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Efficacy evaluation for the treatment of unstable lumbar disc herniation by traditional and modified lamina osteotomy replantation

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Chinese medical Journal 2013年第15期126卷 2840-2845页

作者： XU Hong-hai WANG Xiao-qing ZHANG Yue-lin GUO Xiong LIU Zong-zhi LUO Zhen-qun MA Qiang ZOU Qing- yang LIU Cong FANG Hai-bo Xi An Jiao Tong univ Coll Med Shaanxi Prov Pepoples Hosp Affiliated Hosp 3Dept Orthopaed Xian 710061 Shaanxi Peoples R China Xi An Jiao Tong univ Coll Med Shaanxi Prov Pepoples Hosp Affiliated Hosp 3Dept Neurosurg Xian 710061 Shaanxi Peoples R China Xi An Jiao Tong univ Coll Med Dept Fac Publ Hlth Xian 710061 Shaanxi Peoples R China

Background The traditional lamina osteotomy replantation method is prone to nerve root injury and low back pain recurrence. Our team has proposed a modified approach that improves the osteotomy site and its fixation procedure. The aim of this study was to evaluate the clinical efficacy of traditional and modified lamina replantation methods in treating unstable lumbar disc herniation. Methods From March 2008 to August 2011, 124 patients with unstable lumbar disc herniation were enrolled and randomly divided into the following two groups according to random digital table： group A （traditional group） consisting of 61 patients who underwent traditional laminectomy replantation, and group B （modified group） consisting of 63 patients who underwent modified lamina replantation. Both surgeries were performed by the same surgeons. The two groups had no significant difference in gender, age, symptoms, time of onset and the prominent segment. Visual analogue scale （VAS）, Oswertry disability index （ODI）, and Japanese Orthopaedic Association （JOA） scores, operative time, blood loss, complication rate, radiographic healing rates, and low back pain recurrence rates were compared between the two groups. Results There were 121 patients followed up for more than one year, and the follow-up rate was 97.6%. Nerve injury occurred in two patients （3.3%） in the modified group and 12 patients （20.0%） in the traditional group. Dural injury occurred in one patient （1.6%） in the modified group and seven patients （11.7%） in the traditional group. Pseudarthrosis occurred in two patients in the modified group and in 18 patients in the traditional group with 1-year fusion rates of 96.7% and 70.0%, respectively. Recurrence of lower back pain after one year was noted in three patients （4.9%） in the modified group, and in 15 （25.0%） in the traditional group. Leg pain recurrence was noted in one patient （1.6%） in the modified group and in three cases （5.0%） in the traditional group. The one-year hea

关键词： lumbar disc herniation lamina replantation spine clinical outcome

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Early Goal Directed Sedation, a bridge to better clinical outcomes

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Chinese medical Journal 2014年第10期127卷 1969-1972页

作者： Yahya Shehabi univ New S Wales Sch Clin Randwick NSW 2301 Australia Monash univ Fac Med Nursing & Hlth Sci Melbourne Vic 3004 Australia Prince Wales Hosp Randwick NSW 2031 Australia

Critical care has become a central part of modern medicine and an integral essential to improve the outcomes in acute *** increasing complexity of surgical procedures,severity of co-morbid diseases,life expectancy and societal expectation is likely to escalate the burden and the global need for critical care *** millions of patients are ventilated worldwide every year,projections suggest that the number of ventilated patients is expected to rise by 31% over the following decade.1

关键词： sedation early goal directed sedation ventilation critically ill dexmedetomidine

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PNAS:科学家发现新的精子运动调节器

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现代生物医学进展 2017年第27期17卷 I0001-I0002页

作者： Castaneda, Julio M. Hua, Rong Miyata, Haruhiko Oji, Asami Guo, Yueshuai Cheng, Yiwei Zhou, Tao Guo, Xuejiang Cui, Yiqiang Shen, Bin Wang, Zibin Hu, Zhibin Zhou, Zuomin Sha, Jiahao Prunskaite-Hyyrylainen, Renata Yu, Zhifeng Ramirez-Solis, Ramiro Ikawa, Masahito Matzuk, Martin M. Liu, Mingxi Baylor Coll med Dept Pathol & Immunol Houston TX 77030 USA Osaka univ Res Inst Microbial Dis Suita Osaka 5650871 Japan Nanjing med univ State Key Lab Reprod Med Nanjing 210029 Jiangsu Peoples R China Nanjing med univ Dept Histol & Embryol Nanjing 210029 Jiangsu Peoples R China Osaka univ Grad Sch Pharmaceut Sci Suita Osaka 5650871 Japan Nanjing med univ Anim Core Facil Nanjing 210029 Jiangsu Peoples R China Baylor Coll med Ctr Reprod Med Houston TX 77030 USA univ Oulu Fac Biochem & Mol Med FI-90014 Oulu Finland Baylor Coll med Ctr Drug Discovery Houston TX 77030 USA Wellcome Trust Sanger Inst Hinxton CB10 1SA England univ Tokyo Inst Med Sci Minato Ku Tokyo 1088639 Japan Baylor Coll med Dept Mol & Cellular Biol Houston TX 77030 USA Baylor Coll med Dept Mol & Human Genet Houston TX 77030 USA Baylor Coll med Dept Pharmacol Houston TX 77030 USA

