pressures(e.g.,host immune responses and antiviral therapy).HCV molecular evolution is shaped by different mechanisms including a high mutation rate,genetic bottlenecks,genetic drift,recombination,temporal variations and *** evolutionary processes constantly rearrange the composition of the HCV intrahost population in a staging *** advances in the understanding of the molecular mechanism controlling HCV replication have facilitated the development of a plethora of direct-acting antiviral agents against *** a result,superior sustained viral responses have been *** rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer,more potent antivirals,bringing us one step closer to the interferon-free era.

关键词： Hepatitis C virus Evolution Phylogenetics Drug resistance Clinical outcome

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Historical relationships of the Mesoamerican highlands,with emphasis on tropical montane cloud forests:a temporal cladistic biogeographical analysis

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Journal of Mountain Science 2023年第1期20卷 129-140页

作者： CASTRO-TORREBLAnCA Marisol ESPInOSA David BUEnO-HERnAndeZ Alfredo LUnA-VEGA Isolda Biological Sciences Graduate Program Coordination of Graduate StudiesNational Autonomous University of MexicoUniversity CityCoyoacán04510Mexico CityMexico Comparative Biology and Biodiversity Research Unit Facultad de Estudios Superiores ZaragozaNational Autonomous University of MexicoAv.Batalla del 5 de mayo s/nCol.Ejército de Oriente09230Mexico CityMexico Laboratory of Biogeography and Systematics Department of Evolutionary BiologyFaculty of SciencesNational Autonomous University of MexicoUniversity CityCoyoacán04510Mexico CityMexico

The historical relationships of nine areas of endemism of the tropical montane cloud forests(TMCFs)were analysed based on a temporal cladistic biogeographical *** cladistic biogeographical analyses were conducted based on 29cladograms of terrestrial taxa by partitioning them into three time-slices,namely,Miocene,Pliocene,and *** results showed different area relationships over *** the Miocene and Pliocene time slices,the Isthmus of Tehuantepec acted as a geographic barrier that fragmented the TMCFs into two portions:west of the Isthmus and east of the *** the case of the Pleistocene,the TMCFs were broken into two portions,one related to the neotropical region and the other to the nearctic ***,the analyses allowed us to detect the influences of different geological and paleoclimatological events on the distribution of the TMCFs over ***,the TMCFs current distribution might have been driven by geological events during the Miocene-Pliocene,whereas climatic fluctuations have the highest impact during the Pleistocene.

关键词： Dispersal Evolutionary biogeography Paralogy free subtree analysis Vicariance

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Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration

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neural Regeneration Research 2022年第4期17卷 854-866页

作者： Manuel A.Fernandez-Parrilla David Reyes-Corona Yazmin M.Flores-Martinez Rasajna nadella Michael J.Bannon Lourdes Escobedo Minerva Maldonado-Berny Jaime Santoyo-Salazar Luis O.Soto-Rojas Claudia Luna-Herrera Jose Ayala-Davila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez Irma A.Martínez-Dávila Porfirio nava Daniel Martinez-Fong departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa Institucional de Biomedicina Molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico department of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia department of Pharmacology Wayne State University School of MedicineDetroitMIUSA departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico facultad de estudios superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico departamento de Fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico Laboratorio de Medicina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico Laboratorio de neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Programa de nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's *** human cerebral dopamine neurotrophic factor(h CDnF)has recently emerged as a strong candidate for Parkinson's disease *** study shows that h CDnF expression in dopamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological,biochemical,and behavioral *** independent electron microscopy techniques showed that the neurotensin-polyplex nanoparticles containing the h CDnF gene,ranging in size from 20 to 150 nm,enabled the expression of a secretable h CDnF in *** injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine lesion resulted in detectable h CDnF in dopamine neurons,whose levels remained constant throughout the study in the substantia nigra compacta and *** with the lesioned group,tyrosine hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CDnF *** increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAP43 p)followed TH^(+)cell recovery,as well as dopamine and its catabolite *** reversal(80%)of drugactivated circling behavior and full recovery of spontaneous motor and non-motor behavior were ***-derived neurotrophic factor recovery in dopamine neurons that also occurred suggests its participation in the neurotrophic *** findings support the potential of nanoparticle-mediated h CDnF gene delivery to develop a disease-modifying treatment against Parkinson's *** Institutional Animal Care and Use Committee of Centro de Investigación y de estudios Avanzados approved our experimental procedures for animal use(authorization no.162-15)on June 9,2019.

