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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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Phosphorus Use Efficiency of Bio-Based Fertilizers:Bioavailability and Fractionation

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Pedosphere 2016年第3期26卷 310-325页

作者： Céline VANEECKHAUTE Joery JANDA Peter A.VANROLLEgHEM Filip M.g.TACK Erik MEERS Laboratory for Analytical and Applied Ecochemistry Faculty of Bioscience EngineeringGhent University model EAU Département de Génie Civil et de Génie des EauxFaculté des Sciences et de GénieUniversité Laval

Although to date some technologies producing bio-based phosphorus(P) fertilizers have been proposed and implemented, the efficient use of the recovered products is still limited due to legislative constraints and lack of insights in the P release with time and in the corresponding mechanisms. The aim of this work was to evaluate the fertilizer performance in terms of P release and use efficiency of recovered struvite, FePO_4-sludge, digestate, and animal manure as compared to fossil reserve-based mineral triple superphosphate(TSP). First, product physicochemical characteristics and P fractions in the context of European fertilizer legislation were assessed. Next, a controlled greenhouse experiment was set up to evaluate plant reactions as well as changes of P availability in a sandy soil with high P status and a Rheinsand soil with low P status. Soil P fractions were determined in the extracts with water, ammonium lactate and CaCl_2, and in soil solution sampled with Rhizon soil moisture samplers. Based on all results, it is worth conducting long-term field trials to evaluate the P release effect of struvite and digestate as compared to animal manure and TSP on different soil types with varying P status. These products showed promise as sustainable substitutes for conventional P fertilizers and could contribute to a more efficient use of P in agriculture. A refined classification of P application standards/recommendations in terms of soil P status, soil texture, and fertilizer characteristics, next to the crop P demand, is recommended. Moreover, the additional use of Rhizon samplers for determination of direct available P, including dissolved organic P, is proposed for better understanding and categorization of different P fertilizers in environmental and fertilizer legislations.

关键词： chemical soil analysis digestate nutrient recovery Rhizon samplers struvite

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Static Analysis of Functionally graded Sandwich Plates Using an Efficient and Simple Refined Theory

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Chinese Journal of Aeronautics 2011年第4期24卷 432-433页

作者： Hadj Henni ABdeLAZIZ Hassen Ait ATMANE Ismail MECHAB Lakhdar BOUMIA Abdelouahed TOUNSI Adda Bedia El ABBAS Laboratoire des Matériaux et Hydrologie Université de Sidi Bel Abbes Département de génie Civil Université Ibn Khaldoun Département de génie Civil Faculté de Génie Civil et d'Architecture Univesité de Chlef Département de Physique Université de Sidi Bel Abbes

In this paper, a new displacement based high-order shear deformation theory is introduced for the static response of functionally graded sandwich plate. Unlike any other theory, the number of unknown functions involved is only four, as against five in case of other shear deformation theories. The theory presented is variationally consistent, has strong similarity with classical plate theory in many aspects, does not require shear correction factor, and gives rise to transverse shear stress variation such that the transverse shear stresses vary parabolically across the thickness satisfying shear stress free surface conditions. Two common types of functionally graded sandwich plates, namely, the sandwich with fimctionally graded facesheet and homogeneous core and the sandwich with homogeneous facesheet and functionally graded core, are considered. governing equations are derived from the principle of virtual displacements. The closed-form solution of a simply supported rectangular plate subjected to sinu- soidal loading has been obtained by using the Navier method. The validity of the present theory is investigated by comparing some of the present results with those of the classical, the first-order and the other higher-order theories. It can be concluded that the proposed theory is accurate and simple in solving the static bending behavior of functionally graded sandwich plates.

关键词： functionally graded materials sandwich plates refined plate theory bending Navier solution

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degradation of direct azo dye by Cucurbita pepo free and immobilized peroxidase

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Journal of Environmental Sciences 2013年第6期25卷 1235-1244页

作者： Nabila Boucherit Mahmoud Abouseoud Lydia Adour Université Mouloud Mammeri Laboratoire de Biomatériaux et de Phénomènes deTransports Université Dr.Yahia Fares Laboratoire de Biomatériaux et de Phénomènes de Transports Université Dr.Yahia Fares Laboratoire de génie de la Réaction Faculté de Génie Mécanique et Génie des ProcédésUniversité Houari Boumediene Laboratoire des Biotechnologies Environnementales et génie des Procédés

Enzymatic decolourization of the azo dye, Direct Yellow （DY 106） by Cucurbita pepo （courgette） peroxidase （CP） is a complex process, which is greatly affected by pH, temperature, enzyme activity and the concentrations of H202 and dye. Courgette peroxidase was extracted and its performance was evaluated by using the free-CP （FCP） and immobilized-CP （ICP） forms in the decolourization of DY106. Immobilization of peroxidase in calcium alginate beads was performed according to a strategy aiming to minimize enzyme leakage and keep its activity at a maximum value by optimizing sodium alginate content, enzyme loading and calcium chloride concentration. The initial conditions ~it which the highest DY106 decolourization yield was obtained were found at pH 2, temperature 20~C, H202 dose 1 mmol/L （FCP） and 100 mmol/L （ICP）. The highest decolourization rates were obtained for dye concentrations 50 mg/L （FCP） and 80 mg/L （ICP）. Under optimal conditions, the FCP was able to decolorize more than 87% of the dye within 2 min. While with ICP, the decolourization yield was 75% within 15 rain. The decolourization and removal of DY106 was proved by UV-Vis analysis. Fourier transform infrared （FF-IR） spectroscopy analysis was also performed on DY106 and enzymatic treatment precipitated byproduct.

