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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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新型随动系统的非线性控制和综合方法及实验验证(英文)

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电工技术学报 2006年第4期21卷 79-86页

作者：谭耀龙张洁 florida State University florida fl32310 U.S.A

提出了一种新的电动机随动系统的非线性控制和综合方法。通过引进逆步式设计方法和流程,作者提出了新的随动系统非线性控制的算法和解析解,并且推证了系统的指数式稳定性。进而,作者将非线性控制算法和解析解演化为新的非线性控制系统... 详细信息

提出了一种新的电动机随动系统的非线性控制和综合方法。通过引进逆步式设计方法和流程,作者提出了新的随动系统非线性控制的算法和解析解,并且推证了系统的指数式稳定性。进而,作者将非线性控制算法和解析解演化为新的非线性控制系统结构图。在通过数字仿真验证了理论推导后,作者用了单片DSP(TMS320C32)来实现新的电动机随动系统的非线性数字控制。实验和仿真结果验证了新的控制结构和综合方法可以提高随动控制系统的外环频带宽度,减少对于斜坡给定信号的跟踪误差,和提高抗负荷干扰的性能。

关键词：非线性随动控制单片DSP机数字控制系统系统参数负载变化外环频带宽度和斜坡跟踪误差抗负荷干扰性能

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Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

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Neural Regeneration Research 2025年第8期20卷 2218-2230页

作者： Rahul Mittal Keelin McKenna Grant Keith Evan McKenna Joana R.N.Lemos Jeenu Mittal Khemraj Hirani Diabetes Research Institute University of Miami Miller School of MedicineMiamiFLUSA Department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

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集成双向半导体功率模块矩阵式变频器及其自适应换流(英文)

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电工技术学报 2005年第1期20卷 66-76页

作者：张洁 Sum Tom 王安华 Braun Dennis florida State University fl32310 U.S.A. Rockwell Seientifie Company CA91320 U.S.A.

长期以来,单晶片双向功率开关元件一直处于尚待开发状态,连同电流幅值的大幅度交变所引起的换流电路的困难和系统控制的复杂性,使矩阵式变流器的实验研究限制在很低的功率范围,低于1～3hp.这篇论文提出了一种新的3转1相模块式组合设计方... 详细信息

长期以来,单晶片双向功率开关元件一直处于尚待开发状态,连同电流幅值的大幅度交变所引起的换流电路的困难和系统控制的复杂性,使矩阵式变流器的实验研究限制在很低的功率范围,低于1～3hp.这篇论文提出了一种新的3转1相模块式组合设计方法,和新的中到中高功率级的3合1集成双向半导体元件功率模块(IBPM).这种组合电路分区优化的主电路集成模块设计可减少交-交变频器换流电路的寄生高频电感,使主电路接线终端数最小化,并简化交流总线的结构和配线设计.自适应时序换流的优化设计进一步提高了变流器在高幅度交流负荷下的可靠换流能力.论文给出了该变频器输入输出均获得高于几百Hz基频的满意的实验控制和结果及其双向控制能力,并验证了它的优化设计方法.

关键词：高频单级交-交变换半导体双向功率开关集成双向功率模块(IBPM) 自适应时序换流设计输入电流谐波和控制输入总功率因数FPGA设计

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A novel supercapacitor-fuel cell hybrid cell

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Rare Metals 2006年第Z1期25卷 12-18页

作者： WANG Y ZHENG Jim P Department of Electrical and Computer Engineering Florida A&M University and Florida State University Tallahassee FL 32310 USA Department of Electrical and Computer Engineering Florida A&M University and Florida State University Tallahassee FL 32310 USA

A monolithic hybrid fuel cell (MHFC) with a novel configuration was proposed in an effort to improve the fuel cell performance during instantaneous power changes. A modified direct methanol fuel cell (DMFC) with a layer of hydrous ruthenium dioxide (RuO2·xH2O) sandwiched between the anode catalyst layer and membrane was used to demonstrate the principle of the MHFC. Experimental results indicate that the RuO2·xH2O layer is equivalent to a resistor-capacitor transmission line and functions similar to a capacitor in parallel with the anode electrode. The improvement in dynamic response of the MHFC was experimentally confirmed under step current change and square current pulse operating. The ionic conductivity of the RuO2·xH2O layer was also obtained.