关键词： axonal growth brain-derived neurotrophic factor gene delivery nanoparticles neuritogenesis neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's disease reinnervation substantia nigra

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Antimicrobial Activity of Essential Oil of <i>Zingiber officinale</i>Roscoe (Zingiberaceae)

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American Journal of Plant Sciences 2017年第7期8卷 1511-1524页

作者： Etna Itzel Curiel López Mariana Fernanda Hernández Balcázar Jenyffer Madelein Ramírez Mendoza Areli Dyan Rivas Ortiz María Teresa Ortiz Melo Rocío Serrano Parrales Tzasna Hernández delgado Laboratorio de Farmacognosia UBIPRO Facultad de Estudios Superiores-Iztacala Universidad Nacional Autónoma de México Tlalnepantla México

Zingiber officinale, commonly known as ginger, is a species native of tropical Asia. It is grown and used in tropical countries of America, including Mexico, where it is used for the treatment of throat infections. The aim of this study was to determine the chemical composition of essential oil of Z. officinale rhizome and evaluate their antimicrobial activity. The essential oil was obtained by hydrodistillation, and the chemical composition of the oil was determined by GC-MS. To determine the antimicrobial activity diffusion, agar dilution and radial growth inhibition methods were employed. Microbial growth curves were performed on the strains most susceptible. It was identified 28 compounds in the essential oil, the most abundant were eudesmol (8.19%), γ-terpinene (7.88 %), a-curcumene (7.28%), alloaromadendrene (6.56%), zingiberene (6.06 %), α-pinene (5.76 %), δ-cadinene (3.84%), elemol (3.39%), farnesal (3.45%), E-β-farnesene (3.57%), neril acetate (2.8%) and β-myrcene (2.94%). In antimicrobial activity, the essential oil inhibited the growth of 15 bacterial strains, 3 of yeast fungi and 4 of mycelia fungi. The most susceptible strains were S. aureus FES-I (MIC = 0.25 mg/mL) S. epidemidis FES-C (MIC = 0.5 mg/mL), E. faecalis ATCC 14506 (MIC = 1.0 mg/mL), C. tropicalis (CMI = 0.125 mg/mL) and T. mentagrophytes (CF50 = 0.08 mg/mL). In the microbial growth curves the essential oil showed bactericidal effect on S. aureus FES-I and S. marcescens ATCC 14756 from the first hour of exposure of the strains to oil, eliminating 99.9% of CFU in concentrations of 0.5 and 0.75 mg/mL respectively. The results validate the medicinal use of Z. officinale in the treatment of diseases of possible infectious origin.

关键词： Antibacterial Activity Antifungal Activity Essential Oil Zingiber officinale Monoterpenes Sesquiterpenes

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Use of Propolis for Topical Treatment of dermatophytosis in Dog

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Open Journal of Veterinary Medicine 2014年第10期4卷 239-245页

作者： Tonatiuh Alejandro Cruz Sanchez Perla Alejandra Estrada García Cristian Ismael Lopez Zamora Marcela Autran Martínez Víctor Perez Valencia Amparo Londono Orozco facultad de estudios superiores Cuautitlan Universidad Nacional Autonoma de MexicoCuautitlan IzcalliMexico Belen Veterinary Hospital TultitlanMexico

Here we present three clinical cases of canine dermatophytosis resolved with topical propolis treatment that involved alopecia and well-demarcated erythematous lesions. These cases were positively identified by direct observation of samples from the affected zones with 10% KOH. Each sample was cultured, leading to the isolation of Microsporum gypseum in one case and Microsporum canis in the other two cases. The animals’ subsequent treatment included bathing using a commercial soap with propolis every seven days for 3 to 8 weeks, as well as the use of a propolis-containing ointment elaborated in our laboratory, which was applied to the lesions once a day for three weeks. From the second week of treatment, all cultures were negative. At the end of treatment, all cases displayed full recovery of the injuries and hair growth in these areas. In these clin-ical cases, treatment with propolis was effective, supporting the use of propolis as a promising natural alternative with no known collateral effects.