南京医科大学生殖医学国家重点实验室、基础医学院组织胚胎学系刘明兮课题组与贝勒医学院***课题组、大阪大学MasahitoIkawa课题组等共同解析了一个精子运动调节基因TCTE1，结果发表于《美国科学院院刊》（PNAs）。

关键词：精子运动调节器科学家国家重点实验室组织胚胎学课题组生殖医学医科大学

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Nonlinear dynamics of electroencephalography study in schizophrenic patients

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Chinese medical Journal 2013年第15期126卷 2886-2889页

作者： CHEN Xing-shi XU Yi-feng TANG Yun-xiang FANG Yi-ru ZHANG Chen ZHANG Ming-dao LOU Fei-ying LIANG Jian-hua CHEN Chong PAN Xiao YAN Jin CUI Yi Shanghai Jiao Tong univ Shanghai Mental Hlth Ctr Dept Electrophysiol Shanghai 200030 Peoples R China Shanghai Jiao Tong univ Shanghai Mental Hlth Ctr Dept Psychiat Shanghai 200030 Peoples R China PLA Mil Med Univ 2 Fac Psychol & Mental Hlth Shanghai 200433 Peoples R China

Background Few characteristic changes of linear electroencephalograph （EEG） have been reported in schizophrenia. The aim of the present study was to investigate the changes in temporal-spatial dimensional properties of EEG under different cognitive tasks in patients with schizophrenia. Methods EEG was recorded by using EEG-1518K system and mapping system （Nihon Kohden Tomioka Corporation, Japan） in 45 schizophrenic patients and 47 healthy adults （normal control, NC） under five states： eyes c^osed, eyes open, mental arithmetic test with eyes closed, memory test with eyes open, and number cancellation test. Correlation dimension （D2） and point-wise correlation dimension （PD2） were calculated for all EEG analyses. Results （1） There were no significant differences of D2 and PD2 between NC and schizophrenic patients under states of eyes open and closed. （2） Compared with NC, schizophrenic patients showed decreased performance of D2 in mental arithmetic test with eyes closed and number cancellation test （mental arithmetic test with eyes closed： Nc 5.9±0.6, Sch 3.0＋0.8; number cancellation test： Nc 6.0±0.6, Sch 4.4±0.7; P 〈0.05 or P 〈0.01）. （3） Schizophrenic patients also showed decrease performance of PD2 in mental arithmetic test with eyes closed, memory test with eyes open, and number cancellation test （mental arithmetic test with eyes closed： Nc 6.9±0.7, Sch 4.0±0.8; memory test with eyes open： Nc 6.6±0.8, Sch 5.0±0.9; number cancellation test： Nc 7.1±0.7, Sch 4.8±0.9; P 〈0.05 or P 〈0.01）. Conclusions Nonlinear dynamic analysis provided a new approach in clinical investigation of EEG signals. It was helpful to further understand the cerebral mechanism in schizophrenic cognitive process.

关键词： schizophrenia electroencephalography nonlinear dynamics cognition

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假性表皮剥脱综合征继发小瞳孔患者晶状体超声乳化术中不同扩瞳方法比较

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 51-52页

作者： Akman A. Yilmaz G. Oto S. Akova Y.A. 张磊 Department of Ophthalmolog y Baskent Univ. Fac. of Med.Ankara Turkey Dr.

