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Immunotherapy and immunoescape in colorectal cancer

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World Journal of Gastroenterology 2007年第44期13卷 5822-5831页

作者： Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero Liver Unit Facultad de Ciencias Biomédicas Universidad Austral Presidente Perón 1500 (1635) Derqui-Pilar Buenos Aires Argentina Centro de Investigación Médica Aplicada and Clínica Universitaria Universidad de Navarra Pamplona Spain

Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma.

关键词： Colorectal carcinoma Immunotherapy Gene therapy interleukin-12 dendritic cells CD137 indoleamine 2, 3 dioxygenase

Volatile Components in the Flower, Pedicellate Ovary and Aqueous Residue of <i>Cymbidium</i>sp. (ORCHIDACEAE)

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Journal of Analytical Sciences, Methods and Instrumentation 2013年第4期3卷 212-218页

作者： Víctor García Gaytán María de las Nieves Rodríguez Mendoza Marcos Soto Hernández Libia I. Trejo-Téllez Martha E. Pedraza Santos Guadalupe Valdovinos Ponce facultad de agrobiología “presidente juárez” Uruapan México 4Postgrado en Fitosanidad Colegio de Postgraduados Texcoco México. Postgrado en Botánica Colegio de Postgraduados Texcoco México Postgrado en Edafología Colegio de Postgraduados Texcoco México Postgrado en Fitosanidad Colegio de Postgraduados Texcoco México. Víctor García Gaytán

Cymbidium sp. has several ornamental, medicinal and cosmetic uses. Essential oils were obtained through extraction by hydrodistillation of flower and pedicellate ovary. The chromatographic profile was obtained by thin layer chromatography (TLC), combined with gas chromatography-mass spectrometry (GC/MS), for the identification and relative quantification of various substances in three samples from the orchid (flower, pedicellate ovary and aqueous residue). With TLC, five compounds were identified in the flower, with the most abundant being terpineol, linalool and zingiberene, and five in the pedicellate ovary, with borneol, cineole, and β-bisabolene being in the greatest concentration, while for the aqueous residue, the most abundant was geraniol. Using GC/MS, 25 volatile components associated with the flower were identified, of which the most abundant were linalool (22.92%), 4-methyl-phenol (15.07%) and p-Menth-1-en-8-ol (12.32%). In pedicellate ovaries, 13 components were identified, with the most abundant being 4-methyl-phenol (31.24%), bicycle [4.4.0] dec-1-ene, 2-isopropyl-5-methyl-9-methylene-(17.74%) and 2-hexanone (10.24%), while in the aqueous residue 18 components were found, with the most abundant being 4-methyl-phenol (18.71%) and 2- cyclohexen-1-ol (14.60%).

关键词： Thin Layer Chromatography Gas Chromatography Orchidaceae Hydrodistillation

THERMAL PERFORMANCE OF AN EXTENSIVE GREEN ROOF UNdeR SEMI-ARID CONDITIONS IN CENTRAL ARGENTINA

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Journal of Green Building 2021年第1期16卷 17-42页

作者： Lelia Imhof Edgardo Suárez Natalia Cáceres Federico Robbiati Cecilia Cáceres Alejandra Broilo Lucila Pellizari Mario Suárez Emmanuel Hick Evangelina Matoff Leonardo Galetto IRNASUS(facultad de Ciencias Agropecuarias-facultad de Arquitectura Universidad Católica de Córdoba-CONICET Instituto de Etiquetación Edilicia Urbana Colegio de Arquitectos de la Provincia de Córdoba departamento de Diversidad Biológica y Ecología Facultad de Ciencias ExactasFísicas y NaturalesUniversidad Nacional de Córdoba e Instituto Multidisciplinario de Biología Vegetal(CONICET-UNC) AER INTA Agencia de Extensión Rural Presidente Roca esquina La CoruñaCórdoba

Extensive green roofs improve the provision of ecosystem services in urban environ-ments,particularly in semiarid *** aim of this paper is to compare their thermal performance during six months between two rooms,one with a green roof and the other with a conventional roof,in Córdoba(Argentina).The room with a green(planting)roof showed a lower inside surface temperature since the begin-ning of the study than the control room(between 5-6°C of difference).During the selected period,the indicators such as temperature amplitude(the difference between the maximum and the average temperature)and the anti-interference characteristics of the layers to the outdoor air temperature are produced a better performance for the green roof compared to the conventional *** pattern of a better perfor-mance was consistent across the study for the green roof,characterized by a higher cooling and warming of the roof surface during the day and night,*** green roof was more effective at blocking an upward heat flux during the day and suppressing heat loss during the ***,conductive flux and climatic conditions seem to dominate the thermal performance of green roofs in areas with semiarid climate conditions.