关键词： hybrid devices direct methanol fuel cells hydrous ruthenium dioxide dynamic response

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Determination of growth kinetics of microorganisms linked with 1,4-dioxane degradation in a consortium based on two improved methods

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Frontiers of Environmental Science & Engineering 2022年第5期16卷 97-107页

作者： Yi Xiong Boya Wang Chao Zhou Huan Chen Gang Chen Youneng Tang Department of Civil and Environmental Engineering FAMU-FSU College of EngineeringFlorida State UniversityTallahasseeFL 32310USA Geosyntec Consultants Inc. Huntington BeachCA 92648USA National High Magnetic Field Laboratory TallahasseeFL 32310USA

The conventional method for determining growth kinetics of microbial consortia relies on the total biomass *** may be inaccurate for substrates that are uncommon in nature and can only be degraded by a small portion of the microbial community.1,4-dioxane,an emerging contaminant,is an example of such *** this work,we evaluated an improved method for determining the growth kinetics of a 1,4-dioxane-degrading microbial *** the improved method,we considered only bacterial taxa whose concentration increase correlated to 1,4-dioxane concentration decrease in duplicate microcosm *** PEST(Parameter Estimation),a modelindependent parameter estimator,the kinetic constants were estimated by fitting the Monod kineticsbased simulation results to the experimental data that consisted of the concentrations of 1,4-dioxane and the considered bacterial *** estimated kinetic constants were evaluated by comparing the simulation results with experimental results from another set of microcosm *** evaluation was quantified by the sum of squared relative residual,which was four orders of magnitude lower for the improved method than the conventional *** further dividing the considered bacterial taxa into oligotrophs and copiotrophs,the sum of squared relative residual further decreased.

关键词： Biodegradation 1,4-Dioxane Kinetics Microbial consortium 16S rRNA

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Adaptive base-isolation of civil structures using variable amplification

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Earthquake Engineering and Engineering Vibration 2006年第2期5卷 223-233页

作者： Kenneth K. Walsh Makola M. Abdullah Department of Civil and Environmental Engineering FAMU-FSU College of Engineering Tallahassee FL 32310 USA

Semi-active dampers are used in base-isolation to reduce the seismic response of civil engineering structures. In the present study, a new semi-active damping system using variable amplification will be investigated for adaptive baseisolation. It uses a novel variable amplification device （VAD） connected in series with a passive damper. The VAD is capable of producing multiple amplification factors, each corresponding to a different amplification state. Forces from the damper are amplified to the structure according to the current amplification state, which is selected via a semi-active control algorithm specifically tailored to the system＇s tmique damping characteristics. To demonstrate the effectiveness of the VAD-damper system for adaptive base-isolation, numerical simulations are conducted for three and seven-story base-isolated buildings subject to both far and near-field ground motions. The results indicate that the system can achieve significant reductions in response compared to the base-isolated buildings with no damper. The proposed system is also found to perform well compared to a typical semi-active damper.

关键词： adaptive systems amplification base-isolation damping earthquake resistant structures multistorybuildings seismic isolation structural control

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On the Importance of High-Resolution in Large-Scale Ocean Models

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Advances in Atmospheric Sciences 2021年第10期38卷 1621-1634页

作者： Eric *** Xiaobiao XU Center for Ocean-Atmospheric Prediction Studies(COAPS) Florida State UniversityTallahasseeFL32310USA

Eddying global ocean models are now routinely used for ocean prediction,and the value-added of a better representation of the observed ocean variability and western boundary currents at that resolution is currently being evaluated in climate *** overview article begins with a brief summary of the impact on ocean model biases of resolving eddies in several global ocean-sea ice numerical ***,a series of North and Equatorial Atlantic configurations are used to show that an increase of the horizontal resolution from eddy-resolving to submesoscale-enabled together with the inclusion of high-resolution bathymetry and tides significantly improve the models’abilities to represent the observed ocean variability and western boundary ***,the computational cost of these simulations is extremely large,and for these simulations to become routine,close collaborations with computer scientists are essential to ensure that numerical codes can take full advantage of the latest computing architecture.