Purpose To compare 4 methods for intraoperative pupil dilatation in eyes with pseudoexfoliation syndrome and insufficient pupil size during phacoemulsificatio n. Design Prospective, randomized, comparative, interventional case series. Part icipants Forty eyes of 40 patients with pseudoexfoliation and maximally dilated pupil size smaller than 3.5 mm. Intervention Mechanical pupil dilatation with ir is-retractor hooks (group I), polymethyl methacrylate (PMMA) pupil dilator-rin g (Morcher, Stuttgart, Germany) (group II),Beehler pupil dilator (group III), an d bimanual stretching (group IV). Main outcome measures Performance (pupil size achieved), complications, and added surgical time. Results The mean pupil sizes achieved with the PMMA pupil-dilator ring, Beehler pupil dilator, and bimanual stretching were 5.9±0.6 mm, 5.5±0.8 mm, and 4.9±0.7 mm, respectively. A squar e-shaped pupil was achieved with iris-retractor hooks, and the mean size of th e largest circle that can fit in this square was 5.6±0.6mm. There were no stati stically significant differences in the postdilatation pupil sizes between the 4 study groups (P >0.05). Apart from self-limited intraoperative hemorrhage from pupil margin, iris sphincter rupture was the only observed complication related to mechanical pupil dilatation. This occurred in 4 eyes in groups I and III, 3 eyes in group IV, and 1 eye in group II (P >0.05). The mean added surgical time for placement of iris-retractor hooks and for implantation of a PMMA pupil-dil ator ring was 297±51 and 176±54 seconds, respectively. The additional time req uired for pupil dilatation with the Beehler pupil dilator and bimanual stretchin g was 65±8 and 55±10 seconds, respectively. The time needed for pupil dilatati on in groups I and II is significantly longer than that in groups III and IV(P< 0.001). Conclusions All 4 methods used in this study were effective procedures f or the mechanical dilatation of small pupils secondary to pseudoexfoliation synd rome

关键词：小瞳孔表皮剥脱扩瞳瞳孔缘晶状体乳化术假性剥脱大瞳孔牵引钩拉法扩张器

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Structural and optical properties of nano-spin coated sol-gel porous TiO_2 films

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Transactions of Nonferrous Metals Society of China 2012年第12期22卷 3003-3011页

作者： M.M.El-NAHASS M.H.ALI A.El-DENGLAWEY Physics Department Faculty of Education Ain Shams University Roxy Cairo 11757 Egypt Physics Department Faculty of Science Ain Shams University Cairo Egypt Physics Department Faculty of Science South Valley University Qena 83523 Egypt Phys Dep Fac of Appl Med Sci Turabah 21995 Taif University KSA

Three thicknesses of TiO2 films, 174, 195, and 229 nm, were deposited onto quartz substrates by sol–gel spin coating method. The as-deposited thin films were characterized by nano-crystallite with different sizes (19–46 nm) and relatively high porous structure. Optical constants were determined and showed the lowest refractive index of 1.66 for the as-prepared films that ever reported till now. Obtained results were discussed through current theoretical ideas.

关键词： TiO2 films optical properties nanostructure electron microscopy thin films spin coating technique

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希腊克里特岛5532例孕妇弓形体的感染率:185例高危孕妇的处理

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世界核心医学期刊文摘（妇产科学分册） 2005年第4期1卷 27-28页

作者： Antoniou M. Tzouvali H. Sifakis S. 高雪莲 Laboratory of Clinical Bacteriology Parasitology Zoonoses Geogr. Med. Fac. Med. U. Heraklion Greece

Objectives: To study the incidence of toxoplasmosis in pregnant women in Crete and to test a designed protocol for handling those at risk of delivering congenitally infected infants. Study design: Pregnant women were screened serologically over a period of 5 years. Cases with suspected acute toxoplasmosis were treated, peripheral blood (PB), and amniotic fluid (AF)tested by polymerase chain reaction (PCR) and culture, and fetuses monitored by ultrasonography. The absence of congenital infection in infants was confirmed by serology and clinical evaluation. Results: Of the 5532 pregnant women followed, 70.57%remained seronegative, 29.45%were seropositive, and there was direct evidence of seroconversion in six cases. Acute toxoplasmosis was suspected in 185 cases, maternal parasitemia was detected in five cases and positive amniotic fluid in one case. Congenital infection was excluded in all infants followed, based on the absence of ultrasound findings in utero, lack of clinical symptoms at birth, negative Western blotting (WB) at birth and 3 months later, and descending serology for a year. Conclusion: Overall, 29.45%of the pregnant women followed were seropositive, 3.3%with suspected acute toxoplasmosis, and in 0.02%cases there was evidence of maternofetal transmission. The protocol tested allowed differentiation between acute andlatent toxoplasmosis, safe management of the cases at risk and assisted in avoidance of unwarranted pregnancy terminations.

