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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and Notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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Unveiling the brain’s symphony:exploring the necessity and sufficiency of neural networks in behavior control

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Neural Regeneration Research 2025年第1期20卷 186-187页

作者： Fernando Jose Bustos Instituto de Ciencias Biomedicas Facultad de Medicina y Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile Millennium Nucleus of Neuroepigenetics and Plasticity(EpiNeuro) SantiagoChile

Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas ***,they involve connectivity among brain areas,whether close or *** that time,this approach was considered the optimal way to dissect brain circuitry and *** pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain ***,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely *** animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established.

关键词： behavior connectivity neural

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria S.Aymerich universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-universidad de Navarra PamplonaSpain IdiSNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

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Green Synthesis of Silver Nanoparticles Using Annona diversifolia Leaf Extract and Their Antimicrobial Application

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Journal of Renewable Materials 2020年第9期8卷 1129-1137页

作者： Rogelio Solorzano-Toala Daniel Gonzalez-Mendoza Benjamin Valdez-Salas Vianey Mendez-Trujillo Federico Gutierrez-Miceli Ernesto Beltran-Partida Olivia Tzintzun-Camacho Tecnológico Nacional de México-Campus Tuxtla Gutiérrez Tuxtla Gutiérrez03940México Instituto de Ciencias Agrícolas de la universidad autónoma de baja california Mexicali21705México Instituto de Ingeniería de la universidad autónoma de baja california Mexicali21100México facultad de medicina de la universidad autónoma de baja california Mexicali21100México

The aim of this study was the synthesis of silver nanoparticle using Annona diversifolia *** silver nanoparticles obtained were analyzed by spectroscopic methods and dynamic light scattering *** inhibition of AgNPs was evaluated against Bacillus cereus,Klebsiella pneumoniae and Enterobacter *** results showed that AgNPs have high values at 3 keV and particle size between 45 to 58 nm with a homogenous *** AgNPs showed growth inhibition against Klebsiella pneumoniae and Enterobacter *** studies are needed to confirm the potential antimicrobial of different AgNP from *** in Gram negative and Gram positive bacteria.

关键词： Green chemistry AgNPs plants antimicrobial biotechnology

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Insecticidal Effect of Green Bimetallic Nanoparticles from Crotalaria longirostrata on Cotton Mealybug,Phenacoccus solenopsis

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Journal of Renewable Materials 2022年第10期10卷 2543-2552页

作者： Vianey Mendez-Trujillo Benjamín Valdez-Salas Mario Curiel-Alvarez Ernesto Beltran-Partida Arnoldo Alfaro-Corres EsaúRuiz-Sanchez Gerardo Bautista-Trujillo Olivia Tzintzun Camacho Onecimo Grimaldo-Juarez Carlos Ceceña-Duran Carlos Ail-Catzin Daniel González-Mendoza facultad de medicina de la universidad autónoma de baja california Dr.Humberto Torres Sanginés S/NCentro CívicoMexicaliBaja CaliforniaMéxico Instituto de Ingeniería de la universidad autónoma de baja california Calle de la Normal S/N y Boulevard Benito JuárezMexicaliBaja CaliforniaMéxico Instituto Tecnológico de Conkal División de Estudios de Posgrado e InvestigaciónAntigua Carretera Mérida-MotulConkalYucatánMéxico facultad de medicina Veterinaria y Zootecnia de la universidad autónoma de Chiapas ChiapasMéxico universidad autónoma de baja california Instituto de Ciencias AgrícolasBaja CaliforniaMéxico

The present study was conducted to evaluate the impact of bimetallic nanoparticles(NPs)of copper(Cu)and zinc(Zn)from Crotalaria longirostrata on the insect mortality and cell viability of Phenacoccus *** biosynthesis of bimetallic nanoparticles(Cu/Zn-NPs)from *** was confirmed by the presence of a single peak around 378 *** hydrodynamic diameter of the Cu/Zn nanoparticles varied from 59 to 119 nm and their zeta potential was found to be−30.90 *** EDX analysis showed a strong signal for Cu and Zn(8 and 8.6 keV,respectively).The Cu/Zn-NPs showed an effective insecticide activity against *** with 63%of insect mortality after 96 h ***,further studies about nanotoxicity of Cu/Zn-NPs from *** are needed to reveal the exact mechanism of nanoparticles toxicity in insects.

关键词： Phytonanoparticles chipilin biocontrol agronanotechnology

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Green Synthesis of Bimetallic Nanoparticles From Prosopis juliflora(Sw)DC.,and Its Effect Against Cotton Mealybug,Phenacoccus solenopsis(Hemiptera:Pseudococcidae)

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Phyton-International Journal of Experimental Botany 2019年第3期88卷 269-275页

作者： V.Mendez-Trujillo B.Valdez-Salas M.Carrillo-Beltran M.A.Curiel-Alvarez O.Tzintzun-Camacho C.Ceceña-Duran D.Gonzalez-Mendoza facultad de medicina de la universidad autónoma de baja california Dr.Humberto Torres Sanginés S/NCentro Cívico21000MexicaliBaja CaliforniaMéxico Instituto de Ingeniería de la universidad autónoma de baja california Calle de la Normal S/N y Boulevard Benito Juárez21100MexicaliBaja CaliforniaMéxico Instituto de Ciencias Agrícolas de la universidad autónoma de baja california(ICA-UABC).Carretera a delta S/N C.P.21705 Ejido Nuevo LeónBaja CaliforniaMéxico