关键词： Cucurbita pepo peroxidase immobilization decolourization azo dye

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Numerical study of the performance of multistage Scaba 6SRgT impellers for the agitation of yield stress fluids in cylindrical tanks

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Journal of Hydrodynamics 2015年第3期27卷 436-442页

作者： AMEUR Houari BOUZIT Mohamed gHENAIM Abdellah Laboratoire de Mécanique Appliquée Faculté de Génie MécaniqueUSTO-MB Institut de Technologie Université Ibn Khaldoun INSA de Strasbourg-24 Bd de la Victoire-67084 Strasbourg-France

The 3-D flow fields and power consumption in a vessel stirred by multistage Scaba 6SRgT impeller have been investiga- ted. The Xanthan gum solutions in water were used, which have a shear thinning behavior with yield stress. This study was carried out with the help of a CFD package （CFX 13.0, Ansys Inc.） which is based on the finite volume method to solve the momentum equations. The effects of stirring rate, fluid rheology, impeller number, impeller location and vessel size on the performance of such stirred system are presented. To validate the CFD model, our predicted results have been compared with other literature data and a satisfactory agreement has been found.

关键词： Scaba 6SRgT impeller multistage agitator yield stress fluid stirred tank power consumption

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Stability of highly supersaturated vanadium electrolyte solution and characterization of precipitated phases for vanadium redox flow battery

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Journal of Energy Chemistry 2021年第10期30卷 436-445,I0012页

作者： Waldemir M.Carvalho Jr Laurent Cassayre delphine Quaranta Fabien Chauvet Ranine El-Hage Theodore Tzedakis Béatrice Biscans Laboratoire de génie Chimique Universitéde ToulouseCNRSINPUPSToulouseFrance

The vanadium redox flow battery(VRFB)has been receiving great attention in recent years as one of the most viable energy storage technologies for large-scale ***,higher concentrations of vanadium species are required in the H_(2)O-H_(2)SO_(4) electrolyte in order to improve the VRFB energy *** might lead to unwanted precipitation of vanadium compounds,whose nature has not been accurately characterized *** this purpose,this study reports the preparation ofⅤ^((Ⅱ)),ⅤV^((Ⅲ)),Ⅴ^((Ⅳ))andⅤ^((Ⅴ))supersaturated solutions in a 5 M H_(2)SO_(4)-H_(2)O electrolyte by an electrolytic method,from the only vanadium sulfate compound commercially available(VOSO_(4)).The precipitates obtained by ageing of the stirred solutions are representative of the solids that may form in a VRFB operated with such supersaturated *** solid phases are identified using thermogravimetric analysis,X-ray diffraction and *** report that dissolvedⅤ^((Ⅱ)),Ⅴ^((Ⅲ))andⅤ^((Ⅳ))species precipitate as crystals of VSO_(4),V_(2)(SO_(4))3 and VOSO_(4) hydrates and not in their anhydrous form;conversely V^((Ⅴ))precipitates as an amorphous V_(2) O_(5) oxide partially *** measured hydration degrees(respectively 1.5,9,3 and 0.26 mol of H_(2)O per mol of compound)might significantly affect the overall engineering of VRFB operating with high vanadium concentrations.

关键词： Vanadium Redox Flow Batteries Supersaturated electrolyte Precipitation Vanadium sulfate Vanadium hydrates

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An executive review of sludge pretreatment by sonication

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Journal of Environmental Sciences 2015年第11期27卷 139-153页

作者： Ngoc Tuan Le Carine Julcour-Lebigue Henri delmas University of Science Vietnam National University Université de Toulouse Laboratoire de Génie Chimique

Ultrasonication（US）, which creates hydro-mechanical shear forces in cavitation, is an advanced technology in sludge pretreatment. However, there are many factors affecting the efficacy of cavitation and ultrasonication disintegration of sludge as a *** objective of this work is to present an extensive review of evaluation approaches of sludge US pretreatment efficiency. Besides, optimization methodologies of related parameters,the differences of optimum values and the similarities of affecting trends on cavitation and sludge pretreatment efficiency were specifically pointed out, including ambient conditions,ultrasonic properties, and sludge characteristics. The research is a prerequisite for optimization of sludge US pretreatment efficiency in lab-scale and practical application. There is not-yet a comprehensive method to evaluate the efficiency of sludge US pretreatment, but some main parameters commonly used for this purpose are degree of sludge disintegration, proteins,particle size reduction, etc. Regarding US parameters, power input PUS, intensity IUS, and frequency FSseem to have significant effects. However, the magnitude of the effect of PUSand probe size in terms of IUShas not been clearly detailed. Investigating very low FSseems interesting but has not yet been taken into consideration. In addition, static pressure effect has been marginally studied only and investigation on the effect of pH prior to US process has been restricted. Their effects therefore should be varied separately and simultaneously with other related parameters, i.e. process conditions, ultrasonic properties, and sludge characteristics, to optimize sludge US pretreatment process.