关键词： ocean modeling numerical models horizontal resolution boundary currents

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Incorporating travel time reliability in predicting the likelihood of severe crashes on arterial highways using non-parametric random-effect regression

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第5期6卷 470-481页

作者： Emmanuel Kidando Ren Moses Eren Erman Ozguven Thobias Sando Department of Civil and Environmental Engineering FAMU-FSU College of Engineering Florida State University Tallahassee FL 32310 USA Department of Civil and Environmental Engineering FAMU-FSU College of Engineering Florida A & M University Tallahassee FL 32310 USA School of Engineering University of North Florida Jacksonville FL 32256 USA

Travel time reliability(TTR) modeling has gain attention among researchers’ due to its ability to represent road user satisfaction as well as providing a predictability of a trip travel *** this significant effort,its impact on the severity of a crash is not well *** study analyzes the effect of TTR and other variables on the probability of the crash severity occurring on arterial *** address the unobserved heterogeneity problem,two random-effect regressions were applied;the Dirichlet random-effect(DRE)and the traditional random-effect(TRE) logistic *** difference between the two models is that the random-effect in the DRE is non-parametrically specified while in the TRE model is parametrically *** Markov Chain Monte Carlo simulations were adopted to infer the parameters’ posterior distributions of the two developed *** four-year police-reported crash data and travel speeds from Northeast florida,the analysis of goodness-of-fit found the DRE model to best fit the ***,it was used in studying the influence of TTR and other variables on crash *** DRE model findings suggest that TTR is statistically significant,at 95 percent credible intervals,influencing the severity level of a crash.A unit increases in TTR reduces the likelihood of a severe crash occurrence by 25 ***,among the significant variables,alcohol/drug impairment was found to have the highest impact in influencing the occurrence of severe *** significant factors included traffic volume,weekends,speed,work-zone,land use,visibility,seatbelt usage,segment length,undivided/divided highway,and age.

关键词： Travel time reliability Crash severity Non-parametric distributed random-effect Gaussian distributed random-effect Dirichlet process prior

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Evaluating foot reflexology as a proposed treatment for sensorineural hearing loss:A critical review

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World Journal of Clinical Cases 2025年第4期13卷 15-17页

作者： Carina McClean Brandon Lucke-Wold College of Medicine University of FloridaGainesvilleFL 32610United States Lillian S.Wells Department of Neurosurgery University of FloridaGainesvilleFL 32608United States

This editorial critically evaluates the application of foot reflexology as a treatment for sensorineural hearing loss(SNHL)in infants,as proposed in a case report published in the World of Clinical *** is a condition characterized by damage to the cochlea or the neural pathways that transmit auditory information to the *** etiology of SNHL is often complex,involving genetic mutations,prenatal factors,or perinatal ***,an alternative therapy involving the application of pressure to specific points on the feet,is based on the hypothesis that these points correspond to different organs and systems in the body,including the auditory ***,the biological plausibility and clinical efficacy of foot reflexology in addressing SNHL lack empirical *** editorial examines the pathophysiology of SNHL,assesses the clinical claims of reflexology practitioners,and emphasizes the necessity of evidence-based approaches in treating infant hearing *** complementary therapies may provide ancillary benefits,they should not supplant validated medical treatments in managing SNHL in *** research is needed to evaluate the safety and efficacy of foot reflexology and other alternative therapies in pediatric audiology.

关键词： Sensorineural hearing loss Reflexology Congenital hearing loss Alternative medicine Audiology

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