关键词： thermal performance extensive green roofs semiarid region

Potential Species Distribution and Richness of Ixodidae Ticks Associated with Wild Vertebrates from Michoacán, Mexico

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Journal of Geographic Information System 2014年第5期6卷 467-477页

作者： Margarita Vargas-Sandoval Angel G. Priego-Santander Alejandra Larrazábal Carolina G. Sosa-Gutiérrez Blanca Lara-Chávez Teresita Avila-Val facultad de agrobiología “presidente juárez” Universidad Michoacana de San Nicolás de Hidalgo Uruapan México Centro de Investigaciones en Geografía Ambiental UNAM Antigua Carretera a Pátzcuaro No. 8701 ExHacienda de San José de la Huerta Morelia México Unidad de Investigación Médica de Enfermedades Infecciosas y Parasitarias Hospital de Pediatría Centro Médico Nacional Siglo XXI México DF México

Ticks are regarded as the most relevant vectors of disease-causing pathogens in domestic and wild animals. The diversity of Ixodidae is known for a very small number of ***?are represented by 26 species, and?in?2007 the first reported ticks vectors in Mexico for the causal agent of Lyme disease. Recent rise in tick-borne disease in many parts of the world is a phenomenon in need of an explanation. The main objective of the present work was to map at a regional scale (1:2,000,000)?of?the distribution of ticks of the family Ixodidae that are potentially present on the wild fauna of state of Michoacan, Mexico. We compiled all available literature on ticks at a national level together with complete cartographic and bibliographic georeferenced information of the distribution of hosts in order to build a spatial database in ArcView 3.3. The results indicated that the wild fauna in the state’s territory could potentially include 31 species of ticks of Ixodidae. The map of potential species richness of ixodid ticks on the wild fauna of the state can be categorized into five classes of species richness. The highest potential concentration of ixodid species on wild fauna occurs in the volcanic area of Pico de Tancítaro.

关键词： Ticks Ixodidae Michoacán Geographic Distribution Potential Species Richness

Biological and Chemical Control in Rot Root in Avocado by Phytophthora cinnamomi Rands

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Journal of Agricultural Science and Technology(A) 2012年第7期2卷 882-887页

作者： Ma. Blanca Nieves Lara-Chavez Teresita del Carmen Avila-Val Jestus Alejandro Guerrero-Tejeda Francisco Said Barriga-Gonzalez Eulalio Venegas-Gonzalez Salvador Aguirre-Paleo Margarita Vargas-Sandoval Hector Guillen Andrade Satul Rodriguez-Lopez Universidad Michoacana de San Nicolas de Hidalgo Facultad de Agrobiologla "Presidente Juarez" Uruapan Michoacan C.P.60190 Mexico

＂Avocado sadness＂ caused by the Oomycete Phytophthora cinnamomi Rands, is one of the main diseases affecting this fruit crop in Michoacan, M6xico, without having an efficient control strategy for that. In this research three Trichoderma isolates and Ridomil Gold 4E fungicide were tested in avocado trees infected with this pathogen using the growing and coloring vegetative flow growing. Results were analyzed with an experimental design completely random with four treatments and repetitions. Different responses were presented form avocado trees to each treatment. Trichoderma erinaceum Bissett, Kubicek ＆ Szackacs treatment was the best controlling disease in trees with grade II and III damage. Trichoderma aggressivum Samuels ＆ W. Gams controlled better in trees with grade III damage. At last, Trichoderma arundinaceum Zafari, Graef. and Samuels were the best controlling trees with the highest grade damage. Fungicide Ridomil Gold 4E controlled the disease in trees with the lowest grade damage （I and II）, their medias were similar to witness.

关键词： Biological and chemical control Trichoderma aggressivum T. erinaceum T. arundinaceum Ridomil Gold 4E.