关键词： Canine dermatophytosis Microsporum Treatment Propolis

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Role of Angiotensin-(1-7) on Renal Hypertrophy in Streptozotocin-Induced Diabetes Mellitus

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Pharmacology & Pharmacy 2016年第9期7卷 379-395页

作者： Dante Amato Alma R. núñez-Ortiz José del Carmen Benítez-Flores David Segura-Cobos Pedro López-Sánchez Beatriz Vázquez-Cruz Laboratorio de Farmacología Unidad de Investigación Interdisciplinaria en Ciencias de la Salud y la Educación Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Laboratorio de Histología Unidad de Morfología y Función Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Sección de estudios de Posgrado e Investigación Escuela Superior de Medicina Instituto Politécnico Nacional Ciudad de México México

Participation of angiotensin II in chronic kidney diseases including diabetic nephropathy (Dn) has been extensively described. Similarly, several studies support a protective role for angiotensin-(1-7). However, other studies suggest that some of the cellular effects of angiotensin-(1-7) may be deleterious. The objective of this study was to determine the role of exogenous angiotensin-(1-7) on renal hypertrophy development in rats with streptozotocin-induced diabetes. A control group and three groups of rats with streptozotocin-induced diabetes: untreated diabetic rats, diabetic rats treated with captopril, and diabetic rats treated with angiotensin-(1-7), were studied. After two weeks of treatment, the kidneys were removed under anesthesia with pentobarbital. The kidneys were weighed and the renal cortex was separated for analysis of AT1R, TGF-β1, MASR, and ACE2 expression by western blot. Rats in the three groups with diabetes had hyperglycemia, increased food and water consumption, and higher urinary volume than control rats. Treatment with captopril or angiotensin-(1-7) reversed streptozotocin-induced renal hypertrophy, measured by kidney weight, protein/DnA ratio in renal cortex, glomerular area, or proximal tubular cells area, proteinuria, and creatinine clearance reduction. AT1R, TGF-β1, and MAS receptor expression in renal cortex of diabetic rats increased significantly as compared to controls (p

关键词： Diabetes Mellitus Streptozotocin Ang-(1-7) MAS Receptor Renal Hypertrophy

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Oxidative Stress Evaluation in Cancer-Induced Mice Treated with Ruta graveolens L. Stem lectins

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Journal of Life Sciences 2015年第9期9卷 436-442页

作者： Amairany Torres-Alvarez Ernesto Mendoza-Vallejo Catalina Machuca-Rodriguez Unidad Multidisciplinaria de Investigacion Experimental Zaragoza Facultad de Estudios Superiores Zaragoza Universidad Nacional Autonoma de Mexico Mexico City 09230 Mexico

The production of free radicals is a natural process in aerobic organisms due to the mitochondrial activity. Usually the cells have several mechanisms for scavenging those free radicals, but, in several pathologic processes, such as cancer, those free radicals increase their production, making it impossible to sustain the system stable, generating the condition called oxidative stress. Ruta graveolens L. （Rue） is a plant commonly used in traditional medicine, mainly as antiinflamatory; this has been related to some organic components, such as Rutin, but there hasn＇t been any lectin studies in Rue stem. Lectins are glycoproteins of non-enzymatic and no immune origin, able to bind to simple carbohydrates, which lets them bind selectively to malignant cells against normal cells, killing them via apoptosis and reducing the free radicals level. In this study we intended to characterize rue stem lectins as those weren＇t reported yet. Also, the anticancer and antioxidant activity of these lectins was evaluated, Rue stem lectins were extracted using a saline solution and semipurified to obtain an enriched extract and administrated to nickel oxide treated mice. Oxidative stress was cuantified using the tiobarbituric acid （TBARS） method to quantify Malondialdehyde （MDA）, the Griess method to cuantify nitrites and enzymatic activity of catalase were cuantified in liver. In this study was found that rue stem lectins are useful as a therapeutic auxiliar, considering that its ratio of antioxidant activity is limited, being a prooxidant agent at high concentrations.

关键词： Ruta graveolens L. lectins oxidative stress cancer.

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