Phenacoccus solenopsis has been recognized as an aggressively invasive species on cotton plants in different *** study was conducted to investigate the effect of green synthesized Cu/Zn-nanoparticles using aqueous leaf extract of Prosopis juliflora(mezquite)against *** scanning electron microscope(SEM)showed bimetallic nanoparticles of Cu/Zn-NPs with spherical shape with varying size of 74.33 nm to 59.46 *** than 30%mortality of *** was observed with Cu/Zn-nanoparticles(100 ppm)at 96 hours after *** mortality of *** was recorded with Cu/Zn solution(100 ppm)and aqueous *** *** results of the viability test for Cu/Zn-nanoparticles of *** showed a significant reduction of the cell viability by 50%in insect exposed to Cu/*** studies about nanotoxicity of Cu/Zn-NPs of *** are needed to reveal the mechanism of toxicity this phytonanoparticles in ***.

关键词： Photosynthesis biocontrol cotton mealybug nanoinsecticide

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Green Synthesis of Silver Nanoparticles from Abronia villosa as an Alternative to Control of Pathogenic Microorganisms

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Journal of Renewable Materials 2020年第1期8卷 69-78页

作者： Ali Abdelmoteleb Benjamin Valdez-Salas Ernesto Beltran-Partida Daniel Gonzalez-Mendoza Botany department Faculty of AgricultureMenoufia UniversityShebin El-Kom32511Egypt Instituto de Ingeniería de la universidad autónoma de baja california MexicaliBaja California21100México Instituto de Ciencias Agrícolas de la universidad autónoma de baja california(ICA-UABC) Ejido Nuevo LeónBaja California21705México

The aim of this study was to evaluate the antibacterial and antifungal activities of eco-friendly synthesized silver *** silver nanoparticles were synthesized by biological method using aqueous extract of Abronia *** of silver nanoparticles was confirmed by color change and characterized using UV-visible spectroscopy,scanning electron microscope(SEM),energy dispersive X-ray spectroscopy(EDX),dynamic light scattering(DLS),and zeta potential *** SEM analysis revealed the presence of spherical silver nanoparticles of the size range 21 to 33 *** silver nanoparticles were used to evaluate their antibacterial effects at different concentrations(25,50,75 and 100μg/ml)on gram negative and gram positive *** biggest halo zone was observed at 75 and 100μg/ml concentrations of silver nanoparticles against both gram positive and gram negative *** activity of biosynthesized silver nanoparticles was evaluated against seven different phytopathogenic *** showed high inhibition of radial growth toward all tested *** highest inhibition of fungal growth by AgNPs was recorded against Macrophomina phaseolina(86.06±0.92%).Biosynthesized AgNPs using plant extract are a promising to use safety for various biomedical and agricultural applications.

关键词： Antibacterial activity antifungal activity green synthesis

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Airborne bacteria associated with particulate matter from a highly urbanised metropolis:A potential risk to the population’s health

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Frontiers of Environmental Science & Engineering 2022年第9期16卷 99-114页

作者： María del Carmen Calderón-Ezquerro Elizabeth Selene Gómez-Acata Carolina Brunner-Mendoza Instituto de Ciencias de la Atmósfera y Cambio Climático Universidad Nacional Autónoma de MéxicoCiudad de México 04510Mexico facultad de medicina Universidad Nacional Autónoma de MéxicoCiudad de México 04510Mexico

Bacteria in the air present patterns in space and time produced by different sources and environmental *** studies have focused on the link between airborne pathogenic bacteria in densely populated cities,and the risk to the population’s *** associated with particulate matter(PM)were monitored from the air of Mexico City(Mexico).We employed a metagenomic approach to characterise bacteria using the 16S rRNA *** bacteria sampling was carried out in the north,centre,and south of Mexico City,with different urbanisation rates,during *** added to the particles were sampled using high-volume PM_(10) *** ascertain significant differences in bacterial diversity between zones and seasons,the Kruskal-Wallis,Wilcoxon tests were done on alpha diversity ***-three air samples were collected,and DNA was sequenced using next-generation *** results indicated that the bacterial phyla in the north and south of the city were Firmicutes,Cyanobacteria,Proteobacteria,and Actinobacteria,while in the central zone there were more *** were no differences in the alpha diversity indices between the sampled *** to the OTUs,the richness of bacteria was higher in the central *** diversity was higher in the rainy season than in the dry season;the Shannon index and the OTUs observed were higher in the central zone in the dry *** bacteria such as Kocuria,Paracoccus,and Micrococcus predominated in both seasonal times,while Staphylococcus,Corynebacterium,and Nocardioides were found during the rainy season,with a presence in the central zone.

关键词： Airborne bacteria Urbanisation PM10 Mexico City Microbiome

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