关键词： Ultrasonic pretreatment Waste activated sludge Sludge disintegration Acoustic frequency Intensity effect Pressure effect

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Electrical model parameters identification of radiofrequency discharge in argon through 1D3V/PIC-MC model

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Plasma Science and Technology 2018年第9期20卷 106-113页

作者： Mohamed MOSTAFAOUI Djilali BENYOUCEF Laboratoire génie Electrique et Energies Renouvelables Université Hassiba Benbouali de Chlef

This work represents a contribution to the modeling of a radiofrequency（RF） discharge in argon at low pressure（from 25 to 200 mTorr）.It is started by the validation of the collision cross sections used in the particle model through a comparison between the transport coefficients calculated by these data and the measurements of the transport coefficients already exist in the literature,the particle model is also validated by a comparison between the calculated plasma density and that measured in the *** electrical model proposed in this work consists of replacing the RF discharge by a passive circuit（resistance in series with a capacitor）,where the resistance represents the plasma medium and the obstruction of the passage of the electronic current,and the capacitor represents the sheaths and the appearance of the displacement current in these *** parameters of the electrical model are obtained through particle *** electrical model presented accurately reproduces the current of the discharge,but without considering the phenomenon of *** total harmonic distortion rate follows the variation of the plasma density;its maximum value is 5.75% at 100 mTorr.

关键词： electrical model least square method particle model radiofrequency discharge static parameters identification

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Chemical Availability of Cd, Pb and Zn in Anthropogenically Polluted Soil: Assessing the geochemical Reactivity and Oral Bioaccessibility

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Pedosphere 2017年第3期27卷 616-629页

作者： Christophe WATERLOT Francis DOUAY Aurélie PELFRENE Yncréa Hauts-de-France Laboratoire Génie Civil et géo Environnement (LGCgE)

The most recent in vitro tests used to determine metal bioaccessiblility are generally time-consuming and expensive. This study aimed at determining potential relationships between the concentrations of metals extracted using single-extraction methods and the concentrations of bioaccessible metals assessed by a harmonised in vitro test, the Unified BARgE Method （UBM）. A total number of 27 soil samples were collected from kitchen gardens and lawns with various physicochemical parameters and contamination levels. Significant relationships were obtained between Cd, Pb and Zn extracted in gastric and gastrointestinal phases and using single extractions. The best relationhips were established using acetic and citric acids for Cd, whereas for Pb, citric acid and ethylenedi- aminetetraacetic acid （EDTA） were identified as the best extractants. These relationships were improved by means of a linear multiple regression with a downward stepwise procedure involving agronomic parameters （soil cation exchange capacity and assimilated P）. This method highlighted the fact that the cation exchange capacity and P contents in soils were the two main parameters that controlled the human bioaccessibility of Cd, Pb and Zn in the gastric phase. Besides, the metal concentrations extracted with the acetic and citric acids correlated well with the metal concentrations in the gastric and gastrointestinal phases, suggesting that the bioaceessible metals were mainly in a soluble form, weakly bound to the organic matter and associated with the carbonates and the Fe and Mn oxides/hydroxides in soils.

关键词： gastric phase gastrointestinal phase linear multiple regression single extractant urban soil

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Soil-Structure Interaction Effects on Dynamic Behaviour of Transmission Line Towers

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Computers, Materials & Continua 2022年第1期70卷 1461-1477页

作者： Abir Jendoubi Frédéric Legeron facultéde génie Universitéde SherbrookeQuébecJ1K 2R1Canada Parsons Abu DhabiP.O.5498UAE

As inferred from earthquake engineering literature,considering soil structure interaction(SSI)effects is important in evaluating the response of transmission line towers(TLT)to dynamic loads such as impulse *** proposed study investigates the dynamic effects of SSI on TLT *** and non-linearmodels are *** the linearmodel,the soil is represented by complex impedances,dependent of dynamic frequency,determined from numerical *** nonlinearmodel considers the soil non-linear behavior in its material constitutive law and foundation uplift in a non-linear time history *** simplified structure behavior of a typical lattice transmission tower is *** analysis of frequency and time domain are followed through varying soil stiffness and damping *** different shock durations are *** soil-structure system with equivalent dynamic properties is *** behaviors achieved utilizing a rigid and a flexible base for the structures is compared to estimate the impact of taking SSI into account in the *** current mainstream approach in structural engineering,emphasizing the importance of the SSI effect,is illustrated using an example where the SSI effect could be detrimental to the ***,the non-linear analysis results are analyzed to show the linear approach’s limitations in the event of grand deformations.

关键词： Tower shock loads non-linear dynamic soil-structure interaction

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