关键词：高危孕妇血清学筛查羊水检查弓形体母婴传播血清学阳性寄生虫血症聚合酶链反应高危病例超声监测

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A sperm GPI-anchored protein elicits sperm-cumulus cross-talk leading to the acrosome reaction

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南京医科大学学报（自然科学版） 2009年第4期29卷 529-529页

作者： Yin, L. Chung, C. M. Huo, R. Liu, H. Zhou, C. Xu, W. Zhu, H. Zhang, J. Shi, Q. Wong, H. Y.C. Chen, J. Lu, Y. Bi, Y. Zhao, C. Du, Y. Ma, M. Cai, Y. Chen, W. Y. Fok, K. L. Tsang, L. L. Li, K. Ni, Y. Chung, Y. W. Zhou, Z. Sha, J. Chan, H. C. Nanjing med univ Lab Reprod Med Dept Histol & Embryol Nanjing 210029 Peoples R China. Chinese univ Hong Kong Epithelial Cell Biol Res Ctr Li Ka Shing Inst Hlth Sci Dept Physiol Fac Med Hong Kong Hong Kong Peoples R China. Nanjing Agr univ Coll Anim Sci & Technol Nanjing 210095 Peoples R China. Zhejiang Acad med Sci Dept Reprod Physiol Hangzhou 310013 Zhejiang Peoples R China.

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土耳其人群乳糜泻的发病特征

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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 12-13页

作者： Elsurer R Tatar G Simsek H 徐小杰 Department of Internal M edicine Hacettepe Univ. Med. Fac.Hospital K. Mah. Galdiran Sok. Pk. Apt. 11/1 Ankara 06420 Turkey.Dr

Celiac disease (CD) is characterized by malabsorption of nutrients in the smal l intestine. The availability of highly specific and sensitive serologic tests h as facilitated its diagnosis, increasing the disease prevalence. The aim of this study was to determine the clinical, laboratory, and histopathological features of CD in Turkish adults. Between 1968 and 2002, CD patients presenting to the G astroenterology Unit were evaluated retrospectively. From 2002, newly diagnosed patients were prospectively followed up. Sixty patients (39 female, 21 male)-we re included in the study. Mean body mass index was 22.2 ±5.4 kg/m2. The most co mmon symptoms were diarrhea, weight loss, and flatulence. Most common comorbidit ies were anemia,osteoporosis, type 1 diabetes mellitus, and steatohepatitis. Six (10.0%) patients had a family history of diabetes mellitus; one (1.7%) patient had a family history of CD. Plasma glucose and serum γ-glutamyltransferase levels were significantly hig her in females than males. Most common histopathological findings were increased lymphocytes in the lamina propria (76.2%) and villus epithelium (59.5%). Over the years, the cumulative frequency of CD increased more in females than males. This is thefirst study in the literature showing the characteristics of CD in T urkish adults. In our previous recent study, the prevalence of tissue transgluta minase antibody positivity in Turkish healthy blood donors was 1.3%, indicating a high prevalence of CD in our population. In this study, the cumulative freque ncy of CD increased more in females than males. With the better understanding an d increased suspicion of the disease, more patients are being diagnosed in our p opulation.

关键词：乳糜泻发病特征黏膜固有层肠胃胀气糖尿病家族史吸收障碍骨质疏松肠营养平均体重指数确诊患者

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腹腔镜下子宫颈根治术

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世界核心医学期刊文摘（妇产科学分册） 2005年第10期1卷 39-40页

作者： Cibula D Ungálpálfálvi L 张旸 Dept. of Obstetrics and Gynecology General Faculty Hospital 1st Med. Fac. of Charles University Apolinarska 18 Prague 2 Czech Republic

Background. Radical trachelectomy is a fertility preserving alternative for young women with early stages of cervical cancer. Currently, a technique of abdominal radical approach is used in a few centres. With growing availability of laparoscopy, a novel technique of laparoscopic radical trachelectomy might be an alternative. Case. Presented is one case of laparoscopic pelvic lymphadenectomy with radical trachelectomy in young woman with IB cervical cancer. No intraoperative or postoperative complications occurred. Operation time reached 250 min, estimated blood loss was 250 ml. Limited follow- up of 9 months was uneventful and patient indicates normal menstrual pattern and satisfactory sexual intercourse. Conclusion. Laparoscopic abdominal radical trachelectomy with pelvic lymphadenectomy might be an alternative technique in the treatment of early stages cervical cancer in patients who desire future pregnancy. The procedure is in principle identical to the standard abdominal radical hysterectomy. Centres practising laparoscopic radical hystertectomy can adopt the technique without any special surgical training.

关键词：腔镜根治术早期宫颈癌腹根估计失血量手术时间操作原则

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